SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3dzt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZX_X_T3X500_2
(THYROID HORMONE
RECEPTOR BETA-1)
3dzt D7 PROTEIN
(Aedes
aegypti)
3 / 3 PHE A 110
ARG A  57
ASN A  20
None
0.76A 1xzxX-3dztA:
undetectable
1xzxX-3dztA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEB_A_HSMA145_1
(D7R4 PROTEIN)
3dzt D7 PROTEIN
(Aedes
aegypti)
5 / 7 ILE A 175
TYR A 178
TYR A 248
PHE A 264
ASP A 265
None
TRS  A 306 (-3.8A)
GOL  A 307 (-4.3A)
GOL  A 307 (-4.6A)
TRS  A 306 (-3.6A)
0.71A 2qebA-3dztA:
14.8
2qebA-3dztA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEB_B_HSMB145_1
(D7R4 PROTEIN)
3dzt D7 PROTEIN
(Aedes
aegypti)
5 / 7 ILE A 175
TYR A 178
TYR A 248
PHE A 264
ASP A 265
None
TRS  A 306 (-3.8A)
GOL  A 307 (-4.3A)
GOL  A 307 (-4.6A)
TRS  A 306 (-3.6A)
0.69A 2qebB-3dztA:
14.9
2qebB-3dztA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEO_A_LNRA200_1
(D7R4 PROTEIN)
3dzt D7 PROTEIN
(Aedes
aegypti)
6 / 12 GLU A 158
TYR A 178
HIS A 189
VAL A 193
TYR A 248
ASP A 265
TRS  A 306 ( 4.7A)
TRS  A 306 (-3.8A)
GOL  A 307 (-4.0A)
None
GOL  A 307 (-4.3A)
TRS  A 306 (-3.6A)
0.61A 2qeoA-3dztA:
14.9
2qeoA-3dztA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEO_A_LNRA200_1
(D7R4 PROTEIN)
3dzt D7 PROTEIN
(Aedes
aegypti)
6 / 12 TYR A 178
HIS A 189
VAL A 193
TYR A 248
PHE A 264
ASP A 265
TRS  A 306 (-3.8A)
GOL  A 307 (-4.0A)
None
GOL  A 307 (-4.3A)
GOL  A 307 (-4.6A)
TRS  A 306 (-3.6A)
0.75A 2qeoA-3dztA:
14.9
2qeoA-3dztA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEO_B_LNRB200_1
(D7R4 PROTEIN)
3dzt D7 PROTEIN
(Aedes
aegypti)
6 / 10 GLU A 158
ILE A 175
TYR A 178
HIS A 189
TYR A 248
ASP A 265
TRS  A 306 ( 4.7A)
None
TRS  A 306 (-3.8A)
GOL  A 307 (-4.0A)
GOL  A 307 (-4.3A)
TRS  A 306 (-3.6A)
0.45A 2qeoB-3dztA:
15.0
2qeoB-3dztA:
18.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3DYE_A_LNRA600_1
(D7 PROTEIN)
3dzt D7 PROTEIN
(Aedes
aegypti)
6 / 9 GLU A 158
ILE A 175
TYR A 178
HIS A 189
TYR A 248
ASP A 265
TRS  A 306 ( 4.7A)
None
TRS  A 306 (-3.8A)
GOL  A 307 (-4.0A)
GOL  A 307 (-4.3A)
TRS  A 306 (-3.6A)
0.23A 3dyeA-3dztA:
43.8
3dyeA-3dztA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_C_ROFC903_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)
3dzt D7 PROTEIN
(Aedes
aegypti)
3 / 3 SER A 152
GLN A 151
PHE A 156
None
0.85A 3g4lC-3dztA:
undetectable
3g4lC-3dztA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IB0_A_DIFA701_1
(LACTOTRANSFERRIN)
3dzt D7 PROTEIN
(Aedes
aegypti)
4 / 4 PRO A  63
TYR A  61
GLY A  59
THR A  58
None
None
None
EAH  A 305 ( 4.0A)
1.42A 3ib0A-3dztA:
undetectable
3ib0A-3dztA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CZY_A_SAMA603_0
(LEGIONELLA EFFECTOR
LEGAS4)
3dzt D7 PROTEIN
(Aedes
aegypti)
5 / 12 LEU A 229
PHE A 264
TYR A 199
TYR A 247
LEU A 251
None
GOL  A 307 (-4.6A)
None
None
None
1.23A 5czyA-3dztA:
undetectable
5czyA-3dztA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TJY_A_BEZA304_0
(4-HYDROXY-TETRAHYDRO
DIPICOLINATE
REDUCTASE)
3dzt D7 PROTEIN
(Aedes
aegypti)
3 / 3 MET A 294
GLU A 268
ARG A 176
None
TRS  A 306 ( 4.5A)
None
1.01A 5tjyA-3dztA:
undetectable
5tjyA-3dztA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TJZ_A_BEZA302_0
(4-HYDROXY-TETRAHYDRO
DIPICOLINATE
REDUCTASE)
3dzt D7 PROTEIN
(Aedes
aegypti)
3 / 3 MET A 294
GLU A 268
ARG A 176
None
TRS  A 306 ( 4.5A)
None
0.99A 5tjzA-3dztA:
undetectable
5tjzA-3dztA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YW0_A_ACTA409_0
(UNCHARACTERIZED
PROTEIN KDOO)
3dzt D7 PROTEIN
(Aedes
aegypti)
3 / 3 ASP A 207
PHE A  11
ARG A 267
None
GOL  A 308 (-4.7A)
None
1.15A 5yw0A-3dztA:
undetectable
5yw0A-3dztA:
22.65