SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3e3p'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_1
(CES1 PROTEIN)		 3e3p PROTEIN KINASE,
PUTATIVE GLYCOGEN
SYNTHASE KINASE
(Leishmania
major) 		5 / 12 GLY A 164
LEU A 125
LEU A 323
LEU A 133
LEU A 316
 None
 0.76A 1ya4B-3e3pA:
undetectable		 1ya4B-3e3pA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_1
(CES1 PROTEIN)		 3e3p PROTEIN KINASE,
PUTATIVE GLYCOGEN
SYNTHASE KINASE
(Leishmania
major) 		5 / 12 GLY A 164
LEU A 125
LEU A 323
LEU A 133
LEU A 316
 None
 0.82A 1ya4C-3e3pA:
undetectable		 1ya4C-3e3pA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_B_CCSB417_0
(ESTROGEN RECEPTOR)		 3e3p PROTEIN KINASE,
PUTATIVE GLYCOGEN
SYNTHASE KINASE
(Leishmania
major) 		3 / 3 GLN A 132
LYS A 167
VAL A 157
 None
 0.59A 2jfaB-3e3pA:
undetectable		 2jfaB-3e3pA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KQD_A_ADNA1002_1
(APRATAXIN AND
PNK-LIKE FACTOR)		 3e3p PROTEIN KINASE,
PUTATIVE GLYCOGEN
SYNTHASE KINASE
(Leishmania
major) 		4 / 4 TYR A 114
ASN A 113
CYH A 111
TYR A 115
 None
 1.29A 2kqdA-3e3pA:
0.0		 2kqdA-3e3pA:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YZQ_A_SAMA6075_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN PH1780)		 3e3p PROTEIN KINASE,
PUTATIVE GLYCOGEN
SYNTHASE KINASE
(Leishmania
major) 		5 / 12 ARG A  12
VAL A  98
ILE A  48
GLU A  39
GLN A  80
 None
 1.31A 2yzqA-3e3pA:
undetectable		 2yzqA-3e3pA:
24.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA513_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 3e3p PROTEIN KINASE,
PUTATIVE GLYCOGEN
SYNTHASE KINASE
(Leishmania
major) 		5 / 12 TRP A 271
LEU A 243
LEU A 293
GLY A 214
PHE A 217
 None
 1.10A 3k2hA-3e3pA:
undetectable		 3k2hA-3e3pA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB513_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 3e3p PROTEIN KINASE,
PUTATIVE GLYCOGEN
SYNTHASE KINASE
(Leishmania
major) 		5 / 12 TRP A 271
LEU A 243
LEU A 293
GLY A 214
PHE A 217
 None
 1.12A 3k2hB-3e3pA:
undetectable		 3k2hB-3e3pA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_A_VIVA301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 3e3p PROTEIN KINASE,
PUTATIVE GLYCOGEN
SYNTHASE KINASE
(Leishmania
major) 		5 / 12 VAL A 128
LEU A 133
SER A 136
VAL A 157
VAL A  77
 None
 1.10A 3w68A-3e3pA:
undetectable		 3w68A-3e3pA:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 3e3p PROTEIN KINASE,
PUTATIVE GLYCOGEN
SYNTHASE KINASE
(Leishmania
major) 		4 / 5 LYS A  49
ILE A  64
VAL A  77
LEU A 158
 None
 0.79A 3wzdA-3e3pA:
19.4		 3wzdA-3e3pA:
25.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZE_A_BAXA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 3e3p PROTEIN KINASE,
PUTATIVE GLYCOGEN
SYNTHASE KINASE
(Leishmania
major) 		4 / 8 VAL A  77
LEU A 158
CYH A 169
ASP A 170
 None
 0.70A 3wzeA-3e3pA:
19.1		 3wzeA-3e3pA:
25.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_B_0LIB1000_2
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 3e3p PROTEIN KINASE,
PUTATIVE GLYCOGEN
SYNTHASE KINASE
(Leishmania
major) 		5 / 9 LEU A  36
ILE A  64
MET A  65
LEU A  68
ILE A  76
 None
 1.17A 3zosB-3e3pA:
18.4		 3zosB-3e3pA:
24.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BKJ_A_STIA1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 3e3p PROTEIN KINASE,
PUTATIVE GLYCOGEN
SYNTHASE KINASE
(Leishmania
major) 		6 / 12 VAL A  34
ALA A  47
GLU A  61
ILE A  64
MET A  65
LEU A 158
 None
 0.59A 4bkjA-3e3pA:
19.0		 4bkjA-3e3pA:
24.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CSV_A_STIA1265_1
(SRC-ABL TYROSINE
KINASE ANCESTOR)		 3e3p PROTEIN KINASE,
PUTATIVE GLYCOGEN
SYNTHASE KINASE
(Leishmania
