SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3dwh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_B_VIBB504_1
(YKOF)		 3dwh E3 UBIQUITIN-PROTEIN
LIGASE UHRF1
(Homo
sapiens) 		4 / 6 PRO A 444
HIS A 442
LEU A 508
SER A 481
 None
 1.23A 1sbrA-3dwhA:
undetectable
1sbrB-3dwhA:
undetectable		 1sbrA-3dwhA:
21.70
1sbrB-3dwhA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_B_CLMB1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 3dwh E3 UBIQUITIN-PROTEIN
LIGASE UHRF1
(Homo
sapiens) 		4 / 6 GLY A 588
PRO A 589
ILE A 598
GLY A 594
 None
 0.65A 1usqB-3dwhA:
undetectable		 1usqB-3dwhA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_C_CLMC1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 3dwh E3 UBIQUITIN-PROTEIN
LIGASE UHRF1
(Homo
sapiens) 		4 / 6 GLY A 588
PRO A 589
ILE A 598
GLY A 594
 None
 0.67A 1usqC-3dwhA:
undetectable		 1usqC-3dwhA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_D_CLMD1142_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 3dwh E3 UBIQUITIN-PROTEIN
LIGASE UHRF1
(Homo
sapiens) 		4 / 6 GLY A 588
PRO A 589
ILE A 598
GLY A 594
 None
 0.68A 1usqD-3dwhA:
undetectable		 1usqD-3dwhA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_E_CLME1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 3dwh E3 UBIQUITIN-PROTEIN
LIGASE UHRF1
(Homo
sapiens) 		4 / 6 GLY A 588
PRO A 589
ILE A 598
GLY A 594
 None
 0.67A 1usqE-3dwhA:
undetectable		 1usqE-3dwhA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_F_CLMF1144_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 3dwh E3 UBIQUITIN-PROTEIN
LIGASE UHRF1
(Homo
sapiens) 		4 / 7 GLY A 588
PRO A 589
ILE A 598
GLY A 594
 None
 0.65A 1usqF-3dwhA:
undetectable		 1usqF-3dwhA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_A_CLMA1141_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 3dwh E3 UBIQUITIN-PROTEIN
LIGASE UHRF1
(Homo
sapiens) 		4 / 6 GLY A 588
PRO A 589
ILE A 598
GLY A 594
 None
 0.72A 2jkjA-3dwhA:
undetectable		 2jkjA-3dwhA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_B_CLMB1141_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 3dwh E3 UBIQUITIN-PROTEIN
LIGASE UHRF1
(Homo
sapiens) 		4 / 6 GLY A 588
PRO A 589
ILE A 598
GLY A 594
 None
 0.72A 2jkjB-3dwhA:
undetectable		 2jkjB-3dwhA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_C_CLMC1141_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 3dwh E3 UBIQUITIN-PROTEIN
LIGASE UHRF1
(Homo
sapiens) 		4 / 6 GLY A 588
PRO A 589
ILE A 598
GLY A 594
 None
 0.72A 2jkjC-3dwhA:
undetectable		 2jkjC-3dwhA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_E_CLME1141_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 3dwh E3 UBIQUITIN-PROTEIN
LIGASE UHRF1
(Homo
sapiens) 		4 / 7 GLY A 588
PRO A 589
ILE A 598
GLY A 594
 None
 0.71A 2jkjE-3dwhA:
undetectable		 2jkjE-3dwhA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_A_CLMA1144_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 3dwh E3 UBIQUITIN-PROTEIN
LIGASE UHRF1
(Homo
sapiens) 		4 / 7 GLY A 588
PRO A 589
ILE A 598
GLY A 594
 None
 0.70A 2jklA-3dwhA:
undetectable		 2jklA-3dwhA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_B_CLMB1144_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 3dwh E3 UBIQUITIN-PROTEIN
LIGASE UHRF1
(Homo
sapiens) 		4 / 6 GLY A 588
PRO A 589
ILE A 598
GLY A 594
 None
 0.69A 2jklB-3dwhA:
undetectable		 2jklB-3dwhA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_E_CLME1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 3dwh E3 UBIQUITIN-PROTEIN
LIGASE UHRF1
(Homo
sapiens) 		4 / 7 GLY A 588
PRO A 589
ILE A 598
GLY A 594
 None
 0.69A 2jklE-3dwhA:
undetectable		 2jklE-3dwhA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_A_SAMA238_0
(N,N-DIMETHYLTRANSFER
ASE)		 3dwh E3 UBIQUITIN-PROTEIN
LIGASE UHRF1
(Homo
sapiens) 		5 / 12 ALA A 457
GLY A 451
HIS A 442
LEU A 510
TYR A 578
 None
 1.27A 3bxoA-3dwhA:
undetectable		 3bxoA-3dwhA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_B_SAMB238_0
(N,N-DIMETHYLTRANSFER
ASE)		 3dwh E3 UBIQUITIN-PROTEIN
LIGASE UHRF1
(Homo
sapiens) 		5 / 12 ALA A 457
GLY A 451
HIS A 442
LEU A 510
TYR A 578
 None
 1.35A 3bxoB-3dwhA:
undetectable		 3bxoB-3dwhA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_D_T1CD401_1
(TETX2 PROTEIN)		 3dwh E3 UBIQUITIN-PROTEIN
LIGASE UHRF1
(Homo
sapiens) 		5 / 10 HIS A 442
GLN A 499
ASN A 503
GLY A 483
GLY A 448
 None
 1.41A 3v3oD-3dwhA:
undetectable		 3v3oD-3dwhA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JDS_C_SAMC401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 3dwh E3 UBIQUITIN-PROTEIN
LIGASE UHRF1
(Homo
sapiens) 		5 / 11 ILE A 598
GLY A 594
GLU A 593
GLY A 473
ASN A 474
 None
 1.33A 4jdsC-3dwhA:
undetectable		 4jdsC-3dwhA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0B_A_NVPA901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 3dwh E3 UBIQUITIN-PROTEIN
LIGASE UHRF1
(Homo
sapiens) 		4 / 8 VAL A 562
TYR A 564
TYR A 578
TRP A 576
 None
 1.16A 4q0bA-3dwhA:
undetectable		 4q0bA-3dwhA:
16.26