SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3e0g'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DVX_B_DIFB125_1
(TRANSTHYRETIN)		 3e0g LEUKEMIA INHIBITORY
FACTOR RECEPTOR
(Homo
sapiens) 		4 / 7 ALA A 444
LEU A 442
SER A 440
SER A 401
 None
 0.86A 1dvxA-3e0gA:
undetectable		 1dvxA-3e0gA:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DVX_B_DIFB125_1
(TRANSTHYRETIN)		 3e0g LEUKEMIA INHIBITORY
FACTOR RECEPTOR
(Homo
sapiens) 		4 / 7 LEU A 320
LEU A 359
SER A 368
SER A 370
 None
 0.80A 1dvxA-3e0gA:
undetectable		 1dvxA-3e0gA:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_C_ADNC2502_2
(ADENOSYLHOMOCYSTEINA
SE)		 3e0g LEUKEMIA INHIBITORY
FACTOR RECEPTOR
(Homo
sapiens) 		3 / 3 GLU A 463
THR A 464
LEU A 295
 NAG  A 489 (-4.2A)
None
None
 0.64A 1v8bC-3e0gA:
undetectable		 1v8bC-3e0gA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PRG_A_BRLA1_2
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 3e0g LEUKEMIA INHIBITORY
FACTOR RECEPTOR
(Homo
sapiens) 		3 / 3 ILE A 250
ILE A 210
LEU A 241
 None
 0.54A 2prgA-3e0gA:
undetectable		 2prgA-3e0gA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPB_D_SAMD1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 3e0g LEUKEMIA INHIBITORY
FACTOR RECEPTOR
(Homo
sapiens) 		5 / 10 THR A 261
VAL A 209
ILE A 210
ILE A 253
SER A 254
 None
None
None
None
FUC  A 492 ( 3.8A)
 1.27A 3kpbD-3e0gA:
undetectable		 3kpbD-3e0gA:
13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1475_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 3e0g LEUKEMIA INHIBITORY
FACTOR RECEPTOR
(Homo
sapiens) 		4 / 8 ILE A 216
ASP A 215
ILE A 253
GLY A 279
 None
 0.77A 4acaC-3e0gA:
undetectable		 4acaC-3e0gA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1475_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 3e0g LEUKEMIA INHIBITORY
FACTOR RECEPTOR
(Homo
sapiens) 		4 / 8 ILE A 216
ASP A 215
ILE A 253
GLY A 279
 None
 0.81A 4acbC-3e0gA:
undetectable		 4acbC-3e0gA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAT_A_BEZA1000_0
(BENZOATE-COENZYME A
LIGASE)		 3e0g LEUKEMIA INHIBITORY
FACTOR RECEPTOR
(Homo
sapiens) 		4 / 7 ALA A 278
GLY A 279
GLY A 213
ILE A 253
 None
 0.65A 4eatA-3e0gA:
undetectable		 4eatA-3e0gA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IK7_B_IMNB201_1
(TRANSTHYRETIN)		 3e0g LEUKEMIA INHIBITORY
FACTOR RECEPTOR
(Homo
sapiens) 		4 / 8 THR A 358
SER A 317
THR A 319
VAL A 321
 NAG  A 484 (-3.0A)
None
None
None
 0.40A 4ik7B-3e0gA:
undetectable		 4ik7B-3e0gA:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_A_STRA601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 3e0g LEUKEMIA INHIBITORY
FACTOR RECEPTOR
(Homo
sapiens) 		5 / 12 ALA A  95
ILE A 123
ILE A 193
VAL A 167
VAL A 125
 None
 0.94A 4nkxA-3e0gA:
undetectable		 4nkxA-3e0gA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWW_A_ACAA18_2
(SCRFP-TAG,GP41)		 3e0g LEUKEMIA INHIBITORY
FACTOR RECEPTOR
(Homo
sapiens) 		3 / 3 LYS A 470
TRP A 471
SER A 469
 None
 1.17A 5nwwA-3e0gA:
undetectable		 5nwwA-3e0gA:
7.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X2T_I_PEMI202_1
(HEMOGLOBIN SUBUNIT
ALPHA
HEMOGLOBIN SUBUNIT
BETA)		 3e0g LEUKEMIA INHIBITORY
FACTOR RECEPTOR
(Homo
sapiens) 		4 / 8 PRO A 205
ALA A 247
THR A 217
ALA A 155
 None
 0.95A 5x2tI-3e0gA:
undetectable
5x2tJ-3e0gA:
undetectable
5x2tK-3e0gA:
undetectable
5x2tL-3e0gA:
undetectable		 5x2tI-3e0gA:
14.85
5x2tJ-3e0gA:
18.89
5x2tK-3e0gA:
14.85
5x2tL-3e0gA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BZO_C_FI8C1201_0
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 3e0g LEUKEMIA INHIBITORY
FACTOR RECEPTOR
(Homo
sapiens) 		5 / 12 THR A 261
VAL A 275
VAL A 263
SER A 258
VAL A 311
 None
 1.40A 6bzoC-3e0gA:
undetectable		 6bzoC-3e0gA:
16.71