SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3dzb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_A_GLYA1292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 3dzb PREPHENATE
DEHYDROGENASE
(Streptococcus
thermophilus) 		4 / 8 SER A  99
HIS A 193
SER A 189
HIS A 190
 None
 1.14A 1eqbA-3dzbA:
3.4
1eqbB-3dzbA:
3.3		 1eqbA-3dzbA:
22.14
1eqbB-3dzbA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_B_GLYB2292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 3dzb PREPHENATE
DEHYDROGENASE
(Streptococcus
thermophilus) 		4 / 8 SER A  99
HIS A 193
SER A 189
HIS A 190
 None
 1.14A 1eqbA-3dzbA:
3.3
1eqbB-3dzbA:
3.3		 1eqbA-3dzbA:
22.14
1eqbB-3dzbA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_C_GLYC3292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 3dzb PREPHENATE
DEHYDROGENASE
(Streptococcus
thermophilus) 		4 / 8 SER A  99
HIS A 193
SER A 189
HIS A 190
 None
 1.14A 1eqbC-3dzbA:
3.4
1eqbD-3dzbA:
3.4		 1eqbC-3dzbA:
22.14
1eqbD-3dzbA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_D_GLYD4292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 3dzb PREPHENATE
DEHYDROGENASE
(Streptococcus
thermophilus) 		4 / 8 SER A  99
HIS A 193
SER A 189
HIS A 190
 None
 1.14A 1eqbC-3dzbA:
3.4
1eqbD-3dzbA:
3.4		 1eqbC-3dzbA:
22.14
1eqbD-3dzbA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IA0_B_TXLB502_1
(TUBULIN BETA CHAIN)		 3dzb PREPHENATE
DEHYDROGENASE
(Streptococcus
thermophilus) 		5 / 12 VAL A 120
ASP A 177
THR A 185
PRO A 124
GLY A  98
 None
 1.50A 1ia0B-3dzbA:
undetectable		 1ia0B-3dzbA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ISM_B_NCAB305_0
(BONE MARROW STROMAL
CELL ANTIGEN 1)		 3dzb PREPHENATE
DEHYDROGENASE
(Streptococcus
thermophilus) 		4 / 7 HIS A  26
LEU A 166
SER A 167
ASP A 164
 None
 1.16A 1ismB-3dzbA:
2.4		 1ismB-3dzbA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P33_D_MTXD354_1
(PTERIDINE REDUCTASE
1)		 3dzb PREPHENATE
DEHYDROGENASE
(Streptococcus
thermophilus) 		5 / 12 PHE A 148
PRO A 124
LEU A 166
TYR A 146
TYR A 173
 None
 1.43A 1p33D-3dzbA:
6.5		 1p33D-3dzbA:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TUB_B_TXLB501_1
(TUBULIN)		 3dzb PREPHENATE
DEHYDROGENASE
(Streptococcus
thermophilus) 		5 / 12 VAL A 120
ASP A 177
THR A 185
PRO A 124
GLY A  98
 None
 1.50A 1tubB-3dzbA:
undetectable		 1tubB-3dzbA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WSV_A_THHA3001_1
(AMINOMETHYLTRANSFERA
SE)		 3dzb PREPHENATE
DEHYDROGENASE
(Streptococcus
thermophilus) 		3 / 3 ASP A  38
GLU A  59
TYR A  79
 None
 0.81A 1wsvA-3dzbA:
undetectable		 1wsvA-3dzbA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB1283_1
(CES1 PROTEIN)		 3dzb PREPHENATE
DEHYDROGENASE
(Streptococcus
thermophilus) 		4 / 7 PRO A 124
LEU A 166
GLY A 168
LEU A  18
 None
 0.90A 1ya4B-3dzbA:
undetectable		 1ya4B-3dzbA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 3dzb PREPHENATE
DEHYDROGENASE
(Streptococcus
thermophilus) 		4 / 5 ARG A 222
MET A 224
THR A 225
LEU A 199
 None
 1.15A 2eimW-3dzbA:
undetectable		 2eimW-3dzbA:
12.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_A_KLNA1501_1
