SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3dxn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_B_DVAB8_0
(GRAMICIDIN A)
3dxn CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE ISOFORM 3

(Toxoplasma
gondii)
3 / 3 VAL A 210
VAL A 257
TRP A 206
None
0.79A 1av2A-3dxnA:
undetectable
1av2B-3dxnA:
undetectable
1av2A-3dxnA:
5.49
1av2B-3dxnA:
5.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FMO_E_ADNE351_1
(CAMP-DEPENDENT
PROTEIN KINASE)
3dxn CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE ISOFORM 3

(Toxoplasma
gondii)
7 / 12 LEU A  29
GLY A  30
VAL A  37
ALA A  50
GLU A 107
ASN A 151
ASP A 167
None
0.77A 1fmoE-3dxnA:
25.5
1fmoE-3dxnA:
29.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FMO_E_ADNE351_1
(CAMP-DEPENDENT
PROTEIN KINASE)
3dxn CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE ISOFORM 3

(Toxoplasma
gondii)
7 / 12 LEU A  29
GLY A  30
VAL A  37
ALA A  50
GLU A 107
ASN A 151
LEU A 153
None
0.59A 1fmoE-3dxnA:
25.5
1fmoE-3dxnA:
29.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VPT_A_SAMA400_0
(VP39)
3dxn CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE ISOFORM 3

(Toxoplasma
gondii)
5 / 12 LEU A  38
ILE A  54
GLY A  35
GLY A  30
VAL A  59
None
1.00A 1vptA-3dxnA:
undetectable
1vptA-3dxnA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_B_DVAB8_0
(GRAMICIDIN D)
3dxn CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE ISOFORM 3

(Toxoplasma
gondii)
3 / 3 VAL A 210
VAL A 257
TRP A 206
None
0.77A 1w5uA-3dxnA:
undetectable
1w5uB-3dxnA:
undetectable
1w5uA-3dxnA:
5.49
1w5uB-3dxnA:
5.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XBB_A_STIA1_1
(TYROSINE-PROTEIN
KINASE SYK)
3dxn CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE ISOFORM 3

(Toxoplasma
gondii)
6 / 9 LEU A  29
VAL A  37
ALA A  50
MET A 100
GLY A 106
LEU A 153
None
0.90A 1xbbA-3dxnA:
22.9
1xbbA-3dxnA:
30.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)
3dxn CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE ISOFORM 3

(Toxoplasma
gondii)
5 / 9 LEU A  29
VAL A  37
LEU A  86
LEU A  98
LEU A 170
None
0.72A 1xkkA-3dxnA:
25.2
1xkkA-3dxnA:
27.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOI_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)
3dxn CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE ISOFORM 3

(Toxoplasma
gondii)
4 / 5 LEU A 231
ASP A 227
VAL A 234
ILE A 230
None
0.87A 2aoiB-3dxnA:
undetectable
2aoiB-3dxnA:
16.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2FUM_A_MIXA539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)
3dxn CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE ISOFORM 3

(Toxoplasma
gondii)
7 / 12 LEU A  29
GLY A  30
VAL A  37
ALA A  50
ASP A 146
LYS A 148
ASN A 151
None
0.76A 2fumA-3dxnA:
27.5
2fumA-3dxnA:
30.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2FUM_A_MIXA539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)
3dxn CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE ISOFORM 3

(Toxoplasma
gondii)
7 / 12 LEU A  29
VAL A  37
ALA A  50
ASP A 146
LYS A 148
ASN A 151
ASP A 167
None
0.89A 2fumA-3dxnA:
27.5
2fumA-3dxnA:
30.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2FUM_B_MIXB1539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)
3dxn CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE ISOFORM 3

(Toxoplasma
gondii)
7 / 12 LEU A  29
GLY A  30
VAL A  37
ALA A  50
MET A 100
LYS A 148
ASN A 151
None
0.69A 2fumB-3dxnA:
27.6
2fumB-3dxnA:
30.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2FUM_C_MIXC2539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)
3dxn CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE ISOFORM 3

