SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3e05'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G60_A_SAMA500_0
(ADENINE-SPECIFIC
METHYLTRANSFERASE
MBOIIA)		 3e05 PRECORRIN-6Y
C5,15-METHYLTRANSFER
ASE
(DECARBOXYLATING)
(Geobacter
metallireducens) 		5 / 12 ASP A 254
GLY A 258
SER A 259
ASN A 281
TYR A 284
 None
CL  A   1 ( 4.7A)
CL  A   1 (-4.5A)
None
None
 1.40A 1g60A-3e05A:
4.1		 1g60A-3e05A:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L2I_A_CCSA417_0
(ESTROGEN RECEPTOR)		 3e05 PRECORRIN-6Y
C5,15-METHYLTRANSFER
ASE
(DECARBOXYLATING)
(Geobacter
metallireducens) 		3 / 3 GLU A 364
LYS A 358
VAL A 360
 None
 0.89A 1l2iA-3e05A:
undetectable		 1l2iA-3e05A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_C_AG2C7004_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 3e05 PRECORRIN-6Y
C5,15-METHYLTRANSFER
ASE
(DECARBOXYLATING)
(Geobacter
metallireducens) 		4 / 6 ALA A 307
LEU A 314
GLU A 309
LEU A 302
 None
 0.98A 1mt1D-3e05A:
undetectable
1mt1E-3e05A:
undetectable		 1mt1D-3e05A:
20.11
1mt1E-3e05A:
14.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDV_E_SAME1287_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 3e05 PRECORRIN-6Y
C5,15-METHYLTRANSFER
ASE
(DECARBOXYLATING)
(Geobacter
metallireducens) 		5 / 12 GLY A 256
GLY A 258
GLU A 279
ALA A 307
THR A 232
 None
CL  A   1 ( 4.7A)
None
None
None
 0.63A 2vdvE-3e05A:
11.8		 2vdvE-3e05A:
24.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDV_F_SAMF1287_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 3e05 PRECORRIN-6Y
C5,15-METHYLTRANSFER
ASE
(DECARBOXYLATING)
(Geobacter
metallireducens) 		5 / 11 GLY A 256
GLY A 258
GLU A 279
ALA A 307
THR A 232
 None
CL  A   1 ( 4.7A)
None
None
None
 0.62A 2vdvF-3e05A:
11.8		 2vdvF-3e05A:
24.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9G_A_TOPA1159_1
(DIHYDROFOLATE
REDUCTASE)		 3e05 PRECORRIN-6Y
C5,15-METHYLTRANSFER
ASE
(DECARBOXYLATING)
(Geobacter
metallireducens) 		5 / 10 LEU A 340
ALA A 400
LEU A 348
SER A 325
ILE A 255
 None
None
None
GOL  A 413 (-4.5A)
None
 1.11A 2w9gA-3e05A:
undetectable		 2w9gA-3e05A:
26.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9H_A_TOPA1160_1
(DIHYDROFOLATE
REDUCTASE)		 3e05 PRECORRIN-6Y
C5,15-METHYLTRANSFER
ASE
(DECARBOXYLATING)
(Geobacter
metallireducens) 		5 / 10 LEU A 340
ALA A 400
LEU A 348
SER A 325
ILE A 255
 None
None
None
GOL  A 413 (-4.5A)
None
 1.08A 2w9hA-3e05A:
3.2		 2w9hA-3e05A:
26.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CKK_A_SAMA301_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 3e05 PRECORRIN-6Y
C5,15-METHYLTRANSFER
ASE
(DECARBOXYLATING)
(Geobacter
metallireducens) 		5 / 12 GLY A 256
GLY A 258
GLU A 279
ALA A 307
THR A 232
 None
CL  A   1 ( 4.7A)
None
None
None
 0.69A 3ckkA-3e05A:
12.8		 3ckkA-3e05A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYX_A_ROCA201_1
(HIV-1 PROTEASE)		 3e05 PRECORRIN-6Y
C5,15-METHYLTRANSFER
ASE
(DECARBOXYLATING)
(Geobacter
metallireducens) 		5 / 12 LEU A 285
GLY A 256
ALA A 257
ILE A 275
ILE A 288
 None
 1.07A 3cyxA-3e05A:
undetectable		 3cyxA-3e05A:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRB_X_TOPX300_1
(DIHYDROFOLATE
REDUCTASE)		 3e05 PRECORRIN-6Y
C5,15-METHYLTRANSFER
ASE
(DECARBOXYLATING)
(Geobacter
metallireducens) 		5 / 11 LEU A 340
ALA A 400
LEU A 348
SER A 325
ILE A 255
 None
None
None
GOL  A 413 (-4.5A)
None
 1.12A 3frbX-3e05A:
4.2		 3frbX-3e05A:
26.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QOW_A_SAMA417_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE)		 3e05 PRECORRIN-6Y
C5,15-METHYLTRANSFER
ASE
(DECARBOXYLATING)
(Geobacter
metallireducens) 		3 / 3 THR A 232
ASP A 254
GLU A 279
 None
 0.69A 3qowA-3e05A:
12.3		 3qowA-3e05A:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A81_A_DXCA1161_0
(MAJOR POLLEN
ALLERGEN BET V 1-A)		 3e05 PRECORRIN-6Y
C5,15-METHYLTRANSFER
ASE
(DECARBOXYLATING)
(Geobacter
metallireducens) 		5 / 12 ILE A 255
GLY A 323
ILE A 398
VAL A 370
LEU A 329
 None
 1.19A 4a81A-3e05A:
undetectable		 4a81A-3e05A:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9L_B_CAMB1419_0
(CYTOCHROME P450)		 3e05 PRECORRIN-6Y
C5,15-METHYLTRANSFER
ASE
(DECARBOXYLATING)
(Geobacter
metallireducens) 		5 / 12 ILE A 275
LEU A 244
LEU A 241
THR A 232
ILE A 264
 None
 0.98A 4c9lB-3e05A:
undetectable		 4c9lB-3e05A:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTA_A_ADNA401_1
(APH(2'')-ID)		 3e05 PRECORRIN-6Y
C5,15-METHYLTRANSFER
ASE
(DECARBOXYLATING)
(Geobacter
metallireducens) 		5 / 10 ALA A 400
ILE A 346
ILE A 332
LEU A 329
ILE A 333
 None
 1.15A 4dtaA-3e05A:
undetectable		 4dtaA-3e05A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DLV_B_5D5B927_0
(ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 2)		 3e05 PRECORRIN-6Y
C5,15-METHYLTRANSFER
ASE
(DECARBOXYLATING)
(Geobacter
metallireducens) 		5 / 12 LEU A 363
PHE A 321
LEU A 244
PRO A 317
VAL A 372
 None
 1.42A 5dlvB-3e05A:
undetectable		 5dlvB-3e05A:
14.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FA8_A_SAMA301_1
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE,
PUTATIVE)		 3e05 PRECORRIN-6Y
C5,15-METHYLTRANSFER
ASE
(DECARBOXYLATING)
(Geobacter
metallireducens) 		3 / 3 THR A 232
ASP A 254
GLU A 279
 None
 0.57A 5fa8A-3e05A:
17.6		 5fa8A-3e05A:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_D_SAMD301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 3e05 PRECORRIN-6Y
C5,15-METHYLTRANSFER
ASE
(DECARBOXYLATING)
(Geobacter
metallireducens) 		5 / 12 ALA A 305
GLY A 258
SER A 259
GLU A 279
TYR A 284
 None
CL  A   1 ( 4.7A)
CL  A   1 (-4.5A)
None
None
 1.24A 5hfjD-3e05A:
3.9		 5hfjD-3e05A:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_D_SAMD301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 3e05 PRECORRIN-6Y
C5,15-METHYLTRANSFER
ASE
(DECARBOXYLATING)
(Geobacter
metallireducens) 		5 / 12 ALA A 307
GLY A 258
SER A 259
GLU A 279
TYR A 284
 None
CL  A   1 ( 4.7A)
CL  A   1 (-4.5A)
None
None
 0.79A 5hfjD-3e05A:
3.9		 5hfjD-3e05A:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_E_SAME301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 3e05 PRECORRIN-6Y
C5,15-METHYLTRANSFER
ASE
(DECARBOXYLATING)
(Geobacter
metallireducens) 		5 / 12 ALA A 307
GLY A 258
SER A 259
GLU A 279
TYR A 284
 None
CL  A   1 ( 4.7A)
CL  A   1 (-4.5A)
None
None
 0.89A 5hfjE-3e05A:
3.8		 5hfjE-3e05A:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_F_SAMF301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 3e05 PRECORRIN-6Y
C5,15-METHYLTRANSFER
ASE
(DECARBOXYLATING)
(Geobacter
metallireducens) 		5 / 12 ALA A 305
GLY A 258
SER A 259
GLU A 279
TYR A 284
 None
CL  A   1 ( 4.7A)
CL  A   1 (-4.5A)
None
None
 1.11A 5hfjF-3e05A:
4.1		 5hfjF-3e05A:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_F_SAMF301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 3e05 PRECORRIN-6Y
C5,15-METHYLTRANSFER
ASE
(DECARBOXYLATING)
(Geobacter
metallireducens) 		5 / 12 ALA A 307
GLY A 258
SER A 259
GLU A 279
TYR A 284
 None
CL  A   1 ( 4.7A)
CL  A   1 (-4.5A)
None
None
 0.82A 5hfjF-3e05A:
4.1		 5hfjF-3e05A:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIY_A_OAQA302_0
(SULFOTRANSFERASE)		 3e05 PRECORRIN-6Y
C5,15-METHYLTRANSFER
ASE
(DECARBOXYLATING)
(Geobacter
metallireducens) 		5 / 11 PRO A 317
ILE A 275
VAL A 320
LEU A 241
THR A 240
 None
 1.45A 5tiyA-3e05A:
undetectable		 5tiyA-3e05A:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NJ9_K_SAMK500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 3e05 PRECORRIN-6Y
C5,15-METHYLTRANSFER
ASE
(DECARBOXYLATING)
(Geobacter
metallireducens) 		5 / 12 ASP A 254
GLY A 256
GLY A 258
VAL A 262
PHE A 321
 None
None
CL  A   1 ( 4.7A)
None
None
 0.51A 6nj9K-3e05A:
11.4		 6nj9K-3e05A:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NQA_K_SAMK500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 3e05 PRECORRIN-6Y
C5,15-METHYLTRANSFER
ASE
(DECARBOXYLATING)
(Geobacter
metallireducens) 		5 / 10 THR A 232
ASP A 254
GLY A 256
GLY A 258
VAL A 262
 None
None
None
CL  A   1 ( 4.7A)
None
 0.84A 6nqaK-3e05A:
11.3		 6nqaK-3e05A:
18.87