SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3e0u'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EA1_A_TPFA470_1
(CYTOCHROME P450
51-LIKE RV0764C)		 3e0u GLUTATHIONE
PEROXIDASE
(Trypanosoma
cruzi) 		4 / 8 PHE A  75
MET A 106
THR A  71
LEU A  39
 NH4  A   1 (-4.7A)
None
None
None
 1.28A 1ea1A-3e0uA:
undetectable		 1ea1A-3e0uA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRK_A_TFPA204_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 3e0u GLUTATHIONE
PEROXIDASE
(Trypanosoma
cruzi) 		5 / 9 PHE A  75
VAL A  21
LEU A  31
MET A 123
LEU A  73
 NH4  A   1 (-4.7A)
NH4  A   1 (-4.0A)
None
None
None
 1.05A 1wrkA-3e0uA:
undetectable
1wrkB-3e0uA:
undetectable		 1wrkA-3e0uA:
19.61
1wrkB-3e0uA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QO6_A_CHDA130_0
(LIVER-BASIC FATTY
ACID BINDING PROTEIN)		 3e0u GLUTATHIONE
PEROXIDASE
(Trypanosoma
cruzi) 		5 / 12 TYR A  29
ILE A  41
LEU A  39
HIS A 117
MET A 106
 None
 1.34A 2qo6A-3e0uA:
undetectable		 2qo6A-3e0uA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VN2_A_TLSA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3e0u GLUTATHIONE
PEROXIDASE
(Trypanosoma
cruzi) 		5 / 12 PHE A 103
ILE A 109
TYR A 120
LEU A 119
LEU A  39
 None
NH4  A   1 (-4.6A)
None
None
None
 1.25A 3vn2A-3e0uA:
undetectable		 3vn2A-3e0uA:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE2_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3e0u GLUTATHIONE
PEROXIDASE
(Trypanosoma
cruzi) 		4 / 5 TYR A  55
HIS A  34
PRO A  76
PHE A 103
 None
 1.31A 4ze2A-3e0uA:
undetectable		 4ze2A-3e0uA:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K9D_A_CE9A402_0
(DIHYDROOROTATE
DEHYDROGENASE
(QUINONE),
MITOCHONDRIAL)		 3e0u GLUTATHIONE
PEROXIDASE
(Trypanosoma
cruzi) 		5 / 12 LEU A  73
ALA A  74
PHE A  75
PHE A  99
TYR A  55
 None
None
NH4  A   1 (-4.7A)
None
None
 1.21A 5k9dA-3e0uA:
undetectable		 5k9dA-3e0uA:
19.07