SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3e23'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6K_A_ACTA860_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)
3e23 UNCHARACTERIZED
PROTEIN RPA2492

(Rhodopseudomonas
palustris)
4 / 6 GLY A  55
GLN A  57
VAL A  68
ALA A  70
None
SAM  A 221 ( 4.9A)
None
None
0.92A 1p6kA-3e23A:
undetectable
1p6kA-3e23A:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QVU_A_PRLA196_0
(TRANSCRIPTIONAL
REGULATOR QACR)
3e23 UNCHARACTERIZED
PROTEIN RPA2492

(Rhodopseudomonas
palustris)
4 / 6 LEU A 120
THR A  13
TYR A 155
TYR A 141
None
1.49A 1qvuA-3e23A:
undetectable
1qvuA-3e23A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UUJ_B_ACTB1077_0
(PLATELET-ACTIVATING
FACTOR
ACETYLHYDROLASE IB
ALPHA SUBUNIT)
3e23 UNCHARACTERIZED
PROTEIN RPA2492

(Rhodopseudomonas
palustris)
3 / 3 ARG A 154
TYR A 156
LYS A 142
SO4  A 222 (-3.2A)
SO4  A 222 (-4.6A)
SO4  A 222 (-2.7A)
1.05A 1uujB-3e23A:
undetectable
1uujB-3e23A:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BRF_A_SORA1_0
(LIN-12 AND GLP-1
PHENOTYPE PROTEIN 1,
ISOFORM A)
3e23 UNCHARACTERIZED
PROTEIN RPA2492

(Rhodopseudomonas
palustris)
3 / 3 GLY A  53
ASP A  72
SER A  74
SAM  A 221 (-3.2A)
SAM  A 221 (-2.8A)
SAM  A 221 (-4.6A)
0.69A 3brfA-3e23A:
undetectable
3brfA-3e23A:
17.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3E23_A_SAMA221_0
(UNCHARACTERIZED
PROTEIN RPA2492)
3e23 UNCHARACTERIZED
PROTEIN RPA2492

(Rhodopseudomonas
palustris)
12 / 12 PHE A   9
LEU A  14
TYR A  17
PRO A  29
GLY A  53
GLY A  73
SER A  74
LEU A  77
LEU A  93
PHE A  94
CYH A 111
HIS A 114
None
SAM  A 221 (-4.4A)
SAM  A 221 (-3.8A)
SAM  A 221 (-4.1A)
SAM  A 221 (-3.2A)
SAM  A 221 (-3.2A)
SAM  A 221 (-4.6A)
SAM  A 221 (-4.3A)
SAM  A 221 (-4.0A)
SAM  A 221 (-3.3A)
SAM  A 221 (-4.8A)
SAM  A 221 (-4.3A)
0.02A 3e23A-3e23A:
41.5
3e23A-3e23A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3E23_A_SAMA221_1
(UNCHARACTERIZED
PROTEIN RPA2492)
3e23 UNCHARACTERIZED
PROTEIN RPA2492

(Rhodopseudomonas
palustris)
3 / 3 TYR A  24
ASP A  72
HIS A 109
SAM  A 221 (-4.7A)
SAM  A 221 (-2.8A)
SAM  A 221 ( 3.7A)
0.00A 3e23A-3e23A:
41.5
3e23A-3e23A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GV1_B_BEZB303_0
(DISULFIDE
INTERCHANGE PROTEIN)
3e23 UNCHARACTERIZED
PROTEIN RPA2492

(Rhodopseudomonas
palustris)
4 / 4 LEU A  62
ALA A  70
VAL A  89
PRO A  88
None
0.96A 3gv1B-3e23A:
undetectable
3gv1B-3e23A:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_A_SAMA300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)
3e23 UNCHARACTERIZED
PROTEIN RPA2492

(Rhodopseudomonas
palustris)
5 / 12 LEU A  14
TYR A  17
GLY A  53
GLY A  73
SER A  74
SAM  A 221 (-4.4A)
SAM  A 221 (-3.8A)
SAM  A 221 (-3.2A)
SAM  A 221 (-3.2A)
SAM  A 221 (-4.6A)
0.77A 3ou6A-3e23A:
19.0
3ou6A-3e23A:
27.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_B_SAMB300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)
3e23 UNCHARACTERIZED
PROTEIN RPA2492

