SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3dxx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK2_A_T44A3004_1
(SERUM ALBUMIN)		 3dxx TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE
(Escherichia
coli) 		4 / 7 ALA A 162
GLU A 163
LEU A 164
VAL A 123
 None
 0.94A 1hk2A-3dxxA:
undetectable		 1hk2A-3dxxA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG4_A_SAMA500_1
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 3dxx TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE
(Escherichia
coli) 		4 / 8 GLU A  69
GLY A  71
GLU A  94
ASP A 121
 None
 0.60A 1jg4A-3dxxA:
7.6		 1jg4A-3dxxA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW5_A_SAMA401_1
(MODIFICATION
METHYLASE RSRI)		 3dxx TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE
(Escherichia
coli) 		3 / 3 ASP A 144
HIS A 147
ASP A 180
 None
 0.85A 1nw5A-3dxxA:
2.8		 1nw5A-3dxxA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDV_E_SAME1287_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 3dxx TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE
(Escherichia
coli) 		5 / 12 GLY A  71
GLU A  94
ALA A 122
PHE A 142
ASP A 144
 None
 0.82A 2vdvE-3dxxA:
17.6		 2vdvE-3dxxA:
26.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDV_E_SAME1287_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 3dxx TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE
(Escherichia
coli) 		5 / 12 GLY A  71
GLY A  73
GLU A  94
ALA A 122
PHE A 142
 None
 0.47A 2vdvE-3dxxA:
17.6		 2vdvE-3dxxA:
26.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDV_F_SAMF1287_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 3dxx TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE
(Escherichia
coli) 		5 / 11 GLY A  71
GLU A  94
ALA A 122
PHE A 142
ASP A 144
 None
 0.82A 2vdvF-3dxxA:
17.6		 2vdvF-3dxxA:
26.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDV_F_SAMF1287_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 3dxx TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE
(Escherichia
coli) 		5 / 11 GLY A  71
GLY A  73
GLU A  94
ALA A 122
PHE A 142
 None
 0.47A 2vdvF-3dxxA:
17.6		 2vdvF-3dxxA:
26.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3DXY_A_SAMA1_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 3dxx TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE
(Escherichia
coli) 		10 / 11 GLU A  69
GLY A  71
GLY A  73
ILE A  93
GLU A  94
VAL A  95
HIS A  96
ASP A 121
ALA A 122
PHE A 142
 None
 0.12A 3dxyA-3dxxA:
38.2		 3dxyA-3dxxA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3DXY_A_SAMA1_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 3dxx TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE
(Escherichia
coli) 		5 / 11 GLY A  73
GLU A  94
VAL A  95
ASP A 121
PHE A 141
 None
 1.03A 3dxyA-3dxxA:
38.2		 3dxyA-3dxxA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FUU_A_ADNA0_1
(DIMETHYLADENOSINE
TRANSFERASE)		 3dxx TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE
(Escherichia
coli) 		5 / 12 GLY A  71
GLY A  73
GLU A  94
ALA A 122
ILE A 156
 None
 0.73A 3fuuA-3dxxA:
9.4		 3fuuA-3dxxA:
26.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FUU_A_ADNA0_1
(DIMETHYLADENOSINE
TRANSFERASE)		 3dxx TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE
(Escherichia
coli) 		5 / 12 GLY A  71
GLY A  73
GLU A  94
ASP A 121
ALA A 122
 None
 0.51A 3fuuA-3dxxA:
9.4		 3fuuA-3dxxA:
26.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GRY_A_SAMA300_0
(DIMETHYLADENOSINE
TRANSFERASE)		 3dxx TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE
(Escherichia
coli) 		5 / 12 GLU A  69
GLY A  71
GLU A  94
ASP A 121
ALA A 122
 None
 0.47A 3gryA-3dxxA:
10.9		 3gryA-3dxxA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GRY_A_SAMA300_0
(DIMETHYLADENOSINE
TRANSFERASE)		 3dxx TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE
(Escherichia
coli) 		5 / 12 GLU A  69
GLY A  71
GLY A  73
ASP A 121
ALA A 122
 None
 0.67A 3gryA-3dxxA:
10.9		 3gryA-3dxxA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KRH_A_SAMA900_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
2)		 3dxx TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE
(Escherichia
coli) 		5 / 12 GLY A  71
GLY A  73
ASP A 121
ALA A 122
ILE A 156
 None
 0.85A 4krhA-3dxxA:
12.4		 4krhA-3dxxA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_G_HCYG900_2
(GLUCOCORTICOID
RECEPTOR)		 3dxx TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE
(Escherichia
coli) 		3 / 3 LEU A 115
MET A 118
TYR A  41
 None
 0.95A 4p6xG-3dxxA:
undetectable		 4p6xG-3dxxA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVV_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 3dxx TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE
(Escherichia
coli) 		4 / 8 LYS A 199
GLY A 172
GLY A 173
VAL A 174
 None
 0.72A 4qvvK-3dxxA:
undetectable
4qvvL-3dxxA:
undetectable		 4qvvK-3dxxA:
23.05
4qvvL-3dxxA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVV_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 3dxx TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE
(Escherichia
coli) 		4 / 8 LYS A 199
GLY A 172
GLY A 173
VAL A 174
 None
 0.72A 4qvvY-3dxxA:
undetectable
4qvvZ-3dxxA:
undetectable		 4qvvY-3dxxA:
23.05
4qvvZ-3dxxA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HV1_A_RFPA902_1
(PHOSPHOENOLPYRUVATE
SYNTHASE)		 3dxx TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE
(Escherichia
coli) 		5 / 12 VAL A 138
GLN A 139
ALA A 122
LEU A  78
SER A  77
 None
 1.23A 5hv1A-3dxxA:
undetectable		 5hv1A-3dxxA:
13.32