SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3dwl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_B_DVAB8_0
(GRAMICIDIN A)		 3dwl ACTIN-RELATED
PROTEIN 2/3 COMPLEX
SUBUNIT 2
(Schizosaccharomy
ces
pombe) 		3 / 3 VAL D 179
VAL D 244
TRP D 170
 None
 0.72A 1av2A-3dwlD:
undetectable
1av2B-3dwlD:
undetectable		 1av2A-3dwlD:
5.58
1av2B-3dwlD:
5.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CRB_A_RTLA200_0
(CELLULAR RETINOL
BINDING PROTEIN)		 3dwl ACTIN-RELATED
PROTEIN 3
ACTIN-RELATED
PROTEIN 2/3 COMPLEX
SUBUNIT 2
(Schizosaccharomy
ces
pombe;
Schizosaccharomy
ces
pombe) 		5 / 12 LEU D   4
LEU A  72
ILE A 145
MET A 146
TRP A 109
 None
 1.06A 1crbA-3dwlD:
undetectable		 1crbA-3dwlD:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D1G_B_MTXB171_1
(DIHYDROFOLATE
REDUCTASE)		 3dwl ACTIN-RELATED
PROTEIN 2/3 COMPLEX
SUBUNIT 4
(Schizosaccharomy
ces
pombe) 		5 / 12 ASP F  80
ARG F  88
GLU F  59
ILE F  76
ILE F 146
 None
 1.07A 1d1gB-3dwlF:
undetectable		 1d1gB-3dwlF:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H9Z_A_RWFA3001_1
(SERUM ALBUMIN)		 3dwl ACTIN-RELATED
PROTEIN 2/3 COMPLEX
SUBUNIT 1
(Schizosaccharomy
ces
pombe) 		5 / 11 PHE C 195
ALA C 175
LEU C 161
LEU C 145
SER C 119
 None
 1.12A 1h9zA-3dwlC:
undetectable		 1h9zA-3dwlC:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IEP_A_STIA201_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 3dwl ACTIN-RELATED
PROTEIN 2/3 COMPLEX
SUBUNIT 4
ACTIN-RELATED
PROTEIN 2/3 COMPLEX
SUBUNIT 5
(Schizosaccharomy
ces
pombe) 		4 / 6 VAL F  53
VAL G 145
ILE G 111
ARG F  13
 None
 1.03A 1iepA-3dwlF:
undetectable		 1iepA-3dwlF:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7R_A_NCTA440_1
(CYTOCHROME P450-CAM)		 3dwl ACTIN-RELATED
PROTEIN 2/3 COMPLEX
SUBUNIT 4
ACTIN-RELATED
PROTEIN 2/3 COMPLEX
SUBUNIT 5
(Schizosaccharomy
ces
pombe) 		4 / 7 THR F  15
VAL F  53
VAL G 145
ILE G 142
 None
 0.93A 1p7rA-3dwlF:
undetectable		 1p7rA-3dwlF:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RUK_H_BEZH601_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 3dwl ACTIN-RELATED
PROTEIN 2/3 COMPLEX
SUBUNIT 1
(Schizosaccharomy
ces
pombe) 		4 / 8 ALA C 219
TYR C 233
LEU C 220
GLY C 212
 None
 0.83A 1rukH-3dwlC:
undetectable
1rukL-3dwlC:
undetectable		 1rukH-3dwlC:
21.64
1rukL-3dwlC:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_C_SAMC303_0
(HEMK PROTEIN)		 3dwl ACTIN-RELATED
PROTEIN 3
(Schizosaccharomy
ces
pombe) 		5 / 12 PHE A 388
GLY A 390
ALA A  22
VAL A 162
ALA A 167
 None
 1.10A 1sg9C-3dwlA:
undetectable		 1sg9C-3dwlA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_A_STIA600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3dwl ACTIN-RELATED
PROTEIN 2/3 COMPLEX
SUBUNIT 4
ACTIN-RELATED
PROTEIN 2/3 COMPLEX
SUBUNIT 5
(Schizosaccharomy
ces
pombe) 		4 / 6 VAL F  53
VAL G 145
ILE G 111
ARG F  13
 None
 1.03A 2hyyA-3dwlF:
undetectable		 2hyyA-3dwlF:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_C_DVAC8_0
(GRAMICIDIN D)		 3dwl ACTIN-RELATED
