SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3dwo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CBR_A_REAA200_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
TYPE I)		 3dwo PROBABLE OUTER
MEMBRANE PROTEIN
(Pseudomonas
aeruginosa) 		5 / 12 LEU X 282
ALA X 280
ALA X 278
VAL X 207
LEU X 272
 C8E  X 454 ( 4.9A)
C8E  X 454 ( 3.9A)
None
None
C8E  X 453 ( 4.8A)
 1.25A 1cbrA-3dwoX:
2.8		 1cbrA-3dwoX:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CBR_B_REAB200_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
TYPE I)		 3dwo PROBABLE OUTER
MEMBRANE PROTEIN
(Pseudomonas
aeruginosa) 		5 / 12 LEU X 282
ALA X 280
ALA X 278
VAL X 207
LEU X 272
 C8E  X 454 ( 4.9A)
C8E  X 454 ( 3.9A)
None
None
C8E  X 453 ( 4.8A)
 1.25A 1cbrB-3dwoX:
2.7		 1cbrB-3dwoX:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHF_A_FOLA187_0
(DIHYDROFOLATE
REDUCTASE)		 3dwo PROBABLE OUTER
MEMBRANE PROTEIN
(Pseudomonas
aeruginosa) 		5 / 12 ILE X 373
ALA X   1
PHE X   3
ASN X 238
LEU X 282
 C8E  X 454 ( 4.0A)
None
C8E  X 454 ( 4.7A)
None
C8E  X 454 ( 4.9A)
 1.10A 1dhfA-3dwoX:
undetectable		 1dhfA-3dwoX:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHF_B_FOLB187_0
(DIHYDROFOLATE
REDUCTASE)		 3dwo PROBABLE OUTER
MEMBRANE PROTEIN
(Pseudomonas
aeruginosa) 		5 / 12 ILE X 373
ALA X   1
PHE X   3
ASN X 238
LEU X 282
 C8E  X 454 ( 4.0A)
None
C8E  X 454 ( 4.7A)
None
C8E  X 454 ( 4.9A)
 1.14A 1dhfB-3dwoX:
undetectable		 1dhfB-3dwoX:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T6Z_B_RBFB596_1
(RIBOFLAVIN
KINASE/FMN
ADENYLYLTRANSFERASE)		 3dwo PROBABLE OUTER
MEMBRANE PROTEIN
(Pseudomonas
aeruginosa) 		5 / 11 VAL X 173
VAL X 205
TYR X 244
ARG X 372
LEU X 419
 C8E  X 454 ( 4.3A)
C8E  X 454 ( 4.1A)
None
C8E  X 454 ( 4.8A)
None
 1.37A 1t6zB-3dwoX:
undetectable		 1t6zB-3dwoX:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_B_1FLB2002_1
(SERUM ALBUMIN)		 3dwo PROBABLE OUTER
MEMBRANE PROTEIN
(Pseudomonas
aeruginosa) 		5 / 11 PHE X 230
ALA X 218
ALA X  35
ALA X  29
SER X 289
 None
 0.97A 2bxeB-3dwoX:
undetectable		 2bxeB-3dwoX:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3B_B_FOLB401_0
(DIHYDROFOLATE
REDUCTASE)		 3dwo PROBABLE OUTER
MEMBRANE PROTEIN
(Pseudomonas
aeruginosa) 		5 / 12 ILE X 373
ALA X   1
PHE X   3
ASN X 238
LEU X 282
 C8E  X 454 ( 4.0A)
None
C8E  X 454 ( 4.7A)
None
C8E  X 454 ( 4.9A)
 1.09A 2w3bB-3dwoX:
undetectable		 2w3bB-3dwoX:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3M_A_FOLA1188_0
(DIHYDROFOLATE
REDUCTASE)		 3dwo PROBABLE OUTER
MEMBRANE PROTEIN
(Pseudomonas
aeruginosa) 		5 / 12 ILE X 373
ALA X   1
PHE X   3
ASN X 238
LEU X 282
 C8E  X 454 ( 4.0A)
None
C8E  X 454 ( 4.7A)
None
C8E  X 454 ( 4.9A)
 1.09A 2w3mA-3dwoX:
undetectable		 2w3mA-3dwoX:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3M_B_FOLB1188_0
(DIHYDROFOLATE
REDUCTASE)		 3dwo PROBABLE OUTER
MEMBRANE PROTEIN
(Pseudomonas
aeruginosa) 		5 / 12 ILE X 373
ALA X   1
PHE X   3
ASN X 238
LEU X 282
 C8E  X 454 ( 4.0A)
None
C8E  X 454 ( 4.7A)
None
C8E  X 454 ( 4.9A)
 1.08A 2w3mB-3dwoX:
undetectable		 2w3mB-3dwoX:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_B_DIFB1374_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 3dwo PROBABLE OUTER
MEMBRANE PROTEIN
(Pseudomonas
aeruginosa) 		4 / 6 PRO X 119
ILE X 141
ASN X 238
LEU X 240
 None
C8E  X 454 (-4.1A)
None
None
 1.27A 2wekB-3dwoX:
undetectable		 2wekB-3dwoX:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AX9_B_SALB1340_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 3dwo PROBABLE OUTER
MEMBRANE PROTEIN
(Pseudomonas
aeruginosa) 		4 / 8 PHE X  39
