SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3dyt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_H_ACTH3006_0
(BETA-CARBONIC
ANHYDRASE)		 3dyt SORTING NEXIN-9
(Homo
sapiens) 		4 / 6 GLN A 574
CYH A 427
VAL A 478
HIS A 423
 None
 1.33A 1ekjG-3dytA:
undetectable
1ekjH-3dytA:
undetectable		 1ekjG-3dytA:
19.79
1ekjH-3dytA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D4S_A_TIMA401_2
(BETA-2 ADRENERGIC
RECEPTOR/T4-LYSOZYME
CHIMERA)		 3dyt SORTING NEXIN-9
(Homo
sapiens) 		3 / 3 THR A 275
SER A 282
PHE A 353
 None
 0.88A 3d4sA-3dytA:
3.0		 3d4sA-3dytA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HZN_D_ACTD229_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 3dyt SORTING NEXIN-9
(Homo
sapiens) 		4 / 4 ASP A 410
GLY A 412
LYS A 414
GLU A 415
 None
 1.02A 3hznD-3dytA:
undetectable		 3hznD-3dytA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SMT_A_ACTA1001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD3)		 3dyt SORTING NEXIN-9
(Homo
sapiens) 		4 / 5 LEU A 500
GLY A 501
PHE A 503
PHE A 555
 None
 1.17A 3smtA-3dytA:
undetectable		 3smtA-3dytA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HAJ_A_DXCA75_0
(PPCA)		 3dyt SORTING NEXIN-9
(Homo
sapiens) 		4 / 7 ILE A 344
LYS A 366
PHE A 353
LYS A 288
 None
SO4  A 701 (-2.7A)
None
SO4  A 701 (-2.9A)
 1.03A 4hajA-3dytA:
undetectable		 4hajA-3dytA:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HAJ_A_DXCA75_0
(PPCA)		 3dyt SORTING NEXIN-9
(Homo
sapiens) 		4 / 7 ILE A 581
LEU A 585
LYS A 440
GLY A 439
 None
 0.93A 4hajA-3dytA:
undetectable		 4hajA-3dytA:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K9D_A_ACTA405_0
(DIHYDROOROTATE
DEHYDROGENASE
(QUINONE),
MITOCHONDRIAL)		 3dyt SORTING NEXIN-9
(Homo
sapiens) 		3 / 3 GLN A 332
THR A 336
ASP A 251
 None
 0.86A 5k9dA-3dytA:
undetectable		 5k9dA-3dytA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_A_8LXA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3dyt SORTING NEXIN-9
(Homo
sapiens) 		5 / 12 PHE A 503
GLY A 501
CYH A 502
LEU A 298
LEU A 548
 None
 1.27A 5y2tA-3dytA:
undetectable		 5y2tA-3dytA:
undetectable