SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3e0l'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_A_DCFA353_1
(ADENOSINE DEAMINASE)		 3e0l GUANINE DEAMINASE
(Homo
sapiens) 		6 / 12 HIS A  82
HIS A  84
HIS A 238
GLU A 241
HIS A 277
ASP A 328
 ZN  A1452 (-3.3A)
ZN  A1452 (-3.1A)
ZN  A1452 (-3.2A)
None
None
ZN  A1452 (-2.8A)
 0.64A 1a4lA-3e0lA:
21.4		 1a4lA-3e0lA:
23.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_B_DCFB853_1
(ADENOSINE DEAMINASE)		 3e0l GUANINE DEAMINASE
(Homo
sapiens) 		6 / 12 HIS A  84
LEU A 103
HIS A 238
GLU A 241
HIS A 277
ASP A 328
 ZN  A1452 (-3.1A)
None
ZN  A1452 (-3.2A)
None
None
ZN  A1452 (-2.8A)
 0.79A 1a4lB-3e0lA:
21.3		 1a4lB-3e0lA:
23.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_B_DCFB853_1
(ADENOSINE DEAMINASE)		 3e0l GUANINE DEAMINASE
(Homo
sapiens) 		5 / 12 LEU A  99
HIS A 238
GLU A 241
HIS A 277
ASP A 328
 None
ZN  A1452 (-3.2A)
None
None
ZN  A1452 (-2.8A)
 1.19A 1a4lB-3e0lA:
21.3		 1a4lB-3e0lA:
23.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_1
(ADENOSINE DEAMINASE)		 3e0l GUANINE DEAMINASE
(Homo
sapiens) 		6 / 12 HIS A  82
HIS A  84
HIS A 238
GLU A 241
HIS A 277
ASP A 328
 ZN  A1452 (-3.3A)
ZN  A1452 (-3.1A)
ZN  A1452 (-3.2A)
None
None
ZN  A1452 (-2.8A)
 0.56A 1a4lC-3e0lA:
21.3		 1a4lC-3e0lA:
23.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_D_DCFD1853_1
(ADENOSINE DEAMINASE)		 3e0l GUANINE DEAMINASE
(Homo
sapiens) 		5 / 12 HIS A  84
HIS A 238
GLU A 241
HIS A 277
ASP A 328
 ZN  A1452 (-3.1A)
ZN  A1452 (-3.2A)
None
None
ZN  A1452 (-2.8A)
 0.48A 1a4lD-3e0lA:
21.2		 1a4lD-3e0lA:
23.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BZM_A_MZMA262_1
(CARBONIC ANHYDRASE I)		 3e0l GUANINE DEAMINASE
(Homo
sapiens) 		4 / 8 HIS A 238
HIS A  82
HIS A 277
HIS A  84
 ZN  A1452 (-3.2A)
ZN  A1452 (-3.3A)
None
ZN  A1452 (-3.1A)
 1.00A 1bzmA-3e0lA:
undetectable		 1bzmA-3e0lA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CIL_A_ETSA263_1
(CARBONIC ANHYDRASE
II)		 3e0l GUANINE DEAMINASE
(Homo
sapiens) 		5 / 12 GLN A  87
HIS A  84
HIS A  82
PHE A 108
VAL A 169
 None
ZN  A1452 (-3.1A)
ZN  A1452 (-3.3A)
None
None
 1.07A 1cilA-3e0lA:
undetectable		 1cilA-3e0lA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_A_PPFA410_1
(PHOSPHONOACETATE
HYDROLASE)		 3e0l GUANINE DEAMINASE
(Homo
sapiens) 		4 / 5 ASP A 328
HIS A  84
HIS A 277
HIS A 238
 ZN  A1452 (-2.8A)
ZN  A1452 (-3.1A)
None
ZN  A1452 (-3.2A)
 0.94A 1ei6A-3e0lA:
undetectable		 1ei6A-3e0lA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FXV_B_PNNB1001_0
(PENICILLIN ACYLASE)		 3e0l GUANINE DEAMINASE
(Homo
sapiens) 		4 / 7 PHE A 108
SER A  86
ALA A 110
PHE A  90
 None
 0.97A 1fxvA-3e0lA:
undetectable
1fxvB-3e0lA:
undetectable		 1fxvA-3e0lA:
17.03
1fxvB-3e0lA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I1E_A_DM2A3001_1
