SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3dzc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_T_TRPT81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3dzc UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE
(Vibrio
cholerae) 		4 / 7 GLY A 115
ALA A 119
THR A 143
THR A 100
 None
CL  A 374 ( 4.1A)
None
None
 0.87A 1c9sT-3dzcA:
undetectable
1c9sU-3dzcA:
undetectable		 1c9sT-3dzcA:
11.11
1c9sU-3dzcA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_L_TRPL81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 3dzc UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE
(Vibrio
cholerae) 		4 / 7 GLY A 115
ALA A 119
THR A 143
THR A 100
 None
CL  A 374 ( 4.1A)
None
None
 0.84A 1gtfL-3dzcA:
undetectable
1gtfM-3dzcA:
undetectable		 1gtfL-3dzcA:
11.11
1gtfM-3dzcA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_N_TRPN81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 3dzc UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE
(Vibrio
cholerae) 		4 / 8 GLY A 115
ALA A 119
THR A 143
THR A 100
 None
CL  A 374 ( 4.1A)
None
None
 0.83A 1gtfN-3dzcA:
undetectable
1gtfO-3dzcA:
undetectable		 1gtfN-3dzcA:
11.11
1gtfO-3dzcA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_R_TRPR81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 3dzc UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE
(Vibrio
cholerae) 		5 / 9 GLY A 293
ALA A 298
ILE A 294
GLY A 358
SER A 300
 None
 1.19A 1gtfR-3dzcA:
undetectable
1gtfS-3dzcA:
undetectable		 1gtfR-3dzcA:
11.11
1gtfS-3dzcA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSG_B_MK1B902_1
(HIV-1 PROTEASE)		 3dzc UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE
(Vibrio
cholerae) 		5 / 10 LEU A  92
VAL A  34
ILE A  53
VAL A   4
ILE A   6
 None
 0.98A 1hsgA-3dzcA:
undetectable		 1hsgA-3dzcA:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OHR_A_1UNA201_2
(ASPARTYLPROTEASE)		 3dzc UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE
(Vibrio
cholerae) 		5 / 9 LEU A  92
VAL A  34
ILE A  53
VAL A   4
ILE A   6
 None
 0.96A 1ohrB-3dzcA:
undetectable		 1ohrB-3dzcA:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_U_TRPU81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3dzc UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE
(Vibrio
cholerae) 		5 / 10 GLY A 293
ALA A 298
ILE A 294
GLY A 358
SER A 300
 None
 1.19A 1utdU-3dzcA:
undetectable
1utdV-3dzcA:
undetectable		 1utdU-3dzcA:
11.11
1utdV-3dzcA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEO_A_LNRA200_1
(D7R4 PROTEIN)		 3dzc UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE
(Vibrio
cholerae) 		5 / 12 ARG A 216
TYR A 244
VAL A 256
MET A 308
ASP A 290
 None
 1.45A 2qeoA-3dzcA:
undetectable		 2qeoA-3dzcA:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_A_CHDA2_0
(FERROCHELATASE)		 3dzc UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE
(Vibrio
cholerae) 		4 / 6 MET A 281
ARG A 314
PRO A 245
GLY A 213
 None
 1.29A 3aqiA-3dzcA:
3.6		 3aqiA-3dzcA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_B_CHDB4_0
(FERROCHELATASE)		 3dzc UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE
(Vibrio
cholerae) 		4 / 6 MET A 281
ARG A 314
PRO A 245
GLY A 213
 None
 1.46A 3aqiB-3dzcA:
undetectable		 3aqiB-3dzcA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F78_B_ICFB2_1
(INTEGRIN ALPHA-L)		 3dzc UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE
(Vibrio
cholerae) 		5 / 9 ILE A 112
LYS A   3
LEU A   5
GLU A  86
LEU A  83
 None
 1.45A 3f78B-3dzcA:
5.1		 3f78B-3dzcA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_A_MTXA164_2
(DIHYDROFOLATE