THR X 227
ALA X  35
ALA X  36
 None
 0.92A 3ax9B-3dwoX:
undetectable		 3ax9B-3dwoX:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I5U_B_SAMB401_1
(O-METHYLTRANSFERASE)		 3dwo PROBABLE OUTER
MEMBRANE PROTEIN
(Pseudomonas
aeruginosa) 		3 / 3 ASP X  26
PHE X 101
SER X 438
 None
 0.96A 3i5uB-3dwoX:
undetectable		 3i5uB-3dwoX:
24.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_C_PM6C1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 3dwo PROBABLE OUTER
MEMBRANE PROTEIN
(Pseudomonas
aeruginosa) 		4 / 6 PHE X  39
THR X 227
ALA X  35
ALA X  36
 None
 0.96A 3ns1C-3dwoX:
undetectable		 3ns1C-3dwoX:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_L_PM6L1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 3dwo PROBABLE OUTER
MEMBRANE PROTEIN
(Pseudomonas
aeruginosa) 		4 / 8 PHE X  39
THR X 227
ALA X  35
ALA X  36
 None
 0.95A 3ns1L-3dwoX:
undetectable		 3ns1L-3dwoX:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O7W_A_SAMA801_1
(LEUCINE CARBOXYL
METHYLTRANSFERASE 1)		 3dwo PROBABLE OUTER
MEMBRANE PROTEIN
(Pseudomonas
aeruginosa) 		3 / 3 LYS X 235
ARG X 237
ASP X 316
 None
 1.35A 3o7wA-3dwoX:
undetectable		 3o7wA-3dwoX:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QG2_B_CP6B709_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3dwo PROBABLE OUTER
MEMBRANE PROTEIN
(Pseudomonas
aeruginosa) 		5 / 11 ILE X 373
ALA X   1
MET X 120
PHE X   3
SER X 313
 C8E  X 454 ( 4.0A)
None
None
C8E  X 454 ( 4.7A)
None
 1.19A 3qg2B-3dwoX:
undetectable		 3qg2B-3dwoX:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCJ_A_AZMA229_2
(CARBONIC ANHYDRASE)		 3dwo PROBABLE OUTER
MEMBRANE PROTEIN
(Pseudomonas
aeruginosa) 		3 / 3 GLN X 390
PHE X 389
TYR X 387
 None
 0.84A 3ucjB-3dwoX:
undetectable		 3ucjB-3dwoX:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCJ_B_AZMB229_1
(CARBONIC ANHYDRASE)		 3dwo PROBABLE OUTER
MEMBRANE PROTEIN
(Pseudomonas
aeruginosa) 		3 / 3 GLN X 390
PHE X 389
TYR X 387
 None
 0.90A 3ucjA-3dwoX:
undetectable		 3ucjA-3dwoX:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_B_DXCB1473_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 3dwo PROBABLE OUTER
MEMBRANE PROTEIN
(Pseudomonas
aeruginosa) 		5 / 9 ASP X 283
ILE X 284
THR X 143
GLY X 121
ARG X 378
 None
None
None
C8E  X 455 (-3.5A)
C8E  X 455 (-3.7A)
 1.19A 4acaB-3dwoX:
undetectable
4acaC-3dwoX:
undetectable		 4acaB-3dwoX:
21.06
4acaC-3dwoX:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYT_A_OBNA1104_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 3dwo PROBABLE OUTER
MEMBRANE PROTEIN
(Pseudomonas
aeruginosa) 		4 / 5 PRO X 374
ASP X 375
ILE X  54
VAL X   5
 C8E  X 455 (-3.9A)
C8E  X 455 (-4.2A)
C8E  X 455 (-4.0A)
C8E  X 455 ( 4.8A)
 1.43A 4hytA-3dwoX:
undetectable		 4hytA-3dwoX:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KEB_B_FOLB202_0
(DIHYDROFOLATE
REDUCTASE)		 3dwo PROBABLE OUTER
MEMBRANE PROTEIN
(Pseudomonas
aeruginosa) 		5 / 12 ILE X 373
ALA X   1
PHE X   3
ASN X 238
LEU X 282
 C8E  X 454 ( 4.0A)
None
C8E  X 454 ( 4.7A)
None
C8E  X 454 ( 4.9A)
 1.07A 4kebB-3dwoX:
undetectable		 4kebB-3dwoX:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_A_SAMA601_1
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 3dwo PROBABLE OUTER
MEMBRANE PROTEIN
(Pseudomonas
aeruginosa) 		5 / 5 ASN X   9
ALA X  11
GLY X  12
ASP X 226
ASP X 344
 None
 1.22A 4n48A-3dwoX:
undetectable		 4n48A-3dwoX:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N49_A_SAMA601_1
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 3dwo PROBABLE OUTER
MEMBRANE PROTEIN
(Pseudomonas
aeruginosa) 		4 / 4 ASN X   9