PROTEIN 2/3 COMPLEX
SUBUNIT 2
(Schizosaccharomy
ces
pombe) 		3 / 3 VAL D 244
TRP D 170
VAL D 179
 None
 0.95A 2izqC-3dwlD:
undetectable
2izqD-3dwlD:
undetectable		 2izqC-3dwlD:
5.58
2izqD-3dwlD:
5.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QBO_A_CAMA442_0
(CYTOCHROME P450-CAM)		 3dwl ACTIN-RELATED
PROTEIN 2/3 COMPLEX
SUBUNIT 4
ACTIN-RELATED
PROTEIN 2/3 COMPLEX
SUBUNIT 5
(Schizosaccharomy
ces
pombe;
Schizosaccharomy
ces
pombe) 		5 / 10 THR F  15
VAL F  53
VAL F  52
VAL G 145
ILE G 142
 None
 1.45A 2qboA-3dwlF:
undetectable		 2qboA-3dwlF:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AXZ_A_ADNA401_1
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 3dwl ACTIN-RELATED
PROTEIN 3
(Schizosaccharomy
ces
pombe) 		5 / 12 GLY A 187
GLY A 213
LEU A 338
GLY A 335
GLY A 334
 ATP  A 428 (-3.2A)
ATP  A 428 (-3.7A)
ATP  A 428 ( 3.8A)
ATP  A 428 (-3.2A)
ATP  A 428 (-3.8A)
 1.08A 3axzA-3dwlA:
undetectable		 3axzA-3dwlA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CR4_X_PNTX101_0
(PROTEIN S100-B)		 3dwl ACTIN-RELATED
PROTEIN 2/3 COMPLEX
SUBUNIT 2
(Schizosaccharomy
ces
pombe) 		3 / 3 CYH D 258
HIS D 249
PHE D 250
 None
 1.17A 3cr4X-3dwlD:
0.6		 3cr4X-3dwlD:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW5_B_TOPB208_1
(DIHYDROFOLATE
REDUCTASE)		 3dwl ACTIN-RELATED
PROTEIN 2/3 COMPLEX
SUBUNIT 1
(Schizosaccharomy
ces
pombe) 		5 / 10 ALA C   2
LEU C 276
ILE C 360
LEU C 258
PHE C 363
 None
 1.14A 3jw5B-3dwlC:
undetectable		 3jw5B-3dwlC:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JZJ_A_ACRA405_1
(ACARBOSE/MALTOSE
BINDING PROTEIN GACH)		 3dwl ACTIN-RELATED
PROTEIN 3
(Schizosaccharomy
ces
pombe) 		5 / 12 GLU A 398
GLY A 199
ARG A 177
ALA A 164
GLY A 390
 None
 1.43A 3jzjA-3dwlA:
undetectable		 3jzjA-3dwlA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KM6_B_EAAB222_1
(GLUTATHIONE
S-TRANSFERASE P)		 3dwl ACTIN-RELATED
PROTEIN 3
(Schizosaccharomy
ces
pombe) 		5 / 9 VAL A 376
VAL A 184
VAL A 247
ASN A 344
GLY A 343
 None
 1.43A 3km6B-3dwlA:
undetectable		 3km6B-3dwlA:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MS9_A_STIA1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 3dwl ACTIN-RELATED
PROTEIN 2/3 COMPLEX
SUBUNIT 4
ACTIN-RELATED
PROTEIN 2/3 COMPLEX
SUBUNIT 5
(Schizosaccharomy
ces
pombe) 		4 / 6 VAL F  53
VAL G 145
ILE G 111
ARG F  13
 None
 1.11A 3ms9A-3dwlF:
undetectable		 3ms9A-3dwlF:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MS9_B_STIB1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 3dwl ACTIN-RELATED
PROTEIN 2/3 COMPLEX
SUBUNIT 4
ACTIN-RELATED
PROTEIN 2/3 COMPLEX
SUBUNIT 5
(Schizosaccharomy
ces
pombe) 		4 / 7 VAL F  53
VAL G 145
ILE G 111
ARG F  13
 None
 1.33A 3ms9B-3dwlF:
undetectable		 3ms9B-3dwlF:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_A_STIA1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 3dwl ACTIN-RELATED
PROTEIN 2/3 COMPLEX
SUBUNIT 4
ACTIN-RELATED
PROTEIN 2/3 COMPLEX
SUBUNIT 5
(Schizosaccharomy
ces
pombe) 		4 / 6 VAL F  53
VAL G 145
ILE G 111