(Rhodopseudomonas
palustris)
5 / 12 LEU A  14
TYR A  17
GLY A  53
GLY A  73
SER A  74
SAM  A 221 (-4.4A)
SAM  A 221 (-3.8A)
SAM  A 221 (-3.2A)
SAM  A 221 (-3.2A)
SAM  A 221 (-4.6A)
0.74A 3ou6B-3e23A:
19.0
3ou6B-3e23A:
27.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_C_SAMC300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)
3e23 UNCHARACTERIZED
PROTEIN RPA2492

(Rhodopseudomonas
palustris)
5 / 12 LEU A  14
TYR A  17
GLU A  49
GLY A  73
SER A  74
SAM  A 221 (-4.4A)
SAM  A 221 (-3.8A)
None
SAM  A 221 (-3.2A)
SAM  A 221 (-4.6A)
0.75A 3ou6C-3e23A:
19.1
3ou6C-3e23A:
27.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_C_SAMC300_1
(SAM-DEPENDENT
METHYLTRANSFERASE)
3e23 UNCHARACTERIZED
PROTEIN RPA2492

(Rhodopseudomonas
palustris)
3 / 3 TYR A  24
GLY A  53
ASP A  72
SAM  A 221 (-4.7A)
SAM  A 221 (-3.2A)
SAM  A 221 (-2.8A)
0.31A 3ou6C-3e23A:
18.8
3ou6C-3e23A:
27.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_D_SAMD300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)
3e23 UNCHARACTERIZED
PROTEIN RPA2492

(Rhodopseudomonas
palustris)
5 / 12 LEU A  14
TYR A  17
TYR A  24
GLU A  49
GLY A  73
SAM  A 221 (-4.4A)
SAM  A 221 (-3.8A)
SAM  A 221 (-4.7A)
None
SAM  A 221 (-3.2A)
1.02A 3ou6D-3e23A:
18.9
3ou6D-3e23A:
27.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_D_SAMD300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)
3e23 UNCHARACTERIZED
PROTEIN RPA2492

(Rhodopseudomonas
palustris)
5 / 12 LEU A  14
TYR A  24
GLU A  49
GLY A  73
SER A  74
SAM  A 221 (-4.4A)
SAM  A 221 (-4.7A)
None
SAM  A 221 (-3.2A)
SAM  A 221 (-4.6A)
0.78A 3ou6D-3e23A:
18.9
3ou6D-3e23A:
27.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_A_SAMA300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)
3e23 UNCHARACTERIZED
PROTEIN RPA2492

(Rhodopseudomonas
palustris)
5 / 12 LEU A  14
GLY A  53
TRP A 107
GLY A  73
SER A  74
SAM  A 221 (-4.4A)
SAM  A 221 (-3.2A)
None
SAM  A 221 (-3.2A)
SAM  A 221 (-4.6A)
1.24A 3ou7A-3e23A:
18.6
3ou7A-3e23A:
27.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_A_SAMA300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)
3e23 UNCHARACTERIZED
PROTEIN RPA2492

(Rhodopseudomonas
palustris)
6 / 12 LEU A  14
TYR A  17
TYR A  24
GLY A  53
GLY A  73
SER A  74
SAM  A 221 (-4.4A)
SAM  A 221 (-3.8A)
SAM  A 221 (-4.7A)
SAM  A 221 (-3.2A)
SAM  A 221 (-3.2A)
SAM  A 221 (-4.6A)
0.89A 3ou7A-3e23A:
18.6
3ou7A-3e23A:
27.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_B_SAMB300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)
3e23 UNCHARACTERIZED
PROTEIN RPA2492

(Rhodopseudomonas
palustris)
5 / 12 LEU A  14
TYR A  24
GLY A  53
GLY A  73
SER A  74
SAM  A 221 (-4.4A)
SAM  A 221 (-4.7A)
SAM  A 221 (-3.2A)
SAM  A 221 (-3.2A)
SAM  A 221 (-4.6A)
0.64A 3ou7B-3e23A:
19.1
3ou7B-3e23A:
27.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_B_SAMB300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)
3e23 UNCHARACTERIZED
PROTEIN RPA2492