(BOTULINUM NEUROTOXIN
TYPE B)		 3e0l GUANINE DEAMINASE
(Homo
sapiens) 		5 / 9 GLU A 245
GLU A 241
GLY A 309
HIS A 277
TYR A 280
 None
 1.48A 1i1eA-3e0lA:
1.0		 1i1eA-3e0lA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_A_ADNA1237_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3e0l GUANINE DEAMINASE
(Homo
sapiens) 		5 / 11 MET A 171
THR A 144
GLY A 167
GLU A 182
ILE A 209
 None
 1.42A 1odiA-3e0lA:
undetectable		 1odiA-3e0lA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_B_ADNB1237_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3e0l GUANINE DEAMINASE
(Homo
sapiens) 		5 / 11 MET A 171
THR A 144
GLY A 167
GLU A 182
ILE A 209
 None
 1.40A 1odiB-3e0lA:
undetectable		 1odiB-3e0lA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_C_ADNC1238_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3e0l GUANINE DEAMINASE
(Homo
sapiens) 		5 / 11 MET A 171
THR A 144
GLY A 167
GLU A 182
ILE A 209
 None
 1.43A 1odiC-3e0lA:
undetectable		 1odiC-3e0lA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_D_ADND1237_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3e0l GUANINE DEAMINASE
(Homo
sapiens) 		5 / 11 MET A 171
THR A 144
GLY A 167
GLU A 182
ILE A 209
 None
 1.41A 1odiD-3e0lA:
undetectable		 1odiD-3e0lA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_E_ADNE1237_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3e0l GUANINE DEAMINASE
(Homo
sapiens) 		5 / 11 MET A 171
THR A 144
GLY A 167
GLU A 182
ILE A 209
 None
 1.36A 1odiE-3e0lA:
undetectable		 1odiE-3e0lA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_F_ADNF1238_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3e0l GUANINE DEAMINASE
(Homo
sapiens) 		5 / 11 MET A 171
THR A 144
GLY A 167
GLU A 182
ILE A 209
 None
 1.38A 1odiF-3e0lA:
undetectable		 1odiF-3e0lA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YDB_A_AZMA264_1
(CARBONIC ANHYDRASE
II)		 3e0l GUANINE DEAMINASE
(Homo
sapiens) 		5 / 11 GLN A  87
HIS A  84
HIS A  82
PHE A 108
VAL A 169
 None
ZN  A1452 (-3.1A)
ZN  A1452 (-3.3A)
None
None
 0.98A 1ydbA-3e0lA:
undetectable		 1ydbA-3e0lA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YDD_A_AZMA264_1
(CARBONIC ANHYDRASE
II)		 3e0l GUANINE DEAMINASE
(Homo
sapiens) 		5 / 10 GLN A  87
HIS A  84
HIS A  82
PHE A 108
VAL A 169
 None
ZN  A1452 (-3.1A)
ZN  A1452 (-3.3A)
None
None
 0.97A 1yddA-3e0lA:
undetectable		 1yddA-3e0lA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9Y_A_FUNA500_1
(CARBONIC ANHYDRASE
II)		 3e0l GUANINE DEAMINASE
(Homo
sapiens) 		5 / 12 GLN A  87
HIS A  84
HIS A  82
PHE A 108
VAL A 169
 None
ZN  A1452 (-3.1A)
ZN  A1452 (-3.3A)
None
None
 1.05A 1z9yA-3e0lA:
undetectable		 1z9yA-3e0lA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZSB_A_AZMA264_1
(CARBONIC ANHYDRASE
