SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3dy5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7A_A_PFLA4001_1
(SERUM ALBUMIN)		 3dy5 ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN
(Plexaura
homomalla) 		5 / 9 ILE A 716
LEU A 984
VAL A 746
GLY A 745
ALA A 695
 None
 0.99A 1e7aA-3dy5A:
undetectable		 1e7aA-3dy5A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_A_HLTA4003_1
(SERUM ALBUMIN)		 3dy5 ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN
(Plexaura
homomalla) 		5 / 9 ILE A 716
LEU A 984
VAL A 746
GLY A 745
ALA A 695
 None
 1.01A 1e7bA-3dy5A:
undetectable		 1e7bA-3dy5A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_D_PPFD412_1
(PHOSPHONOACETATE
HYDROLASE)		 3dy5 ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN
(Plexaura
homomalla) 		4 / 8 THR A1064
HIS A 757
ILE A1066
HIS A 762
 None
FE2  A1099 (-3.1A)
None
FE2  A1099 (-3.4A)
 0.99A 1ei6D-3dy5A:
undetectable		 1ei6D-3dy5A:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_B_SAMB200_0
(METHIONINE REPRESSOR)		 3dy5 ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN
(Plexaura
homomalla) 		5 / 11 GLU A1019
PHE A 486
GLY A 488
GLU A 508
ARG A 512
 None
 1.40A 1mjqA-3dy5A:
undetectable
1mjqB-3dy5A:
undetectable		 1mjqA-3dy5A:
7.13
1mjqB-3dy5A:
7.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_C_AG2C7004_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 3dy5 ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN
(Plexaura
homomalla) 		4 / 6 ALA A 162
LEU A 180
ASP A 115
LEU A 106
 None
 0.79A 1mt1D-3dy5A:
undetectable
1mt1E-3dy5A:
undetectable		 1mt1D-3dy5A:
8.60
1mt1E-3dy5A:
4.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBK_A_RAPA225_1
(FKBP25)		 3dy5 ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN
(Plexaura
homomalla) 		5 / 12 GLY A 265
VAL A 267
ILE A 308
ALA A 304
ILE A  77
 None
 0.95A 1pbkA-3dy5A:
undetectable		 1pbkA-3dy5A:
7.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKU_A_ESTA600_1
(ESTRADIOL RECEPTOR)		 3dy5 ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN
(Plexaura
homomalla) 		5 / 10 GLU A 894
LEU A 776
ARG A 505
ILE A 878
LEU A 932
 None
 1.48A 1qkuA-3dy5A:
undetectable		 1qkuA-3dy5A:
12.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKU_B_ESTB600_1
(ESTRADIOL RECEPTOR)		 3dy5 ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN
(Plexaura
homomalla) 		5 / 10 GLU A 894
LEU A 776
ARG A 505
ILE A 878
LEU A 932
 None
 1.48A 1qkuB-3dy5A:
undetectable		 1qkuB-3dy5A:
12.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKU_C_ESTC600_1
(ESTRADIOL RECEPTOR)		 3dy5 ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN
(Plexaura
homomalla) 		5 / 10 GLU A 894
LEU A 776
ARG A 505
ILE A 878
LEU A 932
 None
 1.48A 1qkuC-3dy5A:
undetectable		 1qkuC-3dy5A:
12.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_C_NCAC339_0
(ADP-RIBOSYL CYCLASE)		 3dy5 ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN
(Plexaura
homomalla) 		3 / 3 GLU A 178
ASN A   5
TRP A   3
 None
 1.03A 1r15C-3dy5A:
undetectable		 1r15C-3dy5A:
13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_D_NCAD349_0
(ADP-RIBOSYL CYCLASE)		 3dy5 ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN
(Plexaura
homomalla) 		3 / 3 GLU A 178
ASN A   5
TRP A   3
 None
 1.10A 1r15D-3dy5A:
undetectable		 1r15D-3dy5A:
13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_E_NCAE359_0
(ADP-RIBOSYL CYCLASE)		 3dy5 ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN
(Plexaura
homomalla) 		3 / 3 GLU A 178
ASN A   5
TRP A   3
 None
 1.06A 1r15E-3dy5A:
