SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3dwd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_D_BRLD503_1
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 3dwd ADP-RIBOSYLATION
FACTOR
GTPASE-ACTIVATING
PROTEIN 1
(Homo
sapiens) 		5 / 12 GLY A  26
CYH A  22
HIS A  49
LEU A  99
TYR A 103
 None
ZN  A 501 (-2.3A)
None
None
None
 1.32A 1fm6D-3dwdA:
undetectable		 1fm6D-3dwdA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_X_BRLX504_1
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 3dwd ADP-RIBOSYLATION
FACTOR
GTPASE-ACTIVATING
PROTEIN 1
(Homo
sapiens) 		5 / 12 GLY A  26
CYH A  22
HIS A  49
LEU A  99
TYR A 103
 None
ZN  A 501 (-2.3A)
None
None
None
 1.36A 1fm6X-3dwdA:
undetectable		 1fm6X-3dwdA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT5_A_RTLA176_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 3dwd ADP-RIBOSYLATION
FACTOR
GTPASE-ACTIVATING
PROTEIN 1
(Homo
sapiens) 		5 / 12 LEU A 110
LEU A  87
HIS A  49
ARG A 112
TYR A  37
 None
 1.40A 1kt5A-3dwdA:
undetectable		 1kt5A-3dwdA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_A_UEGA300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 3dwd ADP-RIBOSYLATION
FACTOR
GTPASE-ACTIVATING
PROTEIN 1
(Homo
sapiens) 		5 / 11 GLY A  38
GLY A  79
VAL A  33
MET A  75
VAL A  13
 None
 1.37A 4c5lA-3dwdA:
undetectable		 4c5lA-3dwdA:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_B_PXLB300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 3dwd ADP-RIBOSYLATION
FACTOR
GTPASE-ACTIVATING
PROTEIN 1
(Homo
sapiens) 		5 / 9 GLY A  38
GLY A  79
VAL A  33
MET A  75
VAL A  13
 None
 1.38A 4c5lB-3dwdA:
undetectable		 4c5lB-3dwdA:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_C_UEGC300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 3dwd ADP-RIBOSYLATION
FACTOR
GTPASE-ACTIVATING
PROTEIN 1
(Homo
sapiens) 		5 / 10 GLY A  38
GLY A  79
VAL A  33
MET A  75
VAL A  13
 None
 1.42A 4c5lC-3dwdA:
undetectable		 4c5lC-3dwdA:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_D_UEGD300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 3dwd ADP-RIBOSYLATION
FACTOR
GTPASE-ACTIVATING
PROTEIN 1
(Homo
sapiens) 		5 / 10 GLY A  38
GLY A  79
VAL A  33
MET A  75
VAL A  13
 None
 1.38A 4c5lD-3dwdA:
undetectable		 4c5lD-3dwdA:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_D_UEGD300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 3dwd ADP-RIBOSYLATION
FACTOR
GTPASE-ACTIVATING
PROTEIN 1
(Homo
sapiens) 		5 / 10 GLY A  38
GLY A  79
VAL A  33
MET A  75
VAL A  13
 None
 1.45A 4c5nD-3dwdA:
undetectable		 4c5nD-3dwdA:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JI0_D_BRLD501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3dwd ADP-RIBOSYLATION
FACTOR
GTPASE-ACTIVATING
PROTEIN 1
(Homo
sapiens) 		5 / 12 GLY A  26
CYH A  22
HIS A  49
LEU A  99
TYR A 103
 None
ZN  A 501 (-2.3A)
None
None
None
 1.39A 5ji0D-3dwdA:
undetectable		 5ji0D-3dwdA:
20.52