ARG F  13
 None
 1.11A 3mssA-3dwlF:
undetectable		 3mssA-3dwlF:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_B_STIB1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 3dwl ACTIN-RELATED
PROTEIN 2/3 COMPLEX
SUBUNIT 4
ACTIN-RELATED
PROTEIN 2/3 COMPLEX
SUBUNIT 5
(Schizosaccharomy
ces
pombe) 		4 / 7 VAL F  53
VAL G 145
ILE G 111
ARG F  13
 None
 1.05A 3mssB-3dwlF:
undetectable		 3mssB-3dwlF:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_C_STIC1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 3dwl ACTIN-RELATED
PROTEIN 2/3 COMPLEX
SUBUNIT 4
ACTIN-RELATED
PROTEIN 2/3 COMPLEX
SUBUNIT 5
(Schizosaccharomy
ces
pombe) 		4 / 6 VAL F  53
VAL G 145
ILE G 111
ARG F  13
 None
 1.12A 3mssC-3dwlF:
undetectable		 3mssC-3dwlF:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGY_A_GLYA510_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 3dwl ACTIN-RELATED
PROTEIN 3
ACTIN-RELATED
PROTEIN 2/3 COMPLEX
SUBUNIT 2
(Schizosaccharomy
ces
pombe;
Schizosaccharomy
ces
pombe) 		4 / 6 ILE D   9
GLU D  13
PHE A  31
ASN A  78
 None
 0.99A 3pgyA-3dwlD:
undetectable
3pgyB-3dwlD:
undetectable		 3pgyA-3dwlD:
21.13
3pgyB-3dwlD:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9C_A_ECLA452_1
(CYTOCHROME P450
164A2)		 3dwl ACTIN-RELATED
PROTEIN 2/3 COMPLEX
SUBUNIT 4
(Schizosaccharomy
ces
pombe) 		5 / 12 ALA F  21
LEU F  51
VAL F  53
THR F  15
LEU F  16
 None
 0.93A 3r9cA-3dwlF:
undetectable		 3r9cA-3dwlF:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_G_ACTG305_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 3dwl ACTIN-RELATED
PROTEIN 2/3 COMPLEX
SUBUNIT 2
(Schizosaccharomy
ces
pombe) 		3 / 3 ASP D 290
ARG D 283
LYS D 286
 None
 1.16A 3wipG-3dwlD:
undetectable		 3wipG-3dwlD:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_D_ZPCD1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3dwl ACTIN-RELATED
PROTEIN 2/3 COMPLEX
SUBUNIT 4
(Schizosaccharomy
ces
pombe) 		4 / 8 PHE F 138
VAL F 142
MET F 149
ILE F 146
 None
 1.10A 4a97C-3dwlF:
undetectable		 4a97C-3dwlF:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_I_ZPCI1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3dwl ACTIN-RELATED
PROTEIN 3
(Schizosaccharomy
ces
pombe) 		4 / 6 ILE A 292
PHE A 294
HIS A 192
VAL A 314
 None
 1.08A 4a97I-3dwlA:
undetectable		 4a97I-3dwlA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_J_ZPCJ1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3dwl ACTIN-RELATED
PROTEIN 2/3 COMPLEX
SUBUNIT 4
(Schizosaccharomy
ces
pombe) 		4 / 8 PHE F 138
VAL F 142
MET F 149
ILE F 146
 None
 1.09A 4a97I-3dwlF:
undetectable		 4a97I-3dwlF:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1I_B_LOCB502_2
(TUBULIN BETA CHAIN)		 3dwl ACTIN-RELATED
PROTEIN 2/3 COMPLEX
SUBUNIT 1
(Schizosaccharomy
ces
pombe) 		5 / 12 LEU C 152
ALA C 163
LEU C 145
VAL C 126
ALA C 116
 None
 1.18A 4x1iB-3dwlC:
undetectable		 4x1iB-3dwlC:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE3_A_CL6A502_1
(CYTOCHROME P-450)		 3dwl ACTIN-RELATED
PROTEIN 2/3 COMPLEX
