SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3e1k'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RH3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 3e1k GALACTOSE/LACTOSE
METABOLISM
REGULATORY PROTEIN
GAL80
(Kluyveromyces
lactis) 		5 / 12 ILE A 230
PHE A 227
SER A 176
ILE A 177
LEU A 219
 None
 1.03A 1rh3A-3e1kA:
undetectable		 1rh3A-3e1kA:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 3e1k GALACTOSE/LACTOSE
METABOLISM
REGULATORY PROTEIN
GAL80
(Kluyveromyces
lactis) 		5 / 12 ILE A 230
PHE A 227
SER A 176
ILE A 177
LEU A 219
 None
 1.09A 1rx3A-3e1kA:
undetectable		 1rx3A-3e1kA:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN5_C_T3C601_1
(TRANSTHYRETIN)		 3e1k GALACTOSE/LACTOSE
METABOLISM
REGULATORY PROTEIN
GAL80
(Kluyveromyces
lactis) 		4 / 6 GLU A 122
ALA A 124
LEU A 433
VAL A 205
 None
 1.02A 1sn5A-3e1kA:
undetectable		 1sn5A-3e1kA:
13.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN5_C_T3C601_2
(TRANSTHYRETIN)		 3e1k GALACTOSE/LACTOSE
METABOLISM
REGULATORY PROTEIN
GAL80
(Kluyveromyces
lactis) 		4 / 8 GLU A 122
ALA A 124
LEU A 433
VAL A 205
 None
 1.01A 1sn5C-3e1kA:
undetectable		 1sn5C-3e1kA:
13.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOZ_A_CIAA501_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 3e1k GALACTOSE/LACTOSE
METABOLISM
REGULATORY PROTEIN
GAL80
(Kluyveromyces
lactis) 		5 / 12 ILE A 388
VAL A  91
PHE A  22
ILE A  87
PHE A  47
 None
 1.02A 1xozA-3e1kA:
undetectable		 1xozA-3e1kA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_A_IMNA379_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		 3e1k GALACTOSE/LACTOSE
METABOLISM
REGULATORY PROTEIN
GAL80
(Kluyveromyces
lactis) 		5 / 12 THR A  35
VAL A  91
TYR A 120
ILE A 381
VAL A  32
 None
 1.37A 1z9hA-3e1kA:
undetectable		 1z9hA-3e1kA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_B_IMNB381_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		 3e1k GALACTOSE/LACTOSE
METABOLISM
REGULATORY PROTEIN
GAL80
(Kluyveromyces
lactis) 		5 / 12 THR A  35
VAL A  91
TYR A 120
ILE A 381
VAL A  32
 None
 1.37A 1z9hB-3e1kA:
undetectable		 1z9hB-3e1kA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_C_IMNC379_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		 3e1k GALACTOSE/LACTOSE
METABOLISM
REGULATORY PROTEIN
GAL80
(Kluyveromyces
lactis) 		5 / 12 THR A  35
VAL A  91
TYR A 120
ILE A 381
VAL A  32
 None
 1.37A 1z9hC-3e1kA:
undetectable		 1z9hC-3e1kA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DPM_A_SAMA300_0
(PROTEIN
(ADENINE-SPECIFIC
METHYLTRANSFERASE
DPNII 1))		 3e1k GALACTOSE/LACTOSE
METABOLISM
REGULATORY PROTEIN
GAL80
(Kluyveromyces
lactis) 		5 / 12 GLY A 187
GLY A 183
GLY A 184
ASN A 210
PRO A 260
 None
 1.16A 2dpmA-3e1kA:
5.0		 2dpmA-3e1kA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_A_VIAA901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 3e1k GALACTOSE/LACTOSE
METABOLISM
REGULATORY PROTEIN
