SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3dx5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GEB_A_CAMA418_0
(CYTOCHROME P450-CAM)		 3dx5 UNCHARACTERIZED
PROTEIN ASBF
(Bacillus
anthracis) 		5 / 9 TYR A 121
LEU A 158
VAL A 162
VAL A 139
ILE A 128
 None
 1.39A 1gebA-3dx5A:
undetectable		 1gebA-3dx5A:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_C_ADNC2502_2
(ADENOSYLHOMOCYSTEINA
SE)		 3dx5 UNCHARACTERIZED
PROTEIN ASBF
(Bacillus
anthracis) 		3 / 3 GLU A  53
THR A  50
LEU A  34
 None
 0.44A 1v8bC-3dx5A:
undetectable		 1v8bC-3dx5A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VQ1_A_SAMA301_1
(N5-GLUTAMINE
METHYLTRANSFERASE,
HEMK)		 3dx5 UNCHARACTERIZED
PROTEIN ASBF
(Bacillus
anthracis) 		3 / 3 GLY A  36
ASP A  69
ASN A  41
 None
 0.61A 1vq1A-3dx5A:
undetectable		 1vq1A-3dx5A:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACK_A_EDRA999_1
(ACETYLCHOLINESTERASE)		 3dx5 UNCHARACTERIZED
PROTEIN ASBF
(Bacillus
anthracis) 		4 / 7 TYR A 217
GLU A  33
SER A  68
PHE A 104
 DHB  A 289 (-4.3A)
None
None
None
 1.11A 2ackA-3dx5A:
undetectable		 2ackA-3dx5A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2L8M_A_CAMA415_0
(CAMPHOR
5-MONOOXYGENASE)		 3dx5 UNCHARACTERIZED
PROTEIN ASBF
(Bacillus
anthracis) 		5 / 9 TYR A 121
LEU A 158
VAL A 162
VAL A 139
ILE A 128
 None
 1.45A 2l8mA-3dx5A:
undetectable		 2l8mA-3dx5A:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O94_A_NCAA192_0
(NICOTINAMIDASE)		 3dx5 UNCHARACTERIZED
PROTEIN ASBF
(Bacillus
anthracis) 		5 / 11 ASP A 237
PHE A 230
LEU A 229
PHE A 199
ILE A 239
 None
 1.39A 3o94A-3dx5A:
1.6		 3o94A-3dx5A:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O94_B_NCAB192_0
(NICOTINAMIDASE)		 3dx5 UNCHARACTERIZED
PROTEIN ASBF
(Bacillus
anthracis) 		5 / 11 ASP A 237
PHE A 230
LEU A 229
PHE A 199
ILE A 239
 None
 1.39A 3o94B-3dx5A:
undetectable		 3o94B-3dx5A:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O94_C_NCAC192_0
(NICOTINAMIDASE)		 3dx5 UNCHARACTERIZED
PROTEIN ASBF
(Bacillus
anthracis) 		5 / 11 ASP A 237
PHE A 230
LEU A 229
PHE A 199
ILE A 239
 None
 1.39A 3o94C-3dx5A:
1.5		 3o94C-3dx5A:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O94_D_NCAD192_0
(NICOTINAMIDASE)		 3dx5 UNCHARACTERIZED
PROTEIN ASBF
(Bacillus
anthracis) 		5 / 11 ASP A 237
PHE A 230
LEU A 229
PHE A 199
ILE A 239
 None
 1.40A 3o94D-3dx5A:
undetectable		 3o94D-3dx5A:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M51_A_BEZA501_0
(AMIDOHYDROLASE
FAMILY PROTEIN)		 3dx5 UNCHARACTERIZED
PROTEIN ASBF
(Bacillus
anthracis) 		4 / 6 ILE A  32
ILE A  15
SER A  16
LEU A  42
 None
 0.98A 4m51A-3dx5A:
5.6		 4m51A-3dx5A:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE5_A_OBNA1104_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 3dx5 UNCHARACTERIZED
PROTEIN ASBF
(Bacillus
anthracis) 		5 / 12 GLN A  22
GLU A  26
LEU A  57
PHE A  10
ILE A  64
 None
None
GOL  A 291 ( 4.3A)
None
None
 1.21A 4xe5A-3dx5A:
undetectable		 4xe5A-3dx5A:
13.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6J_A_ACTA404_0
(L-LYSINE
3-HYDROXYLASE)		 3dx5 UNCHARACTERIZED
PROTEIN ASBF
(Bacillus
anthracis) 		4 / 6 ILE A 125
LEU A 148
VAL A 162
ARG A 118
 None
None
None
TRS  A 290 (-4.2A)
 1.29A 6f6jA-3dx5A:
undetectable		 6f6jA-3dx5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6J_D_ACTD404_0
(L-LYSINE
3-HYDROXYLASE)		 3dx5 UNCHARACTERIZED
PROTEIN ASBF
(Bacillus
anthracis) 		4 / 6 GLN A  88
GLU A  87
HIS A 135
ALA A  90
 None
 1.30A 6f6jC-3dx5A:
undetectable
6f6jD-3dx5A:
undetectable		 6f6jC-3dx5A:
22.42
6f6jD-3dx5A:
22.42