SUBUNIT 4
ACTIN-RELATED
PROTEIN 2/3 COMPLEX
SUBUNIT 5
(Schizosaccharomy
ces
pombe) 		4 / 5 ALA F  11
THR F  15
VAL G 145
ILE G 142
 None
 0.96A 4xe3A-3dwlF:
undetectable		 4xe3A-3dwlF:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE3_A_CL6A502_1
(CYTOCHROME P-450)		 3dwl ACTIN-RELATED
PROTEIN 2/3 COMPLEX
SUBUNIT 4
ACTIN-RELATED
PROTEIN 2/3 COMPLEX
SUBUNIT 5
(Schizosaccharomy
ces
pombe) 		4 / 5 LEU G 126
ALA F  11
THR F  15
ILE G 142
 None
 0.89A 4xe3A-3dwlG:
undetectable		 4xe3A-3dwlG:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE3_B_CL6B502_1
(CYTOCHROME P-450)		 3dwl ACTIN-RELATED
PROTEIN 2/3 COMPLEX
SUBUNIT 4
ACTIN-RELATED
PROTEIN 2/3 COMPLEX
SUBUNIT 5
(Schizosaccharomy
ces
pombe) 		4 / 5 LEU G 126
ALA F  11
THR F  15
VAL G 145
 None
 0.94A 4xe3B-3dwlG:
undetectable		 4xe3B-3dwlG:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE3_B_CL6B502_1
(CYTOCHROME P-450)		 3dwl ACTIN-RELATED
PROTEIN 2/3 COMPLEX
SUBUNIT 4
ACTIN-RELATED
PROTEIN 2/3 COMPLEX
SUBUNIT 5
(Schizosaccharomy
ces
pombe) 		4 / 5 LEU G 126
THR F  15
VAL G 145
ILE G 142
 None
 0.90A 4xe3B-3dwlG:
undetectable		 4xe3B-3dwlG:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XZK_A_AG2A700_1
(PUTATIVE
NAD(+)--ARGININE
ADP-RIBOSYLTRANSFERA
SE VIS)		 3dwl ACTIN-RELATED
PROTEIN 2/3 COMPLEX
SUBUNIT 1
ACTIN-RELATED
PROTEIN 2/3 COMPLEX
SUBUNIT 4
(Schizosaccharomy
ces
pombe) 		4 / 7 SER C 147
SER F  43
PHE F  25
GLU F  45
 None
 1.40A 4xzkA-3dwlC:
undetectable		 4xzkA-3dwlC:
25.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y03_B_SALB801_1
(PROTEIN POLYBROMO-1)		 3dwl ACTIN-RELATED
PROTEIN 2/3 COMPLEX
SUBUNIT 5
(Schizosaccharomy
ces
pombe) 		4 / 5 LEU G  59
ALA G  52
ASN G  86
ILE G  47
 None
 1.16A 4y03B-3dwlG:
undetectable		 4y03B-3dwlG:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AQF_A_ADNA1382_1
(HEAT SHOCK COGNATE
71 KDA PROTEIN)		 3dwl ACTIN-RELATED
PROTEIN 3
(Schizosaccharomy
ces
pombe) 		5 / 10 GLY A 213
GLU A 238
LYS A 241
GLY A 335
SER A 336
 ATP  A 428 (-3.7A)
ATP  A 428 (-3.8A)
ATP  A 428 (-2.8A)
ATP  A 428 (-3.2A)
ATP  A 428 (-4.4A)
 0.63A 5aqfA-3dwlA:
8.0		 5aqfA-3dwlA:
24.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AQF_C_ADNC1382_1
(HEAT SHOCK COGNATE
71 KDA PROTEIN)		 3dwl ACTIN-RELATED
PROTEIN 3
(Schizosaccharomy
ces
pombe) 		5 / 10 GLY A 213
GLU A 238
LYS A 241
GLY A 335
SER A 336
 ATP  A 428 (-3.7A)
ATP  A 428 (-3.8A)
ATP  A 428 (-2.8A)
ATP  A 428 (-3.2A)
ATP  A 428 (-4.4A)
 0.65A 5aqfC-3dwlA:
4.0		 5aqfC-3dwlA:
24.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AQY_A_ADNA1389_1
(HEAT SHOCK 70 KDA
PROTEIN 1A)		 3dwl ACTIN-RELATED
PROTEIN 3
(Schizosaccharomy
ces
pombe) 		5 / 10 GLY A 213
GLU A 238
LYS A 241
GLY A 335
SER A 336
 ATP  A 428 (-3.7A)
ATP  A 428 (-3.8A)
ATP  A 428 (-2.8A)
ATP  A 428 (-3.2A)
ATP  A 428 (-4.4A)
 0.63A 5aqyA-3dwlA:
20.6		 5aqyA-3dwlA:
24.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HP1_A_PPFA602_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 3dwl ACTIN-RELATED
