SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3e2n'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1AEG_A_4APA296_1
(CYTOCHROME C
PEROXIDASE)		 3e2n CYTOCHROME C
PEROXIDASE
(Pisum
sativum;
Saccharomyces
cerevisiae) 		7 / 8 HIS A 168
GLY A 171
LYS A 172
THR A 173
MET A 223
LEU A 225
ASP A 228
 HEM  A 296 (-3.2A)
HEM  A 296 (-3.2A)
None
HEM  A 296 (-4.3A)
None
HEM  A 296 (-4.8A)
None
 0.96A 1aegA-3e2nA:
47.6		 1aegA-3e2nA:
93.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HTT_A_HISA450_0
(HISTIDYL-TRNA
SYNTHETASE)		 3e2n CYTOCHROME C
PEROXIDASE
(Pisum
sativum;
Saccharomyces
cerevisiae) 		5 / 10 GLU A 284
THR A 281
TYR A  23
GLU A 111
GLY A 114
 None
 1.32A 1httA-3e2nA:
undetectable		 1httA-3e2nA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IE4_B_T44B328_1
(TRANSTHYRETIN)		 3e2n CYTOCHROME C
PEROXIDASE
(Pisum
sativum;
Saccharomyces
cerevisiae) 		5 / 8 GLU A  91
LEU A 103
LYS A  29
GLU A  32
THR A 107
 None
 1.23A 1ie4B-3e2nA:
undetectable
1ie4D-3e2nA:
undetectable		 1ie4B-3e2nA:
18.11
1ie4D-3e2nA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LWC_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 3e2n CYTOCHROME C
PEROXIDASE
(Pisum
sativum;
Saccharomyces
cerevisiae) 		5 / 11 PRO A 138
LEU A 154
GLY A  57
TRP A  44
LEU A 262
 HEM  A 296 (-4.4A)
None
None
HEM  A 296 (-3.5A)
None
 1.50A 1lwcA-3e2nA:
undetectable		 1lwcA-3e2nA:
21.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1OAF_A_ASCA1253_0
(ASCORBATE PEROXIDASE)		 3e2n CYTOCHROME C
PEROXIDASE
(Pisum
sativum;
Saccharomyces
cerevisiae) 		4 / 6 CYH A  35
PRO A  37
HIS A 174
ARG A 177
 None
HEM  A 296 (-4.7A)
HEM  A 296 (-3.7A)
HEM  A 296 (-4.9A)
 0.35A 1oafA-3e2nA:
35.6		 1oafA-3e2nA:
39.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HMA_A_SAMA375_0
(PROBABLE TRNA
(5-METHYLAMINOMETHYL
-2-THIOURIDYLATE)-ME
THYLTRANSFERASE)		 3e2n CYTOCHROME C
PEROXIDASE
(Pisum
sativum;
Saccharomyces
cerevisiae) 		5 / 11 GLY A  57
SER A  59
ASN A  75
THR A  49
GLY A  48
 None
 1.24A 2hmaA-3e2nA:
undetectable		 2hmaA-3e2nA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_B_ASDB1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 3e2n CYTOCHROME C
PEROXIDASE
(Pisum
sativum;
Saccharomyces
cerevisiae) 		5 / 6 PHE A 259
LEU A 170
ALA A 108
LEU A  39
ALA A  43
 None
HEM  A 296 ( 4.8A)
None
None
None
 1.39A 2vcvB-3e2nA:
undetectable		 2vcvB-3e2nA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_K_ASDK1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 3e2n CYTOCHROME C
PEROXIDASE
(Pisum
sativum;
Saccharomyces
cerevisiae) 		5 / 6 PHE A 259
LEU A 170
ALA A 108
LEU A  39
ALA A  43
 None
HEM  A 296 ( 4.8A)
None
None
None
 1.44A 2vcvK-3e2nA:
undetectable		 2vcvK-3e2nA:
22.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2X08_A_ASCA1253_0
(CYTOCHROME C
PEROXIDASE,
MITOCHONDRIAL)		 3e2n CYTOCHROME C
PEROXIDASE
(Pisum
sativum;
Saccharomyces
cerevisiae) 		5 / 9 PRO A  37
VAL A  38
ASN A  80
HIS A 174
ARG A 177
 HEM  A 296 (-4.7A)
HEM  A 296 ( 4.8A)
None
HEM  A 296 (-3.7A)
HEM  A 296 (-4.9A)
 0.21A 2x08A-3e2nA:
49.4		 2x08A-3e2nA:
95.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BRF_A_SORA1_0
(LIN-12 AND GLP-1
PHENOTYPE PROTEIN 1,
ISOFORM A)		 3e2n CYTOCHROME C
PEROXIDASE
(Pisum
sativum;
Saccharomyces
cerevisiae) 		3 / 3 GLY A  62
ASP A 125
SER A  96
 None
 0.71A 3brfA-3e2nA:
undetectable		 3brfA-3e2nA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D2T_A_1FLA502_1
(TRANSTHYRETIN)		 3e2n CYTOCHROME C
PEROXIDASE
(Pisum
sativum;
Saccharomyces
cerevisiae) 		4 / 7 LEU A 103
LEU A 100
