SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3dwb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7W_A_MTXA301_1
(PTERIDINE REDUCTASE)		 3dwb ENDOTHELIN-CONVERTIN
G ENZYME 1
(Homo
sapiens) 		5 / 12 PRO A 586
LEU A 596
LEU A 698
LEU A 112
MET A 115
 None
 1.31A 1e7wA-3dwbA:
undetectable		 1e7wA-3dwbA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EA1_A_TPFA470_1
(CYTOCHROME P450
51-LIKE RV0764C)		 3dwb ENDOTHELIN-CONVERTIN
G ENZYME 1
(Homo
sapiens) 		4 / 8 PHE A 531
PHE A 538
THR A 233
LEU A 398
 None
 1.12A 1ea1A-3dwbA:
undetectable		 1ea1A-3dwbA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IG3_A_VIBA502_1
(THIAMIN
PYROPHOSPHOKINASE)		 3dwb ENDOTHELIN-CONVERTIN
G ENZYME 1
(Homo
sapiens) 		4 / 8 LEU A 292
SER A 403
GLN A 408
ASP A 407
 None
 0.95A 1ig3A-3dwbA:
undetectable
1ig3B-3dwbA:
undetectable		 1ig3A-3dwbA:
17.65
1ig3B-3dwbA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IG3_B_VIBB501_1
(THIAMIN
PYROPHOSPHOKINASE)		 3dwb ENDOTHELIN-CONVERTIN
G ENZYME 1
(Homo
sapiens) 		4 / 7 GLN A 408
ASP A 407
LEU A 292
SER A 403
 None
 1.17A 1ig3A-3dwbA:
undetectable
1ig3B-3dwbA:
undetectable		 1ig3A-3dwbA:
17.65
1ig3B-3dwbA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT5_A_RTLA176_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 3dwb ENDOTHELIN-CONVERTIN
G ENZYME 1
(Homo
sapiens) 		5 / 12 LEU A 695
LEU A 708
ALA A 129
MET A 115
LEU A 112
 None
 1.41A 1kt5A-3dwbA:
undetectable		 1kt5A-3dwbA:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_A_ACTA1869_0
(FPRA)		 3dwb ENDOTHELIN-CONVERTIN
G ENZYME 1
(Homo
sapiens) 		4 / 4 ASP A 671
HIS A 607
ARG A 738
GLU A 667
 None
ZN  A 771 ( 3.4A)
RDF  A 817 (-3.0A)
ZN  A 771 ( 2.1A)
 1.13A 1lqtA-3dwbA:
undetectable		 1lqtA-3dwbA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q13_A_TESA501_1
(PROSTAGLANDIN-E2
9-REDUCTASE)		 3dwb ENDOTHELIN-CONVERTIN
G ENZYME 1
(Homo
sapiens) 		4 / 6 TYR A 682
TYR A 679
HIS A 752
PRO A 593
 None
 1.42A 1q13A-3dwbA:
undetectable		 1q13A-3dwbA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG1_A_SPMA999_1
(TYROSYL-DNA
PHOSPHODIESTERASE 1)		 3dwb ENDOTHELIN-CONVERTIN
G ENZYME 1
(Homo
sapiens) 		3 / 3 TRP A 146
VAL A 139
PRO A 140
 None
 1.00A 1rg1A-3dwbA:
undetectable		 1rg1A-3dwbA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_B_DESB459_1
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 3dwb ENDOTHELIN-CONVERTIN
G ENZYME 1
(Homo
sapiens) 		5 / 12 LEU A 308
LEU A 389
LEU A 381
TYR A 393
LEU A 260
 None
 1.28A 1s9pB-3dwbA:
undetectable		 1s9pB-3dwbA:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_Q_TRPQ81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3dwb ENDOTHELIN-CONVERTIN
G ENZYME 1
(Homo
sapiens) 		5 / 10 HIS A 607
ALA A 677
THR A 610
HIS A 611
ILE A 471