(Toxoplasma
gondii)
6 / 12 LEU A  29
GLY A  30
VAL A  37
ALA A  50
MET A 100
ASN A 151
None
0.67A 2fumC-3dxnA:
26.7
2fumC-3dxnA:
30.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2FUM_C_MIXC2539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)
3dxn CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE ISOFORM 3

(Toxoplasma
gondii)
6 / 12 LEU A  29
VAL A  37
ALA A  50
MET A 100
ASN A 151
ASP A 167
None
0.77A 2fumC-3dxnA:
26.7
2fumC-3dxnA:
30.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2FUM_D_MIXD3539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)
3dxn CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE ISOFORM 3

(Toxoplasma
gondii)
8 / 12 LEU A  29
GLY A  30
VAL A  37
ALA A  50
MET A 100
LYS A 148
ASN A 151
ASP A 167
None
0.97A 2fumD-3dxnA:
27.2
2fumD-3dxnA:
30.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_C_DVAC8_0
(GRAMICIDIN D)
3dxn CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE ISOFORM 3

(Toxoplasma
gondii)
3 / 3 VAL A 257
TRP A 206
VAL A 210
None
0.68A 2izqC-3dxnA:
undetectable
2izqD-3dxnA:
undetectable
2izqC-3dxnA:
5.49
2izqD-3dxnA:
5.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_B_CHDB5_0
(FERROCHELATASE)
3dxn CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE ISOFORM 3

(Toxoplasma
gondii)
3 / 3 PRO A 149
LEU A 108
ARG A 115
None
0.78A 3aqiB-3dxnA:
undetectable
3aqiB-3dxnA:
24.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_B_FMMB91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)
3dxn CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE ISOFORM 3

(Toxoplasma
gondii)
8 / 12 VAL A  37
ALA A  50
LEU A  86
GLY A 106
LEU A 153
ASP A 167
PHE A 168
LEU A 170
None
0.76A 3bbtB-3dxnA:
25.4
3bbtB-3dxnA:
26.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_D_FMMD91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)
3dxn CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE ISOFORM 3

(Toxoplasma
gondii)
8 / 12 VAL A  37
ALA A  50
LEU A  98
GLY A 106
LEU A 153
ASP A 167
PHE A 168
LEU A 170
None
0.86A 3bbtD-3dxnA:
25.3
3bbtD-3dxnA:
26.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCP_B_CHDB4_0
(FERROCHELATASE,
MITOCHONDRIAL)
3dxn CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE ISOFORM 3

(Toxoplasma
gondii)
3 / 3 GLY A 237
PRO A 221
LEU A 261
None
0.49A 3hcpB-3dxnA:
undetectable
3hcpB-3dxnA:
24.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_L_CLML221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)
3dxn CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE ISOFORM 3

(Toxoplasma
gondii)
5 / 12 PHE A  89
THR A  61
PHE A 174
TYR A  96
SER A  63
None
1.38A 3u9fJ-3dxnA:
undetectable
3u9fL-3dxnA:
undetectable
3u9fJ-3dxnA:
20.07
3u9fL-3dxnA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)
3dxn CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE ISOFORM 3

(Toxoplasma
gondii)
6 / 12 LEU A  29
GLY A  30
ALA A  50
GLY A 106
PHE A 168
LEU A 170
None
0.84A 3wzdA-3dxnA:
22.9
3wzdA-3dxnA:
28.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)
3dxn CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE ISOFORM 3

(Toxoplasma
gondii)
6 / 12 LEU A  29
VAL A  37
ALA A  50
GLY A 106
PHE A 168
LEU A 170
None
1.04A 3wzdA-3dxnA:
22.9
3wzdA-3dxnA:
28.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AN2_A_EUIA1382_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)
3dxn CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE ISOFORM 3

