SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3dwc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J37_A_X8ZA801_1
(ANGIOTENSIN
CONVERTING ENZYME)		 3dwc METALLOCARBOXYPEPTID
ASE
(Trypanosoma
cruzi) 		5 / 11 HIS A 265
GLU A 266
HIS A 269
GLU A 296
TYR A 421
 CO  A 999 (-3.3A)
CO  A 999 ( 4.6A)
CO  A 999 (-3.5A)
CO  A 999 (-2.6A)
SO4  A 609 (-4.7A)
 0.91A 1j37A-3dwcA:
20.7		 1j37A-3dwcA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J37_B_X8ZB802_1
(ANGIOTENSIN
CONVERTING ENZYME)		 3dwc METALLOCARBOXYPEPTID
ASE
(Trypanosoma
cruzi) 		5 / 11 HIS A 265
GLU A 266
HIS A 269
GLU A 296
TYR A 421
 CO  A 999 (-3.3A)
CO  A 999 ( 4.6A)
CO  A 999 (-3.5A)
CO  A 999 (-2.6A)
SO4  A 609 (-4.7A)
 0.91A 1j37B-3dwcA:
20.7		 1j37B-3dwcA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_D_AG2D7015_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 3dwc METALLOCARBOXYPEPTID
ASE
(Trypanosoma
cruzi) 		4 / 7 LEU A 300
GLU A 266
LEU A 292
GLY A 293
 None
CO  A 999 ( 4.6A)
None
None
 0.85A 1n13D-3dwcA:
undetectable
1n13E-3dwcA:
undetectable		 1n13D-3dwcA:
13.17
1n13E-3dwcA:
9.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1O86_A_LPRA702_1
(ANGIOTENSIN
CONVERTING ENZYME)		 3dwc METALLOCARBOXYPEPTID
ASE
(Trypanosoma
cruzi) 		5 / 12 HIS A 265
GLU A 266
HIS A 269
GLU A 296
TYR A 356
 CO  A 999 (-3.3A)
CO  A 999 ( 4.6A)
CO  A 999 (-3.5A)
CO  A 999 (-2.6A)
None
 1.23A 1o86A-3dwcA:
21.4		 1o86A-3dwcA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TMX_A_BEZA881_0
(HYDROXYQUINOL
1,2-DIOXYGENASE)		 3dwc METALLOCARBOXYPEPTID
ASE
(Trypanosoma
cruzi) 		5 / 11 LEU A 431
GLY A 297
ILE A 464
HIS A 295
HIS A 269
 None
None
None
None
CO  A 999 (-3.5A)
 1.48A 1tmxA-3dwcA:
undetectable		 1tmxA-3dwcA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_B_LPRB705_1
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		 3dwc METALLOCARBOXYPEPTID
ASE
(Trypanosoma
cruzi) 		5 / 12 HIS A 265
GLU A 266
HIS A 269
GLU A 296
TYR A 421
 CO  A 999 (-3.3A)
CO  A 999 ( 4.6A)
CO  A 999 (-3.5A)
CO  A 999 (-2.6A)
SO4  A 609 (-4.7A)
 0.99A 2c6nB-3dwcA:
20.1		 2c6nB-3dwcA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		 3dwc METALLOCARBOXYPEPTID
ASE
(Trypanosoma
cruzi) 		4 / 7 PHE A 312
LEU A 320
GLU A 303
ARG A 308
 None
 0.98A 2jn3A-3dwcA:
undetectable		 2jn3A-3dwcA:
13.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NV4_A_ACTA148_0
(UPF0066 PROTEIN
AF_0241)		 3dwc METALLOCARBOXYPEPTID
ASE
(Trypanosoma
cruzi) 		3 / 3 VAL A 100
GLU A  97
GLU A 101
 None
 0.68A 2nv4A-3dwcA:
undetectable		 2nv4A-3dwcA:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_F_SNLF6001_2
(MINERALOCORTICOID
RECEPTOR)		 3dwc METALLOCARBOXYPEPTID
ASE
(Trypanosoma
cruzi) 		4 / 5 LEU A 127
LEU A 130
LEU A 136
MET A 371
 None
 1.11A 2oaxF-3dwcA:
undetectable		 2oaxF-3dwcA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X8Z_A_X8ZA1615_1
(ANGIOTENSIN
CONVERTING ENZYME)		 3dwc METALLOCARBOXYPEPTID
ASE
(Trypanosoma
cruzi) 		5 / 11 HIS A 265
GLU A 266
HIS A 269
GLU A 296
TYR A 356
 CO  A 999 (-3.3A)
CO  A 999 ( 4.6A)
CO  A 999 (-3.5A)
CO  A 999 (-2.6A)
None
 1.25A 2x8zA-3dwcA:
20.7		 2x8zA-3dwcA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X91_A_LPRA1615_1
(ANGIOTENSIN
CONVERTING ENZYME)		 3dwc METALLOCARBOXYPEPTID
ASE
(Trypanosoma
cruzi) 		5 / 12 HIS A 265
GLU A 266
HIS A 269
GLU A 296
TYR A 356
 CO  A 999 (-3.3A)
CO  A 999 ( 4.6A)
CO  A 999 (-3.5A)
CO  A 999 (-2.6A)
None