II)		 3e0l GUANINE DEAMINASE
(Homo
sapiens) 		5 / 12 GLN A  87
HIS A  84
HIS A  82
PHE A 108
VAL A 169
 None
ZN  A1452 (-3.1A)
ZN  A1452 (-3.3A)
None
None
 0.94A 1zsbA-3e0lA:
undetectable		 1zsbA-3e0lA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CIZ_A_ACTA1320_0
(CHLOROPEROXIDASE)		 3e0l GUANINE DEAMINASE
(Homo
sapiens) 		4 / 6 ALA A 395
PHE A 387
ILE A  42
VAL A  36
 None
 0.93A 2cizA-3e0lA:
undetectable		 2cizA-3e0lA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGF_A_ADNA501_1
(ADENOSINE DEAMINASE)		 3e0l GUANINE DEAMINASE
(Homo
sapiens) 		5 / 12 HIS A  82
HIS A 238
GLU A 241
SER A 302
ASP A 328
 ZN  A1452 (-3.3A)
ZN  A1452 (-3.2A)
None
None
ZN  A1452 (-2.8A)
 1.42A 2pgfA-3e0lA:
21.6		 2pgfA-3e0lA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGF_A_ADNA501_1
(ADENOSINE DEAMINASE)		 3e0l GUANINE DEAMINASE
(Homo
sapiens) 		6 / 12 HIS A  84
HIS A 238
GLU A 241
HIS A 277
SER A 302
ASP A 328
 ZN  A1452 (-3.1A)
ZN  A1452 (-3.2A)
None
None
None
ZN  A1452 (-2.8A)
 0.37A 2pgfA-3e0lA:
21.6		 2pgfA-3e0lA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_1
(ADENOSINE DEAMINASE)		 3e0l GUANINE DEAMINASE
(Homo
sapiens) 		6 / 12 HIS A  82
HIS A  84
HIS A 238
GLU A 241
HIS A 277
ASP A 328
 ZN  A1452 (-3.3A)
ZN  A1452 (-3.1A)
ZN  A1452 (-3.2A)
None
None
ZN  A1452 (-2.8A)
 0.45A 2pgrA-3e0lA:
21.6		 2pgrA-3e0lA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_1
(ADENOSINE DEAMINASE)		 3e0l GUANINE DEAMINASE
(Homo
sapiens) 		5 / 12 HIS A 238
HIS A 277
GLY A 326
HIS A  82
HIS A  84
 ZN  A1452 (-3.2A)
None
None
ZN  A1452 (-3.3A)
ZN  A1452 (-3.1A)
 1.12A 2pgrA-3e0lA:
21.6		 2pgrA-3e0lA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2POU_A_I7AA1000_1
(CARBONIC ANHYDRASE 2)		 3e0l GUANINE DEAMINASE
(Homo
sapiens) 		5 / 12 GLN A  87
HIS A  84
HIS A  82
PHE A 108
VAL A 169
 None
ZN  A1452 (-3.1A)
ZN  A1452 (-3.3A)
None
None
 1.05A 2pouA-3e0lA:
undetectable		 2pouA-3e0lA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q0I_A_BEZA990_0
(QUINOLONE SIGNAL
RESPONSE PROTEIN)		 3e0l GUANINE DEAMINASE
(Homo
sapiens) 		4 / 8 ASP A 328
HIS A 277
SER A 308
LEU A 306
 ZN  A1452 (-2.8A)
None
None
None
 1.01A 2q0iA-3e0lA:
undetectable		 2q0iA-3e0lA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q0J_B_BEZB500_0
(QUINOLONE SIGNAL
RESPONSE PROTEIN)		 3e0l GUANINE DEAMINASE
(Homo
sapiens) 		5 / 11 ASP A 328
HIS A  82
HIS A 277
SER A 308
LEU A 306
 ZN  A1452 (-2.8A)
ZN  A1452 (-3.3A)
None
None
None
 1.03A 2q0jB-3e0lA:
undetectable		 2q0jB-3e0lA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BL1_A_BL1A300_1
(CARBONIC ANHYDRASE 2)		 3e0l GUANINE DEAMINASE
(Homo
sapiens) 		5 / 12 GLN A  87
HIS A  84
HIS A  82
PHE A 108
VAL A 169
 None
ZN  A1452 (-3.1A)
ZN  A1452 (-3.3A)
None
None
 0.99A 3bl1A-3e0lA:
undetectable		 3bl1A-3e0lA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZV_A_AZMA263_1
(CARBONIC ANHYDRASE
13)		 3e0l GUANINE DEAMINASE
(Homo
sapiens) 		5 / 12 GLN A  87
HIS A  84
HIS A  82
PHE A 108
VAL A 169
 None
ZN  A1452 (-3.1A)
ZN  A1452 (-3.3A)
None
None
 0.90A 3czvA-3e0lA:
undetectable
3czvB-3e0lA:
undetectable		 3czvA-3e0lA:
20.95
3czvB-3e0lA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DC3_A_AZMA263_1
(CARBONIC ANHYDRASE 2)		 3e0l GUANINE DEAMINASE
(Homo
sapiens) 		5 / 12 GLN A  87
HIS A  84
HIS A  82
PHE A 108
VAL A 169
 None
ZN  A1452 (-3.1A)
ZN  A1452 (-3.3A)
None
None
 0.96A 3dc3A-3e0lA:
undetectable		 3dc3A-3e0lA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DL9_A_V2HA602_1
(CYTOCHROME P450 2R1)		 3e0l GUANINE DEAMINASE
(Homo
sapiens) 		4 / 5 ASN A 258
LEU A 311
GLY A 278
THR A 273
 None
 0.87A 3dl9A-3e0lA:
undetectable		 3dl9A-3e0lA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HGG_A_CHDA211_0
(CMER)		 3e0l GUANINE DEAMINASE
(Homo
sapiens) 		4 / 7 PHE A 119
PHE A 114
PHE A  90
SER A  89
 None
 1.20A 3hggA-3e0lA:
undetectable		 3hggA-3e0lA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HKU_A_TORA300_1
(CARBONIC ANHYDRASE 2)		 3e0l GUANINE DEAMINASE
(Homo
sapiens) 		5 / 12 GLN A  87
HIS A  84
HIS A  82
PHE A 108
VAL A 169
 None
ZN  A1452 (-3.1A)
ZN  A1452 (-3.3A)
None
None
 1.01A 3hkuA-3e0lA:
undetectable		 3hkuA-3e0lA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS4_A_AZMA701_1
(CARBONIC ANHYDRASE 2)		 3e0l GUANINE DEAMINASE
(Homo
sapiens) 		5 / 11 GLN A  87
HIS A  84
HIS A  82
PHE A 108
VAL A 169
 None
ZN  A1452 (-3.1A)
ZN  A1452 (-3.3A)
None
None
 0.98A 3hs4A-3e0lA:
undetectable		 3hs4A-3e0lA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_K_TFPK202_1
(PROTEIN S100-A4)		 3e0l GUANINE DEAMINASE
(Homo
sapiens) 		5 / 12 LEU A 427
PHE A 367
LEU A 338
ASP A 339
SER A 348
 None
 1.13A 3ko0K-3e0lA:
undetectable
3ko0L-3e0lA:
undetectable
3ko0S-3e0lA:
undetectable
3ko0T-3e0lA:
undetectable		 3ko0K-3e0lA:
13.11
3ko0L-3e0lA:
13.11
3ko0S-3e0lA:
13.11
3ko0T-3e0lA:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXE_A_TORA262_1
(CARBONIC ANHYDRASE 1)		 3e0l GUANINE DEAMINASE
(Homo
sapiens) 		5 / 12 PHE A  90
GLN A  87
HIS A  84
HIS A 238
LEU A 306
 None
None
ZN  A1452 (-3.1A)
ZN  A1452 (-3.2A)
None
 1.49A 3lxeA-3e0lA:
undetectable		 3lxeA-3e0lA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXE_B_TORB262_1
(CARBONIC ANHYDRASE 1)		 3e0l GUANINE DEAMINASE
(Homo
sapiens) 		5 / 12 PHE A  90
GLN A  87
HIS A  84
HIS A 238
LEU A 306
 None
None
ZN  A1452 (-3.1A)
ZN  A1452 (-3.2A)
None
 1.48A 3lxeB-3e0lA:
undetectable		 3lxeB-3e0lA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ML5_A_AZMA264_1
(CARBONIC ANHYDRASE 7)		 3e0l GUANINE DEAMINASE
(Homo
sapiens) 		5 / 11 GLN A  87
