SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3dwf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_A_GLYA1292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 3dwf 11-BETA-HYDROXYSTERO
ID DEHYDROGENASE 1
(Cavia
porcellus) 		4 / 8 SER A 151
HIS A 120
SER A 146
PHE A 194
 None
 1.25A 1eqbA-3dwfA:
3.1
1eqbB-3dwfA:
3.2		 1eqbA-3dwfA:
20.95
1eqbB-3dwfA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_B_GLYB2292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 3dwf 11-BETA-HYDROXYSTERO
ID DEHYDROGENASE 1
(Cavia
porcellus) 		4 / 8 PHE A 194
SER A 151
HIS A 120
SER A 146
 None
 1.27A 1eqbA-3dwfA:
3.1
1eqbB-3dwfA:
3.2		 1eqbA-3dwfA:
20.95
1eqbB-3dwfA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_C_GLYC3292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 3dwf 11-BETA-HYDROXYSTERO
ID DEHYDROGENASE 1
(Cavia
porcellus) 		4 / 8 SER A 151
HIS A 120
SER A 146
PHE A 194
 None
 1.25A 1eqbC-3dwfA:
3.2
1eqbD-3dwfA:
3.2		 1eqbC-3dwfA:
20.95
1eqbD-3dwfA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_D_GLYD4292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 3dwf 11-BETA-HYDROXYSTERO
ID DEHYDROGENASE 1
(Cavia
porcellus) 		4 / 8 PHE A 194
SER A 151
HIS A 120
SER A 146
 None
 1.27A 1eqbC-3dwfA:
3.2
1eqbD-3dwfA:
3.2		 1eqbC-3dwfA:
20.95
1eqbD-3dwfA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_5
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 3dwf 11-BETA-HYDROXYSTERO
ID DEHYDROGENASE 1
(Cavia
porcellus) 		4 / 4 LEU A  71
VAL A  75
CYH A  78
ALA A  55
 None
 1.08A 1mz9E-3dwfA:
undetectable		 1mz9E-3dwfA:
10.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_5
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 3dwf 11-BETA-HYDROXYSTERO
ID DEHYDROGENASE 1
(Cavia
porcellus) 		4 / 4 LEU A  71
VAL A  75
CYH A  78
ALA A  83
 None
 1.14A 1mz9E-3dwfA:
undetectable		 1mz9E-3dwfA:
10.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N4H_A_REAA500_1
(NUCLEAR RECEPTOR
ROR-BETA)		 3dwf 11-BETA-HYDROXYSTERO
ID DEHYDROGENASE 1
(Cavia
porcellus) 		5 / 11 ILE A  50
ALA A  42
VAL A  39
LEU A  32
ALA A  59
 None
 1.21A 1n4hA-3dwfA:
undetectable		 1n4hA-3dwfA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SA1_B_PODB700_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 3dwf 11-BETA-HYDROXYSTERO
ID DEHYDROGENASE 1
(Cavia
porcellus) 		5 / 12 CYH A  78
LEU A  79
ALA A  83
MET A 110
ALA A  51
 None
 1.08A 1sa1A-3dwfA:
7.2
1sa1B-3dwfA:
7.1		 1sa1A-3dwfA:
20.82
1sa1B-3dwfA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SA1_D_PODD701_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 3dwf 11-BETA-HYDROXYSTERO
ID DEHYDROGENASE 1
(Cavia
porcellus) 		5 / 12 CYH A  78
LEU A  79
ALA A  83
MET A 110
ALA A  51
 None
 1.02A 1sa1C-3dwfA:
7.2
1sa1D-3dwfA:
7.4		 1sa1C-3dwfA:
20.82
1sa1D-3dwfA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BU8_A_TF4A1379_1
(PYRUVATE
DEHYDROGENASE KINASE
ISOENZYME 2)		 3dwf 11-BETA-HYDROXYSTERO
ID DEHYDROGENASE 1
(Cavia
porcellus) 		4 / 8 LEU A  54
ILE A 117
ILE A 246
ILE A 245
 None
 0.77A 2bu8A-3dwfA:
undetectable		 2bu8A-3dwfA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3dwf 11-BETA-HYDROXYSTERO
ID DEHYDROGENASE 1
(Cavia
porcellus) 		4 / 7 LYS A  68
LEU A  71
GLN A  72
PHE A 102
 None
 1.02A 2eijP-3dwfA:
undetectable
2eijW-3dwfA:
undetectable		 2eijP-3dwfA:
21.57
2eijW-3dwfA:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_A_VIAA901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 3dwf 11-BETA-HYDROXYSTERO
