SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3dw8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK7_B_ADNB1246_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3dw8 SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
55 KDA REGULATORY
SUBUNIT B ALPHA
ISOFORM
(Homo
sapiens) 		4 / 8 GLY B  46
VAL B  52
SER B  32
ILE B  99
 None
 0.83A 1pk7B-3dw8B:
undetectable		 1pk7B-3dw8B:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VE3_A_SAMA302_0
(HYPOTHETICAL PROTEIN
PH0226)		 3dw8 SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
55 KDA REGULATORY
SUBUNIT B ALPHA
ISOFORM
(Homo
sapiens) 		5 / 12 ALA B  28
GLY B  50
ILE B  30
SER B  32
ALA B  26
 None
 1.09A 1ve3A-3dw8B:
undetectable		 1ve3A-3dw8B:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_A_H4BA1290_1
(PTERIDINE REDUCTASE
1)		 3dw8 SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
55 KDA REGULATORY
SUBUNIT B ALPHA
ISOFORM
(Homo
sapiens) 		4 / 8 SER B 289
PHE B 346
LEU B 336
LEU B 329
 None
 0.98A 2bfpA-3dw8B:
undetectable		 2bfpA-3dw8B:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_B_H4BB1290_1
(PTERIDINE REDUCTASE
1)		 3dw8 SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
55 KDA REGULATORY
SUBUNIT B ALPHA
ISOFORM
(Homo
sapiens) 		4 / 8 SER B 289
PHE B 346
LEU B 336
LEU B 329
 None
 0.95A 2bfpB-3dw8B:
undetectable		 2bfpB-3dw8B:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EBZ_B_017B201_1
(PROTEASE)		 3dw8 SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
55 KDA REGULATORY
SUBUNIT B ALPHA
ISOFORM
(Homo
sapiens) 		5 / 11 ARG B 330
LEU B 333
ASP B 340
ILE B 285
ILE B 342
 None
 1.14A 3ebzA-3dw8B:
undetectable		 3ebzA-3dw8B:
12.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FBX_A_ACTA608_0
(PUTATIVE
PHOSPHOLIPASE B-LIKE
2)		 3dw8 SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
55 KDA REGULATORY
SUBUNIT B ALPHA
ISOFORM
(Homo
sapiens) 		3 / 3 GLU B 407
VAL B 397
CYH B 398
 None
 0.93A 3fbxA-3dw8B:
undetectable		 3fbxA-3dw8B:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_D_ROFD904_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 3dw8 SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
55 KDA REGULATORY
SUBUNIT B ALPHA
ISOFORM
(Homo
sapiens) 		3 / 3 ASN B 386
MET B 368
PHE B 442
 None
 0.84A 3g4lD-3dw8B:
undetectable		 3g4lD-3dw8B:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_A_FLRA700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3dw8 SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
55 KDA REGULATORY
SUBUNIT B ALPHA
ISOFORM
(Homo
sapiens) 		5 / 12 VAL B  52
LEU B 111
VAL B 164
ALA B 166
SER B 167
 None
 1.00A 3rr3A-3dw8B:
undetectable		 3rr3A-3dw8B:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_B_FLRB700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3dw8 SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
55 KDA REGULATORY
SUBUNIT B ALPHA
ISOFORM
(Homo
sapiens) 		5 / 12 VAL B  52
LEU B 111
VAL B 164
ALA B 166
SER B 167
 None
 0.98A 3rr3B-3dw8B:
undetectable		 3rr3B-3dw8B:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_C_FLRC700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3dw8 SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
55 KDA REGULATORY
SUBUNIT B ALPHA
ISOFORM
(Homo
sapiens) 		5 / 12 VAL B  52
LEU B 111
VAL B 164
ALA B 166
SER B 167
 None
 0.99A 3rr3C-3dw8B:
undetectable		 3rr3C-3dw8B:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_D_FLRD700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3dw8 SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
55 KDA REGULATORY
SUBUNIT B ALPHA
ISOFORM
(Homo
sapiens) 		5 / 12 VAL B  52
LEU B 111
VAL B 164
ALA B 166
SER B 167
 None
 0.99A 3rr3D-3dw8B:
undetectable		 3rr3D-3dw8B:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUM_A_IMNA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3dw8 SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
55 KDA REGULATORY
SUBUNIT B ALPHA
ISOFORM
(Homo
sapiens) 		5 / 12 HIS B 326
LEU B 306
LEU B 333
LEU B 336
TYR B 305
 None
 1.29A 4xumA-3dw8B:
undetectable		 4xumA-3dw8B:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DLV_A_5D5A930_0
(ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 2)		 3dw8 SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
55 KDA REGULATORY
SUBUNIT B ALPHA
ISOFORM
(Homo
sapiens) 		5 / 12 LEU B 253
THR B 191
LEU B 202
ILE B 217
PHE B 242
 None
 1.39A 5dlvA-3dw8B:
undetectable		 5dlvA-3dw8B:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DLV_B_5D5B927_0
(ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 2)		 3dw8 SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
55 KDA REGULATORY
SUBUNIT B ALPHA
ISOFORM
(Homo
sapiens) 		5 / 12 LEU B 253
THR B 191
LEU B 202
ILE B 217
PHE B 242
 None
 1.40A 5dlvB-3dw8B:
undetectable		 5dlvB-3dw8B:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DSG_A_0HKA1201_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M4,ENDOLYSIN,ENDOLYS
IN,MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4)		 3dw8 SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
55 KDA REGULATORY
SUBUNIT B ALPHA
ISOFORM
(Homo
sapiens) 		3 / 3 ASN B 237
LEU B 313
PHE B 234
 None
 0.77A 5dsgA-3dw8B:
undetectable		 5dsgA-3dw8B:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSA_A_X2NA590_2
(CYP51 VARIANT1)		 3dw8 SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
55 KDA REGULATORY
SUBUNIT B ALPHA
ISOFORM
(Homo
sapiens) 		3 / 3 PRO B 236
ILE B  99
SER B 296
 None
 0.79A 5fsaA-3dw8B:
undetectable		 5fsaA-3dw8B:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A7P_B_9SCB601_0
(SERUM ALBUMIN)		 3dw8 SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
55 KDA REGULATORY
SUBUNIT B ALPHA
ISOFORM
(Homo
sapiens) 		5 / 12 ILE B  30
LEU B 306
LEU B 336
PHE B 415
LEU B 413
 None
 1.50A 6a7pB-3dw8B:
undetectable		 6a7pB-3dw8B:
22.17