undetectable		 1r15E-3dy5A:
13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_F_NCAF369_0
(ADP-RIBOSYL CYCLASE)		 3dy5 ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN
(Plexaura
homomalla) 		3 / 3 GLU A 178
ASN A   5
TRP A   3
 None
 1.09A 1r15F-3dy5A:
undetectable		 1r15F-3dy5A:
13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S14_B_NOVB2300_1
(TOPOISOMERASE IV
SUBUNIT B)		 3dy5 ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN
(Plexaura
homomalla) 		5 / 12 ASP A 302
ASP A  82
PRO A  86
ASP A 204
ALA A 202
 None
 1.46A 1s14B-3dy5A:
undetectable		 1s14B-3dy5A:
10.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TUV_A_VK3A4558_1
(PROTEIN YGIN)		 3dy5 ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN
(Plexaura
homomalla) 		4 / 7 TYR A 883
HIS A 780
LEU A 776
ILE A 899
 None
 1.20A 1tuvA-3dy5A:
undetectable		 1tuvA-3dy5A:
7.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_W_CHDW4060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 3dy5 ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN
(Plexaura
homomalla) 		4 / 7 ILE A 462
ARG A 397
THR A 395
LEU A 410
 None
 0.94A 1v54N-3dy5A:
undetectable
1v54W-3dy5A:
undetectable		 1v54N-3dy5A:
17.95
1v54W-3dy5A:
4.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZX_A_TRPA602_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3dy5 ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN
(Plexaura
homomalla) 		4 / 8 LEU A 101
ILE A 121
PHE A 322
HIS A 103
 None
None
HEM  A1100 (-4.9A)
None
 0.90A 2azxA-3dy5A:
undetectable		 2azxA-3dy5A:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E7F_A_C2FA3000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 3dy5 ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN
(Plexaura
homomalla) 		5 / 12 GLU A 140
ILE A  24
LEU A  20
ASN A   5
ARG A 229
 None
 1.26A 2e7fA-3dy5A:
undetectable		 2e7fA-3dy5A:
13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E7F_B_C2FB4000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 3dy5 ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN
(Plexaura
homomalla) 		5 / 12 GLU A 140
ILE A  24
LEU A  20
ASN A   5
ARG A 229
 None
 1.21A 2e7fB-3dy5A:
undetectable		 2e7fB-3dy5A:
13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HZQ_A_STRA300_1
(APOLIPOPROTEIN D)		 3dy5 ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN
(Plexaura
homomalla) 		4 / 7 THR A 765
ALA A 945
TYR A 860
PHE A 937
 None
 1.05A 2hzqA-3dy5A:
1.8		 2hzqA-3dy5A:
9.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OQE_E_CUE801_0
(PEROXISOMAL COPPER
AMINE OXIDASE)		 3dy5 ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN
(Plexaura
homomalla) 		4 / 4 LEU A1000
HIS A 762
HIS A 757
HIS A 943
 None
FE2  A1099 (-3.4A)
FE2  A1099 (-3.1A)
FE2  A1099 (-3.1A)
 1.33A 2oqeE-3dy5A:
undetectable		 2oqeE-3dy5A:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PK4_A_ACAA100_1
(HUMAN PLASMINOGEN
KRINGLE 4)		 3dy5 ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN
(Plexaura
homomalla) 		4 / 7 LYS A  45
ASP A1025
ASP A1022
PHE A  49
 None
 1.03A 2pk4A-3dy5A:
undetectable		 2pk4A-3dy5A:
5.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD3_A_CHDA501_0
(FERROCHELATASE)		 3dy5 ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN
(Plexaura
homomalla) 		5 / 11 LEU A 776
LEU A 786
ILE A 895
THR A 938
VAL A 902
 None
 1.28A 2qd3A-3dy5A:
undetectable		 2qd3A-3dy5A:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZM7_A_ACAA501_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 3dy5 ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN
(Plexaura
homomalla) 		4 / 7 ALA A 141
TYR A 174
ILE A 291
HIS A  28
 None
 1.18A 2zm7A-3dy5A:
undetectable		 2zm7A-3dy5A:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A35_A_RBFA191_1
(LUMAZINE PROTEIN)		 3dy5 ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN
(Plexaura
homomalla) 		5 / 12 SER A 548
GLN A 542
ALA A 795
THR A 798
ILE A 799
 None
 1.09A 3a35A-3dy5A:
undetectable		 3a35A-3dy5A:
11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A35_B_RBFB191_1
(LUMAZINE PROTEIN)		 3dy5 ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN
(Plexaura
homomalla) 		5 / 12 SER A 548
GLN A 542
ALA A 795
THR A 798
ILE A 799
 None
 1.12A 3a35B-3dy5A:
undetectable		 3a35B-3dy5A:
11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A3B_A_RBFA191_1
(LUMAZINE PROTEIN)		 3dy5 ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN
(Plexaura
homomalla) 		5 / 12 SER A 548
GLN A 542
ALA A 795
THR A 798
ILE A 799
 None
 1.07A 3a3bA-3dy5A:
undetectable		 3a3bA-3dy5A:
11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3dy5 ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN
(Plexaura
homomalla) 		4 / 8 ILE A 462
ARG A 397
THR A 395
LEU A 410
 None
 0.86A 3abkA-3dy5A:
undetectable
3abkJ-3dy5A:
undetectable		 3abkA-3dy5A:
17.95
3abkJ-3dy5A:
4.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9M_A_SALA1200_1
(SERUM ALBUMIN)		 3dy5 ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN
(Plexaura
homomalla) 		4 / 5 ILE A 238
TYR A 167
ARG A 236
GLY A   7
 None
 1.14A 3b9mA-3dy5A:
1.9		 3b9mA-3dy5A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DDY_A_RBFA187_1
(LUMAZINE PROTEIN)		 3dy5 ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN
(Plexaura
homomalla) 		5 / 12 SER A 548
GLN A 542
ALA A 795
THR A 798
ILE A 799
 None
 1.11A 3ddyA-3dy5A:
undetectable		 3ddyA-3dy5A:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DEU_B_SALB306_1
(TRANSCRIPTIONAL
REGULATOR SLYA)		 3dy5 ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN
(Plexaura
homomalla) 		4 / 6 THR A 765
SER A 934
LEU A 935
THR A 938
 None
 0.91A 3deuB-3dy5A:
undetectable		 3deuB-3dy5A:
8.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_A_THHA642_1
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 3dy5 ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN
(Plexaura
homomalla) 		3 / 3 ASN A 611
ASP A 862
ARG A 641
 None
 0.85A 3k13A-3dy5A:
undetectable		 3k13A-3dy5A:
14.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OEZ_A_STIA601_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3dy5 ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN
(Plexaura
homomalla) 		4 / 5 LYS A 481
VAL A 541
ILE A 480
ARG A 774
 None
 1.48A 3oezA-3dy5A:
undetectable		 3oezA-3dy5A:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OI8_A_ADNA2_1
(UNCHARACTERIZED
PROTEIN)		 3dy5 ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN
(Plexaura
homomalla) 		4 / 6 ASN A 947
HIS A 943
LEU A 758
ASP A 797
 FE2  A1099 (-2.8A)
FE2  A1099 (-3.1A)
None
None
 1.26A 3oi8A-3dy5A:
undetectable		 3oi8A-3dy5A:
9.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OLS_B_ESTB600_1
(ESTROGEN RECEPTOR
BETA)		 3dy5 ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN
(Plexaura
homomalla) 		5 / 12 GLU A 894
LEU A 776
ARG A 505
ILE A 878
LEU A 932
 None
 1.19A 3olsB-3dy5A:
undetectable		 3olsB-3dy5A:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RAV_A_RAVA183_1
(FERRITIN LIGHT CHAIN)		 3dy5 ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN
(Plexaura
homomalla) 		4 / 6 LEU A  40
SER A1014