 ZN  A 771 ( 3.4A)
None
None
ZN  A 771 ( 3.3A)
None
 1.34A 1utdQ-3dwbA:
undetectable
1utdR-3dwbA:
undetectable		 1utdQ-3dwbA:
7.51
1utdR-3dwbA:
7.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_A_CRNA401_1
(CREATININE
AMIDOHYDROLASE)		 3dwb ENDOTHELIN-CONVERTIN
G ENZYME 1
(Homo
sapiens) 		4 / 8 GLU A 667
HIS A 607
HIS A 611
GLU A 608
 ZN  A 771 ( 2.1A)
ZN  A 771 ( 3.4A)
ZN  A 771 ( 3.3A)
RDF  A 817 (-2.4A)
 0.75A 1v7zA-3dwbA:
undetectable		 1v7zA-3dwbA:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_B_CRNB3401_1
(CREATININE
AMIDOHYDROLASE)		 3dwb ENDOTHELIN-CONVERTIN
G ENZYME 1
(Homo
sapiens) 		4 / 8 GLU A 667
HIS A 607
HIS A 611
GLU A 608
 ZN  A 771 ( 2.1A)
ZN  A 771 ( 3.4A)
ZN  A 771 ( 3.3A)
RDF  A 817 (-2.4A)
 0.75A 1v7zB-3dwbA:
undetectable		 1v7zB-3dwbA:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_C_CRNC4401_1
(CREATININE
AMIDOHYDROLASE)		 3dwb ENDOTHELIN-CONVERTIN
G ENZYME 1
(Homo
sapiens) 		4 / 8 GLU A 667
HIS A 607
HIS A 611
GLU A 608
 ZN  A 771 ( 2.1A)
ZN  A 771 ( 3.4A)
ZN  A 771 ( 3.3A)
RDF  A 817 (-2.4A)
 0.76A 1v7zC-3dwbA:
undetectable		 1v7zC-3dwbA:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_D_CRND5401_1
(CREATININE
AMIDOHYDROLASE)		 3dwb ENDOTHELIN-CONVERTIN
G ENZYME 1
(Homo
sapiens) 		4 / 8 GLU A 667
HIS A 607
HIS A 611
GLU A 608
 ZN  A 771 ( 2.1A)
ZN  A 771 ( 3.4A)
ZN  A 771 ( 3.3A)
RDF  A 817 (-2.4A)
 0.78A 1v7zD-3dwbA:
undetectable		 1v7zD-3dwbA:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_E_CRNE6401_1
(CREATININE
AMIDOHYDROLASE)		 3dwb ENDOTHELIN-CONVERTIN
G ENZYME 1
(Homo
sapiens) 		4 / 8 GLU A 667
HIS A 607
HIS A 611
GLU A 608
 ZN  A 771 ( 2.1A)
ZN  A 771 ( 3.4A)
ZN  A 771 ( 3.3A)
RDF  A 817 (-2.4A)
 0.78A 1v7zE-3dwbA:
undetectable		 1v7zE-3dwbA:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_F_CRNF7401_1
(CREATININE
AMIDOHYDROLASE)		 3dwb ENDOTHELIN-CONVERTIN
G ENZYME 1
(Homo
sapiens) 		4 / 8 GLU A 667
HIS A 607
HIS A 611
GLU A 608
 ZN  A 771 ( 2.1A)
ZN  A 771 ( 3.4A)
ZN  A 771 ( 3.3A)
RDF  A 817 (-2.4A)
 0.77A 1v7zF-3dwbA:
undetectable		 1v7zF-3dwbA:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X70_B_715B801_1
(DIPEPTIDYL PEPTIDASE
IV)		 3dwb ENDOTHELIN-CONVERTIN
G ENZYME 1
(Homo
sapiens) 		5 / 12 GLU A 327
ARG A 325
SER A 242
VAL A 252
TYR A 370
 None
 1.44A 1x70B-3dwbA:
undetectable		 1x70B-3dwbA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVS_B_MK1B902_1
(POL POLYPROTEIN)		 3dwb ENDOTHELIN-CONVERTIN
G ENZYME 1
(Homo
sapiens) 		5 / 12 GLY A 674
ILE A 601
GLY A 600
GLY A 599
ILE A 471
 None
 0.73A 2avsA-3dwbA:
undetectable		 2avsA-3dwbA:
9.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_A_MK1A901_1
(POL POLYPROTEIN)		 3dwb ENDOTHELIN-CONVERTIN
G ENZYME 1
(Homo
sapiens) 		5 / 12 GLY A 674