SER A  97
VAL A  10
 None
 1.00A 3d2tA-3e2nA:
undetectable		 3d2tA-3e2nA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LOQ_A_ACTA279_0
(UNIVERSAL STRESS
PROTEIN)		 3e2n CYTOCHROME C
PEROXIDASE
(Pisum
sativum;
Saccharomyces
cerevisiae) 		4 / 4 SER A 102
SER A  47
THR A  46
SER A  59
 None
 1.46A 3loqA-3e2nA:
undetectable		 3loqA-3e2nA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K4Y_E_ACTE503_0
(RNA-DEPENDENT RNA
POLYMERASE)		 3e2n CYTOCHROME C
PEROXIDASE
(Pisum
sativum;
Saccharomyces
cerevisiae) 		4 / 4 LYS A 261
LEU A 262
GLU A 160
LEU A 164
 None
None
None
HEM  A 296 (-4.0A)
 1.42A 4k4yE-3e2nA:
undetectable		 4k4yE-3e2nA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBQ_A_DIFA602_1
(SERUM ALBUMIN)		 3e2n CYTOCHROME C
PEROXIDASE
(Pisum
sativum;
Saccharomyces
cerevisiae) 		4 / 8 ASN A  24
ALA A  25
LYS A  29
GLU A  32
 None
 0.81A 4zbqA-3e2nA:
undetectable		 4zbqA-3e2nA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_A_SORA1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 3e2n CYTOCHROME C
PEROXIDASE
(Pisum
sativum;
Saccharomyces
cerevisiae) 		4 / 7 ILE A  26
LEU A  39
GLY A 105
GLY A 104
 None
 0.74A 5a06A-3e2nA:
undetectable		 5a06A-3e2nA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_B_SORB1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 3e2n CYTOCHROME C
PEROXIDASE
(Pisum
sativum;
Saccharomyces
cerevisiae) 		4 / 7 ILE A  26
LEU A  39
GLY A 105
GLY A 104
 None
 0.74A 5a06B-3e2nA:
undetectable		 5a06B-3e2nA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_C_SORC1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 3e2n CYTOCHROME C
PEROXIDASE
(Pisum
sativum;
Saccharomyces
cerevisiae) 		4 / 7 ILE A  26
LEU A  39
GLY A 105
GLY A 104
 None
 0.73A 5a06C-3e2nA:
undetectable		 5a06C-3e2nA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_E_SORE1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 3e2n CYTOCHROME C
PEROXIDASE
(Pisum
sativum;
Saccharomyces
cerevisiae) 		4 / 7 ILE A  26
LEU A  39
GLY A 105
GLY A 104
 None
 0.74A 5a06E-3e2nA:
undetectable		 5a06E-3e2nA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_F_SORF1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 3e2n CYTOCHROME C
PEROXIDASE
(Pisum
sativum;
Saccharomyces
cerevisiae) 		4 / 7 ILE A  26
LEU A  39
GLY A 105
GLY A 104
 None
 0.76A 5a06F-3e2nA:
undetectable		 5a06F-3e2nA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYI_B_NIZB806_1
(CATALASE-PEROXIDASE)		 3e2n CYTOCHROME C
PEROXIDASE
(Pisum
sativum;
Saccharomyces
cerevisiae) 		4 / 5 ARG A  41
TRP A  44
HIS A  45
SER A 178
 HEM  A 296 (-4.2A)
HEM  A 296 (-3.5A)
None
HEM  A 296 (-2.6A)
 0.36A 5syiB-3e2nA:
31.6		 5syiB-3e2nA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYJ_A_NIZA810_1
(CATALASE-PEROXIDASE)		 3e2n CYTOCHROME C
PEROXIDASE
(Pisum
sativum;
Saccharomyces
cerevisiae) 		4 / 6 ARG A  41
TRP A  44
HIS A  45
SER A 178
 HEM  A 296 (-4.2A)
HEM  A 296 (-3.5A)
None
HEM  A 296 (-2.6A)
 0.38A 5syjA-3e2nA:
31.7		 5syjA-3e2nA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYJ_B_NIZB810_1
(CATALASE-PEROXIDASE)		 3e2n CYTOCHROME C
PEROXIDASE
(Pisum
sativum;
Saccharomyces
cerevisiae) 		4 / 6 ARG A  41
TRP A  44
HIS A  45
SER A 178
 HEM  A 296 (-4.2A)
HEM  A 296 (-3.5A)
None
HEM  A 296 (-2.6A)
 0.40A 5syjB-3e2nA:
31.5		 5syjB-3e2nA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CI6_A_NBOA607_1
(SERUM ALBUMIN)		 3e2n CYTOCHROME C
PEROXIDASE
(Pisum
sativum;
Saccharomyces
cerevisiae) 		4 / 7 ASN A  24
ALA A  25
LYS A  29
GLU A  32
 None
 0.87A 6ci6A-3e2nA:
undetectable		 6ci6A-3e2nA:
15.33