GAL80
(Kluyveromyces
lactis) 		5 / 11 ILE A 388
VAL A  91
PHE A  22
ILE A  87
PHE A  47
 None
 1.10A 2h42A-3e1kA:
undetectable		 2h42A-3e1kA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_A_VIAA901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 3e1k GALACTOSE/LACTOSE
METABOLISM
REGULATORY PROTEIN
GAL80
(Kluyveromyces
lactis) 		5 / 11 TYR A 120
VAL A  91
PHE A  22
ILE A  87
PHE A  47
 None
 1.22A 2h42A-3e1kA:
undetectable		 2h42A-3e1kA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDY_B_HCYB1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 3e1k GALACTOSE/LACTOSE
METABOLISM
REGULATORY PROTEIN
GAL80
(Kluyveromyces
lactis) 		5 / 12 VAL A 440
THR A 215
PHE A 280
ASN A 206
PHE A 212
 None
 1.37A 2vdyB-3e1kA:
undetectable		 2vdyB-3e1kA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B2R_A_VDNA1_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 3e1k GALACTOSE/LACTOSE
METABOLISM
REGULATORY PROTEIN
GAL80
(Kluyveromyces
lactis) 		5 / 12 ILE A  40
ILE A 388
VAL A  91
PHE A  22
ILE A  87
 None
 1.06A 3b2rA-3e1kA:
undetectable		 3b2rA-3e1kA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZU_A_9CRA7223_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3e1k GALACTOSE/LACTOSE
METABOLISM
REGULATORY PROTEIN
GAL80
(Kluyveromyces
lactis) 		5 / 12 ILE A 106
GLN A  83
ILE A  87
PHE A  81
VAL A 121
 None
 1.06A 3dzuA-3e1kA:
undetectable		 3dzuA-3e1kA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZU_A_9CRA7223_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3e1k GALACTOSE/LACTOSE
METABOLISM
REGULATORY PROTEIN
GAL80
(Kluyveromyces
lactis) 		5 / 12 ILE A 106
ILE A  87
PHE A  81
LEU A  78
VAL A 121
 None
 0.94A 3dzuA-3e1kA:
undetectable		 3dzuA-3e1kA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZY_A_9CRA463_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3e1k GALACTOSE/LACTOSE
METABOLISM
REGULATORY PROTEIN
GAL80
(Kluyveromyces
lactis) 		5 / 12 ILE A 106
GLN A  83
PHE A  81
VAL A 121
LEU A 145
 None
 0.92A 3dzyA-3e1kA:
undetectable		 3dzyA-3e1kA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_D_MTXD164_1
(DIHYDROFOLATE
REDUCTASE)		 3e1k GALACTOSE/LACTOSE
METABOLISM
REGULATORY PROTEIN
GAL80
(Kluyveromyces
lactis) 		5 / 12 ILE A 230
PHE A 227
SER A 176
ILE A 177
LEU A 219
 None
 1.14A 3ia4D-3e1kA:
undetectable		 3ia4D-3e1kA:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_A_TFPA202_1
(PROTEIN S100-A4)		 3e1k GALACTOSE/LACTOSE
METABOLISM
REGULATORY PROTEIN
GAL80
(Kluyveromyces
lactis) 		5 / 12 LEU A  25
PHE A  22
ILE A  49
LEU A  69
PHE A  81
 None
 1.23A 3ko0A-3e1kA:
undetectable
3ko0B-3e1kA:
undetectable
3ko0C-3e1kA:
undetectable
3ko0D-3e1kA:
undetectable		 3ko0A-3e1kA:
13.62
3ko0B-3e1kA:
13.62
3ko0C-3e1kA:
13.62
3ko0D-3e1kA:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_I_TFPI202_1
(PROTEIN S100-A4)		 3e1k GALACTOSE/LACTOSE
METABOLISM
REGULATORY PROTEIN
GAL80
(Kluyveromyces
