SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3dzv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AKD_A_CAMA420_0
(CYTOCHROME P450CAM)		 3dzv 4-METHYL-5-(BETA-HYD
ROXYETHYL)THIAZOLE
KINASE
(Enterococcus
faecalis) 		5 / 11 THR A 172
LEU A 203
VAL A 204
GLY A 205
VAL A  95
 ADP  A 500 (-3.5A)
None
None
None
None
 1.19A 1akdA-3dzvA:
undetectable		 1akdA-3dzvA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P93_C_DEXC3999_1
(GLUCOCORTICOID
RECEPTOR)		 3dzv 4-METHYL-5-(BETA-HYD
ROXYETHYL)THIAZOLE
KINASE
(Enterococcus
faecalis) 		5 / 12 ASN A 230
GLY A 233
LEU A 254
LEU A 203
THR A 172
 ADP  A 500 (-2.8A)
None
None
None
ADP  A 500 (-3.5A)
 1.38A 1p93C-3dzvA:
undetectable		 1p93C-3dzvA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_A_TFPA201_1
(PROTEIN S100-A4)		 3dzv 4-METHYL-5-(BETA-HYD
ROXYETHYL)THIAZOLE
KINASE
(Enterococcus
faecalis) 		5 / 9 GLY A 205
CYH A 232
PHE A 246
GLY A 199
PHE A 197
 None
 1.45A 3ko0A-3dzvA:
undetectable
3ko0C-3dzvA:
undetectable		 3ko0A-3dzvA:
18.29
3ko0C-3dzvA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_G_TFPG201_1
(PROTEIN S100-A4)		 3dzv 4-METHYL-5-(BETA-HYD
ROXYETHYL)THIAZOLE
KINASE
(Enterococcus
faecalis) 		5 / 9 GLY A 199
PHE A 197
GLY A 205
CYH A 232
PHE A 246
 None
 1.40A 3ko0F-3dzvA:
undetectable
3ko0G-3dzvA:
0.0		 3ko0F-3dzvA:
18.29
3ko0G-3dzvA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_R_TFPR201_1
(PROTEIN S100-A4)		 3dzv 4-METHYL-5-(BETA-HYD
ROXYETHYL)THIAZOLE
KINASE
(Enterococcus
faecalis) 		5 / 10 GLY A 205
CYH A 232
PHE A 246
GLY A 199
PHE A 197
 None
 1.43A 3ko0R-3dzvA:
undetectable
3ko0T-3dzvA:
undetectable		 3ko0R-3dzvA:
18.29
3ko0T-3dzvA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_A_PFLA319_1
(GLR4197 PROTEIN)		 3dzv 4-METHYL-5-(BETA-HYD
ROXYETHYL)THIAZOLE
KINASE
(Enterococcus
faecalis) 		4 / 7 ILE A  38
LEU A  13
ILE A  10
ASN A 216
 None
 0.94A 3p50A-3dzvA:
undetectable		 3p50A-3dzvA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_B_PFLB319_1
(GLR4197 PROTEIN)		 3dzv 4-METHYL-5-(BETA-HYD
ROXYETHYL)THIAZOLE
KINASE
(Enterococcus
faecalis) 		4 / 7 ILE A  38
LEU A  13
ILE A  10
ASN A 216
 None
 0.95A 3p50B-3dzvA:
undetectable		 3p50B-3dzvA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_C_PFLC319_1
(GLR4197 PROTEIN)		 3dzv 4-METHYL-5-(BETA-HYD
ROXYETHYL)THIAZOLE
KINASE
(Enterococcus
faecalis) 		4 / 7 ILE A  38
LEU A  13
ILE A  10
ASN A 216
 None
 0.96A 3p50C-3dzvA:
undetectable		 3p50C-3dzvA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_D_PFLD320_1
(GLR4197 PROTEIN)		 3dzv 4-METHYL-5-(BETA-HYD
ROXYETHYL)THIAZOLE
KINASE
(Enterococcus
faecalis) 		4 / 7 ILE A  38
LEU A  13
ILE A  10
ASN A 216
 None
 0.96A 3p50D-3dzvA:
undetectable		 3p50D-3dzvA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_E_PFLE319_1
(GLR4197 PROTEIN)		 3dzv 4-METHYL-5-(BETA-HYD
ROXYETHYL)THIAZOLE
KINASE
(Enterococcus
faecalis) 		4 / 7 ILE A  38
LEU A  13
ILE A  10
ASN A 216
 None
 0.96A 3p50E-3dzvA:
undetectable		 3p50E-3dzvA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1A_A_AB1A101_2
(MDR769 HIV-1
PROTEASE)		 3dzv 4-METHYL-5-(BETA-HYD
ROXYETHYL)THIAZOLE
KINASE
(Enterococcus
faecalis) 		4 / 6 ASP A 202
GLY A 120
PRO A 115
THR A  90
 None
 1.10A 4l1aB-3dzvA:
undetectable		 4l1aB-3dzvA:
19.25