SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3e2v'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DLS_A_MTXA188_2
(DIHYDROFOLATE
REDUCTASE)		 3e2v 3'-5'-EXONUCLEASE
(Saccharomyces
cerevisiae) 		4 / 4 TYR A  38
ARG A  74
VAL A 392
THR A 326
 None
 1.35A 1dlsA-3e2vA:
0.0		 1dlsA-3e2vA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBM_B_RTLB951_0
(PROTEIN (CARTILAGE
OLIGOMERIC MATRIX
PROTEIN))		 3e2v 3'-5'-EXONUCLEASE
(Saccharomyces
cerevisiae) 		4 / 4 THR A 408
LEU A 322
LEU A 286
GLN A 287
 None
 1.21A 1fbmA-3e2vA:
undetectable		 1fbmA-3e2vA:
8.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I9G_A_SAMA301_1
(HYPOTHETICAL PROTEIN
RV2118C)		 3e2v 3'-5'-EXONUCLEASE
(Saccharomyces
cerevisiae) 		3 / 3 GLU A 185
HIS A 114
ASP A  47
 MG  A 427 ( 4.5A)
None
None
 0.85A 1i9gA-3e2vA:
undetectable		 1i9gA-3e2vA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_B_VIBB504_1
(YKOF)		 3e2v 3'-5'-EXONUCLEASE
(Saccharomyces
cerevisiae) 		4 / 6 PRO A 318
PHE A 234
LEU A 292
ILE A 296
 None
 1.11A 1sbrA-3e2vA:
undetectable
1sbrB-3e2vA:
undetectable		 1sbrA-3e2vA:
18.59
1sbrB-3e2vA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_D_TFPD207_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 3e2v 3'-5'-EXONUCLEASE
(Saccharomyces
cerevisiae) 		4 / 8 LEU A 225
LEU A 254
PHE A 241
SER A 219
 None
 0.95A 1wrlC-3e2vA:
undetectable
1wrlD-3e2vA:
undetectable		 1wrlC-3e2vA:
14.36
1wrlD-3e2vA:
14.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_B_SAMB530_0
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 3e2v 3'-5'-EXONUCLEASE
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 333
ALA A 328
GLY A 302
ASN A 385
PRO A 383
 None
None
None
GOL  A 426 (-3.4A)
None
 1.09A 2y7hB-3e2vA:
undetectable		 2y7hB-3e2vA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_B_ROCB201_4
(HIV-1 PROTEASE)		 3e2v 3'-5'-EXONUCLEASE
(Saccharomyces
cerevisiae) 		4 / 4 ARG A 181
ASP A 327
GLY A 299
THR A 412
 None
MG  A 427 (-2.5A)
None
None
 1.04A 3k4vB-3e2vA:
undetectable		 3k4vB-3e2vA:
12.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_E_ACTE503_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 3e2v 3'-5'-EXONUCLEASE
(Saccharomyces
cerevisiae) 		3 / 3 GLN A 388
THR A 326
ASN A 385
 GOL  A 426 ( 4.9A)
None
GOL  A 426 (-3.4A)
 0.66A 3v4tE-3e2vA:
undetectable		 3v4tE-3e2vA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DX7_A_DM2A1106_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 3e2v 3'-5'-EXONUCLEASE
(Saccharomyces
cerevisiae) 		5 / 11 MET A 227
PHE A 234
PHE A 279
LEU A 274
GLN A 287
 None
 1.50A 4dx7A-3e2vA:
0.0		 4dx7A-3e2vA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FVQ_A_ACTA904_0
(TYROSINE-PROTEIN
KINASE JAK2)		 3e2v 3'-5'-EXONUCLEASE
(Saccharomyces
cerevisiae) 		3 / 3 PHE A 279
VAL A 313
GLU A 309
 None
 0.79A 4fvqA-3e2vA:
0.0		 4fvqA-3e2vA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IJI_H_BEZH501_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN YIBF)		 3e2v 3'-5'-EXONUCLEASE
(Saccharomyces
cerevisiae) 		4 / 7 ALA A 338
SER A 339
VAL A 396
TYR A 342
 None
 1.13A 4ijiH-3e2vA:
undetectable		 4ijiH-3e2vA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O7G_A_ASCA303_0
(PROBABLE
TRANSMEMBRANE
ASCORBATE
FERRIREDUCTASE 2)		 3e2v 3'-5'-EXONUCLEASE
(Saccharomyces
cerevisiae) 		4 / 7 PHE A 180
ILE A 183
ASN A 215
ARG A 272
 None
 1.05A 4o7gA-3e2vA:
undetectable
4o7gB-3e2vA:
undetectable		 4o7gA-3e2vA:
20.26
4o7gB-3e2vA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QD3_A_5AEA201_1
(PEPTIDYL-TRNA
HYDROLASE)		 3e2v 3'-5'-EXONUCLEASE
(Saccharomyces
cerevisiae) 		5 / 9 LEU A 322
GLY A 299
ASN A 301
VAL A 314
VAL A 393
 None
 1.19A 4qd3A-3e2vA:
undetectable		 4qd3A-3e2vA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UIL_H_QI9H1223_0
(FAB 314.1)		 3e2v 3'-5'-EXONUCLEASE
(Saccharomyces
cerevisiae) 		5 / 12 GLU A 120
PHE A 121
GLN A 208
GLY A 112
LEU A 168
 None
 1.08A 4uilH-3e2vA:
undetectable
4uilL-3e2vA:
undetectable		 4uilH-3e2vA:
20.36
4uilL-3e2vA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WCX_C_SAMC503_0
(BIOTIN AND THIAMIN
SYNTHESIS ASSOCIATED)		 3e2v 3'-5'-EXONUCLEASE
(Saccharomyces
cerevisiae) 		5 / 12 GLU A 387
GLU A 332
PHE A 357
LEU A  68
ALA A  79
 None
GOL  A 426 (-2.9A)
None
None
None
 0.97A 4wcxC-3e2vA:
8.2		 4wcxC-3e2vA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDT_A_ACTA407_0
(FAD:PROTEIN FMN
TRANSFERASE)		 3e2v 3'-5'-EXONUCLEASE
(Saccharomyces
cerevisiae) 		3 / 3 ASP A 327
GLY A  42
ASP A  40
 MG  A 427 (-2.5A)
None
None
 0.69A 4xdtA-3e2vA:
undetectable		 4xdtA-3e2vA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZXI_A_GLYA1402_0
(TYROCIDINE
SYNTHETASE 3)		 3e2v 3'-5'-EXONUCLEASE
(Saccharomyces
cerevisiae) 		4 / 7 ASP A  40
ILE A  41
GLY A 299
THR A 326
 None
 1.12A 4zxiA-3e2vA:
undetectable		 4zxiA-3e2vA:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZB_D_ACTD403_0
(PROTON-GATED ION
CHANNEL)		 3e2v 3'-5'-EXONUCLEASE
(Saccharomyces
cerevisiae) 		4 / 4 ILE A 405
ARG A  74
TYR A  38
GLU A 387
 None
 1.49A 4zzbD-3e2vA:
undetectable		 4zzbD-3e2vA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EB5_A_010A609_0
(HNL ISOENZYME 5)		 3e2v 3'-5'-EXONUCLEASE
(Saccharomyces
cerevisiae) 		5 / 11 ALA A  79
VAL A  96
LEU A  45
LEU A  67
VAL A  99
 None
 1.30A 5eb5A-3e2vA:
undetectable		 5eb5A-3e2vA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_A_HISA402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 3e2v 3'-5'-EXONUCLEASE
(Saccharomyces
cerevisiae) 		5 / 10 GLY A  42
LEU A  43
VAL A  96
ALA A  92
LEU A 107
 None
 0.92A 6czmA-3e2vA:
undetectable
6czmC-3e2vA:
undetectable		 6czmA-3e2vA:
21.75
6czmC-3e2vA:
21.75