HIS A  84
HIS A  82
PHE A 108
VAL A 169
 None
ZN  A1452 (-3.1A)
ZN  A1452 (-3.3A)
None
None
 1.02A 3ml5A-3e0lA:
undetectable		 3ml5A-3e0lA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RAE_F_LFXF101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		 3e0l GUANINE DEAMINASE
(Homo
sapiens) 		3 / 4 SER A 150
GLY A 213
GLU A 241
 None
 0.61A 3raeA-3e0lA:
undetectable
3raeC-3e0lA:
undetectable		 3raeA-3e0lA:
24.30
3raeC-3e0lA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UAY_A_ADNA236_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 3e0l GUANINE DEAMINASE
(Homo
sapiens) 		5 / 10 MET A 171
THR A 144
GLY A 167
GLU A 182
ILE A 209
 None
 1.41A 3uayA-3e0lA:
undetectable		 3uayA-3e0lA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V2J_A_AZMA302_1
(CARBONIC ANHYDRASE 2)		 3e0l GUANINE DEAMINASE
(Homo
sapiens) 		5 / 11 GLN A  87
HIS A  84
HIS A  82
PHE A 108
VAL A 169
 None
ZN  A1452 (-3.1A)
ZN  A1452 (-3.3A)
None
None
 1.00A 3v2jA-3e0lA:
undetectable		 3v2jA-3e0lA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WSJ_A_MK1A201_2
(PROTEASE)		 3e0l GUANINE DEAMINASE
(Homo
sapiens) 		4 / 7 LEU A 427
ALA A 370
VAL A 313
ILE A 341
 None
 0.96A 3wsjB-3e0lA:
undetectable		 3wsjB-3e0lA:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7B_A_HAEA1273_1
(COLLAGENASE 3)		 3e0l GUANINE DEAMINASE
(Homo
sapiens) 		4 / 6 LEU A 306
HIS A  82
HIS A  84
HIS A 238
 None
ZN  A1452 (-3.3A)
ZN  A1452 (-3.1A)
ZN  A1452 (-3.2A)
 0.92A 4a7bA-3e0lA:
undetectable		 4a7bA-3e0lA:
17.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4AQL_A_TXCA1452_1
(GUANINE DEAMINASE)		 3e0l GUANINE DEAMINASE
(Homo
sapiens) 		7 / 12 GLN A  87
HIS A 238
GLU A 241
ALA A 248
HIS A 277
SER A 302
ASP A 328
 None
ZN  A1452 (-3.2A)
None
None
None
None
ZN  A1452 (-2.8A)
 0.36A 4aqlA-3e0lA:
66.7		 4aqlA-3e0lA:
94.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4AQL_A_TXCA1452_1
(GUANINE DEAMINASE)		 3e0l GUANINE DEAMINASE
(Homo
sapiens) 		6 / 12 GLN A  87
HIS A 238
GLU A 241
GLU A 245
SER A 302
ASP A 328
 None
ZN  A1452 (-3.2A)
None
None
None
ZN  A1452 (-2.8A)
 1.06A 4aqlA-3e0lA:
66.7		 4aqlA-3e0lA:
94.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4AQL_A_TXCA1452_1
(GUANINE DEAMINASE)		 3e0l GUANINE DEAMINASE
(Homo
sapiens) 		7 / 12 GLN A  87
LEU A 103
GLU A 241
ALA A 248
HIS A 277
SER A 302
ASP A 328
 None
None
None
None
None
None
ZN  A1452 (-2.8A)
 0.69A 4aqlA-3e0lA:
66.7		 4aqlA-3e0lA:
94.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4AQL_A_TXCA1452_1
(GUANINE DEAMINASE)		 3e0l GUANINE DEAMINASE
(Homo
sapiens) 		6 / 12 GLN A  87
LEU A 103
GLU A 241
GLU A 245
SER A 302
ASP A 328
 None
None
None
None
None
ZN  A1452 (-2.8A)
 1.02A 4aqlA-3e0lA:
66.7		 4aqlA-3e0lA:
94.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4AQL_A_TXCA1452_1