ID DEHYDROGENASE 1
(Cavia
porcellus) 		5 / 11 TYR A 123
ASN A 143
ILE A  46
LEU A 190
ILE A 214
 NAP  A 301 (-4.8A)
None
NAP  A 301 (-3.8A)
None
None
 1.15A 2h42A-3dwfA:
undetectable		 2h42A-3dwfA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_B_VIAB902_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 3dwf 11-BETA-HYDROXYSTERO
ID DEHYDROGENASE 1
(Cavia
porcellus) 		5 / 12 TYR A 123
ASN A 143
ILE A  46
LEU A 190
ILE A 214
 NAP  A 301 (-4.8A)
None
NAP  A 301 (-3.8A)
None
None
 1.10A 2h42B-3dwfA:
undetectable		 2h42B-3dwfA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZUL_A_SAMA376_1
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 3dwf 11-BETA-HYDROXYSTERO
ID DEHYDROGENASE 1
(Cavia
porcellus) 		3 / 3 SER A  67
GLU A 221
ASP A 219
 NAP  A 301 (-4.9A)
SO4  A   1 (-4.6A)
None
 0.83A 2zulA-3dwfA:
4.0		 2zulA-3dwfA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3dwf 11-BETA-HYDROXYSTERO
ID DEHYDROGENASE 1
(Cavia
porcellus) 		4 / 7 LYS A  68
LEU A  71
GLN A  72
PHE A 102
 None
 0.99A 2zxwC-3dwfA:
undetectable
2zxwJ-3dwfA:
undetectable		 2zxwC-3dwfA:
21.57
2zxwJ-3dwfA:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DMH_A_SAMA384_1
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 3dwf 11-BETA-HYDROXYSTERO
ID DEHYDROGENASE 1
(Cavia
porcellus) 		3 / 3 SER A  67
GLU A 221
ASP A 219
 NAP  A 301 (-4.9A)
SO4  A   1 (-4.6A)
None
 0.82A 3dmhA-3dwfA:
7.5		 3dmhA-3dwfA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9V_B_DXCB1_0
(INVASIN IPAD)		 3dwf 11-BETA-HYDROXYSTERO
ID DEHYDROGENASE 1
(Cavia
porcellus) 		4 / 7 LEU A 190
LEU A 118
HIS A 145
VAL A 103
 None
 0.96A 3r9vA-3dwfA:
undetectable
3r9vB-3dwfA:
undetectable		 3r9vA-3dwfA:
23.78
3r9vB-3dwfA:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UBO_B_ADNB353_2
(ADENOSINE KINASE)		 3dwf 11-BETA-HYDROXYSTERO
ID DEHYDROGENASE 1
(Cavia
porcellus) 		4 / 5 SER A 170
ILE A  46
TYR A 183
GLY A 216
 NAP  A 301 (-3.4A)
NAP  A 301 (-3.8A)
NAP  A 301 (-4.8A)
GOL  A   9 (-4.6A)
 1.04A 3uboB-3dwfA:
6.5		 3uboB-3dwfA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UT5_D_LOCD502_1
(TUBULIN BETA CHAIN)		 3dwf 11-BETA-HYDROXYSTERO
ID DEHYDROGENASE 1
(Cavia
porcellus) 		5 / 12 CYH A  78
LEU A  79
ALA A  83
MET A 110
ALA A  51
 None
 1.13A 3ut5D-3dwfA:
7.3		 3ut5D-3dwfA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_A_SASA806_1
(SEPIAPTERIN
REDUCTASE)		 3dwf 11-BETA-HYDROXYSTERO
ID DEHYDROGENASE 1
(Cavia
porcellus) 		5 / 12 LEU A 251
ALA A 166
ASP A 114
MET A 115
GLY A 163
 None
 1.26A 4j7xA-3dwfA:
24.1		 4j7xA-3dwfA:
28.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z2E_F_TR6F101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
SYMMETRIZED E-SITE
DNA)		 3dwf 11-BETA-HYDROXYSTERO
ID DEHYDROGENASE 1
(Cavia
porcellus) 		4 / 5 GLY A 269
ARG A 273
GLY A 272
GLU A 277
 None
 1.23A 4z2eB-3dwfA:
undetectable
4z2eC-3dwfA:
2.4		 4z2eB-3dwfA:
20.52
4z2eC-3dwfA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWA_A_GCSA303_1
(CHITOSANASE)		 3dwf 11-BETA-HYDROXYSTERO
ID DEHYDROGENASE 1
(Cavia
porcellus) 		4 / 5 HIS A  53
VAL A  61
GLY A  58
ALA A  83
 None
 0.92A 5hwaA-3dwfA:
undetectable		 5hwaA-3dwfA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZR_E_PFLE409_1
(PROTON-GATED ION
CHANNEL)		 3dwf 11-BETA-HYDROXYSTERO
ID DEHYDROGENASE 1
(Cavia
porcellus) 		4 / 8 PRO A 178
TYR A 177
THR A 176
ILE A 175
 None
GOL  A   9 ( 4.6A)
None
None
 0.92A 5mzrE-3dwfA:
undetectable		 5mzrE-3dwfA:
14.17