(Rhodopseudomonas
palustris)
5 / 12 TYR A  24
GLY A  53
GLY A  73
SER A  74
ALA A 110
SAM  A 221 (-4.7A)
SAM  A 221 (-3.2A)
SAM  A 221 (-3.2A)
SAM  A 221 (-4.6A)
SAM  A 221 (-4.3A)
1.06A 3ou7B-3e23A:
19.1
3ou7B-3e23A:
27.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_C_SAMC300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)
3e23 UNCHARACTERIZED
PROTEIN RPA2492

(Rhodopseudomonas
palustris)
5 / 12 LEU A  14
TYR A  17
TYR A  24
GLY A  73
SER A  74
SAM  A 221 (-4.4A)
SAM  A 221 (-3.8A)
SAM  A 221 (-4.7A)
SAM  A 221 (-3.2A)
SAM  A 221 (-4.6A)
0.93A 3ou7C-3e23A:
19.0
3ou7C-3e23A:
27.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_D_SAMD300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)
3e23 UNCHARACTERIZED
PROTEIN RPA2492

(Rhodopseudomonas
palustris)
5 / 12 LEU A  14
GLY A  53
TRP A 107
GLY A  73
SER A  74
SAM  A 221 (-4.4A)
SAM  A 221 (-3.2A)
None
SAM  A 221 (-3.2A)
SAM  A 221 (-4.6A)
1.25A 3ou7D-3e23A:
18.9
3ou7D-3e23A:
27.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_D_SAMD300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)
3e23 UNCHARACTERIZED
PROTEIN RPA2492

(Rhodopseudomonas
palustris)
6 / 12 LEU A  14
TYR A  17
TYR A  24
GLY A  53
GLY A  73
SER A  74
SAM  A 221 (-4.4A)
SAM  A 221 (-3.8A)
SAM  A 221 (-4.7A)
SAM  A 221 (-3.2A)
SAM  A 221 (-3.2A)
SAM  A 221 (-4.6A)
0.89A 3ou7D-3e23A:
18.9
3ou7D-3e23A:
27.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GBO_A_CUA301_0
(E7)
3e23 UNCHARACTERIZED
PROTEIN RPA2492

(Rhodopseudomonas
palustris)
4 / 5 HIS A 196
ALA A 110
HIS A 109
TYR A 138
SO4  A 223 (-4.4A)
SAM  A 221 (-4.3A)
SAM  A 221 ( 3.7A)
None
1.18A 4gboA-3e23A:
undetectable
4gboA-3e23A:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KRH_A_SAMA900_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
2)
3e23 UNCHARACTERIZED
PROTEIN RPA2492

(Rhodopseudomonas
palustris)
6 / 12 TYR A  17
GLY A  51
GLY A  53
SER A  74
CYH A 111
HIS A 114
SAM  A 221 (-3.8A)
SAM  A 221 (-4.0A)
SAM  A 221 (-3.2A)
SAM  A 221 (-4.6A)
SAM  A 221 (-4.8A)
SAM  A 221 (-4.3A)
0.83A 4krhA-3e23A:
19.5
4krhA-3e23A:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KRH_B_SAMB900_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
2)
3e23 UNCHARACTERIZED
PROTEIN RPA2492

(Rhodopseudomonas
palustris)
6 / 12 TYR A  17
GLY A  51
GLY A  53
SER A  74
CYH A 111
HIS A 114
SAM  A 221 (-3.8A)
SAM  A 221 (-4.0A)
SAM  A 221 (-3.2A)
SAM  A 221 (-4.6A)
SAM  A 221 (-4.8A)
SAM  A 221 (-4.3A)
0.79A 4krhB-3e23A:
19.5
4krhB-3e23A:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DPD_A_SAMA601_0
(PROTEIN LYSINE
METHYLTRANSFERASE 1)
3e23 UNCHARACTERIZED
PROTEIN RPA2492