(GUANINE DEAMINASE)		 3e0l GUANINE DEAMINASE
(Homo
sapiens) 		6 / 12 LEU A  99
GLU A 241
ALA A 248
HIS A 277
SER A 302
ASP A 328
 None
None
None
None
None
ZN  A1452 (-2.8A)
 1.35A 4aqlA-3e0lA:
66.7		 4aqlA-3e0lA:
94.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4AQL_A_TXCA1452_2
(GUANINE DEAMINASE)		 3e0l GUANINE DEAMINASE
(Homo
sapiens) 		4 / 5 HIS A  84
LEU A 100
TRP A 102
ASP A 244
 ZN  A1452 (-3.1A)
None
None
None
 1.04A 4aqlA-3e0lA:
66.7		 4aqlA-3e0lA:
94.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EF3_A_CUA1002_0
(BLUE COPPER OXIDASE
CUEO)		 3e0l GUANINE DEAMINASE
(Homo
sapiens) 		4 / 4 HIS A  82
HIS A  84
HIS A 277
HIS A 238
 ZN  A1452 (-3.3A)
ZN  A1452 (-3.1A)
None
ZN  A1452 (-3.2A)
 1.22A 4ef3A-3e0lA:
undetectable		 4ef3A-3e0lA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G19_A_ACTA304_0
(GLUTATHIONE
TRANSFERASE GTE1)		 3e0l GUANINE DEAMINASE
(Homo
sapiens) 		4 / 5 ALA A 402
ILE A 407
LEU A 409
ASN A 434
 None
 1.21A 4g19A-3e0lA:
undetectable		 4g19A-3e0lA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HXY_B_ACAB502_1
(PLM1)		 3e0l GUANINE DEAMINASE
(Homo
sapiens) 		4 / 7 VAL A 216
SER A 237
MET A 221
LEU A 224
 None
 1.25A 4hxyB-3e0lA:
undetectable		 4hxyB-3e0lA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I41_A_MIXA500_2
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 3e0l GUANINE DEAMINASE
(Homo
sapiens) 		4 / 4 LEU A 378
LEU A 372
GLN A 162
GLU A 392
 None
 1.22A 4i41A-3e0lA:
undetectable		 4i41A-3e0lA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKI_B_IMNB201_1
(TRANSTHYRETIN)		 3e0l GUANINE DEAMINASE
(Homo
sapiens) 		4 / 6 LEU A 338
ALA A 340
SER A 334
THR A 327
 None
 0.98A 4ikiB-3e0lA:
undetectable		 4ikiB-3e0lA:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKJ_A_SUZA201_1
(TRANSTHYRETIN)		 3e0l GUANINE DEAMINASE
(Homo
sapiens) 		4 / 7 LEU A 338
ALA A 340
SER A 334
THR A 327
 None
 1.06A 4ikjA-3e0lA:
undetectable
4ikjB-3e0lA:
undetectable		 4ikjA-3e0lA:
15.84
4ikjB-3e0lA:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKK_B_SUZB201_1
(TRANSTHYRETIN)		 3e0l GUANINE DEAMINASE
(Homo
sapiens) 		4 / 7 LEU A 338
ALA A 340
SER A 334
THR A 327
 None
 1.00A 4ikkA-3e0lA:
undetectable
4ikkB-3e0lA:
undetectable		 4ikkA-3e0lA:
15.84
4ikkB-3e0lA:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKL_A_SUZA201_1
(TRANSTHYRETIN)		 3e0l GUANINE DEAMINASE
(Homo
sapiens) 		4 / 7 LEU A 338
ALA A 340
SER A 334
THR A 327
 None
 1.00A 4iklA-3e0lA:
undetectable
4iklB-3e0lA:
undetectable		 4iklA-3e0lA:
15.84
4iklB-3e0lA:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKL_B_SUZB201_1
(TRANSTHYRETIN)		 3e0l GUANINE DEAMINASE
(Homo
sapiens) 		4 / 8 LEU A 338
ALA A 340
SER A 334
THR A 327
 None
 0.98A 4iklA-3e0lA:
undetectable
4iklB-3e0lA:
undetectable		 4iklA-3e0lA:
15.84
4iklB-3e0lA:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JUO_F_LFXF101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B
E-SITE DNA)		 3e0l GUANINE DEAMINASE
(Homo
sapiens) 		3 / 4 SER A 150
GLY A 213
GLU A 241
 None
 0.59A 4juoA-3e0lA:
undetectable
4juoC-3e0lA:
undetectable		 4juoA-3e0lA:
24.30
4juoC-3e0lA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2R_A_BZ1A302_1
(CARBONIC ANHYDRASE 2)		 3e0l GUANINE DEAMINASE
(Homo
sapiens) 		5 / 12 GLN A  87
HIS A  84
HIS A  82
PHE A 108
VAL A 169
 None
ZN  A1452 (-3.1A)
ZN  A1452 (-3.3A)
None
None
 1.03A 4m2rA-3e0lA:
undetectable		 4m2rA-3e0lA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZT_C_RTLC201_0
(RETINOL-BINDING
PROTEIN 2)		 3e0l GUANINE DEAMINASE
(Homo
sapiens) 		5 / 12 ILE A  95
GLN A  87
SER A 302
LEU A 306
LEU A 103
 None
 1.05A 4qztC-3e0lA:
undetectable		 4qztC-3e0lA:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R88_A_1LDA501_0
(CYTOSINE DEAMINASE)		 3e0l GUANINE DEAMINASE
(Homo
sapiens) 		5 / 12 HIS A  84
HIS A 238
HIS A 277
LEU A 306
ASP A 328
 ZN  A1452 (-3.1A)
ZN  A1452 (-3.2A)
None
None
ZN  A1452 (-2.8A)
 0.44A 4r88A-3e0lA:
31.0		 4r88A-3e0lA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R88_A_1LDA501_0
(CYTOSINE DEAMINASE)		 3e0l GUANINE DEAMINASE
(Homo
sapiens) 		5 / 12 HIS A  84
LEU A 306
HIS A 238
HIS A 277
ASP A 328
 ZN  A1452 (-3.1A)
None
ZN  A1452 (-3.2A)
None
ZN  A1452 (-2.8A)
 1.30A 4r88A-3e0lA:
31.0		 4r88A-3e0lA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R88_B_1LDB501_0
(CYTOSINE DEAMINASE)		 3e0l GUANINE DEAMINASE
(Homo
sapiens) 		5 / 12 HIS A  84
HIS A 238
GLU A 241
LEU A 306
ASP A 328
 ZN  A1452 (-3.1A)
ZN  A1452 (-3.2A)
None
None
ZN  A1452 (-2.8A)
 0.48A 4r88B-3e0lA:
31.5		 4r88B-3e0lA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R88_C_1LDC501_0
(CYTOSINE DEAMINASE)		 3e0l GUANINE DEAMINASE
(Homo
sapiens) 		5 / 12 HIS A  84
HIS A 238
GLU A 241
LEU A 306
ASP A 328
 ZN  A1452 (-3.1A)
ZN  A1452 (-3.2A)
None
None
ZN  A1452 (-2.8A)
 0.48A 4r88C-3e0lA:
31.0		 4r88C-3e0lA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R88_D_1LDD501_0
(CYTOSINE DEAMINASE)		 3e0l GUANINE DEAMINASE
(Homo
sapiens) 		5 / 12 HIS A  84
HIS A 238
GLU A 241
LEU A 306
ASP A 328
 ZN  A1452 (-3.1A)
ZN  A1452 (-3.2A)
None
None
ZN  A1452 (-2.8A)
 0.49A 4r88D-3e0lA:
30.9		 4r88D-3e0lA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R88_E_1LDE501_0
(CYTOSINE DEAMINASE)		 3e0l GUANINE DEAMINASE
(Homo
sapiens) 		5 / 12 HIS A  84
HIS A 238
GLU A 241
LEU A 306
ASP A 328
 ZN  A1452 (-3.1A)
ZN  A1452 (-3.2A)
None
None
ZN  A1452 (-2.8A)
 0.49A 4r88E-3e0lA:
30.8		 4r88E-3e0lA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R88_F_1LDF502_0
(CYTOSINE DEAMINASE)		 3e0l GUANINE DEAMINASE