ILE A 601
GLY A 600
GLY A 599
ILE A 471
 None
 0.72A 2avvA-3dwbA:
undetectable		 2avvA-3dwbA:
10.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZQ_A_PCFA954_0
(CATECHOL
1,2-DIOXYGENASE)		 3dwb ENDOTHELIN-CONVERTIN
G ENZYME 1
(Homo
sapiens) 		5 / 9 THR A 385
LEU A 389
GLU A 311
ALA A 313
LEU A 278
 None
 1.21A 2azqA-3dwbA:
undetectable		 2azqA-3dwbA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_A_LPRA705_1
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		 3dwb ENDOTHELIN-CONVERTIN
G ENZYME 1
(Homo
sapiens) 		5 / 12 ALA A 567
HIS A 607
GLU A 608
HIS A 611
GLU A 667
 RDF  A 817 (-4.4A)
ZN  A 771 ( 3.4A)
RDF  A 817 (-2.4A)
ZN  A 771 ( 3.3A)
ZN  A 771 ( 2.1A)
 0.38A 2c6nA-3dwbA:
4.3		 2c6nA-3dwbA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA2_A_SCKA901_1
(ACETYLCHOLINESTERASE)		 3dwb ENDOTHELIN-CONVERTIN
G ENZYME 1
(Homo
sapiens) 		4 / 8 TYR A 652
TRP A 714
TYR A 649
HIS A 607
 None
None
None
ZN  A 771 ( 3.4A)
 1.36A 2ha2A-3dwbA:
undetectable		 2ha2A-3dwbA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA2_B_SCKB951_1
(ACETYLCHOLINESTERASE)		 3dwb ENDOTHELIN-CONVERTIN
G ENZYME 1
(Homo
sapiens) 		4 / 8 TYR A 652
TRP A 714
TYR A 649
HIS A 607
 None
None
None
ZN  A 771 ( 3.4A)
 1.34A 2ha2B-3dwbA:
undetectable		 2ha2B-3dwbA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LBD_A_REAA500_1
(RETINOIC ACID
RECEPTOR GAMMA)		 3dwb ENDOTHELIN-CONVERTIN
G ENZYME 1
(Homo
sapiens) 		5 / 12 CYH A 388
MET A 304
ILE A 307
GLY A 289
LEU A 199
 None
 1.16A 2lbdA-3dwbA:
0.9		 2lbdA-3dwbA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNJ_A_225A501_1
(CYTOCHROME P450 2C8)		 3dwb ENDOTHELIN-CONVERTIN
G ENZYME 1
(Homo
sapiens) 		5 / 10 ILE A 346
ALA A 343
VAL A 369
ILE A 367
VAL A 334
 None
 1.06A 2nnjA-3dwbA:
undetectable		 2nnjA-3dwbA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_L_ASDL1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 3dwb ENDOTHELIN-CONVERTIN
G ENZYME 1
(Homo
sapiens) 		4 / 7 LEU A 675
ALA A 678
PHE A 598
PHE A 706
 None
 0.95A 2vcvL-3dwbA:
2.8		 2vcvL-3dwbA:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDY_B_HCYB1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 3dwb ENDOTHELIN-CONVERTIN
G ENZYME 1
(Homo
sapiens) 		5 / 12 SER A 634
THR A 610
PHE A 475
SER A 478
PHE A 613
 None
 1.42A 2vdyB-3dwbA:
undetectable		 2vdyB-3dwbA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WLK_B_SPMB1302_1
(ATP-SENSITIVE INWARD
RECTIFIER POTASSIUM
CHANNEL 10)		 3dwb ENDOTHELIN-CONVERTIN
G ENZYME 1
(Homo
sapiens) 		4 / 4 ALA A 681
TYR A 682
ALA A 677
TYR A 679
 None
 1.18A 2wlkA-3dwbA:
undetectable
2wlkB-3dwbA:
undetectable		 2wlkA-3dwbA:
19.63
2wlkB-3dwbA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XUD_A_DMEA1544_1
(ACETYLCHOLINESTERASE)		 3dwb ENDOTHELIN-CONVERTIN
