SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3dwv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_B_ADNB602_1
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 3dwv GLUTATHIONE
PEROXIDASE-LIKE
PROTEIN
(Trypanosoma
brucei) 		5 / 12 LEU A  39
GLU A 152
LEU A 171
LEU A 170
PHE A 154
 None
 1.44A 1d4fB-3dwvA:
undetectable		 1d4fB-3dwvA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FML_A_RTLA401_0
(RETINOL DEHYDRATASE)		 3dwv GLUTATHIONE
PEROXIDASE-LIKE
PROTEIN
(Trypanosoma
brucei) 		5 / 12 TYR A  41
LEU A  38
LEU A  39
HIS A 116
LEU A 118
 None
 1.35A 1fmlA-3dwvA:
undetectable		 1fmlA-3dwvA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRK_A_TFPA204_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 3dwv GLUTATHIONE
PEROXIDASE-LIKE
PROTEIN
(Trypanosoma
brucei) 		5 / 9 PHE A  74
VAL A  20
LEU A  30
MET A 122
LEU A  72
 None
 1.08A 1wrkA-3dwvA:
undetectable
1wrkB-3dwvA:
undetectable		 1wrkA-3dwvA:
18.39
1wrkB-3dwvA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3C_A_PNXA1435_1
(CHITINASE)		 3dwv GLUTATHIONE
PEROXIDASE-LIKE
PROTEIN
(Trypanosoma
brucei) 		4 / 6 TYR A  28
GLY A  68
PHE A  69
SER A  36
 None
 1.21A 2a3cA-3dwvA:
undetectable		 2a3cA-3dwvA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3dwv GLUTATHIONE
PEROXIDASE-LIKE
PROTEIN
(Trypanosoma
brucei) 		4 / 8 ILE A  15
LEU A  30
PHE A  16
ARG A 146
 None
 0.93A 2einA-3dwvA:
undetectable
2einJ-3dwvA:
undetectable		 2einA-3dwvA:
16.96
2einJ-3dwvA:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QO6_A_CHDA130_0
(LIVER-BASIC FATTY
ACID BINDING PROTEIN)		 3dwv GLUTATHIONE
PEROXIDASE-LIKE
PROTEIN
(Trypanosoma
brucei) 		5 / 12 TYR A  28
ILE A  40
LEU A  38
HIS A 116
MET A 105
 None
 1.32A 2qo6A-3dwvA:
undetectable		 2qo6A-3dwvA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VN1_A_FK5A501_2
(70 KDA
PEPTIDYLPROLYL
ISOMERASE)		 3dwv GLUTATHIONE
PEROXIDASE-LIKE
PROTEIN
(Trypanosoma
brucei) 		4 / 6 LEU A 170
SER A  14
PHE A  16
ASP A  17
 None
 1.06A 2vn1B-3dwvA:
undetectable		 2vn1B-3dwvA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3dwv GLUTATHIONE
PEROXIDASE-LIKE
PROTEIN
(Trypanosoma
brucei) 		4 / 6 ILE A  15
LEU A  30
PHE A  16
ARG A 146
 None
 1.06A 5b1aN-3dwvA:
undetectable
5b1aW-3dwvA:
undetectable		 5b1aN-3dwvA:
16.96
5b1aW-3dwvA:
16.77