 1.22A 2x91A-3dwcA:
20.8		 2x91A-3dwcA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_C_ROFC903_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 3dwc METALLOCARBOXYPEPTID
ASE
(Trypanosoma
cruzi) 		3 / 3 SER A 299
GLN A 298
PHE A 301
 CO  A 999 ( 3.9A)
None
None
 0.82A 3g4lC-3dwcA:
undetectable		 3g4lC-3dwcA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O7W_A_SAMA801_0
(LEUCINE CARBOXYL
METHYLTRANSFERASE 1)		 3dwc METALLOCARBOXYPEPTID
ASE
(Trypanosoma
cruzi) 		5 / 12 GLY A 163
ASP A 170
LEU A 169
ARG A 368
VAL A 157
 None
 0.96A 3o7wA-3dwcA:
undetectable		 3o7wA-3dwcA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C2P_A_X8ZA709_1
(ANGIOTENSIN-CONVERTI
NG ENZYME)		 3dwc METALLOCARBOXYPEPTID
ASE
(Trypanosoma
cruzi) 		5 / 11 HIS A 265
GLU A 266
HIS A 269
GLU A 296
TYR A 421
 CO  A 999 (-3.3A)
CO  A 999 ( 4.6A)
CO  A 999 (-3.5A)
CO  A 999 (-2.6A)
SO4  A 609 (-4.7A)
 0.89A 4c2pA-3dwcA:
21.4		 4c2pA-3dwcA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF2_A_4CHA506_0
(NADPH DEHYDROGENASE)		 3dwc METALLOCARBOXYPEPTID
ASE
(Trypanosoma
cruzi) 		4 / 6 THR A 420
TYR A 417
HIS A 269
HIS A 295
 None
None
CO  A 999 (-3.5A)
None
 1.49A 4df2A-3dwcA:
undetectable		 4df2A-3dwcA:
24.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0V_A_MIXA1301_1
(DNA TOPOISOMERASE
2-BETA)		 3dwc METALLOCARBOXYPEPTID
ASE
(Trypanosoma
cruzi) 		4 / 7 GLY A 239
ILE A 247
GLU A 266
MET A  44
 None
None
CO  A 999 ( 4.6A)
GOL  A 710 ( 3.7A)
 1.10A 4g0vA-3dwcA:
2.9		 4g0vA-3dwcA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L3G_F_ACTF401_0
(METHYLAMINE
DEHYDROGENASE HEAVY
CHAIN)		 3dwc METALLOCARBOXYPEPTID
ASE
(Trypanosoma
cruzi) 		3 / 3 ARG A  87
LEU A  91
GLU A  90
 None
 0.76A 4l3gF-3dwcA:
undetectable		 4l3gF-3dwcA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R7I_A_STIA1001_2
(MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR)		 3dwc METALLOCARBOXYPEPTID
ASE
(Trypanosoma
cruzi) 		4 / 5 LEU A 292
VAL A 360
TYR A 417
ARG A 491
 None
 1.13A 4r7iA-3dwcA:
undetectable		 4r7iA-3dwcA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R7L_A_SHHA709_1
(LEUKOTRIENE A-4
HYDROLASE)		 3dwc METALLOCARBOXYPEPTID
ASE
(Trypanosoma
cruzi) 		5 / 12 HIS A 265
GLU A 266
HIS A 269
GLU A 296
TYR A 417
 CO  A 999 (-3.3A)
CO  A 999 ( 4.6A)
CO  A 999 (-3.5A)
CO  A 999 (-2.6A)
None
 1.39A 4r7lA-3dwcA:
6.9		 4r7lA-3dwcA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_A_DGXA1107_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 3dwc METALLOCARBOXYPEPTID
ASE
(Trypanosoma
cruzi) 		5 / 12 GLN A 274
LEU A 457
GLY A 268
ALA A 302
ARG A 215
 None
 1.25A 4retA-3dwcA:
4.0		 4retA-3dwcA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_C_DGXC2005_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 3dwc METALLOCARBOXYPEPTID
ASE
(Trypanosoma
cruzi) 		5 / 12 GLN A 274
LEU A 457
GLY A 268
ALA A 302
ARG A 215
 None
 1.25A 4retC-3dwcA:
3.3		 4retC-3dwcA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_A_BEZA201_0
(HYDROXYNITRILE LYASE)		 3dwc METALLOCARBOXYPEPTID
ASE
(Trypanosoma
cruzi) 		5 / 9 VAL A 380
VAL A 383
TYR A 153
TRP A 410
LEU A 370
 None
 1.45A 5e4dA-3dwcA:
undetectable		 5e4dA-3dwcA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESF_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3dwc METALLOCARBOXYPEPTID
ASE
(Trypanosoma
cruzi) 		4 / 8 ILE A 159
TYR A 160
PHE A 137
THR A 107
 None
 0.92A 5esfA-3dwcA:
undetectable		 5esfA-3dwcA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESH_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3dwc METALLOCARBOXYPEPTID
ASE
(Trypanosoma
cruzi) 		5 / 12 LEU A 362
ILE A 159
TYR A 160
PHE A 137
THR A 107
 None
 1.06A 5eshA-3dwcA:
undetectable		 5eshA-3dwcA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESH_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3dwc METALLOCARBOXYPEPTID
ASE
(Trypanosoma
cruzi) 		5 / 12 LEU A 362
TYR A 417
ILE A 159
TYR A 160
THR A 107
 None
 1.23A 5eshA-3dwcA:
undetectable		 5eshA-3dwcA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESK_A_1YNA701_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3dwc METALLOCARBOXYPEPTID
ASE
(Trypanosoma
cruzi) 		5 / 12 GLY A 403
ILE A 159
TYR A 160
PHE A 137
THR A 107
 None
 1.00A 5eskA-3dwcA:
undetectable		 5eskA-3dwcA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESL_A_1YNA701_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3dwc METALLOCARBOXYPEPTID
ASE
(Trypanosoma
cruzi) 		5 / 12 GLY A 403
ILE A 159
TYR A 160
PHE A 137
THR A 107
 None
 1.00A 5eslA-3dwcA:
undetectable		 5eslA-3dwcA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G6S_A_RAUA400_1
(IMINE REDUCTASE)		 3dwc METALLOCARBOXYPEPTID
ASE
(Trypanosoma
cruzi) 		5 / 11 VAL A 338
LEU A 261
PHE A 256
MET A 313
GLY A 307
 None
 1.33A 5g6sA-3dwcA:
0.4
5g6sG-3dwcA:
0.4		 5g6sA-3dwcA:
21.53
5g6sG-3dwcA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G6S_B_RAUB400_1
(IMINE REDUCTASE)		 3dwc METALLOCARBOXYPEPTID
ASE
(Trypanosoma
cruzi) 		5 / 11 VAL A 338
LEU A 261
PHE A 256
MET A 313
GLY A 307
 None
 1.34A 5g6sB-3dwcA:
0.9
5g6sC-3dwcA:
0.9		 5g6sB-3dwcA:
21.53
5g6sC-3dwcA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G6S_C_RAUC400_1
(IMINE REDUCTASE)		 3dwc METALLOCARBOXYPEPTID
ASE
(Trypanosoma
cruzi) 		5 / 12 MET A 313
GLY A 307
VAL A 338
LEU A 261
PHE A 256
 None
 1.32A 5g6sB-3dwcA:
0.9
5g6sC-3dwcA:
undetectable		 5g6sB-3dwcA:
21.53
5g6sC-3dwcA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G6S_D_RAUD400_1
(IMINE REDUCTASE)		 3dwc METALLOCARBOXYPEPTID
ASE
(Trypanosoma
cruzi) 		5 / 10 VAL A 338
LEU A 261
PHE A 256
MET A 313
GLY A 307
 None
 1.33A 5g6sD-3dwcA:
0.1
5g6sF-3dwcA:
0.1		 5g6sD-3dwcA:
21.53
5g6sF-3dwcA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G6S_E_RAUE400_1
(IMINE REDUCTASE)		 3dwc METALLOCARBOXYPEPTID
ASE
(Trypanosoma
cruzi) 		5 / 11 VAL A 338
LEU A 261
PHE A 256
MET A 313
GLY A 307
 None
 1.34A 5g6sE-3dwcA:
0.3
5g6sH-3dwcA:
0.4		 5g6sE-3dwcA:
21.53
5g6sH-3dwcA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G6S_F_RAUF400_1
(IMINE REDUCTASE)		 3dwc METALLOCARBOXYPEPTID
ASE
(Trypanosoma
cruzi) 		5 / 10 MET A 313
GLY A 307
VAL A 338
LEU A 261
PHE A 256
 None
 1.33A 5g6sD-3dwcA:
0.3
5g6sF-3dwcA:
0.4		 5g6sD-3dwcA:
21.53
5g6sF-3dwcA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G6S_G_RAUG400_1
(IMINE REDUCTASE)		 3dwc METALLOCARBOXYPEPTID
ASE
(Trypanosoma
cruzi) 		5 / 10 MET A 313
GLY A 307
VAL A 338
LEU A 261
PHE A 256
 None
 1.34A 5g6sA-3dwcA:
0.4
5g6sG-3dwcA:
0.4		 5g6sA-3dwcA:
21.53
5g6sG-3dwcA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6I_A_8PRA509_1
(ENVELOPE
GLYCOPROTEIN,GP,GP1
ENVELOPE
GLYCOPROTEIN)		 3dwc METALLOCARBOXYPEPTID
ASE
(Trypanosoma
cruzi) 		5 / 12 VAL A 294
GLY A 424
LEU A 485
THR A 420
LEU A 477
 None
 1.07A 6f6iA-3dwcA:
undetectable
6f6iB-3dwcA:
undetectable		 6f6iA-3dwcA:
11.65
6f6iB-3dwcA:
10.88