lactis) 		5 / 12 PHE A  81
LEU A  25
PHE A  22
ILE A  49
LEU A  69
 None
 1.25A 3ko0G-3e1kA:
undetectable
3ko0H-3e1kA:
undetectable
3ko0I-3e1kA:
undetectable
3ko0J-3e1kA:
undetectable		 3ko0G-3e1kA:
13.62
3ko0H-3e1kA:
13.62
3ko0I-3e1kA:
13.62
3ko0J-3e1kA:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_J_TFPJ202_1
(PROTEIN S100-A4)		 3e1k GALACTOSE/LACTOSE
METABOLISM
REGULATORY PROTEIN
GAL80
(Kluyveromyces
lactis) 		5 / 11 PHE A  81
LEU A  69
LEU A  25
PHE A  22
ILE A  49
 None
 1.21A 3ko0A-3e1kA:
undetectable
3ko0B-3e1kA:
undetectable
3ko0I-3e1kA:
undetectable
3ko0J-3e1kA:
undetectable		 3ko0A-3e1kA:
13.62
3ko0B-3e1kA:
13.62
3ko0I-3e1kA:
13.62
3ko0J-3e1kA:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QOW_A_SAMA417_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE)		 3e1k GALACTOSE/LACTOSE
METABOLISM
REGULATORY PROTEIN
GAL80
(Kluyveromyces
lactis) 		5 / 12 GLY A  24
GLY A  21
ALA A  72
ASP A  86
PHE A  81
 None
 1.25A 3qowA-3e1kA:
2.1		 3qowA-3e1kA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SP9_A_IL2A901_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR DELTA)		 3e1k GALACTOSE/LACTOSE
METABOLISM
REGULATORY PROTEIN
GAL80
(Kluyveromyces
lactis) 		5 / 12 THR A  35
ILE A 315
VAL A  91
ILE A 384
TYR A 374
 None
 1.25A 3sp9A-3e1kA:
undetectable		 3sp9A-3e1kA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_C_HCYC1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 3e1k GALACTOSE/LACTOSE
METABOLISM
REGULATORY PROTEIN
GAL80
(Kluyveromyces
lactis) 		5 / 12 VAL A 440
PHE A 280
ASN A 206
PHE A 212
HIS A 214
 None
 1.38A 4c49C-3e1kA:
undetectable		 4c49C-3e1kA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_C_HCYC1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 3e1k GALACTOSE/LACTOSE
METABOLISM
REGULATORY PROTEIN
GAL80
(Kluyveromyces
lactis) 		5 / 12 VAL A 440
THR A 215
PHE A 280
ASN A 206
HIS A 214
 None
 1.33A 4c49C-3e1kA:
undetectable		 4c49C-3e1kA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_D_HCYD1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 3e1k GALACTOSE/LACTOSE
METABOLISM
REGULATORY PROTEIN
GAL80
(Kluyveromyces
lactis) 		5 / 12 VAL A 440
PHE A 280
ASN A 206
PHE A 212
HIS A 214
 None
 1.36A 4c49D-3e1kA:
undetectable		 4c49D-3e1kA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_D_HCYD1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 3e1k GALACTOSE/LACTOSE
METABOLISM
REGULATORY PROTEIN
GAL80
(Kluyveromyces
lactis) 		5 / 12 VAL A 440
THR A 215
PHE A 280
ASN A 206
HIS A 214
 None
 1.29A 4c49D-3e1kA:
undetectable		 4c49D-3e1kA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IK6_B_LURB201_1
(TRANSTHYRETIN)		 3e1k GALACTOSE/LACTOSE
METABOLISM
REGULATORY PROTEIN
GAL80
(Kluyveromyces
lactis) 		4 / 8 GLU A 122
ALA A 124
LEU A 433
VAL A 205
 None
 0.96A 4ik6B-3e1kA:
undetectable		 4ik6B-3e1kA:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NQA_A_9CRA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3e1k GALACTOSE/LACTOSE