(Toxoplasma
gondii)
6 / 12 LEU A  75
MET A 100
ASP A 146
LYS A 148
ASN A 151
ASP A 167
None
0.78A 4an2A-3dxnA:
27.1
4an2A-3dxnA:
28.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AN2_A_EUIA1382_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)
3dxn CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE ISOFORM 3

(Toxoplasma
gondii)
6 / 12 LEU A  86
ASP A 146
LYS A 148
ASN A 151
ASP A 167
GLY A 169
None
0.95A 4an2A-3dxnA:
27.1
4an2A-3dxnA:
28.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AN2_A_EUIA1382_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)
3dxn CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE ISOFORM 3

(Toxoplasma
gondii)
6 / 12 MET A 100
ASP A 146
LYS A 148
ASN A 151
ASP A 167
GLY A 169
None
0.68A 4an2A-3dxnA:
27.1
4an2A-3dxnA:
28.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I22_A_IREA9001_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)
3dxn CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE ISOFORM 3

(Toxoplasma
gondii)
8 / 12 VAL A  37
ALA A  50
LEU A  98
MET A 100
GLY A 106
ASP A 110
LEU A 153
ASP A 167
None
0.84A 4i22A-3dxnA:
24.5
4i22A-3dxnA:
26.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLR_A_CHDA505_0
(FERROCHELATASE,
MITOCHONDRIAL)
3dxn CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE ISOFORM 3

(Toxoplasma
gondii)
4 / 5 LEU A 108
PRO A 149
LEU A 152
ILE A 163
None
1.06A 4klrA-3dxnA:
undetectable
4klrA-3dxnA:
25.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9I_A_8PRA601_1
(RHODOPSIN KINASE)
3dxn CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE ISOFORM 3

(Toxoplasma
gondii)
4 / 7 VAL A  37
ALA A  50
MET A 100
LEU A 153
None
0.49A 4l9iA-3dxnA:
8.8
4l9iA-3dxnA:
24.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LMN_A_EUIA503_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)
3dxn CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE ISOFORM 3

(Toxoplasma
gondii)
5 / 12 MET A 100
ASN A 151
ASP A 167
PHE A 168
GLY A 169
None
0.73A 4lmnA-3dxnA:
27.4
4lmnA-3dxnA:
27.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MA7_A_P2ZA301_1
(MAJOR PRION PROTEIN)
3dxn CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE ISOFORM 3

(Toxoplasma
gondii)
4 / 8 VAL A  72
LEU A  86
TYR A  87
VAL A  37
None
0.93A 4ma7A-3dxnA:
undetectable
4ma7A-3dxnA:
17.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4O0S_A_ADNA500_1
(AURORA KINASE A)
3dxn CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE ISOFORM 3

(Toxoplasma
gondii)
7 / 11 LEU A  29
GLY A  30
VAL A  37
ALA A  50
ASN A 151
LEU A 153
ASP A 167
None
0.66A 4o0sA-3dxnA:
29.5
4o0sA-3dxnA:
32.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4O0W_A_ADNA501_1
(AURORA KINASE A)
3dxn CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE ISOFORM 3

(Toxoplasma
gondii)
5 / 6 LEU A  29
GLY A  30
VAL A  37
ALA A  50
LEU A 153
None
0.52A 4o0wA-3dxnA:
29.4
4o0wA-3dxnA:
32.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TYJ_A_0LIA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)
3dxn CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE ISOFORM 3

(Toxoplasma
gondii)
4 / 6 LEU A  29
VAL A  37
ILE A  83
ILE A 165
None
0.69A 4tyjA-3dxnA:
22.8
4tyjA-3dxnA:
25.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WAN_C_ACTC303_0
(BRANCHPOINT-BRIDGING
PROTEIN)
3dxn CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE ISOFORM 3

(Toxoplasma
gondii)
3 / 3 ASP A 200
ARG A 268
PRO A 265
None
1.00A 4wanC-3dxnA:
undetectable
4wanC-3dxnA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WBO_C_ANWC601_0
(RHODOPSIN KINASE)
3dxn CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE ISOFORM 3