TYR A1013
ALA A1015
 None
 0.95A 3ravA-3dy5A:
undetectable		 3ravA-3dy5A:
10.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T01_A_PPFA503_1
(PHOSPHONOACETATE
HYDROLASE)		 3dy5 ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN
(Plexaura
homomalla) 		4 / 7 THR A1064
HIS A 757
ILE A1066
HIS A 762
 None
FE2  A1099 (-3.1A)
None
FE2  A1099 (-3.4A)
 1.04A 3t01A-3dy5A:
undetectable		 3t01A-3dy5A:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W6H_A_AZMA303_1
(CARBONIC ANHYDRASE 1)		 3dy5 ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN
(Plexaura
homomalla) 		4 / 8 GLN A 753
HIS A 757
HIS A 943
HIS A 762
 None
FE2  A1099 (-3.1A)
FE2  A1099 (-3.1A)
FE2  A1099 (-3.4A)
 0.86A 3w6hA-3dy5A:
undetectable		 3w6hA-3dy5A:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3dy5 ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN
(Plexaura
homomalla) 		4 / 6 ILE A 462
ARG A 397
THR A 395
LEU A 410
 None
 0.88A 3wg7N-3dy5A:
undetectable
3wg7W-3dy5A:
undetectable		 3wg7N-3dy5A:
17.95
3wg7W-3dy5A:
4.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7A_B_RGZB601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 3dy5 ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN
(Plexaura
homomalla) 		5 / 12 LEU A 935
LEU A 932
LEU A 928
ILE A 899
GLN A 896
 None
 0.77A 4a7aB-3dy5A:
undetectable		 4a7aB-3dy5A:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTZ_B_LDPB501_1
(CYTOCHROME P450 BM3
VARIANT 8C8)		 3dy5 ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN
(Plexaura
homomalla) 		4 / 6 PHE A 825
ALA A 665
ALA A 696
PRO A 697
 None
 1.06A 4dtzB-3dy5A:
undetectable		 4dtzB-3dy5A:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EM2_A_SALA501_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR SAR2349)		 3dy5 ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN
(Plexaura
homomalla) 		4 / 5 LEU A 855
TYR A 655
LEU A 618
ARG A 847
 None
 0.69A 4em2A-3dy5A:
0.4		 4em2A-3dy5A:
10.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G19_D_ACTD302_0
(GLUTATHIONE
TRANSFERASE GTE1)		 3dy5 ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN
(Plexaura
homomalla) 		3 / 3 TYR A 353
PHE A 144
ARG A 349
 HEM  A1100 (-4.2A)
HEM  A1100 ( 4.7A)
HEM  A1100 (-3.3A)
 1.22A 4g19D-3dy5A:
undetectable		 4g19D-3dy5A:
14.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J24_C_ESTC600_1
(ESTROGEN RECEPTOR
BETA)		 3dy5 ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN
(Plexaura
homomalla) 		5 / 12 GLU A 894
LEU A 776
ARG A 505
ILE A 878
LEU A 932
 None
 1.31A 4j24C-3dy5A:
undetectable		 4j24C-3dy5A:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J26_B_ESTB600_1
(ESTROGEN RECEPTOR
BETA)		 3dy5 ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN
(Plexaura
homomalla) 		5 / 12 GLU A 894
LEU A 776
ARG A 505
ILE A 878
LEU A 932
 None
 1.26A 4j26B-3dy5A:
undetectable		 4j26B-3dy5A:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JTP_A_ASCA802_0
(RRNA N-GLYCOSIDASE)		 3dy5 ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN
(Plexaura
homomalla) 		4 / 5 TYR A 471
ILE A 439
TYR A 376
ILE A 398
 None
 1.02A 4jtpA-3dy5A:
undetectable		 4jtpA-3dy5A:
13.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JVL_A_ESTA702_1
(ESTROGEN
SULFOTRANSFERASE)		 3dy5 ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN
(Plexaura
homomalla) 		4 / 9 CYH A 941
HIS A 789
PHE A1030
ILE A1037
 None
 1.37A 4jvlA-3dy5A:
undetectable		 4jvlA-3dy5A:
13.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTT_C_SAMC404_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 3dy5 ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN
(Plexaura
homomalla) 		5 / 8 GLU A 869
ASP A1036
ILE A1037
ASP A 863
ILE A1041
 None
 1.14A 4kttD-3dy5A:
undetectable		 4kttD-3dy5A:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L64_A_C2FA802_0
(5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE)		 3dy5 ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN
(Plexaura
homomalla) 		4 / 7 SER A 194
TYR A 212
VAL A 196
TRP A 293
 None
None
HEM  A1100 ( 4.2A)
None
 1.31A 4l64A-3dy5A:
undetectable		 4l64A-3dy5A:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1Z_A_MXMA807_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 3dy5 ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN
(Plexaura
homomalla) 		5 / 12 LEU A 964
GLY A 745
ALA A 747
SER A 749
LEU A 754
 None
 0.87A 4o1zA-3dy5A:
undetectable		 4o1zA-3dy5A:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_A_ADNA501_2
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 3dy5 ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN
(Plexaura
homomalla) 		3 / 3 PRO A 625
LEU A 624
HIS A 634
 None
 0.72A 4pevA-3dy5A:
undetectable		 4pevA-3dy5A:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R87_J_SPMJ202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 3dy5 ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN
(Plexaura
homomalla) 		4 / 7 TRP A   3
GLU A 224
GLU A 140
ARG A 213
 None
 1.36A 4r87J-3dy5A:
undetectable
4r87L-3dy5A:
undetectable		 4r87J-3dy5A:
9.66
4r87L-3dy5A:
9.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTM_A_SAMA301_0
(DNA ADENINE
METHYLASE)		 3dy5 ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN
(Plexaura
homomalla) 		5 / 12 GLY A 421
GLY A 383
PHE A 418
GLY A 389
ALA A 388
 None
 1.00A 4rtmA-3dy5A:
undetectable		 4rtmA-3dy5A:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1I_B_LOCB502_2
(TUBULIN BETA CHAIN)		 3dy5 ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN
(Plexaura
homomalla) 		5 / 12 CYH A 694
LEU A 662
ALA A 665
VAL A 746
ALA A 747
 None
 1.12A 4x1iB-3dy5A:
undetectable		 4x1iB-3dy5A:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y4D_A_CFFA411_1
(ENDOTHIAPEPSIN)		 3dy5 ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN
(Plexaura
homomalla) 		4 / 6 LEU A 492
ASP A 892
LEU A 776
ILE A 878
 None
 1.13A 4y4dA-3dy5A:
undetectable		 4y4dA-3dy5A:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YO9_B_ACTB401_0
(3C-LIKE PROTEINASE)		 3dy5 ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN
(Plexaura
homomalla) 		3 / 3 ARG A 243
ASP A 110
TYR A 253
 None
 0.86A 4yo9B-3dy5A:
undetectable		 4yo9B-3dy5A:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE3_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3dy5 ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN
(Plexaura
homomalla) 		4 / 7 TYR A 171
ILE A 143
GLY A 139
LEU A 292
 None
 0.78A 4ze3A-3dy5A:
2.1		 4ze3A-3dy5A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZ8_A_GCSA208_1
(GLUCANASE/CHITOSANAS
E)		 3dy5 ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN
(Plexaura
homomalla) 		4 / 7 GLU A 178
ARG A 229
GLU A 226
TYR A 193
 None
 1.01A 4zz8A-3dy5A:
undetectable		 4zz8A-3dy5A:
8.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_E_ACTE406_0
(PROTON-GATED ION
CHANNEL)		 3dy5 ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN
(Plexaura
homomalla) 		4 / 5 ILE A 238
ILE A 240
ARG A 182
GLU A 234
 None
 1.10A 4zzcE-3dy5A:
undetectable		 4zzcE-3dy5A:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3dy5 ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN
(Plexaura
homomalla) 		4 / 7 ILE A 462
ARG A 397
THR A 395
LEU A 410
 None
 0.86A 5b1bA-3dy5A:
undetectable
5b1bJ-3dy5A:
undetectable		 5b1bA-3dy5A:
17.95
5b1bJ-3dy5A:
4.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3dy5 ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN
(Plexaura
homomalla) 		4 / 7 ILE A 462
ARG A 397
THR A 395
LEU A 410
 None
 0.85A 5b1bN-3dy5A:
undetectable
5b1bW-3dy5A:
undetectable		 5b1bN-3dy5A:
17.95
5b1bW-3dy5A:
4.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3dy5 ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN
(Plexaura
homomalla) 		4 / 7 ILE A 462
ARG A 397
THR A 395
LEU A 410
 None
 0.91A 5b3sN-3dy5A:
undetectable
5b3sW-3dy5A:
undetectable		 5b3sN-3dy5A:
17.95
5b3sW-3dy5A:
4.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_G_SAMG301_1
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 3dy5 ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN
(Plexaura
homomalla) 		3 / 3 GLU A 648
HIS A 653
ASP A 640
 None
 0.87A 5c0oG-3dy5A:
undetectable		 5c0oG-3dy5A:
13.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_G_EVPG2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 3dy5 ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN
(Plexaura
homomalla) 		5 / 6 SER A 749
GLU A 748
GLY A 819
ASP A 812
GLY A 821
 None
 1.12A 5cdnA-3dy5A:
undetectable
5cdnB-3dy5A:
undetectable		 5cdnA-3dy5A:
18.63
5cdnB-3dy5A:
11.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERG_B_SAMB401_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRM61)		 3dy5 ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN
(Plexaura
homomalla) 		5 / 12 ILE A 500
VAL A 501
GLY A 400
VAL A 460
LEU A 485
 None
 1.18A 5ergB-3dy5A:
undetectable		 5ergB-3dy5A:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESF_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3dy5 ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN
(Plexaura
homomalla) 		4 / 8 TYR A 171
ILE A 143
GLY A 139
LEU A 292
 None
 0.78A 5esfA-3dy5A:
undetectable		 5esfA-3dy5A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESJ_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3dy5 ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN
(Plexaura
homomalla) 		4 / 8 TYR A 171
ILE A 143
GLY A 139
LEU A 292
 None
 0.77A 5esjA-3dy5A:
0.4		 5esjA-3dy5A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIK_A_SAMA301_0
(GLYCINE SARCOSINE
N-METHYLTRANSFERASE)		 3dy5 ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN
(Plexaura
homomalla) 		5 / 12 GLY A 818
ASN A 750
GLY A 806
SER A 807
SER A 814
 None
 1.09A 5hikA-3dy5A:
undetectable		 5hikA-3dy5A:
14.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1O_H_DVAH9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 3dy5 ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN
(Plexaura
homomalla) 		3 / 3 ALA A 558
ASN A 561
LEU A 562
 None
 0.50A 5i1oA-3dy5A:
undetectable		 5i1oA-3dy5A:
2.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1P_G_DVAG9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 3dy5 ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN
(Plexaura
homomalla) 		3 / 3 ALA A 558
ASN A 561
LEU A 562
 None
 0.46A 5i1pD-3dy5A:
undetectable		 5i1pD-3dy5A:
2.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3dy5 ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN
(Plexaura
homomalla) 		4 / 7 ILE A 462
ARG A 397
THR A 395
LEU A 410
 None
 0.94A 5iy5A-3dy5A:
undetectable
5iy5J-3dy5A:
undetectable		 5iy5A-3dy5A:
17.95
5iy5J-3dy5A:
4.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1805_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 3dy5 ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN
(Plexaura
homomalla) 		4 / 7 PHE A 494
HIS A 780
PRO A 781
ILE A 782
 None
 1.02A 5vkqA-3dy5A:
2.3
5vkqD-3dy5A:
2.3		 5vkqA-3dy5A:
20.89
5vkqD-3dy5A:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WEA_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 3dy5 ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN
(Plexaura
homomalla) 		4 / 5 LEU A 348
LYS A  45
LEU A 150
GLU A 151
 HEM  A1100 ( 4.5A)
None
None
None
 0.83A 5weaA-3dy5A:
undetectable		 5weaA-3dy5A:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_C_SAMC902_0
(MRNA CAPPING ENZYME
P5)		 3dy5 ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN
(Plexaura
homomalla) 		5 / 12 GLY A 383
ALA A1015
ASP A 384
GLU A 419
THR A 382
 None
 1.18A 5x6yC-3dy5A:
undetectable		 5x6yC-3dy5A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3dy5 ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN
(Plexaura
homomalla) 		4 / 7 ILE A 462
ARG A 397
THR A 395
LEU A 410
 None
 0.80A 5xdqA-3dy5A:
1.3
5xdqJ-3dy5A:
undetectable		 5xdqA-3dy5A:
17.95
5xdqJ-3dy5A:
4.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2O_A_8N6A501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3dy5 ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN
(Plexaura
homomalla) 		5 / 12 PHE A 123
SER A 330
HIS A  88
PHE A  97
LEU A 303
 None
 1.31A 5y2oA-3dy5A:
undetectable		 5y2oA-3dy5A:
5.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_A_8LXA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3dy5 ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN
(Plexaura
homomalla) 		3 / 3 SER A 940
HIS A 789
TYR A1013
 None
 0.92A 5y2tA-3dy5A:
undetectable		 5y2tA-3dy5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3dy5 ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN
(Plexaura
homomalla) 		4 / 6 ILE A 462
ARG A 397
THR A 395
LEU A 410
 None
 0.92A 5z86N-3dy5A:
1.3
5z86W-3dy5A:
undetectable		 5z86N-3dy5A:
17.95
5z86W-3dy5A:
4.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3dy5 ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN
(Plexaura
homomalla) 		4 / 6 ILE A 462
ARG A 397
THR A 395
LEU A 410
 None
 0.95A 5zcoN-3dy5A:
undetectable
5zcoW-3dy5A:
undetectable		 5zcoN-3dy5A:
17.95
5zcoW-3dy5A:
4.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWO_A_SREA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 3dy5 ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN
(Plexaura
homomalla) 		5 / 9 ALA A 713
ILE A 714
PHE A 609
GLY A 606
PHE A 701
 None
 1.35A 6awoA-3dy5A:
undetectable		 6awoA-3dy5A:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWQ_A_SREA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 3dy5 ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN
(Plexaura
homomalla) 		5 / 9 ALA A 713
ILE A 714
PHE A 609
GLY A 606
PHE A 701
 None
 1.36A 6awqA-3dy5A:
undetectable		 6awqA-3dy5A:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXM_A_SAMA402_0
(DIPHTHAMIDE
BIOSYNTHESIS ENZYME
DPH2)		 3dy5 ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN
(Plexaura
homomalla) 		5 / 12 LEU A 817
GLY A 818
ARG A 692
ILE A 691
ASP A 690
 None
 1.24A 6bxmA-3dy5A:
undetectable		 6bxmA-3dy5A:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DEB_B_MTXB303_1
(BIFUNCTIONAL PROTEIN
FOLD)		 3dy5 ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN
(Plexaura
homomalla) 		4 / 5 TYR A 551
GLN A 552
GLY A 808
ILE A 810
 None
 1.22A 6debB-3dy5A:
undetectable		 6debB-3dy5A:
6.45