G ENZYME 1
(Homo
sapiens) 		4 / 6 TYR A 652
TRP A 714
TYR A 649
HIS A 607
 None
None
None
ZN  A 771 ( 3.4A)
 1.34A 2xudA-3dwbA:
undetectable		 2xudA-3dwbA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_A_CRNA303_1
(CREATININE
AMIDOHYDROLASE)		 3dwb ENDOTHELIN-CONVERTIN
G ENZYME 1
(Homo
sapiens) 		4 / 8 GLU A 667
HIS A 607
HIS A 611
GLU A 608
 ZN  A 771 ( 2.1A)
ZN  A 771 ( 3.4A)
ZN  A 771 ( 3.3A)
RDF  A 817 (-2.4A)
 0.76A 3a6jA-3dwbA:
undetectable		 3a6jA-3dwbA:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_B_CRNB304_1
(CREATININE
AMIDOHYDROLASE)		 3dwb ENDOTHELIN-CONVERTIN
G ENZYME 1
(Homo
sapiens) 		4 / 7 GLU A 667
HIS A 607
HIS A 611
GLU A 608
 ZN  A 771 ( 2.1A)
ZN  A 771 ( 3.4A)
ZN  A 771 ( 3.3A)
RDF  A 817 (-2.4A)
 0.73A 3a6jB-3dwbA:
undetectable		 3a6jB-3dwbA:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_C_CRNC305_1
(CREATININE
AMIDOHYDROLASE)		 3dwb ENDOTHELIN-CONVERTIN
G ENZYME 1
(Homo
sapiens) 		4 / 8 GLU A 667
HIS A 607
HIS A 611
GLU A 608
 ZN  A 771 ( 2.1A)
ZN  A 771 ( 3.4A)
ZN  A 771 ( 3.3A)
RDF  A 817 (-2.4A)
 0.73A 3a6jC-3dwbA:
undetectable		 3a6jC-3dwbA:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_E_CRNE306_1
(CREATININE
AMIDOHYDROLASE)		 3dwb ENDOTHELIN-CONVERTIN
G ENZYME 1
(Homo
sapiens) 		4 / 8 GLU A 667
HIS A 607
HIS A 611
GLU A 608
 ZN  A 771 ( 2.1A)
ZN  A 771 ( 3.4A)
ZN  A 771 ( 3.3A)
RDF  A 817 (-2.4A)
 0.77A 3a6jE-3dwbA:
undetectable		 3a6jE-3dwbA:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_F_CRNF307_1
(CREATININE
AMIDOHYDROLASE)		 3dwb ENDOTHELIN-CONVERTIN
G ENZYME 1
(Homo
sapiens) 		4 / 8 GLU A 667
HIS A 607
HIS A 611
GLU A 608
 ZN  A 771 ( 2.1A)
ZN  A 771 ( 3.4A)
ZN  A 771 ( 3.3A)
RDF  A 817 (-2.4A)
 0.73A 3a6jF-3dwbA:
undetectable		 3a6jF-3dwbA:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYX_A_ROCA201_3
(HIV-1 PROTEASE)		 3dwb ENDOTHELIN-CONVERTIN
G ENZYME 1
(Homo
sapiens) 		5 / 12 GLY A 674
ILE A 601
GLY A 600
GLY A 599
ILE A 471
 None
 0.78A 3cyxB-3dwbA:
undetectable		 3cyxB-3dwbA:
9.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCP_B_CHDB4_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3dwb ENDOTHELIN-CONVERTIN
G ENZYME 1
(Homo
sapiens) 		3 / 3 GLY A 599
PRO A 593
LEU A 705
 None
 0.57A 3hcpB-3dwbA:
undetectable		 3hcpB-3dwbA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEC_B_HAEB271_1
(COLLAGENASE 3)		 3dwb ENDOTHELIN-CONVERTIN
G ENZYME 1
(Homo
sapiens) 		3 / 3 HIS A 607
GLU A 608
HIS A 611
 ZN  A 771 ( 3.4A)
RDF  A 817 (-2.4A)
ZN  A 771 ( 3.3A)
 0.20A 3kecB-3dwbA:
4.2		 3kecB-3dwbA:
13.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ONN_A_ACTA270_0
(PROTEIN SSM1)		 3dwb ENDOTHELIN-CONVERTIN
G ENZYME 1
(Homo
sapiens) 		4 / 5 LEU A 406
ARG A 409
LEU A 199
PRO A 198
