SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3dzm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JLF_A_NVPA999_1
(HIV-1 RT A-CHAIN
HIV-1 RT B-CHAIN)		 3dzm HYPOTHETICAL
CONSERVED PROTEIN
(Thermus
thermophilus) 		4 / 8 VAL A  62
TYR A  51
GLY A  60
TYR A 109
 None
 1.02A 1jlfA-3dzmA:
undetectable
1jlfB-3dzmA:
undetectable		 1jlfA-3dzmA:
17.47
1jlfB-3dzmA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LWE_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 3dzm HYPOTHETICAL
CONSERVED PROTEIN
(Thermus
thermophilus) 		4 / 7 VAL A  62
TYR A  51
GLY A  60
TYR A 109
 None
 0.94A 1lweA-3dzmA:
undetectable		 1lweA-3dzmA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W76_A_GNTA1538_1
(ACETYLCHOLINESTERASE)		 3dzm HYPOTHETICAL
CONSERVED PROTEIN
(Thermus
thermophilus) 		5 / 11 TRP A  59
GLY A 108
GLY A 107
PHE A 105
PHE A 189
 None
None
None
C8E  A 209 ( 4.8A)
None
 1.27A 1w76A-3dzmA:
undetectable		 1w76A-3dzmA:
18.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3dzm HYPOTHETICAL
CONSERVED PROTEIN
(Thermus
thermophilus) 		3 / 3 LEU A  31
PRO A  32
LEU A  33
 None
 0.61A 2po5B-3dzmA:
undetectable		 2po5B-3dzmA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO7_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3dzm HYPOTHETICAL
CONSERVED PROTEIN
(Thermus
thermophilus) 		3 / 3 LEU A  31
PRO A  32
LEU A  33
 None
 0.55A 2po7B-3dzmA:
undetectable		 2po7B-3dzmA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_C_SVRC505_2
(PHOSPHOLIPASE A2)		 3dzm HYPOTHETICAL
CONSERVED PROTEIN
(Thermus
thermophilus) 		4 / 5 VAL A  35
VAL A  23
GLN A  19
ARG A 200
 None
 1.34A 3bjwH-3dzmA:
undetectable		 3bjwH-3dzmA:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCR_A_CHDA4_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3dzm HYPOTHETICAL
CONSERVED PROTEIN
(Thermus
thermophilus) 		3 / 3 LEU A  31
PRO A  32
LEU A  33
 None
 0.48A 3hcrA-3dzmA:
undetectable		 3hcrA-3dzmA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WDM_A_ADNA901_1
(4-PHOSPHOPANTOATE--B
ETA-ALANINE LIGASE)		 3dzm HYPOTHETICAL
CONSERVED PROTEIN
(Thermus
thermophilus) 		5 / 9 ALA A 137
ARG A 135
GLY A 148
LEU A 146
LEU A 201
 None
 1.12A 3wdmA-3dzmA:
undetectable		 3wdmA-3dzmA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_G_ACTG305_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 3dzm HYPOTHETICAL
CONSERVED PROTEIN
(Thermus
thermophilus) 		3 / 3 ASP A 153
ARG A 200
LYS A 198
 None
 0.95A 3wipG-3dzmA:
undetectable		 3wipG-3dzmA:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BQF_A_QPSA951_1
(ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC)		 3dzm HYPOTHETICAL
CONSERVED PROTEIN
(Thermus
thermophilus) 		4 / 6 GLY A  34
ARG A 206
GLU A   7
ARG A  36
 None
 1.32A 4bqfA-3dzmA:
undetectable		 4bqfA-3dzmA:
13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWK_A_BEZA301_0
(GLUTATHIONE-SPECIFIC
GAMMA-GLUTAMYLCYCLOT
RANSFERASE)		 3dzm HYPOTHETICAL
CONSERVED PROTEIN
(Thermus
thermophilus) 		5 / 10 GLY A 131
GLY A  99
LEU A 130
LEU A 128
TYR A 102
 None
 1.31A 5hwkA-3dzmA:
undetectable		 5hwkA-3dzmA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWK_B_BEZB301_0
(GLUTATHIONE-SPECIFIC
GAMMA-GLUTAMYLCYCLOT
RANSFERASE)		 3dzm HYPOTHETICAL
CONSERVED PROTEIN
(Thermus
thermophilus) 		5 / 10 GLY A 131
GLY A  99
LEU A 130
LEU A 128
TYR A 102
 None
 1.32A 5hwkB-3dzmA:
undetectable		 5hwkB-3dzmA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MXB_A_ML1A222_1
(CLASS 10 PLANT
PATHOGENESIS-RELATED
PROTEIN)		 3dzm HYPOTHETICAL
CONSERVED PROTEIN
(Thermus
thermophilus) 		5 / 10 VAL A  75
THR A  76
GLY A  18
ALA A  42
PHE A  41
 None
 1.17A 5mxbA-3dzmA:
1.4		 5mxbA-3dzmA:
18.75