SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3dxb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1F86_B_T44B528_1
(TRANSTHYRETIN
THR119MET VARIANT)		 3dxb THIOREDOXIN
N-TERMINALLY FUSED
TO PUF60(UHM)
(Escherichia
coli;
Homo
sapiens) 		4 / 4 LYS A 426
LEU A 424
ALA A 366
LEU A 368
 None
 0.89A 1f86B-3dxbA:
undetectable		 1f86B-3dxbA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B302_1
(THIOPURINE
S-METHYLTRANSFERASE)		 3dxb THIOREDOXIN
N-TERMINALLY FUSED
TO PUF60(UHM)
(Escherichia
coli;
Homo
sapiens) 		4 / 7 PHE A 446
LEU A 424
LEU A 397
LEU A 368
 None
 0.80A 3bgdB-3dxbA:
undetectable		 3bgdB-3dxbA:
24.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O02_B_JN3B1_1
(CELL INVASION
PROTEIN SIPD)		 3dxb THIOREDOXIN
N-TERMINALLY FUSED
TO PUF60(UHM)
(Escherichia
coli;
Homo
sapiens) 		5 / 10 ASN A 427
ALA A 366
LEU A 447
ASN A 450
LEU A 451
 None
 1.17A 3o02A-3dxbA:
undetectable
3o02B-3dxbA:
undetectable		 3o02A-3dxbA:
21.23
3o02B-3dxbA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWW_A_ROCA1001_1
(ENDOTHIAPEPSIN)		 3dxb THIOREDOXIN
N-TERMINALLY FUSED
TO PUF60(UHM)
(Escherichia
coli;
Homo
sapiens) 		5 / 12 ASP A 370
GLY A 436
LEU A 386
ILE A 404
ILE A 416
 None
 1.02A 3pwwA-3dxbA:
undetectable		 3pwwA-3dxbA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		 3dxb THIOREDOXIN
N-TERMINALLY FUSED
TO PUF60(UHM)
(Escherichia
coli;
Homo
sapiens) 		4 / 7 LYS A 426
LEU A 424
ALA A 366
LEU A 368
 None
 0.79A 4d7bA-3dxbA:
undetectable		 4d7bA-3dxbA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJW_A_SRYA2001_2
(TRANSCRIPTIONAL
REGULATOR TCAR)		 3dxb THIOREDOXIN
N-TERMINALLY FUSED
TO PUF60(UHM)
(Escherichia
coli;
Homo
sapiens) 		4 / 6 GLU A 542
ILE A 526
ASN A 530
GLU A 483
 None
 0.99A 4ejwB-3dxbA:
undetectable		 4ejwB-3dxbA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IIZ_A_LURA201_1
(TRANSTHYRETIN)		 3dxb THIOREDOXIN
N-TERMINALLY FUSED
TO PUF60(UHM)
(Escherichia
coli;
Homo
sapiens) 		3 / 3 LYS A 426
LEU A 424
ALA A 366
 None
 0.79A 4iizA-3dxbA:
undetectable		 4iizA-3dxbA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IIZ_B_LURB201_1
(TRANSTHYRETIN)		 3dxb THIOREDOXIN
N-TERMINALLY FUSED
TO PUF60(UHM)
(Escherichia
coli;
Homo
sapiens) 		4 / 8 LYS A 426
LEU A 424
ALA A 366
LEU A 368
 None
 0.68A 4iizB-3dxbA:
undetectable		 4iizB-3dxbA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V0V_A_8QSA615_1
(SERUM ALBUMIN)		 3dxb THIOREDOXIN
N-TERMINALLY FUSED
TO PUF60(UHM)
(Escherichia
coli;
Homo
sapiens) 		4 / 8 LEU A 386
HIS A 350
LEU A 397
ILE A 349
 None
CL  A   1 (-4.5A)
None
None
 0.85A 5v0vA-3dxbA:
undetectable		 5v0vA-3dxbA:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_B_LLLB301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 3dxb THIOREDOXIN
N-TERMINALLY FUSED
TO PUF60(UHM)
(Escherichia
coli;
Homo
sapiens) 		4 / 7 ASP A 553
TYR A 496
GLU A 498
GLU A 429
 None
 1.19A 6mn5B-3dxbA:
undetectable		 6mn5B-3dxbA:
18.13