SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3e3q'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2G72_A_SAMA2001_0 (PHENYLETHANOLAMINE N-METHYLTRANSFERASE)	3e3q	T-CELL RECEPTOR ALPHA CHAIN V REGION PHDS58 (Mus musculus)	5 / 12	TYR D 88 LEU D 75 VAL D 12 VAL D 112 TYR D 38	None	1.45A	2g72A-3e3qD: undetectable	2g72A-3e3qD: 19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2W98_B_P1ZB1358_1 (PROSTAGLANDIN REDUCTASE 2)	3e3q	T-CELL RECEPTOR ALPHA CHAIN V REGION PHDS58 (Mus musculus)	4 / 6	ASP D 53 TYR D 50 PHE D 66 LEU D 32	None	1.16A	2w98A-3e3qD: undetectable 2w98B-3e3qD: undetectable	2w98A-3e3qD: 15.13 2w98B-3e3qD: 15.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5LAK_I_BEZI1_0 (3CL PROTEASE BEZ-TYR-TYR-ASN-ECC PEPTIDE INHIBITOR)	3e3q	T-CELL RECEPTOR ALPHA CHAIN V REGION PHDS58 (Mus musculus)	3 / 3	SER D 51 TYR D 50 TYR D 49	None	0.71A	5lakA-3e3qD: undetectable 5lakI-3e3qD: undetectable	5lakA-3e3qD: 14.47 5lakI-3e3qD: 8.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5LAK_J_BEZJ1_0 (3CL PROTEASE BEZ-TYR-TYR-ASN-ECC PEPTIDE INHIBITOR)	3e3q	T-CELL RECEPTOR ALPHA CHAIN V REGION PHDS58 (Mus musculus)	3 / 3	SER D 51 TYR D 50 TYR D 49	None	0.55A	5lakC-3e3qD: undetectable 5lakJ-3e3qD: undetectable	5lakC-3e3qD: 14.47 5lakJ-3e3qD: 8.33

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["2G72_A_SAMA2001_0","PHENYLETHANOLAMINE N-METHYLTRANSFERASE","3e3q","T-CELL RECEPTOR ALPHA CHAIN V REGION PHDS58","Mus musculus",5,"TYR D  88;LEU D  75;VAL D  12;VAL D 112;TYR D  38","None","1.45A","2g72A-3e3qD:undetectable","2g72A-3e3qD:19.53"],["2W98_B_P1ZB1358_1","PROSTAGLANDIN REDUCTASE 2;PROSTAGLANDIN REDUCTASE 2","3e3q","T-CELL RECEPTOR ALPHA CHAIN V REGION PHDS58","Mus musculus",4,"ASP D  53;TYR D  50;PHE D  66;LEU D  32","None","1.16A","2w98A-3e3qD:undetectable;2w98B-3e3qD:undetectable","2w98A-3e3qD:15.13;2w98B-3e3qD:15.13"],["5LAK_I_BEZI1_0","3CL PROTEASE;BEZ-TYR-TYR-ASN-ECC PEPTIDE INHIBITOR","3e3q","T-CELL RECEPTOR ALPHA CHAIN V REGION PHDS58","Mus musculus",3,"SER D  51;TYR D  50;TYR D  49","None","0.71A","5lakA-3e3qD:undetectable;5lakI-3e3qD:undetectable","5lakA-3e3qD:14.47;5lakI-3e3qD:8.33"],["5LAK_J_BEZJ1_0","3CL PROTEASE;BEZ-TYR-TYR-ASN-ECC PEPTIDE INHIBITOR","3e3q","T-CELL RECEPTOR ALPHA CHAIN V REGION PHDS58","Mus musculus",3,"SER D  51;TYR D  50;TYR D  49","None","0.55A","5lakC-3e3qD:undetectable;5lakJ-3e3qD:undetectable","5lakC-3e3qD:14.47;5lakJ-3e3qD:8.33"]]