SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3e3m'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BSX_A_T3A1_1
(PROTEIN (THYROID
HORMONE RECEPTOR
BETA))		 3e3m TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY
(Ruegeria
pomeroyi) 		5 / 12 ALA A 146
LEU A 121
LEU A 130
ILE A 150
HIS A 135
 None
 1.13A 1bsxA-3e3mA:
undetectable		 1bsxA-3e3mA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BSX_B_T3B2_1
(PROTEIN (THYROID
HORMONE RECEPTOR
BETA))		 3e3m TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY
(Ruegeria
pomeroyi) 		5 / 12 ALA A 146
LEU A 121
LEU A 130
ILE A 150
HIS A 135
 None
 1.13A 1bsxB-3e3mA:
undetectable		 1bsxB-3e3mA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_A_RBFA501_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 3e3m TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY
(Ruegeria
pomeroyi) 		5 / 12 GLY A 307
LEU A 333
ILE A 331
ILE A 314
LEU A 313
 None
 0.91A 1kyvA-3e3mA:
7.3
1kyvE-3e3mA:
4.7		 1kyvA-3e3mA:
17.93
1kyvE-3e3mA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_C_RBFC503_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 3e3m TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY
(Ruegeria
pomeroyi) 		5 / 12 ILE A 314
LEU A 313
GLY A 307
LEU A 333
ILE A 331
 None
 0.89A 1kyvB-3e3mA:
7.3
1kyvC-3e3mA:
7.3		 1kyvB-3e3mA:
17.93
1kyvC-3e3mA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_D_RBFD504_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 3e3m TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY
(Ruegeria
pomeroyi) 		5 / 12 ILE A 314
LEU A 313
GLY A 307
LEU A 333
ILE A 331
 None
 0.89A 1kyvC-3e3mA:
7.3
1kyvD-3e3mA:
7.3		 1kyvC-3e3mA:
17.93
1kyvD-3e3mA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_E_RBFE505_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 3e3m TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY
(Ruegeria
pomeroyi) 		5 / 12 ILE A 314
LEU A 313
GLY A 307
LEU A 333
ILE A 331
 None
 0.90A 1kyvD-3e3mA:
7.3
1kyvE-3e3mA:
4.7		 1kyvD-3e3mA:
17.93
1kyvE-3e3mA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_B_SAMB300_1
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 3e3m TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY
(Ruegeria
pomeroyi) 		4 / 5 SER A  89
GLY A 307
ASP A 257
ASP A 302
 None
 0.84A 2oxtB-3e3mA:
2.2		 2oxtB-3e3mA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YS6_A_GLYA431_0
(PHOSPHORIBOSYLGLYCIN
AMIDE SYNTHETASE)		 3e3m TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY
(Ruegeria
pomeroyi) 		4 / 8 ASP A 133
ASN A 169
ARG A 204
GLY A 201
 None
 1.04A 2ys6A-3e3mA:
3.4		 2ys6A-3e3mA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_D_ADND500_2
(ADENOSYLHOMOCYSTEINA
SE)		 3e3m TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY
(Ruegeria
pomeroyi) 		4 / 5 LEU A 101
GLN A  88
THR A  91
LEU A  78
 None
 1.09A 3ce6D-3e3mA:
2.2		 3ce6D-3e3mA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9V_B_DXCB1_0
(INVASIN IPAD)		 3e3m TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY
(Ruegeria
pomeroyi) 		4 / 7 ILE A 188
LEU A 180
LEU A 337
SER A 168
 None
 0.97A 3r9vA-3e3mA:
undetectable
3r9vB-3e3mA:
undetectable		 3r9vA-3e3mA:
22.06
3r9vB-3e3mA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S8P_B_SAMB500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 3e3m TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY
(Ruegeria
pomeroyi) 		5 / 12 GLY A 226
ALA A 227
SER A 256
PHE A 190
GLU A 222
 None
 1.26A 3s8pB-3e3mA:
undetectable		 3s8pB-3e3mA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BUP_B_SAMB500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 3e3m TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY
(Ruegeria
pomeroyi) 		5 / 12 GLY A 226
ALA A 227
SER A 256
PHE A 190
GLU A 222
 None
 1.25A 4bupB-3e3mA:
undetectable		 4bupB-3e3mA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_A_TCWA1126_1
(TRANSTHYRETIN)		 3e3m TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY
(Ruegeria
pomeroyi) 		4 / 6 LEU A 318
LEU A 315
SER A 312
THR A 310
 None
 1.13A 4d7bB-3e3mA:
undetectable		 4d7bB-3e3mA:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQ4_B_SALB601_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 3e3m TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY
(Ruegeria
pomeroyi) 		4 / 8 THR A  86
ILE A 153
VAL A 151
GLY A 311
 None
 0.73A 4eq4B-3e3mA:
2.9		 4eq4B-3e3mA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I13_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 3e3m TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY
(Ruegeria
pomeroyi) 		3 / 3 ASP A 257
ARG A 200
THR A 298
 None
 0.89A 4i13A-3e3mA:
2.4		 4i13A-3e3mA:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K13_A_ETSA304_1
(CARBONIC ANHYDRASE 2)		 3e3m TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY
(Ruegeria
pomeroyi) 		5 / 12 VAL A 278
LEU A 243
LEU A 267
VAL A 274
LEU A 263
 None
 0.99A 4k13A-3e3mA:
undetectable		 4k13A-3e3mA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKT_A_198A1001_1
(ANDROGEN RECEPTOR)		 3e3m TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY
(Ruegeria
pomeroyi) 		5 / 12 LEU A  75
LEU A  74
VAL A  71
THR A  86
ILE A 306
 None
 1.28A 4oktA-3e3mA:
undetectable		 4oktA-3e3mA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P3R_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 3e3m TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY
(Ruegeria
pomeroyi) 		3 / 3 ASP A 257
ARG A 200
THR A 298
 None
 0.88A 4p3rA-3e3mA:
2.1		 4p3rA-3e3mA:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCK_A_SAMA2409_1
(RNA-DIRECTED RNA
POLYMERASE L)		 3e3m TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY
(Ruegeria
pomeroyi) 		3 / 3 SER A  89
ASP A 257
ASP A 302
 None
 0.72A 4uckA-3e3mA:
undetectable		 4uckA-3e3mA:
23.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CPR_B_SAMB402_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 3e3m TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY
(Ruegeria
pomeroyi) 		5 / 12 GLY A 226
ALA A 227
SER A 256
PHE A 190
GLU A 222
 None
 1.27A 5cprB-3e3mA:
undetectable		 5cprB-3e3mA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_B_6J3B201_0
(TRANSTHYRETIN)		 3e3m TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY
(Ruegeria
pomeroyi) 		4 / 6 LEU A 318
LEU A 315
SER A 312
THR A 310
 None
 1.15A 5l4iB-3e3mA:
undetectable		 5l4iB-3e3mA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WBV_A_SAMA402_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
KMT5B)		 3e3m TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY
(Ruegeria
pomeroyi) 		5 / 12 GLY A 226
ALA A 227
SER A 256
PHE A 190
GLU A 222
 None
 1.26A 5wbvA-3e3mA:
undetectable		 5wbvA-3e3mA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9Y_A_ACTA412_0
(UNCHARACTERIZED
PROTEIN KDOO)		 3e3m TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY
(Ruegeria
pomeroyi) 		3 / 3 ARG A 204
PHE A  83
ARG A 200
 None
 1.23A 5y9yA-3e3mA:
undetectable		 5y9yA-3e3mA:
24.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_A_GMJA301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 3e3m TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY
(Ruegeria
pomeroyi) 		5 / 12 TYR A 108
PHE A 167
VAL A 301
LEU A  78
TYR A 105
 None
 1.23A 6djzA-3e3mA:
undetectable		 6djzA-3e3mA:
21.04