REDUCTASE)		 3dzc UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE
(Vibrio
cholerae) 		4 / 4 ILE A 366
PHE A 147
ILE A 369
THR A 173
 None
 1.15A 3ia4A-3dzcA:
undetectable		 3ia4A-3dzcA:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KW4_A_TICA600_1
(CYTOCHROME P450 2B4)		 3dzc UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE
(Vibrio
cholerae) 		5 / 11 ILE A  75
ALA A 102
THR A 139
VAL A   7
VAL A  91
 None
 0.94A 3kw4A-3dzcA:
undetectable		 3kw4A-3dzcA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFN_A_ROCA402_1
(HIV-1 PROTEASE)		 3dzc UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE
(Vibrio
cholerae) 		4 / 5 ARG A 216
LEU A 248
PRO A 245
VAL A 246
 None
 1.06A 3ufnA-3dzcA:
undetectable
3ufnB-3dzcA:
undetectable		 3ufnA-3dzcA:
14.14
3ufnB-3dzcA:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_B_DXCB1473_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 3dzc UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE
(Vibrio
cholerae) 		5 / 9 ILE A 294
GLY A 293
VAL A 211
THR A 289
GLY A 213
 None
 1.28A 4acaB-3dzcA:
4.9
4acaC-3dzcA:
6.6		 4acaB-3dzcA:
23.18
4acaC-3dzcA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1475_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 3dzc UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE
(Vibrio
cholerae) 		4 / 8 ILE A 167
PHE A 147
SER A 104
GLY A 115
 None
 0.82A 4acaC-3dzcA:
6.6		 4acaC-3dzcA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0V_D_MIXD101_1
(DNA TOPOISOMERASE
2-BETA)		 3dzc UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE
(Vibrio
cholerae) 		4 / 6 ARG A 136
GLY A  95
ASN A 172
GLU A 118
 None
 1.24A 4g0vB-3dzcA:
3.2		 4g0vB-3dzcA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0V_D_MIXD101_1
(DNA TOPOISOMERASE
2-BETA)		 3dzc UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE
(Vibrio
cholerae) 		4 / 6 GLY A  95
ASN A 172
GLU A 118
GLN A  39
 None
 1.21A 4g0vB-3dzcA:
3.2		 4g0vB-3dzcA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODO_B_FK5B203_2
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD)		 3dzc UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE
(Vibrio
cholerae) 		3 / 3 ALA A 336
GLN A 295
GLY A 292
 None
 0.57A 4odoC-3dzcA:
undetectable		 4odoC-3dzcA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3dzc UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE
(Vibrio
cholerae) 		4 / 8 THR A 100
GLY A 115
ALA A 119
THR A 143
 None
None
CL  A 374 ( 4.1A)
None
 0.85A 5eevL-3dzcA:
undetectable
5eevV-3dzcA:
undetectable		 5eevL-3dzcA:
11.11
5eevV-3dzcA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3dzc UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE
(Vibrio
cholerae) 		4 / 8 THR A 100
GLY A 115
ALA A 119
THR A 143
 None
None
CL  A 374 ( 4.1A)
None
 0.85A 5eewL-3dzcA:
undetectable
5eewV-3dzcA:
undetectable		 5eewL-3dzcA:
11.11
5eewV-3dzcA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3dzc UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE
(Vibrio
cholerae) 		4 / 8 THR A 100
GLY A 115
ALA A 119
THR A 143
 None
None
CL  A 374 ( 4.1A)
None
 0.85A 5eezL-3dzcA:
undetectable
5eezV-3dzcA:
undetectable		 5eezL-3dzcA:
11.11
5eezV-3dzcA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3dzc UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE
(Vibrio
cholerae) 		4 / 8 THR A 100
GLY A 115
ALA A 119
THR A 143
 None
None
CL  A 374 ( 4.1A)
None
 0.85A 5ef1L-3dzcA:
undetectable
5ef1V-3dzcA:
undetectable		 5ef1L-3dzcA:
11.11
5ef1V-3dzcA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3dzc UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE
(Vibrio
cholerae) 		4 / 8 THR A 100
