SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3e18'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AFS_A_TESA325_1
(3-ALPHA-HYDROXYSTERO
ID DEHYDROGENASE)		 3e18 OXIDOREDUCTASE
(Listeria
innocua) 		4 / 7 LEU A  21
TYR A 306
HIS A  18
TRP A 125
 None
 1.27A 1afsA-3e18A:
undetectable		 1afsA-3e18A:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AFS_B_TESB325_1
(3-ALPHA-HYDROXYSTERO
ID DEHYDROGENASE)		 3e18 OXIDOREDUCTASE
(Listeria
innocua) 		4 / 7 LEU A  21
TYR A 306
HIS A  18
TRP A 125
 None
 1.28A 1afsB-3e18A:
undetectable		 1afsB-3e18A:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_D_BRLD503_2
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 3e18 OXIDOREDUCTASE
(Listeria
innocua) 		4 / 4 ILE A 106
LEU A  59
VAL A  67
ILE A  69
 None
 0.94A 1fm6D-3e18A:
undetectable		 1fm6D-3e18A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_T_TRPT81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 3e18 OXIDOREDUCTASE
(Listeria
innocua) 		5 / 10 THR A 229
HIS A 152
THR A 228
ILE A 157
SER A 199
 None
GOL  A 365 (-4.5A)
None
None
None
 1.41A 1gtfT-3e18A:
undetectable
1gtfU-3e18A:
undetectable		 1gtfT-3e18A:
14.08
1gtfU-3e18A:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK7_C_ADNC1247_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3e18 OXIDOREDUCTASE
(Listeria
innocua) 		5 / 10 GLY A 209
VAL A 226
GLU A 225
SER A 199
ASP A 208
 None
 1.07A 1pk7C-3e18A:
undetectable		 1pk7C-3e18A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK9_C_2FAC308_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3e18 OXIDOREDUCTASE
(Listeria
innocua) 		5 / 11 GLY A 209
VAL A 226
GLU A 225
SER A 199
ASP A 208
 None
 1.06A 1pk9C-3e18A:
undetectable		 1pk9C-3e18A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_H_SVRH511_2
(PHOSPHOLIPASE A2)		 3e18 OXIDOREDUCTASE
(Listeria
innocua) 		4 / 5 VAL A 226
VAL A 151
THR A 212
THR A 228
 None
GOL  A 365 (-3.7A)
None
None
 1.22A 3bjwD-3e18A:
undetectable		 3bjwD-3e18A:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_C_PFLC319_1
(GLR4197 PROTEIN)		 3e18 OXIDOREDUCTASE
(Listeria
innocua) 		5 / 7 PRO A 296
ILE A 132
LEU A 147
THR A 140
ILE A 141
 None
 1.42A 3p50C-3e18A:
undetectable		 3p50C-3e18A:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_D_PFLD320_1
(GLR4197 PROTEIN)		 3e18 OXIDOREDUCTASE
(Listeria
innocua) 		5 / 7 PRO A 296
ILE A 132
LEU A 147
THR A 140
ILE A 141
 None
 1.42A 3p50D-3e18A:
undetectable		 3p50D-3e18A:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_E_PFLE319_1
(GLR4197 PROTEIN)		 3e18 OXIDOREDUCTASE
(Listeria
innocua) 		5 / 7 PRO A 296
ILE A 132
LEU A 147
THR A 140
ILE A 141
 None
 1.41A 3p50E-3e18A:
undetectable		 3p50E-3e18A:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R24_A_SAMA302_1
(2'-O-METHYL
TRANSFERASE)		 3e18 OXIDOREDUCTASE
(Listeria
innocua) 		3 / 3 TYR A  52
ASP A  65
ASP A  61
 None
 0.70A 3r24A-3e18A:
undetectable		 3r24A-3e18A:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFN_A_ROCA402_1
(HIV-1 PROTEASE)		 3e18 OXIDOREDUCTASE
(Listeria
innocua) 		4 / 5 ARG A 123
LEU A 179
VAL A 151
ASP A 126
 GOL  A 362 (-4.0A)
None
GOL  A 365 (-3.7A)
None
 1.03A 3ufnA-3e18A:
undetectable
3ufnB-3e18A:
undetectable		 3ufnA-3e18A:
