SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3e20'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GS4_A_ZK5A1918_1
(ANDROGEN RECEPTOR)		 3e20 EUKARYOTIC PEPTIDE
CHAIN RELEASE FACTOR
SUBUNIT 1
(Schizosaccharomy
ces
pombe) 		5 / 12 LEU C 372
GLN C  20
ALA C 378
LEU C 377
PHE C 390
 None
 1.12A 1gs4A-3e20C:
undetectable		 1gs4A-3e20C:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK3_A_T44A3002_1
(SERUM ALBUMIN)		 3e20 EUKARYOTIC PEPTIDE
CHAIN RELEASE FACTOR
SUBUNIT 1
(Schizosaccharomy
ces
pombe) 		4 / 8 GLN C 310
LEU C 373
ARG C 327
LEU C 317
 None
 0.97A 1hk3A-3e20C:
2.0		 1hk3A-3e20C:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UOB_A_PNNA1311_1
(DEACETOXYCEPHALOSPOR
IN C SYNTHETASE)		 3e20 EUKARYOTIC PEPTIDE
CHAIN RELEASE FACTOR
SUBUNIT 1
(Schizosaccharomy
ces
pombe) 		3 / 3 ARG C  16
ARG C  15
ILE C  22
 None
 0.62A 1uobA-3e20C:
undetectable		 1uobA-3e20C:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BU8_A_TF4A1379_1
(PYRUVATE
DEHYDROGENASE KINASE
ISOENZYME 2)		 3e20 EUKARYOTIC PEPTIDE
CHAIN RELEASE FACTOR
SUBUNIT 1
(Schizosaccharomy
ces
pombe) 		4 / 8 LEU C  79
TYR C  82
ILE C  36
ILE C  92
 None
 0.66A 2bu8A-3e20C:
undetectable		 2bu8A-3e20C:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9C_C_ACTC1120_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 3e20 EUKARYOTIC PEPTIDE
CHAIN RELEASE FACTOR
GTP-BINDING SUBUNIT
(Schizosaccharomy
ces
pombe) 		3 / 3 LYS A 467
TYR A 637
PRO A 468
 None
 1.26A 2j9cC-3e20A:
undetectable		 2j9cC-3e20A:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NV4_A_ACTA148_0
(UPF0066 PROTEIN
AF_0241)		 3e20 EUKARYOTIC PEPTIDE
CHAIN RELEASE FACTOR
GTP-BINDING SUBUNIT
(Schizosaccharomy
ces
pombe) 		3 / 3 VAL A 580
GLU A 588
GLU A 589
 None
 0.81A 2nv4A-3e20A:
2.6		 2nv4A-3e20A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMZ_B_LDPB502_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE)		 3e20 EUKARYOTIC PEPTIDE
CHAIN RELEASE FACTOR
SUBUNIT 1
(Schizosaccharomy
ces
pombe) 		4 / 5 GLN C 400
PHE C 288
PHE C 287
GLY C 406
 None
 1.38A 2qmzA-3e20C:
undetectable
2qmzB-3e20C:
undetectable		 2qmzA-3e20C:
20.15
2qmzB-3e20C:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VN0_A_TDZA501_1
(CYTOCHROME P450 2C8)		 3e20 EUKARYOTIC PEPTIDE
CHAIN RELEASE FACTOR
GTP-BINDING SUBUNIT
(Schizosaccharomy
ces
pombe) 		5 / 12 ILE A 473
VAL A 541
VAL A 499
GLU A 509
ILE A 513
 None
 1.02A 2vn0A-3e20A:
undetectable		 2vn0A-3e20A:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A27_A_SAMA250_1
(UNCHARACTERIZED
PROTEIN MJ1557)		 3e20 EUKARYOTIC PEPTIDE
CHAIN RELEASE FACTOR
SUBUNIT 1
(Schizosaccharomy
ces
pombe) 		3 / 3 MET C  48
GLU C  40
ASN C 118
 None
 1.05A 3a27A-3e20C:
undetectable		 3a27A-3e20C:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KMO_A_EAAA214_1
(GLUTATHIONE
S-TRANSFERASE P)		 3e20 EUKARYOTIC PEPTIDE
CHAIN RELEASE FACTOR
SUBUNIT 1
(Schizosaccharomy
ces
pombe) 		5 / 9 VAL C  85
GLY C  39
GLN C 121
ASN C  88
GLY C  89
 None
 1.43A 3kmoA-3e20C:
undetectable		 3kmoA-3e20C:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S56_B_ROCB203_1
(PROTEASE)		 3e20 EUKARYOTIC PEPTIDE
CHAIN RELEASE FACTOR
SUBUNIT 1
(Schizosaccharomy
ces
pombe) 		4 / 7 LEU C  79
LEU C  34
PRO C  37
ILE C  36
 None
 0.93A 3s56B-3e20C:
undetectable		 3s56B-3e20C:
13.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_G_HCYG900_2
(GLUCOCORTICOID
RECEPTOR)		 3e20 EUKARYOTIC PEPTIDE
CHAIN RELEASE FACTOR
SUBUNIT 1
(Schizosaccharomy
ces
pombe) 		3 / 3 LEU C 318
MET C 412
TYR C 381
 None
 0.88A 4p6xG-3e20C:
undetectable		 4p6xG-3e20C:
22.12