SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3e0m'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_2
(DNA GYRASE SUBUNIT B)		 3e0m PEPTIDE METHIONINE
SULFOXIDE REDUCTASE
MSRA/MSRB 1
(Streptococcus
pneumoniae) 		3 / 3 ASP A  76
PHE A  72
VAL A 123
 None
 0.73A 1kijB-3e0mA:
undetectable		 1kijB-3e0mA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TPX_E_ACTE204_0
(E3 UBIQUITIN-PROTEIN
LIGASE MDM2)		 3e0m PEPTIDE METHIONINE
SULFOXIDE REDUCTASE
MSRA/MSRB 1
(Streptococcus
pneumoniae) 		3 / 3 LYS A 159
PRO A 160
LEU A 161
 None
 0.82A 3tpxE-3e0mA:
undetectable		 3tpxE-3e0mA:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_C_ACTC502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 3e0m PEPTIDE METHIONINE
SULFOXIDE REDUCTASE
MSRA/MSRB 1
(Streptococcus
pneumoniae) 		3 / 3 PRO A 104
ASP A 102
GLU A 100
 None
 0.83A 3v4tC-3e0mA:
undetectable		 3v4tC-3e0mA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW7_A_VPXA2001_1
(PROTEINASE-ACTIVATED
RECEPTOR 1, LYSOZYME)		 3e0m PEPTIDE METHIONINE
SULFOXIDE REDUCTASE
MSRA/MSRB 1
(Streptococcus
pneumoniae) 		5 / 12 LEU A 242
LEU A 290
LEU A 310
LEU A 306
TYR A 303
 None
 1.17A 3vw7A-3e0mA:
undetectable		 3vw7A-3e0mA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LVC_A_ADNA501_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE))		 3e0m PEPTIDE METHIONINE
SULFOXIDE REDUCTASE
MSRA/MSRB 1
(Streptococcus
pneumoniae) 		4 / 5 GLN A  35
THR A  47
THR A  52
LEU A 128
 None
 1.28A 4lvcA-3e0mA:
undetectable		 4lvcA-3e0mA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LVC_C_ADNC501_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE))		 3e0m PEPTIDE METHIONINE
SULFOXIDE REDUCTASE
MSRA/MSRB 1
(Streptococcus
pneumoniae) 		4 / 5 GLN A  35
THR A  47
THR A  52
LEU A 128
 None
 1.29A 4lvcC-3e0mA:
undetectable		 4lvcC-3e0mA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PB1_A_RBVA501_1
(NUPC FAMILY PROTEIN)		 3e0m PEPTIDE METHIONINE
SULFOXIDE REDUCTASE
MSRA/MSRB 1
(Streptococcus
pneumoniae) 		5 / 12 GLY A  30
ALA A 134
TYR A 137
LEU A  44
PHE A  11
 None
 1.36A 4pb1A-3e0mA:
undetectable		 4pb1A-3e0mA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5K_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 3e0m PEPTIDE METHIONINE
SULFOXIDE REDUCTASE
MSRA/MSRB 1
(Streptococcus
pneumoniae) 		4 / 4 GLN A  35
THR A  47
THR A  52
LEU A 128
 None
 1.31A 5m5kA-3e0mA:
undetectable		 5m5kA-3e0mA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5K_C_ADNC502_2
(ADENOSYLHOMOCYSTEINA
SE)		 3e0m PEPTIDE METHIONINE
SULFOXIDE REDUCTASE
MSRA/MSRB 1
(Streptococcus
pneumoniae) 		4 / 4 GLN A  35
THR A  47
THR A  52
LEU A 128
 None
 1.28A 5m5kC-3e0mA:
undetectable		 5m5kC-3e0mA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M66_B_ADNB502_2
(ADENOSYLHOMOCYSTEINA
SE)		 3e0m PEPTIDE METHIONINE
SULFOXIDE REDUCTASE
MSRA/MSRB 1
(Streptococcus
pneumoniae) 		4 / 4 GLN A  35
THR A  47
THR A  52
LEU A 128
 None
 1.30A 5m66B-3e0mA:
undetectable		 5m66B-3e0mA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D8F_A_ACTA803_0
(UNCHARACTERIZED
PROTEIN)		 3e0m PEPTIDE METHIONINE
SULFOXIDE REDUCTASE
MSRA/MSRB 1
(Streptococcus
pneumoniae) 		3 / 3 GLU A  66
LEU A  69
ARG A  73
 None
 0.61A 6d8fA-3e0mA:
undetectable		 6d8fA-3e0mA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3M_B_ADNB502_2
(-)		 3e0m PEPTIDE METHIONINE
SULFOXIDE REDUCTASE
MSRA/MSRB 1
(Streptococcus
pneumoniae) 		4 / 4 GLN A  35
THR A  47
THR A  52
LEU A 128
 None
 1.30A 6f3mB-3e0mA:
undetectable		 6f3mB-3e0mA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_A_ADNA501_2
(-)		 3e0m PEPTIDE METHIONINE
SULFOXIDE REDUCTASE
MSRA/MSRB 1
(Streptococcus
pneumoniae) 		4 / 5 GLN A  35
THR A  47
THR A  52
LEU A 128
 None
 1.30A 6gbnA-3e0mA:
undetectable		 6gbnA-3e0mA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_D_ADND501_2
(-)		 3e0m PEPTIDE METHIONINE
SULFOXIDE REDUCTASE
MSRA/MSRB 1
(Streptococcus
pneumoniae) 		4 / 5 GLN A  35
THR A  47
THR A  52
LEU A 128
 None
 1.29A 6gbnD-3e0mA:
undetectable		 6gbnD-3e0mA:
22.00