METABOLISM
REGULATORY PROTEIN
GAL80
(Kluyveromyces
lactis) 		5 / 11 ILE A 106
GLN A  83
LEU A  78
VAL A 121
LEU A 145
 None
 0.94A 4nqaA-3e1kA:
undetectable		 4nqaA-3e1kA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NQA_A_9CRA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3e1k GALACTOSE/LACTOSE
METABOLISM
REGULATORY PROTEIN
GAL80
(Kluyveromyces
lactis) 		5 / 11 ILE A 106
GLN A  83
PHE A  81
LEU A  78
VAL A 121
 None
 1.06A 4nqaA-3e1kA:
undetectable		 4nqaA-3e1kA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IWU_A_ACTA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 3e1k GALACTOSE/LACTOSE
METABOLISM
REGULATORY PROTEIN
GAL80
(Kluyveromyces
lactis) 		4 / 6 PHE A  22
VAL A  91
TYR A 120
ILE A 381
 None
 1.10A 5iwuA-3e1kA:
0.9		 5iwuA-3e1kA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JI0_A_9CRA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3e1k GALACTOSE/LACTOSE
METABOLISM
REGULATORY PROTEIN
GAL80
(Kluyveromyces
lactis) 		5 / 11 ILE A 106
GLN A  83
PHE A  81
LEU A  78
VAL A 121
 None
 1.09A 5ji0A-3e1kA:
undetectable		 5ji0A-3e1kA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NN8_A_ACRA1015_1
(LYSOSOMAL
ALPHA-GLUCOSIDASE)		 3e1k GALACTOSE/LACTOSE
METABOLISM
REGULATORY PROTEIN
GAL80
(Kluyveromyces
lactis) 		5 / 12 LEU A 436
ILE A 216
ASP A 217
ARG A 154
PHE A 419
 None
 1.45A 5nn8A-3e1kA:
undetectable		 5nn8A-3e1kA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U63_A_ACTA405_0
(THIOREDOXIN
REDUCTASE)		 3e1k GALACTOSE/LACTOSE
METABOLISM
REGULATORY PROTEIN
GAL80
(Kluyveromyces
lactis) 		3 / 3 GLY A 153
LEU A 151
HIS A 214
 None
 0.66A 5u63A-3e1kA:
3.1		 5u63A-3e1kA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U63_B_ACTB405_0
(THIOREDOXIN
REDUCTASE)		 3e1k GALACTOSE/LACTOSE
METABOLISM
REGULATORY PROTEIN
GAL80
(Kluyveromyces
lactis) 		3 / 3 GLY A 153
LEU A 151
HIS A 214
 None
 0.67A 5u63B-3e1kA:
3.3		 5u63B-3e1kA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9M_A_NIOA401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 3e1k GALACTOSE/LACTOSE
METABOLISM
REGULATORY PROTEIN
GAL80
(Kluyveromyces
lactis) 		4 / 8 LEU A 269
VAL A 274
VAL A 276
ILE A 297
 None
 0.74A 5y9mA-3e1kA:
undetectable		 5y9mA-3e1kA:
11.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9M_X_NIOX401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 3e1k GALACTOSE/LACTOSE
METABOLISM
REGULATORY PROTEIN
GAL80
(Kluyveromyces
lactis) 		4 / 8 LEU A 269
VAL A 274
VAL A 276
ILE A 297
 None
 0.69A 5y9mX-3e1kA:
undetectable		 5y9mX-3e1kA:
11.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_B_FK5B201_0
(PEPTIDYLPROLYL
ISOMERASE)		 3e1k GALACTOSE/LACTOSE
METABOLISM
REGULATORY PROTEIN
GAL80
(Kluyveromyces
lactis) 		5 / 12 ASP A 217
PHE A 419
ILE A 455
ILE A 437
ILE A 177
 None
 1.28A 6mkeB-3e1kA:
undetectable
6mkeC-3e1kA:
undetectable		 6mkeB-3e1kA:
10.59
6mkeC-3e1kA:
10.59