(Homo
sapiens) 		5 / 12 HIS A  84
HIS A 238
GLU A 241
LEU A 306
ASP A 328
 ZN  A1452 (-3.1A)
ZN  A1452 (-3.2A)
None
None
ZN  A1452 (-2.8A)
 0.47A 4r88F-3e0lA:
31.1		 4r88F-3e0lA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XYZ_A_ACTA103_0
(POLYUBIQUITIN-C)		 3e0l GUANINE DEAMINASE
(Homo
sapiens) 		4 / 4 LEU A 378
ILE A 209
HIS A 234
VAL A 274
 None
 1.12A 4xyzA-3e0lA:
undetectable		 4xyzA-3e0lA:
11.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_B_BEZB202_0
(HYDROXYNITRILE LYASE)		 3e0l GUANINE DEAMINASE
(Homo
sapiens) 		4 / 7 VAL A 422
MET A  26
VAL A  28
THR A  16
 None
 1.04A 5e4dA-3e0lA:
undetectable
5e4dB-3e0lA:
undetectable		 5e4dA-3e0lA:
18.10
5e4dB-3e0lA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1805_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 3e0l GUANINE DEAMINASE
(Homo
sapiens) 		4 / 7 VAL A 195
ILE A 235
SER A 187
THR A 191
 None
 1.07A 5vkqA-3e0lA:
undetectable
5vkqD-3e0lA:
undetectable		 5vkqA-3e0lA:
14.41
5vkqD-3e0lA:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BCC_A_EZLA302_1
(CARBONIC ANHYDRASE 2)		 3e0l GUANINE DEAMINASE
(Homo
sapiens) 		5 / 12 GLN A  87
HIS A  84
HIS A  82
PHE A 108
VAL A 169
 None
ZN  A1452 (-3.1A)
ZN  A1452 (-3.3A)
None
None
 1.05A 6bccA-3e0lA:
undetectable		 6bccA-3e0lA:
10.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CK2_C_IPHC101_0
(INSULIN A CHAIN
INSULIN B CHAIN)		 3e0l GUANINE DEAMINASE
(Homo
sapiens) 		4 / 4 ILE A 209
LEU A 153
HIS A  84
ALA A  85
 None
None
ZN  A1452 (-3.1A)
None
 1.02A 6ck2C-3e0lA:
undetectable
6ck2D-3e0lA:
undetectable		 6ck2C-3e0lA:
7.28
6ck2D-3e0lA:
6.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FI4_B_DVAB8_0
(14-3-3 PROTEIN SIGMA
PRO-SEP-LEU-PRO-DVA)		 3e0l GUANINE DEAMINASE
(Homo
sapiens) 		4 / 5 SER A 261
VAL A 262
LYS A 265
ASN A 266
 None
 0.55A 6fi4A-3e0lA:
2.3
6fi4B-3e0lA:
undetectable		 6fi4A-3e0lA:
20.66
6fi4B-3e0lA:
0.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N91_A_DCFA401_0
(ADENOSINE DEAMINASE)		 3e0l GUANINE DEAMINASE
(Homo
sapiens) 		5 / 12 HIS A  84
HIS A 238
GLU A 241
HIS A 277
ASP A 328
 ZN  A1452 (-3.1A)
ZN  A1452 (-3.2A)
None
None
ZN  A1452 (-2.8A)
 0.36A 6n91A-3e0lA:
22.7		 6n91A-3e0lA:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N91_A_DCFA401_0
(ADENOSINE DEAMINASE)		 3e0l GUANINE DEAMINASE
(Homo
sapiens) 		5 / 12 LEU A  99
HIS A 238
GLU A 241
HIS A 277
ASP A 328
 None
ZN  A1452 (-3.2A)
None
None
ZN  A1452 (-2.8A)
 1.24A 6n91A-3e0lA:
22.7		 6n91A-3e0lA:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N91_B_DCFB401_0
(ADENOSINE DEAMINASE)		 3e0l GUANINE DEAMINASE
(Homo
sapiens) 		5 / 12 HIS A  84
HIS A 238
GLU A 241
HIS A 277
ASP A 328
 ZN  A1452 (-3.1A)
ZN  A1452 (-3.2A)
None
None
ZN  A1452 (-2.8A)
 0.37A 6n91B-3e0lA:
22.8		 6n91B-3e0lA:
13.78