SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3dzd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_A_ACTA1872_0
(FPRA)		 3dzd TRANSCRIPTIONAL
REGULATOR (NTRC
FAMILY)
(Aquifex
aeolicus) 		4 / 5 ASN A 187
ALA A 189
ASP A 230
GLU A 231
 None
None
ADP  A 370 ( 4.6A)
None
 1.36A 1lqtA-3dzdA:
undetectable
1lqtB-3dzdA:
2.5		 1lqtA-3dzdA:
22.48
1lqtB-3dzdA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_A_ACTA1429_0
(FPRA)		 3dzd TRANSCRIPTIONAL
REGULATOR (NTRC
FAMILY)
(Aquifex
aeolicus) 		4 / 5 ASN A 187
ALA A 189
ASP A 230
GLU A 231
 None
None
ADP  A 370 ( 4.6A)
None
 1.35A 1lquA-3dzdA:
2.2
1lquB-3dzdA:
2.5		 1lquA-3dzdA:
22.48
1lquB-3dzdA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_A_1N1A1000_2
(P38A)		 3dzd TRANSCRIPTIONAL
REGULATOR (NTRC
FAMILY)
(Aquifex
aeolicus) 		3 / 3 GLU A 135
LEU A 140
LEU A 299
 None
 0.77A 3ohtA-3dzdA:
undetectable		 3ohtA-3dzdA:
24.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_B_1N1B1000_2
(P38A)		 3dzd TRANSCRIPTIONAL
REGULATOR (NTRC
FAMILY)
(Aquifex
aeolicus) 		3 / 3 GLU A 135
LEU A 140
LEU A 299
 None
 0.73A 3ohtB-3dzdA:
undetectable		 3ohtB-3dzdA:
24.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DM8_A_REAA501_1
(RETINOIC ACID
RECEPTOR BETA)		 3dzd TRANSCRIPTIONAL
REGULATOR (NTRC
FAMILY)
(Aquifex
aeolicus) 		5 / 11 PHE A 284
LEU A 247
LEU A 244
LEU A 229
LEU A 157
 None
 0.88A 4dm8A-3dzdA:
undetectable		 4dm8A-3dzdA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HES_A_032A401_2
(MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT)		 3dzd TRANSCRIPTIONAL
REGULATOR (NTRC
FAMILY)
(Aquifex
aeolicus) 		4 / 6 LYS A 102
PHE A  99
VAL A   6
ASP A  52
 None
 1.20A 5hesA-3dzdA:
undetectable		 5hesA-3dzdA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZR_C_PFLC409_1
(PROTON-GATED ION
CHANNEL)		 3dzd TRANSCRIPTIONAL
REGULATOR (NTRC
FAMILY)
(Aquifex
aeolicus) 		5 / 10 PRO A  28
ILE A  20
VAL A   6
TYR A  26
ILE A 113
 None
 1.26A 5mzrC-3dzdA:
undetectable		 5mzrC-3dzdA:
12.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZR_D_PFLD410_1
(PROTON-GATED ION
CHANNEL)		 3dzd TRANSCRIPTIONAL
REGULATOR (NTRC
FAMILY)
(Aquifex
aeolicus) 		5 / 9 PRO A  28
ILE A  20
VAL A   6
TYR A  26
ILE A 113
 None
 1.25A 5mzrD-3dzdA:
undetectable		 5mzrD-3dzdA:
12.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_D_GLYD713_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 3dzd TRANSCRIPTIONAL
REGULATOR (NTRC
FAMILY)
(Aquifex
aeolicus) 		3 / 3 ARG A 171
HIS A 174
ARG A 175
 None
 0.93A 6dwdD-3dzdA:
undetectable		 6dwdD-3dzdA:
22.73