(Toxoplasma
gondii)
4 / 6 LEU A  29
ALA A  50
MET A 100
LEU A 153
None
0.75A 4wboC-3dxnA:
17.4
4wboC-3dxnA:
21.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5H2U_B_1N1B501_1
(PROTEIN-TYROSINE
KINASE 6)
3dxn CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE ISOFORM 3

(Toxoplasma
gondii)
6 / 12 LEU A  29
VAL A  37
ALA A  50
GLY A 106
LEU A 153
ASP A 167
None
0.78A 5h2uB-3dxnA:
27.2
5h2uB-3dxnA:
31.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_G_IPHG101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)
3dxn CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE ISOFORM 3

(Toxoplasma
gondii)
4 / 6 HIS A 138
LEU A 137
CYH A 203
LEU A 147
None
1.41A 5hrqD-3dxnA:
undetectable
5hrqG-3dxnA:
undetectable
5hrqH-3dxnA:
undetectable
5hrqD-3dxnA:
6.71
5hrqG-3dxnA:
4.96
5hrqH-3dxnA:
6.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_B_1E8B1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)
3dxn CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE ISOFORM 3

(Toxoplasma
gondii)
6 / 12 GLY A  30
VAL A  37
ALA A  50
LEU A  98
ASP A 110
ASP A 167
None
0.82A 5yu9B-3dxnA:
24.8
5yu9B-3dxnA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_B_1E8B1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)
3dxn CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE ISOFORM 3

(Toxoplasma
gondii)
6 / 12 VAL A  37
ALA A  50
LEU A  98
ASP A 110
LEU A 153
ASP A 167
None
0.73A 5yu9B-3dxnA:
24.8
5yu9B-3dxnA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_C_1E8C1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)
3dxn CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE ISOFORM 3

(Toxoplasma
gondii)
5 / 12 VAL A  37
ALA A  50
LEU A  98
ASP A 110
ASP A 167
None
0.57A 5yu9C-3dxnA:
24.6
5yu9C-3dxnA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_C_1E8C1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)
3dxn CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE ISOFORM 3

(Toxoplasma
gondii)
5 / 12 VAL A  37
ALA A  50
LEU A  98
GLY A 106
ASP A 167
None
0.55A 5yu9C-3dxnA:
24.6
5yu9C-3dxnA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_D_1E8D1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)
3dxn CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE ISOFORM 3

(Toxoplasma
gondii)
6 / 12 VAL A  37
ALA A  50
GLY A 106
LEU A 153
ASP A 167
LEU A 170
None
0.68A 5yu9D-3dxnA:
24.9
5yu9D-3dxnA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_D_1E8D1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)
3dxn CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE ISOFORM 3

(Toxoplasma
gondii)
6 / 12 VAL A  37
ALA A  50
MET A 100
ASP A 110
LEU A 153
ASP A 167
None
0.97A 5yu9D-3dxnA:
24.9
5yu9D-3dxnA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_D_1E8D1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)
3dxn CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE ISOFORM 3

(Toxoplasma
gondii)
6 / 12 VAL A  37
ALA A  50
MET A 100
LEU A 153
ASP A 167
LEU A 170
None
0.93A 5yu9D-3dxnA:
24.9
5yu9D-3dxnA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC605_0
(ALPHA-AMYLASE)
3dxn CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE ISOFORM 3

(Toxoplasma
gondii)
4 / 8 GLY A 133
ILE A  83
ASP A 204
HIS A 144
None
1.06A 6ag0C-3dxnA:
undetectable
6ag0C-3dxnA:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_G_EY4G501_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)
3dxn CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE ISOFORM 3

(Toxoplasma
gondii)
4 / 7 ILE A 126
GLN A 129
VAL A 130
ILE A 211
None
0.95A 6cduF-3dxnA:
undetectable
6cduG-3dxnA:
undetectable
6cduF-3dxnA:
21.01
6cduG-3dxnA:
21.01