GLY A 115
ALA A 119
THR A 143
 None
None
CL  A 374 ( 4.1A)
None
 0.85A 5ef2L-3dzcA:
undetectable
5ef2V-3dzcA:
undetectable		 5ef2L-3dzcA:
11.11
5ef2V-3dzcA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3dzc UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE
(Vibrio
cholerae) 		4 / 8 THR A 100
GLY A 115
ALA A 119
THR A 143
 None
None
CL  A 374 ( 4.1A)
None
 0.85A 5ef3L-3dzcA:
undetectable
5ef3V-3dzcA:
undetectable		 5ef3L-3dzcA:
11.11
5ef3V-3dzcA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G44_A_YTZA1512_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		 3dzc UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE
(Vibrio
cholerae) 		5 / 9 LEU A 202
LEU A 208
VAL A 278
MET A 281
ALA A 284
 None
 1.49A 5g44A-3dzcA:
undetectable		 5g44A-3dzcA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KB5_A_ADNA401_1
(ADENOSINE KINASE)		 3dzc UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE
(Vibrio
cholerae) 		5 / 12 LEU A 301
GLY A 292
GLY A 293
ALA A 298
GLY A 213
 None
 0.91A 5kb5A-3dzcA:
8.4		 5kb5A-3dzcA:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_F_SAMF501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 3dzc UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE
(Vibrio
cholerae) 		5 / 10 GLN A  39
LEU A  76
GLY A  78
VAL A  71
ALA A 102
 None
 1.18A 5o96E-3dzcA:
4.1
5o96F-3dzcA:
undetectable		 5o96E-3dzcA:
24.69
5o96F-3dzcA:
24.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_A_ERMA2001_2
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 3dzc UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE
(Vibrio
cholerae) 		4 / 7 THR A 212
VAL A 181
GLN A 192
GLU A 196
 None
 1.06A 5tudA-3dzcA:
undetectable		 5tudA-3dzcA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_A_SALA201_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 3dzc UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE
(Vibrio
cholerae) 		4 / 5 VAL A 174
PRO A 149
GLY A 171
TYR A 357
 None
 1.43A 5x80A-3dzcA:
undetectable
5x80B-3dzcA:
undetectable		 5x80A-3dzcA:
20.60
5x80B-3dzcA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_D_SALD201_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 3dzc UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE
(Vibrio
cholerae) 		4 / 5 PRO A 149
GLY A 171
TYR A 357
VAL A 174
 None
 1.38A 5x80C-3dzcA:
undetectable
5x80D-3dzcA:
undetectable		 5x80C-3dzcA:
20.60
5x80D-3dzcA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_B_ECLB1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 3dzc UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE
(Vibrio
cholerae) 		4 / 7 ALA A 371
ILE A   6
LEU A  24
ILE A 112
 None
 0.89A 6b5vA-3dzcA:
undetectable
6b5vB-3dzcA:
undetectable		 6b5vA-3dzcA:
13.20
6b5vB-3dzcA:
13.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BEO_A_DHIA4_0
((DPR)PY(DHI)PKDL(DGN
))		 3dzc UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE
(Vibrio
cholerae) 		3 / 3 TYR A 279
PRO A 276
LEU A 275
 None
 0.93A 6beoA-3dzcA:
undetectable		 6beoA-3dzcA:
4.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_D_GLYD713_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 3dzc UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE
(Vibrio
cholerae) 		3 / 3 ARG A  11
HIS A  40
ARG A  41
 None
 1.16A 6dwdD-3dzcA:
undetectable		 6dwdD-3dzcA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G2P_A_TRPA502_0
(FLAVIN-DEPENDENT
L-TRYPTOPHAN OXIDASE
VIOA)		 3dzc UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE
(Vibrio
cholerae) 		4 / 7 ARG A  41
HIS A  40
LEU A  68
VAL A  71
 None
 1.12A 6g2pA-3dzcA:
undetectable		 6g2pA-3dzcA:
22.63