GLY X  12
ASP X 226
ASP X 344
 None
 1.23A 4n49A-3dwoX:
undetectable		 4n49A-3dwoX:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_A_377A402_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3dwo PROBABLE OUTER
MEMBRANE PROTEIN
(Pseudomonas
aeruginosa) 		5 / 9 ALA X  38
ALA X  36
ALA X  29
SER X 149
ALA X 111
 None
 1.18A 4twdA-3dwoX:
undetectable
4twdB-3dwoX:
undetectable
4twdC-3dwoX:
undetectable
4twdD-3dwoX:
undetectable
4twdE-3dwoX:
undetectable		 4twdA-3dwoX:
23.67
4twdB-3dwoX:
23.67
4twdC-3dwoX:
23.67
4twdD-3dwoX:
23.67
4twdE-3dwoX:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_F_377F402_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3dwo PROBABLE OUTER
MEMBRANE PROTEIN
(Pseudomonas
aeruginosa) 		5 / 8 ALA X  29
SER X 149
ALA X 111
ALA X  38
ALA X  36
 None
 1.09A 4twdF-3dwoX:
undetectable
4twdG-3dwoX:
undetectable
4twdH-3dwoX:
undetectable
4twdI-3dwoX:
undetectable
4twdJ-3dwoX:
undetectable		 4twdF-3dwoX:
23.67
4twdG-3dwoX:
23.67
4twdH-3dwoX:
23.67
4twdI-3dwoX:
23.67
4twdJ-3dwoX:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CVT_B_ACTB200_0
(N5-CARBOXYAMINOIMIDA
ZOLE RIBONUCLEOTIDE
MUTASE)		 3dwo PROBABLE OUTER
MEMBRANE PROTEIN
(Pseudomonas
aeruginosa) 		3 / 3 ASN X   9
ALA X  11
ARG X  15
 None
 0.66A 5cvtB-3dwoX:
undetectable		 5cvtB-3dwoX:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DB5_A_CYSA503_0
(CYSTEINE DESULFURASE)		 3dwo PROBABLE OUTER
MEMBRANE PROTEIN
(Pseudomonas
aeruginosa) 		4 / 8 ALA X  11
ARG X 354
ARG X  15
THR X 440
 None
 1.24A 5db5A-3dwoX:
undetectable
5db5B-3dwoX:
undetectable		 5db5A-3dwoX:
24.49
5db5B-3dwoX:
24.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H5F_A_SAMA301_1
(PROTEIN ARGININE
N-METHYLTRANSFERASE
SFM1)		 3dwo PROBABLE OUTER
MEMBRANE PROTEIN
(Pseudomonas
aeruginosa) 		4 / 5 PRO X  98
THR X   7
GLN X 116
THR X 147
 None
 1.02A 5h5fA-3dwoX:
undetectable		 5h5fA-3dwoX:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_A_ACRA608_0
(ALPHA-AMYLASE)		 3dwo PROBABLE OUTER
MEMBRANE PROTEIN
(Pseudomonas
aeruginosa) 		4 / 6 GLY X 376
THR X 362
GLN X 361
TYR X 359
 None
None
C8E  X 461 ( 4.4A)
C8E  X 456 ( 4.9A)
 1.28A 6ag0A-3dwoX:
undetectable		 6ag0A-3dwoX:
11.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC606_0
(ALPHA-AMYLASE)		 3dwo PROBABLE OUTER
MEMBRANE PROTEIN
(Pseudomonas
aeruginosa) 		4 / 6 GLY X 376
THR X 362
GLN X 361
TYR X 359
 None
None
C8E  X 461 ( 4.4A)
C8E  X 456 ( 4.9A)
 1.28A 6ag0C-3dwoX:
undetectable		 6ag0C-3dwoX:
11.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_E_GBME2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 3dwo PROBABLE OUTER
MEMBRANE PROTEIN
(Pseudomonas
aeruginosa) 		3 / 3 LEU X 424
THR X  85
ASN X  86
 None
 0.70A 6baaE-3dwoX:
undetectable		 6baaE-3dwoX:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_F_GBMF2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 3dwo PROBABLE OUTER
MEMBRANE PROTEIN
(Pseudomonas
aeruginosa) 		3 / 3 LEU X 424
THR X  85
ASN X  86
 None
 0.70A 6baaF-3dwoX:
undetectable		 6baaF-3dwoX:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_G_GBMG2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 3dwo PROBABLE OUTER
MEMBRANE PROTEIN
(Pseudomonas
aeruginosa) 		3 / 3 LEU X 424
THR X  85
ASN X  86
 None
 0.71A 6baaG-3dwoX:
undetectable		 6baaG-3dwoX:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_H_GBMH2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 3dwo PROBABLE OUTER
MEMBRANE PROTEIN
(Pseudomonas
aeruginosa) 		3 / 3 LEU X 424
THR X  85
ASN X  86
 None
 0.71A 6baaH-3dwoX:
undetectable		 6baaH-3dwoX:
14.29