SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3e10'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		 3e10 PUTATIVE NADH
OXIDASE
(Clostridium
acetobutylicum) 		4 / 8 CYH A 139
LEU A  56
ALA A  72
LEU A  47
 None
EDO  A 503 (-4.2A)
None
None
 1.02A 1hwiC-3e10A:
4.6		 1hwiC-3e10A:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC2_A_NCAA506_0
(NAD-DEPENDENT
DEACETYLASE 2)		 3e10 PUTATIVE NADH
OXIDASE
(Clostridium
acetobutylicum) 		4 / 6 PHE A 129
ASN A  52
ILE A  53
ASP A  49
 EDO  A 503 (-4.0A)
EDO  A 503 (-3.4A)
None
None
 0.99A 1yc2A-3e10A:
undetectable		 1yc2A-3e10A:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXP_A_P1ZA3001_1
(SERUM ALBUMIN)		 3e10 PUTATIVE NADH
OXIDASE
(Clostridium
acetobutylicum) 		5 / 12 LEU A  71
ALA A  72
ILE A  73
SER A 142
ALA A 110
 None
 1.04A 2bxpA-3e10A:
undetectable		 2bxpA-3e10A:
14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXQ_A_IMNA2001_1
(SERUM ALBUMIN)		 3e10 PUTATIVE NADH
OXIDASE
(Clostridium
acetobutylicum) 		5 / 10 ALA A 110
ALA A  72
LEU A  47
LEU A  56
LEU A 100
 None
None
None
EDO  A 503 (-4.2A)
None
 1.10A 2bxqA-3e10A:
undetectable		 2bxqA-3e10A:
14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_A_1N1A1000_2
(P38A)		 3e10 PUTATIVE NADH
OXIDASE
(Clostridium
acetobutylicum) 		3 / 3 GLU A  97
LEU A 101
LEU A  27
 None
 0.73A 3ohtA-3e10A:
undetectable		 3ohtA-3e10A:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_B_1N1B1000_2
(P38A)		 3e10 PUTATIVE NADH
OXIDASE
(Clostridium
acetobutylicum) 		3 / 3 GLU A  97
LEU A 101
LEU A  27
 None
 0.77A 3ohtB-3e10A:
undetectable		 3ohtB-3e10A:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PSS_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3e10 PUTATIVE NADH
OXIDASE
(Clostridium
acetobutylicum) 		5 / 12 ILE A 141
LEU A 108
ALA A 104
ILE A  23
ILE A  73
 None
 0.91A 4pssA-3e10A:
undetectable		 4pssA-3e10A:
21.86