(CYTOCHROME P450 3A4)		 3dzb PREPHENATE
DEHYDROGENASE
(Streptococcus
thermophilus) 		5 / 10 ASP A 182
ILE A  14
THR A 185
ILE A   8
GLY A 121
 None
 1.35A 2v0mA-3dzbA:
undetectable		 2v0mA-3dzbA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_B_GLYB502_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 3dzb PREPHENATE
DEHYDROGENASE
(Streptococcus
thermophilus) 		4 / 8 SER A  99
HIS A 193
SER A 189
HIS A 190
 None
 1.14A 2vmyA-3dzbA:
3.7
2vmyB-3dzbA:
3.3		 2vmyA-3dzbA:
22.14
2vmyB-3dzbA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A301_1
(THIOPURINE
S-METHYLTRANSFERASE)		 3dzb PREPHENATE
DEHYDROGENASE
(Streptococcus
thermophilus) 		4 / 6 PHE A  60
ALA A  64
LEU A  86
PRO A  62
 None
 0.91A 3bgdA-3dzbA:
3.9		 3bgdA-3dzbA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM4_A_DR7A100_2
(PROTEASE)		 3dzb PREPHENATE
DEHYDROGENASE
(Streptococcus
thermophilus) 		5 / 9 ALA A 136
ASP A 137
GLY A  21
VAL A  50
ILE A  49
 None
 1.10A 3em4B-3dzbA:
undetectable		 3em4B-3dzbA:
13.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDW_A_RITA100_2
(PROTEASE)		 3dzb PREPHENATE
DEHYDROGENASE
(Streptococcus
thermophilus) 		5 / 9 ALA A 136
ASP A 137
GLY A  21
VAL A  50
ILE A  49
 None
 1.06A 3ndwB-3dzbA:
undetectable		 3ndwB-3dzbA:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_D_SUED1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 3dzb PREPHENATE
DEHYDROGENASE
(Streptococcus
thermophilus) 		5 / 12 GLY A  16
VAL A  71
GLY A  48
ALA A  44
ALA A  53
 None
 1.03A 3sudD-3dzbA:
undetectable		 3sudD-3dzbA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3THR_C_C2FC1410_0
(GLYCINE
N-METHYLTRANSFERASE)		 3dzb PREPHENATE
DEHYDROGENASE
(Streptococcus
thermophilus) 		3 / 3 ARG A 256
PRO A 192
PHE A 253
 None
 0.89A 3thrC-3dzbA:
4.7		 3thrC-3dzbA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUD_A_SAMA303_0
(CATECHOL
O-METHYLTRANSFERASE)		 3dzb PREPHENATE
DEHYDROGENASE
(Streptococcus
thermophilus) 		5 / 12 VAL A 105
GLY A  98
ILE A  14
SER A 296
HIS A 123
 None
 1.46A 4xudA-3dzbA:
5.8		 4xudA-3dzbA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y03_B_SALB801_1
(PROTEIN POLYBROMO-1)		 3dzb PREPHENATE
DEHYDROGENASE
(Streptococcus
thermophilus) 		4 / 5 LEU A 166
TYR A 146
ALA A  97
ILE A  14
 None
 1.02A 4y03B-3dzbA:
undetectable		 4y03B-3dzbA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCE_A_RITA602_1
(CYTOCHROME P450 3A4)		 3dzb PREPHENATE
DEHYDROGENASE
(Streptococcus
thermophilus) 		5 / 12 ILE A  22
ILE A  68
ALA A  97
ALA A 126
GLU A 142
 None
 1.02A 5vceA-3dzbA:
undetectable		 5vceA-3dzbA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_D_SAMD601_0
(NS5
METHYLTRANSFERASE)		 3dzb PREPHENATE
DEHYDROGENASE
(Streptococcus
thermophilus) 		5 / 12 GLY A  10
GLY A  98
GLY A  15
ASP A 182
ILE A  73
 None
 1.04A 5wz1D-3dzbA:
3.7		 5wz1D-3dzbA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_C_CHDC401_0
(BILE SALT HYDROLASE)		 3dzb PREPHENATE
DEHYDROGENASE
(Streptococcus
thermophilus) 		4 / 8 LEU A  69
TYR A  79
ALA A  61
LEU A  88
 None
 0.87A 5y7pC-3dzbA:
undetectable		 5y7pC-3dzbA:
24.54