SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3dzz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IWI_A_CAMA418_0
(CYTOCHROME P450-CAM)		 3dzz PUTATIVE PYRIDOXAL
5'-PHOSPHATE-DEPENDE
NT C-S LYASE
(Lactobacillus
delbrueckii) 		4 / 8 LEU A 290
VAL A 293
ASP A  37
VAL A 374
 None
 0.93A 1iwiA-3dzzA:
undetectable		 1iwiA-3dzzA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7R_A_NCTA440_1
(CYTOCHROME P450-CAM)		 3dzz PUTATIVE PYRIDOXAL
5'-PHOSPHATE-DEPENDE
NT C-S LYASE
(Lactobacillus
delbrueckii) 		4 / 7 PHE A 337
VAL A 309
VAL A 325
ILE A 327
 None
 0.79A 1p7rA-3dzzA:
undetectable		 1p7rA-3dzzA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PHG_A_MYTA422_1
(CYTOCHROME P450-CAM)		 3dzz PUTATIVE PYRIDOXAL
5'-PHOSPHATE-DEPENDE
NT C-S LYASE
(Lactobacillus
delbrueckii) 		5 / 11 PHE A 337
LEU A 347
VAL A 325
ILE A 327
VAL A 312
 None
 1.22A 1phgA-3dzzA:
undetectable		 1phgA-3dzzA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T87_B_CAMB2422_0
(CYTOCHROME P450-CAM)		 3dzz PUTATIVE PYRIDOXAL
5'-PHOSPHATE-DEPENDE
NT C-S LYASE
(Lactobacillus
delbrueckii) 		4 / 7 PHE A 337
VAL A 309
VAL A 325
ILE A 327
 None
 0.90A 1t87B-3dzzA:
undetectable		 1t87B-3dzzA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZLQ_A_ACTA1502_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 3dzz PUTATIVE PYRIDOXAL
5'-PHOSPHATE-DEPENDE
NT C-S LYASE
(Lactobacillus
delbrueckii) 		4 / 5 PRO A 171
GLY A 357
ASN A 358
GLY A 359
 None
 0.99A 1zlqA-3dzzA:
undetectable		 1zlqA-3dzzA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q7L_A_TESA155_1
(ANDROGEN RECEPTOR)		 3dzz PUTATIVE PYRIDOXAL
5'-PHOSPHATE-DEPENDE
NT C-S LYASE
(Lactobacillus
delbrueckii) 		5 / 12 LEU A 322
ASN A 170
GLY A 173
VAL A 325
ARG A 302
 None
LLP  A 233 ( 3.9A)
None
None
PEG  A 397 (-4.1A)
 1.39A 2q7lA-3dzzA:
undetectable		 2q7lA-3dzzA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UYQ_A_SAMA1311_0
(HYPOTHETICAL PROTEIN
ML2640)		 3dzz PUTATIVE PYRIDOXAL
5'-PHOSPHATE-DEPENDE
NT C-S LYASE
(Lactobacillus
delbrueckii) 		4 / 7 ALA A  96
VAL A 124
ASP A 198
LEU A 228
 None
None
LLP  A 233 ( 2.8A)
None
 0.85A 2uyqA-3dzzA:
3.6		 2uyqA-3dzzA:
24.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_B_EPAB3_2
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 3dzz PUTATIVE PYRIDOXAL
5'-PHOSPHATE-DEPENDE
NT C-S LYASE
(Lactobacillus
delbrueckii) 		5 / 12 LEU A 341
PHE A 362
VAL A 309
VAL A 385
LEU A 330
 None
 1.06A 3gwxB-3dzzA:
undetectable		 3gwxB-3dzzA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNW_A_T3A502_1
(THYROID HORMONE
RECEPTOR ALPHA)		 3dzz PUTATIVE PYRIDOXAL
5'-PHOSPHATE-DEPENDE
NT C-S LYASE
(Lactobacillus
delbrueckii) 		4 / 8 SER A 135
ASP A 150
VAL A 160
THR A 157
 None
 0.97A 4lnwA-3dzzA:
undetectable		 4lnwA-3dzzA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KF8_A_GCSA404_1
(PREDICTED
ACETYLTRANSFERASE)		 3dzz PUTATIVE PYRIDOXAL
5'-PHOSPHATE-DEPENDE
NT C-S LYASE
(Lactobacillus
delbrueckii) 		4 / 8 TRP A  73
GLU A  74
PRO A 213
GLY A 202
 None
 1.06A 5kf8A-3dzzA:
undetectable		 5kf8A-3dzzA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AK3_B_P2EB1201_1
(PROSTAGLANDIN E2
RECEPTOR EP3
SUBTYPE,SOLUBLE
CYTOCHROME B562)		 3dzz PUTATIVE PYRIDOXAL
5'-PHOSPHATE-DEPENDE
NT C-S LYASE
(Lactobacillus
delbrueckii) 		4 / 5 VAL A 132
GLY A 352
TRP A 324
VAL A 117
 None
 1.08A 6ak3B-3dzzA:
undetectable		 6ak3B-3dzzA:
10.59