SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3dxp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WU8_B_ADNB501_1
(HYPOTHETICAL PROTEIN
PH0463)		 3dxp PUTATIVE ACYL-COA
DEHYDROGENASE
(Cupriavidus
pinatubonensis) 		5 / 11 HIS A 249
ASP A 253
PRO A 250
VAL A 218
PHE A 174
 None
 1.27A 1wu8B-3dxpA:
0.0
1wu8C-3dxpA:
0.0		 1wu8B-3dxpA:
20.72
1wu8C-3dxpA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y7I_A_SALA501_1
(SALICYLIC
ACID-BINDING PROTEIN
2)		 3dxp PUTATIVE ACYL-COA
DEHYDROGENASE
(Cupriavidus
pinatubonensis) 		5 / 9 GLY A 248
SER A 216
LEU A 247
TRP A 242
HIS A 155
 None
 1.45A 1y7iA-3dxpA:
undetectable		 1y7iA-3dxpA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_E_CLME1141_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 3dxp PUTATIVE ACYL-COA
DEHYDROGENASE
(Cupriavidus
pinatubonensis) 		5 / 7 GLY A 171
PRO A 170
THR A 246
GLY A 248
TYR A 173
 None
 1.27A 2jkjE-3dxpA:
undetectable		 2jkjE-3dxpA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIF_B_SAMB298_1
(PUTATIVE
MODIFICATION
METHYLASE)		 3dxp PUTATIVE ACYL-COA
DEHYDROGENASE
(Cupriavidus
pinatubonensis) 		3 / 3 ASP A  96
THR A 141
GLU A 146
 None
ACT  A 360 (-4.3A)
None
 0.77A 2zifB-3dxpA:
undetectable		 2zifB-3dxpA:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCR_A_CHDA424_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3dxp PUTATIVE ACYL-COA
DEHYDROGENASE
(Cupriavidus
pinatubonensis) 		4 / 8 LEU A  92
ARG A  84
ARG A  87
GLY A 165
 None
 1.12A 3hcrA-3dxpA:
undetectable		 3hcrA-3dxpA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_A_CHDA1504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3dxp PUTATIVE ACYL-COA
DEHYDROGENASE
(Cupriavidus
pinatubonensis) 		4 / 4 PRO A 265
LEU A 274
ILE A 281
ARG A 140
 None
EDO  A 361 (-3.8A)
None
None
 1.43A 3w1wA-3dxpA:
undetectable		 3w1wA-3dxpA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ARC_A_LEUA1001_0
(LEUCINE--TRNA LIGASE)		 3dxp PUTATIVE ACYL-COA
DEHYDROGENASE
(Cupriavidus
pinatubonensis) 		4 / 7 TYR A 173
SER A 216
TYR A 291
HIS A 155
 None
 1.37A 4arcA-3dxpA:
undetectable		 4arcA-3dxpA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1803_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 3dxp PUTATIVE ACYL-COA
DEHYDROGENASE
(Cupriavidus
pinatubonensis) 		5 / 10 TYR A 306
ILE A 281
LEU A 132
HIS A 155
ILE A 151
 None
 1.43A 5vkqA-3dxpA:
undetectable
5vkqD-3dxpA:
undetectable		 5vkqA-3dxpA:
11.73
5vkqD-3dxpA:
11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1808_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 3dxp PUTATIVE ACYL-COA
DEHYDROGENASE
(Cupriavidus
pinatubonensis) 		5 / 10 HIS A 155
ILE A 151
TYR A 306
ILE A 281
LEU A 132
 None
 1.40A 5vkqA-3dxpA:
undetectable
5vkqB-3dxpA:
undetectable		 5vkqA-3dxpA:
11.73
5vkqB-3dxpA:
11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1801_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 3dxp PUTATIVE ACYL-COA
DEHYDROGENASE
(Cupriavidus
pinatubonensis) 		5 / 10 HIS A 155
ILE A 151
TYR A 306
ILE A 281
LEU A 132
 None
 1.42A 5vkqC-3dxpA:
undetectable
5vkqD-3dxpA:
undetectable		 5vkqC-3dxpA:
11.73
5vkqD-3dxpA:
11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W3J_B_TA1B502_1
(TUBULIN BETA CHAIN)		 3dxp PUTATIVE ACYL-COA
DEHYDROGENASE
(Cupriavidus
pinatubonensis) 		4 / 8 VAL A 157
ASP A 158
GLN A 160
GLY A 165
 None
 0.61A 5w3jB-3dxpA:
undetectable		 5w3jB-3dxpA:
20.73