15.97
3ufnB-3e18A:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DT8_B_ADNB401_1
(APH(2'')-ID)		 3e18 OXIDOREDUCTASE
(Listeria
innocua) 		5 / 10 ALA A 335
ILE A 336
ILE A 224
LEU A 183
ILE A 214
 None
 1.11A 4dt8B-3e18A:
undetectable		 4dt8B-3e18A:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTA_A_ADNA401_1
(APH(2'')-ID)		 3e18 OXIDOREDUCTASE
(Listeria
innocua) 		5 / 10 ALA A 335
ILE A 336
ILE A 224
LEU A 183
ILE A 214
 None
 1.16A 4dtaA-3e18A:
undetectable		 4dtaA-3e18A:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3e18 OXIDOREDUCTASE
(Listeria
innocua) 		3 / 3 LEU A 253
ILE A 248
ARG A 236
 None
 0.54A 4mk4B-3e18A:
3.1		 4mk4B-3e18A:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_O_EVPO2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 3e18 OXIDOREDUCTASE
(Listeria
innocua) 		5 / 6 SER A 100
GLU A 101
GLY A 170
ASP A 207
GLY A 168
 None
 1.39A 5cdnC-3e18A:
undetectable
5cdnD-3e18A:
undetectable		 5cdnC-3e18A:
21.46
5cdnD-3e18A:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_R_TRPR101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3e18 OXIDOREDUCTASE
(Listeria
innocua) 		5 / 9 THR A 229
HIS A 152
THR A 228
ILE A 157
SER A 199
 None
GOL  A 365 (-4.5A)
None
None
None
 1.41A 5eezQ-3e18A:
undetectable
5eezR-3e18A:
undetectable		 5eezQ-3e18A:
14.08
5eezR-3e18A:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_R_TRPR101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3e18 OXIDOREDUCTASE
(Listeria
innocua) 		5 / 9 THR A 229
HIS A 152
THR A 228
ILE A 157
SER A 199
 None
GOL  A 365 (-4.5A)
None
None
None
 1.41A 5ef0Q-3e18A:
undetectable
5ef0R-3e18A:
undetectable		 5ef0Q-3e18A:
14.08
5ef0R-3e18A:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_R_TRPR101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3e18 OXIDOREDUCTASE
(Listeria
innocua) 		5 / 9 THR A 229
HIS A 152
THR A 228
ILE A 157
SER A 199
 None
GOL  A 365 (-4.5A)
None
None
None
 1.41A 5ef1Q-3e18A:
undetectable
5ef1R-3e18A:
undetectable		 5ef1Q-3e18A:
14.08
5ef1R-3e18A:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_R_TRPR101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3e18 OXIDOREDUCTASE
(Listeria
innocua) 		5 / 9 THR A 229
HIS A 152
THR A 228
ILE A 157
SER A 199
 None
GOL  A 365 (-4.5A)
None
None
None
 1.41A 5ef2Q-3e18A:
undetectable
5ef2R-3e18A:
undetectable		 5ef2Q-3e18A:
14.08
5ef2R-3e18A:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_R_TRPR101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3e18 OXIDOREDUCTASE
(Listeria
innocua) 		5 / 9 THR A 229
HIS A 152
THR A 228
ILE A 157
SER A 199
 None
GOL  A 365 (-4.5A)
None
None
None
 1.41A 5ef3Q-3e18A:
undetectable
5ef3R-3e18A:
undetectable		 5ef3Q-3e18A:
14.08
5ef3R-3e18A:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_A_P06A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3e18 OXIDOREDUCTASE
(Listeria
innocua) 		4 / 7 GLY A 159
PHE A 210
ASP A 204
PHE A 200
 None
 1.04A 5hieA-3e18A:
undetectable		 5hieA-3e18A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OV9_B_CVIB603_0
(ACETYLCHOLINESTERASE)		 3e18 OXIDOREDUCTASE
(Listeria
innocua) 		4 / 7 TYR A 306
GLN A   5
ASP A  65
HIS A  89
 None
 1.39A 5ov9B-3e18A:
2.5		 5ov9B-3e18A:
20.32