PROTEIN 2/3 COMPLEX
SUBUNIT 2
ACTIN-RELATED
PROTEIN 3
(Schizosaccharomy
ces
pombe) 		4 / 6 ARG D 266
ASP A 123
GLY D  36
ASP D  35
 None
 1.04A 5hp1A-3dwlD:
3.1		 5hp1A-3dwlD:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KLA_A_ACTA1505_0
(MATERNAL PROTEIN
PUMILIO)		 3dwl ACTIN-RELATED
PROTEIN 2/3 COMPLEX
SUBUNIT 2
(Schizosaccharomy
ces
pombe) 		3 / 3 HIS D 272
LYS D   1
PHE D 271
 None
 1.40A 5klaA-3dwlD:
undetectable		 5klaA-3dwlD:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJE_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 3dwl ACTIN-RELATED
PROTEIN 3
(Schizosaccharomy
ces
pombe) 		4 / 6 LEU A  72
ILE A 145
MET A 146
TRP A 109
 None
 0.84A 5ljeA-3dwlA:
undetectable		 5ljeA-3dwlA:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUE_A_VIVA302_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 3dwl ACTIN-RELATED
PROTEIN 2/3 COMPLEX
SUBUNIT 2
ACTIN-RELATED
PROTEIN 2/3 COMPLEX
SUBUNIT 4
(Schizosaccharomy
ces
pombe;
Schizosaccharomy
ces
pombe) 		5 / 12 VAL F 142
PHE F 116
VAL D 294
LEU D 295
ILE F 103
 None
 0.93A 5mueA-3dwlF:
undetectable		 5mueA-3dwlF:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0W_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 3dwl ACTIN-RELATED
PROTEIN 2/3 COMPLEX
SUBUNIT 5
(Schizosaccharomy
ces
pombe) 		4 / 4 SER G  45
ALA G  43
GLN G  54
THR G  58
 None
 1.45A 5n0wA-3dwlG:
undetectable		 5n0wA-3dwlG:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE8_C_08JC602_1
(CYTOCHROME P450 3A4)		 3dwl ACTIN-RELATED
PROTEIN 2/3 COMPLEX
SUBUNIT 4
ACTIN-RELATED
PROTEIN 2/3 COMPLEX
SUBUNIT 5
(Schizosaccharomy
ces
pombe) 		5 / 7 LEU G 115
ALA F  11
THR F  15
ILE F  63
LEU F  51
 None
 1.21A 5te8C-3dwlG:
undetectable		 5te8C-3dwlG:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W7P_A_SAMA501_0
(OXAC)		 3dwl ACTIN-RELATED
PROTEIN 2/3 COMPLEX
SUBUNIT 2
ACTIN-RELATED
PROTEIN 2/3 COMPLEX
SUBUNIT 4
(Schizosaccharomy
ces
pombe;
Schizosaccharomy
ces
pombe) 		5 / 12 PHE D 291
GLU F 137
LEU D 295
PHE F 116
LEU F 104
 None
 1.08A 5w7pA-3dwlD:
undetectable		 5w7pA-3dwlD:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_C_GLYC713_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 3dwl ACTIN-RELATED
PROTEIN 3
ACTIN-RELATED
PROTEIN 2/3 COMPLEX
SUBUNIT 2
(Schizosaccharomy
ces
pombe;
Schizosaccharomy
ces
pombe) 		3 / 3 GLN D  29
TYR A  21
ASN A  24
 None
 1.01A 6dwdC-3dwlD:
undetectable		 6dwdC-3dwlD:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_B_STIB601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3dwl ACTIN-RELATED
PROTEIN 3
(Schizosaccharomy
ces
pombe) 		4 / 7 VAL A 374
ILE A 377
GLY A 187
ARG A 348
 None
None
ATP  A 428 (-3.2A)
None
 0.91A 6hd6B-3dwlA:
undetectable		 6hd6B-3dwlA:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6J20_A_GBQA1201_0
(SUBSTANCE-P
RECEPTOR,ENDOLYSIN)		 3dwl ACTIN-RELATED
PROTEIN 3
(Schizosaccharomy
ces
pombe) 		5 / 12 PRO A 308
VAL A 311
ILE A 292
THR A 208
ILE A 193
 None
 1.37A 6j20A-3dwlA:
undetectable		 6j20A-3dwlA:
21.05