SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3e15'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZM_A_BZMA600_0
(ODORANT-BINDING
PROTEIN)		 3e15 GLUCOSE-6-PHOSPHATE
1-DEHYDROGENASE
(Plasmodium
vivax) 		4 / 8 VAL A  67
ASN A  31
GLY A 285
LEU A 249
 None
 0.96A 1dzmA-3e15A:
undetectable		 1dzmA-3e15A:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_A_NOVA400_2
(DNA GYRASE SUBUNIT B)		 3e15 GLUCOSE-6-PHOSPHATE
1-DEHYDROGENASE
(Plasmodium
vivax) 		3 / 3 ASN A 195
PHE A 172
VAL A 193
 None
 0.76A 1kijA-3e15A:
undetectable		 1kijA-3e15A:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW5_A_SAMA401_1
(MODIFICATION
METHYLASE RSRI)		 3e15 GLUCOSE-6-PHOSPHATE
1-DEHYDROGENASE
(Plasmodium
vivax) 		3 / 3 ASP A 221
HIS A 163
ASP A  90
 None
 0.87A 1nw5A-3e15A:
undetectable		 1nw5A-3e15A:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DQY_A_CHDA1_0
(LIVER
CARBOXYLESTERASE 1)		 3e15 GLUCOSE-6-PHOSPHATE
1-DEHYDROGENASE
(Plasmodium
vivax) 		4 / 5 GLY A 159
LYS A 248
LEU A 243
PRO A  64
 None
 1.15A 2dqyA-3e15A:
0.0		 2dqyA-3e15A:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_D_KLND1499_1
(CYTOCHROME P450 3A4)		 3e15 GLUCOSE-6-PHOSPHATE
1-DEHYDROGENASE
(Plasmodium
vivax) 		4 / 5 PHE A 241
SER A  59
PHE A 162
ILE A  89
 None
 1.09A 2v0mD-3e15A:
undetectable		 2v0mD-3e15A:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_A_PZIA800_0
(GLUTAMATE RECEPTOR 2)		 3e15 GLUCOSE-6-PHOSPHATE
1-DEHYDROGENASE
(Plasmodium
vivax) 		4 / 7 TYR A 137
ASN A 102
ASP A  90
SER A  59
 None
 1.42A 3lslA-3e15A:
undetectable
3lslD-3e15A:
undetectable		 3lslA-3e15A:
23.81
3lslD-3e15A:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_D_PZID800_0
(GLUTAMATE RECEPTOR 2)		 3e15 GLUCOSE-6-PHOSPHATE
1-DEHYDROGENASE
(Plasmodium
vivax) 		4 / 7 SER A  59
TYR A 137
ASN A 102
ASP A  90
 None
 1.41A 3lslA-3e15A:
undetectable
3lslD-3e15A:
undetectable		 3lslA-3e15A:
23.81
3lslD-3e15A:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PMZ_E_TUBE220_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3e15 GLUCOSE-6-PHOSPHATE
1-DEHYDROGENASE
(Plasmodium
vivax) 		4 / 6 TYR A 180
GLN A 181
SER A 189
SER A 190
 None
 1.22A 3pmzD-3e15A:
undetectable		 3pmzD-3e15A:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q5P_A_TACA7101_1
(MULTIDRUG-EFFLUX
TRANSPORTER 1
REGULATOR)		 3e15 GLUCOSE-6-PHOSPHATE
1-DEHYDROGENASE
(Plasmodium
vivax) 		5 / 12 PRO A  64
TYR A  37
ILE A  65
TYR A  68
ILE A  38
 None
 1.41A 3q5pA-3e15A:
undetectable		 3q5pA-3e15A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q5R_A_KANA2002_1
(MULTIDRUG-EFFLUX
TRANSPORTER 1
REGULATOR)		 3e15 GLUCOSE-6-PHOSPHATE
1-DEHYDROGENASE
(Plasmodium
vivax) 		5 / 11 PRO A  64
TYR A  37
ILE A  65
TYR A  68
ILE A  38
 None
 1.35A 3q5rA-3e15A:
0.0		 3q5rA-3e15A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROD_C_NCAC302_0
(NICOTINAMIDE
N-METHYLTRANSFERASE)		 3e15 GLUCOSE-6-PHOSPHATE
1-DEHYDROGENASE
(Plasmodium
vivax) 		5 / 10 TYR A 180
TYR A 186
ASP A 231
TYR A 213
SER A 229
 None
 1.28A 3rodC-3e15A:
2.8		 3rodC-3e15A:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WXO_A_NIZA804_1
(CATALASE-PEROXIDASE)		 3e15 GLUCOSE-6-PHOSPHATE
1-DEHYDROGENASE
(Plasmodium
vivax) 		3 / 3 ASN A 102
GLU A  91
ARG A 225
 None
K  A 306 ( 4.3A)
None
 1.07A 3wxoA-3e15A:
undetectable		 3wxoA-3e15A:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PD9_A_ADNA501_2
(NUPC FAMILY PROTEIN)		 3e15 GLUCOSE-6-PHOSPHATE
1-DEHYDROGENASE
(Plasmodium
vivax) 		3 / 3 THR A 227
ASN A 170
PHE A 172
 None
 0.79A 4pd9A-3e15A:
undetectable		 4pd9A-3e15A:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RP9_A_ASCA501_0
(ASCORBATE-SPECIFIC
PERMEASE IIC
COMPONENT ULAA)		 3e15 GLUCOSE-6-PHOSPHATE
1-DEHYDROGENASE
(Plasmodium
vivax) 		5 / 12 TYR A  68
ILE A  88
ASP A  90
ALA A 165
ILE A 155
 None
 1.32A 4rp9A-3e15A:
undetectable		 4rp9A-3e15A:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_E_ACTE406_0
(PROTON-GATED ION
CHANNEL)		 3e15 GLUCOSE-6-PHOSPHATE
1-DEHYDROGENASE
(Plasmodium
vivax) 		4 / 5 ILE A 175
ILE A 185
TYR A 213
GLU A 210
 None
 1.11A 4zzcE-3e15A:
undetectable		 4zzcE-3e15A:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGR_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 3e15 GLUCOSE-6-PHOSPHATE
1-DEHYDROGENASE
(Plasmodium
vivax) 		3 / 3 VAL A  74
TYR A  36
GLN A  32
 None
 0.73A 5qgrA-3e15A:
undetectable		 5qgrA-3e15A:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGT_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 3e15 GLUCOSE-6-PHOSPHATE
1-DEHYDROGENASE
(Plasmodium
vivax) 		3 / 3 VAL A  74
TYR A  36
GLN A  32
 None
 0.74A 5qgtA-3e15A:
undetectable		 5qgtA-3e15A:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZOV_B_ASCB501_0
(PTS
ASCORBATE-SPECIFIC
SUBUNIT IIBC)		 3e15 GLUCOSE-6-PHOSPHATE
1-DEHYDROGENASE
(Plasmodium
vivax) 		5 / 12 TYR A  68
ILE A  88
ASP A  90
ALA A 165
ILE A 155
 None
 1.34A 5zovB-3e15A:
0.0		 5zovB-3e15A:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_A_AQ4A602_1
(CYTOCHROME P450 1A1)		 3e15 GLUCOSE-6-PHOSPHATE
1-DEHYDROGENASE
(Plasmodium
vivax) 		4 / 5 ILE A 153
SER A 238
ALA A  43
LEU A  84
 None
 1.01A 6dwnA-3e15A:
undetectable		 6dwnA-3e15A:
12.00