 None
 1.37A 3onnA-3dwbA:
undetectable		 3onnA-3dwbA:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QL6_A_NIMA614_1
(LACTOPEROXIDASE)		 3dwb ENDOTHELIN-CONVERTIN
G ENZYME 1
(Homo
sapiens) 		4 / 7 GLN A 548
GLU A 575
PHE A 509
PRO A 507
 5HD  A 816 ( 4.7A)
None
5HD  A 816 ( 3.9A)
None
 1.37A 3ql6A-3dwbA:
undetectable		 3ql6A-3dwbA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9C_A_ECLA452_1
(CYTOCHROME P450
164A2)		 3dwb ENDOTHELIN-CONVERTIN
G ENZYME 1
(Homo
sapiens) 		5 / 12 LEU A 381
ALA A 313
THR A 312
ASN A 316
LEU A 262
 None
 1.14A 3r9cA-3dwbA:
0.8		 3r9cA-3dwbA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB504_1
(HEMOLYTIC LECTIN
CEL-III)		 3dwb ENDOTHELIN-CONVERTIN
G ENZYME 1
(Homo
sapiens) 		4 / 5 ASP A 371
GLU A 373
TYR A 374
GLN A 257
 None
 1.44A 3w9tB-3dwbA:
undetectable		 3w9tB-3dwbA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1477_0
(MJ0495-LIKE PROTEIN)		 3dwb ENDOTHELIN-CONVERTIN
G ENZYME 1
(Homo
sapiens) 		4 / 6 THR A 212
GLY A 294
ILE A 300
LEU A 292
 None
 1.14A 4ac9C-3dwbA:
undetectable		 4ac9C-3dwbA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1477_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 3dwb ENDOTHELIN-CONVERTIN
G ENZYME 1
(Homo
sapiens) 		4 / 6 THR A 212
GLY A 294
ILE A 300
LEU A 292
 None
 1.13A 4acaC-3dwbA:
undetectable		 4acaC-3dwbA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTT_C_SAMC404_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 3dwb ENDOTHELIN-CONVERTIN
G ENZYME 1
(Homo
sapiens) 		4 / 8 HIS A 732
ASP A 730
SER A 735
SER A 716
 RDF  A 817 (-3.6A)
RDF  A 817 ( 4.8A)
None
None
 1.11A 4kttC-3dwbA:
undetectable		 4kttC-3dwbA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMC_A_29JA604_1
(TRANSPORTER)		 3dwb ENDOTHELIN-CONVERTIN
G ENZYME 1
(Homo
sapiens) 		4 / 7 ILE A 346
PHE A 237
LEU A 224
THR A 385
 None
 0.93A 4mmcA-3dwbA:
undetectable		 4mmcA-3dwbA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NDN_C_SAMC405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 3dwb ENDOTHELIN-CONVERTIN
G ENZYME 1
(Homo
sapiens) 		4 / 7 HIS A 732
PRO A 731
ASP A 730
SER A 150
 RDF  A 817 (-3.6A)
RDF  A 817 (-4.7A)
RDF  A 817 ( 4.8A)
None
 1.25A 4ndnC-3dwbA:
undetectable		 4ndnC-3dwbA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O5F_A_PAUA301_0
(TYPE III
PANTOTHENATE KINASE)		 3dwb ENDOTHELIN-CONVERTIN
G ENZYME 1
(Homo
sapiens) 		5 / 12 GLY A 699
THR A 108
ILE A 111
GLN A 704
LEU A 708
 None
 1.10A 4o5fA-3dwbA:
undetectable
4o5fB-3dwbA:
undetectable		 4o5fA-3dwbA:
18.93
4o5fB-3dwbA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O5F_B_PAUB302_0
(TYPE III
PANTOTHENATE KINASE)		 3dwb ENDOTHELIN-CONVERTIN
G ENZYME 1
(Homo
sapiens) 		5 / 12 GLN A 704
LEU A 708
GLY A 699
THR A 108
ILE A 111
 None