(Rhodopseudomonas
palustris)
5 / 12 GLU A  49
GLY A  51
SER A  74
HIS A 109
VAL A 115
None
SAM  A 221 (-4.0A)
SAM  A 221 (-4.6A)
SAM  A 221 ( 3.7A)
None
1.08A 5dpdA-3e23A:
14.8
5dpdA-3e23A:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GQB_A_GCSA602_1
(CHITINASE)
3e23 UNCHARACTERIZED
PROTEIN RPA2492

(Rhodopseudomonas
palustris)
3 / 3 TRP A 163
GLU A 170
ASP A 118
SO4  A 224 ( 4.3A)
None
None
1.06A 5gqbA-3e23A:
undetectable
5gqbA-3e23A:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HBS_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)
3e23 UNCHARACTERIZED
PROTEIN RPA2492

(Rhodopseudomonas
palustris)
4 / 8 LEU A  41
LEU A 131
TYR A 138
MET A  61
None
1.01A 5hbsA-3e23A:
undetectable
5hbsA-3e23A:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGY_A_ERYA403_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)
3e23 UNCHARACTERIZED
PROTEIN RPA2492

(Rhodopseudomonas
palustris)
4 / 6 TYR A 158
ASP A 188
ARG A 149
TYR A  17
None
None
None
SAM  A 221 (-3.8A)
1.21A 5igyA-3e23A:
undetectable
5igyA-3e23A:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKZ_A_ASCA1004_0
(CYTOCHROME B
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)
3e23 UNCHARACTERIZED
PROTEIN RPA2492

(Rhodopseudomonas
palustris)
4 / 6 HIS A 109
TYR A  17
ARG A 154
HIS A 114
SAM  A 221 ( 3.7A)
SAM  A 221 (-3.8A)
SO4  A 222 (-3.2A)
SAM  A 221 (-4.3A)
1.31A 5kkzA-3e23A:
undetectable
5kkzG-3e23A:
undetectable
5kkzA-3e23A:
19.31
5kkzG-3e23A:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKZ_O_ASCO1004_0
(CYTOCHROME B
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)
3e23 UNCHARACTERIZED
PROTEIN RPA2492

(Rhodopseudomonas
palustris)
4 / 7 HIS A 114
HIS A 109
TYR A  17
ARG A 154
SAM  A 221 (-4.3A)
SAM  A 221 ( 3.7A)
SAM  A 221 (-3.8A)
SO4  A 222 (-3.2A)
1.31A 5kkzM-3e23A:
undetectable
5kkzO-3e23A:
undetectable
5kkzM-3e23A:
22.71
5kkzO-3e23A:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TDM_A_ADNA904_1
(ATP-CITRATE SYNTHASE)
3e23 UNCHARACTERIZED
PROTEIN RPA2492

(Rhodopseudomonas
palustris)
4 / 4 THR A  13
ASP A  11
ARG A  15
LEU A  14
None
None
None
SAM  A 221 (-4.4A)
1.49A 5tdmA-3e23A:
undetectable
5tdmA-3e23A:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UIZ_A_CUA301_0
(AA10A)
3e23 UNCHARACTERIZED
PROTEIN RPA2492

(Rhodopseudomonas
palustris)
4 / 5 HIS A 196
ALA A 110
HIS A 109
TYR A 138
SO4  A 223 (-4.4A)
SAM  A 221 (-4.3A)
SAM  A 221 ( 3.7A)
None
1.17A 5uizA-3e23A:
undetectable
5uizA-3e23A:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6S_B_CXQB705_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)
3e23 UNCHARACTERIZED
PROTEIN RPA2492

(Rhodopseudomonas
palustris)
4 / 6 VAL A 106
LEU A  50
LEU A 112
LEU A 126
None
1.00A 6f6sA-3e23A:
undetectable
6f6sB-3e23A:
undetectable
6f6sA-3e23A:
18.23
6f6sB-3e23A:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_B_LLLB301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)
3e23 UNCHARACTERIZED
PROTEIN RPA2492

(Rhodopseudomonas
palustris)
4 / 7 ASP A 118
ARG A 117
TYR A 155
GLU A 147
None
SO4  A 225 (-3.0A)
None
None
1.34A 6mn5B-3e23A:
undetectable
6mn5B-3e23A:
18.54