major) 		7 / 12 VAL A  34
ALA A  47
GLU A  61
ILE A  64
MET A  65
VAL A  77
LEU A 158
 None
 0.86A 4csvA-3e3pA:
19.9		 4csvA-3e3pA:
26.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_C_FOLC703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3e3p PROTEIN KINASE,
PUTATIVE GLYCOGEN
SYNTHASE KINASE
(Leishmania
major) 		5 / 11 VAL A 147
SER A 136
PHE A 336
VAL A 145
THR A 206
 None
 1.42A 4eilC-3e3pA:
undetectable		 4eilC-3e3pA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_E_FOLE703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3e3p PROTEIN KINASE,
PUTATIVE GLYCOGEN
SYNTHASE KINASE
(Leishmania
major) 		5 / 11 VAL A 147
SER A 136
PHE A 336
VAL A 145
THR A 206
 None
 1.45A 4eilE-3e3pA:
undetectable		 4eilE-3e3pA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM4_B_8PRB603_1
(TRANSPORTER)		 3e3p PROTEIN KINASE,
PUTATIVE GLYCOGEN
SYNTHASE KINASE
(Leishmania
major) 		5 / 12 VAL A  99
ALA A  47
VAL A  34
PHE A  20
GLY A  37
 None
 1.29A 4mm4B-3e3pA:
undetectable		 4mm4B-3e3pA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U0I_A_0LIA1001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR
KIT,MAST/STEM CELL
GROWTH FACTOR
RECEPTOR KIT)		 3e3p PROTEIN KINASE,
PUTATIVE GLYCOGEN
SYNTHASE KINASE
(Leishmania
major) 		6 / 10 VAL A  34
GLU A  61
LEU A  68
ILE A  76
VAL A  77
VAL A  98
 None
 0.78A 4u0iA-3e3pA:
19.1		 4u0iA-3e3pA:
27.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E72_A_SAMA400_0
(N2,
N2-DIMETHYLGUANOSINE
TRNA
METHYLTRANSFERASE)		 3e3p PROTEIN KINASE,
PUTATIVE GLYCOGEN
SYNTHASE KINASE
(Leishmania
major) 		5 / 12 ILE A 134
PHE A 129
GLY A 214
ILE A 216
ILE A 124
 None
 1.03A 5e72A-3e3pA:
undetectable		 5e72A-3e3pA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JW1_A_CELA602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3e3p PROTEIN KINASE,
PUTATIVE GLYCOGEN
SYNTHASE KINASE
(Leishmania
major) 		4 / 6 LEU A 243
ARG A 241
ILE A 239
PHE A 227
 None
 0.89A 5jw1A-3e3pA:
undetectable		 5jw1A-3e3pA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3e3p PROTEIN KINASE,
PUTATIVE GLYCOGEN
SYNTHASE KINASE
(Leishmania
major) 		4 / 4 LEU A 243
ARG A 241
ILE A 239
PHE A 227
 None
 0.88A 5kirB-3e3pA:
undetectable		 5kirB-3e3pA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U4S_A_BEZA301_0
(PUTATIVE SHORT CHAIN
DEHYDROGENASE)		 3e3p PROTEIN KINASE,
PUTATIVE GLYCOGEN
SYNTHASE KINASE
(Leishmania
major) 		4 / 7 SER A 136
ILE A 137
LEU A 133
LEU A 166
 None
 0.93A 5u4sA-3e3pA:
undetectable		 5u4sA-3e3pA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VC3_A_DB8A601_2
(WEE1-LIKE PROTEIN
KINASE)		 3e3p PROTEIN KINASE,
PUTATIVE GLYCOGEN
SYNTHASE KINASE
(Leishmania
major) 		4 / 4 VAL A  34
LYS A  49
VAL A  77
ASN A 156
 None
 0.89A 5vc3A-3e3pA:
16.7		 5vc3A-3e3pA:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_A_8LXA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3e3p PROTEIN KINASE,
PUTATIVE GLYCOGEN
SYNTHASE KINASE
(Leishmania
major) 		5 / 12 PHE A 131
LEU A 293
ILE A 216
MET A 220
LEU A 352
 None
 1.18A 5y2tA-3e3pA:
undetectable		 5y2tA-3e3pA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_B_STIB601_0
(TYROSINE-PROTEIN
KINASE ABL1)		 3e3p PROTEIN KINASE,
PUTATIVE GLYCOGEN
SYNTHASE KINASE
(Leishmania
major) 		7 / 12 LEU A  36
VAL A  34
ALA A  47
LYS A  49
GLU A  61
VAL A  77
LEU A 158
 None
 1.27A 6hd6B-3e3pA:
19.2		 6hd6B-3e3pA:
10.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_A_FFOA403_0
(THYMIDYLATE SYNTHASE)		 3e3p PROTEIN KINASE,
PUTATIVE GLYCOGEN
SYNTHASE KINASE
(Leishmania
major) 		5 / 12 TRP A 271
LEU A 243
LEU A 293
GLY A 214
PHE A 217
 None
 1.12A 6r2eA-3e3pA:
undetectable		 6r2eA-3e3pA:
20.62