 1.09A 4o5fA-3dwbA:
undetectable
4o5fB-3dwbA:
undetectable		 4o5fA-3dwbA:
18.93
4o5fB-3dwbA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODJ_A_SAMA500_0
(S-ADENOSYLMETHIONINE
SYNTHASE)		 3dwb ENDOTHELIN-CONVERTIN
G ENZYME 1
(Homo
sapiens) 		4 / 7 HIS A 732
PRO A 731
ASP A 730
SER A 150
 RDF  A 817 (-3.6A)
RDF  A 817 (-4.7A)
RDF  A 817 ( 4.8A)
None
 1.30A 4odjA-3dwbA:
undetectable		 4odjA-3dwbA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0Q_A_PX9A201_1
(BETA-LACTOGLOBULIN)		 3dwb ENDOTHELIN-CONVERTIN
G ENZYME 1
(Homo
sapiens) 		3 / 3 LYS A 496
ILE A 500
ILE A 576
 None
 0.69A 4y0qA-3dwbA:
undetectable		 4y0qA-3dwbA:
13.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A1I_A_SAMA405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 3dwb ENDOTHELIN-CONVERTIN
G ENZYME 1
(Homo
sapiens) 		4 / 7 HIS A 732
PRO A 731
ASP A 730
SER A 150
 RDF  A 817 (-3.6A)
RDF  A 817 (-4.7A)
RDF  A 817 ( 4.8A)
None
 1.26A 5a1iA-3dwbA:
undetectable		 5a1iA-3dwbA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8H_A_PAUA302_0
(TYPE III
PANTOTHENATE KINASE)		 3dwb ENDOTHELIN-CONVERTIN
G ENZYME 1
(Homo
sapiens) 		5 / 12 GLY A 699
THR A 108
ILE A 111
GLN A 704
LEU A 708
 None
 1.11A 5b8hA-3dwbA:
undetectable
5b8hB-3dwbA:
undetectable		 5b8hA-3dwbA:
18.12
5b8hB-3dwbA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8H_B_PAUB302_0
(TYPE III
PANTOTHENATE KINASE)		 3dwb ENDOTHELIN-CONVERTIN
G ENZYME 1
(Homo
sapiens) 		5 / 12 GLN A 704
LEU A 708
GLY A 699
THR A 108
ILE A 111
 None
 1.10A 5b8hA-3dwbA:
undetectable
5b8hB-3dwbA:
undetectable		 5b8hA-3dwbA:
18.12
5b8hB-3dwbA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTI_E_LFXE101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 3dwb ENDOTHELIN-CONVERTIN
G ENZYME 1
(Homo
sapiens) 		4 / 5 SER A 127
ARG A 738
GLY A 741
THR A 664
 None
RDF  A 817 (-3.0A)
None
None
 1.06A 5btiA-3dwbA:
undetectable
5btiB-3dwbA:
undetectable		 5btiA-3dwbA:
19.82
5btiB-3dwbA:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQF_A_LCRA612_1
(SERUM ALBUMIN)		 3dwb ENDOTHELIN-CONVERTIN
G ENZYME 1
(Homo
sapiens) 		5 / 9 LEU A 443
GLY A 444
LEU A 447
LEU A 164
ALA A 178
 None
 0.90A 5dqfA-3dwbA:
undetectable		 5dqfA-3dwbA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_A_486A801_1
(GLUCOCORTICOID
RECEPTOR)		 3dwb ENDOTHELIN-CONVERTIN
G ENZYME 1
(Homo
sapiens) 		5 / 12 LEU A 705
LEU A 708
GLY A 709
GLN A 712
VAL A 713
 None
 0.38A 5uc1A-3dwbA:
undetectable		 5uc1A-3dwbA:
8.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_B_486B801_2
(GLUCOCORTICOID
RECEPTOR)		 3dwb ENDOTHELIN-CONVERTIN
G ENZYME 1
(Homo
sapiens) 		5 / 12 LEU A 705
LEU A 708
GLY A 709
GLN A 712
VAL A 713
 None
 0.36A 5uc1B-3dwbA:
undetectable		 5uc1B-3dwbA:
8.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CBD_A_TRPA902_0
(PROTEIN ARGONAUTE-2)		 3dwb ENDOTHELIN-CONVERTIN
G ENZYME 1
(Homo
sapiens) 		4 / 4 VAL A 603
ALA A 677
PHE A 706
PHE A 598
 None
 1.25A 6cbdA-3dwbA:
0.0		 6cbdA-3dwbA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FCB_A_SAMA405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 3dwb ENDOTHELIN-CONVERTIN
G ENZYME 1
(Homo
sapiens) 		4 / 8 HIS A 732
ASP A 730
SER A 735
SER A 716
 RDF  A 817 (-3.6A)
RDF  A 817 ( 4.8A)
None
None
 1.11A 6fcbA-3dwbA:
undetectable		 6fcbA-3dwbA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G6R_A_SAMA406_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 3dwb ENDOTHELIN-CONVERTIN
G ENZYME 1
(Homo
sapiens) 		4 / 7 HIS A 732
PRO A 731
ASP A 730
SER A 150
 RDF  A 817 (-3.6A)
RDF  A 817 (-4.7A)
RDF  A 817 ( 4.8A)
None
 1.26A 6g6rA-3dwbA:
undetectable		 6g6rA-3dwbA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_A_TKTA508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 3dwb ENDOTHELIN-CONVERTIN
G ENZYME 1
(Homo
sapiens) 		4 / 8 ASP A 615
ILE A 669
ARG A 325
ASN A 745
 None
 1.20A 6hisA-3dwbA:
undetectable
6hisB-3dwbA:
undetectable		 6hisA-3dwbA:
6.91
6hisB-3dwbA:
6.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_B_TKTB508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 3dwb ENDOTHELIN-CONVERTIN
G ENZYME 1
(Homo
sapiens) 		4 / 8 ASP A 615
ILE A 669
ARG A 325
ASN A 745
 None
 1.20A 6hisB-3dwbA:
undetectable
6hisC-3dwbA:
undetectable		 6hisB-3dwbA:
6.91
6hisC-3dwbA:
6.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_C_TKTC508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 3dwb ENDOTHELIN-CONVERTIN
G ENZYME 1
(Homo
sapiens) 		4 / 8 ASP A 615
ILE A 669
ARG A 325
ASN A 745
 None
 1.21A 6hisC-3dwbA:
undetectable
6hisD-3dwbA:
undetectable		 6hisC-3dwbA:
6.91
6hisD-3dwbA:
6.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_D_TKTD501_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 3dwb ENDOTHELIN-CONVERTIN
G ENZYME 1
(Homo
sapiens) 		4 / 8 ASP A 615
ILE A 669
ARG A 325
ASN A 745
 None
 1.19A 6hisD-3dwbA:
undetectable
6hisE-3dwbA:
undetectable		 6hisD-3dwbA:
6.91
6hisE-3dwbA:
6.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_E_TKTE501_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 3dwb ENDOTHELIN-CONVERTIN
G ENZYME 1
(Homo
sapiens) 		4 / 8 ASN A 745
ASP A 615
ILE A 669
ARG A 325
 None
 1.21A 6hisA-3dwbA:
undetectable
6hisE-3dwbA:
undetectable		 6hisA-3dwbA:
6.91
6hisE-3dwbA:
6.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NM4_B_SAMB402_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
PRDM9)		 3dwb ENDOTHELIN-CONVERTIN
G ENZYME 1
(Homo
sapiens) 		5 / 9 LEU A 206
GLY A 213
ASN A 391
CYH A 388
ARG A 387
 None
 0.98A 6nm4B-3dwbA:
undetectable		 6nm4B-3dwbA:
14.50