SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3e3x'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JB0_B_PQNB2002_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 3e3x BIPA
(Vibrio
parahaemolyticus) 		5 / 11 MET A  33
PHE A  35
SER A 107
ILE A 309
LEU A 104
 None
None
MLY  A 314 ( 4.8A)
None
None
 1.12A 1jb0B-3e3xA:
undetectable		 1jb0B-3e3xA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXG_A_ACRA442_1
(ALPHA AMYLASE)		 3e3x BIPA
(Vibrio
parahaemolyticus) 		5 / 11 GLY A 148
PHE A 124
GLY A 171
GLY A 202
GLY A 201
 MLY  A 147 ( 2.4A)
MLY  A 200 ( 4.7A)
None
MLY  A 147 ( 3.8A)
MLY  A 200 ( 2.4A)
 1.08A 1mxgA-3e3xA:
undetectable		 1mxgA-3e3xA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_A_8MOA501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		 3e3x BIPA
(Vibrio
parahaemolyticus) 		5 / 11 PHE A 179
PHE A 175
ASN A 142
ILE A 139
GLY A 138
 None
 1.04A 1z11A-3e3xA:
undetectable		 1z11A-3e3xA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_B_8MOB501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		 3e3x BIPA
(Vibrio
parahaemolyticus) 		5 / 11 PHE A 179
PHE A 175
ASN A 142
ILE A 139
GLY A 138
 None
 0.94A 1z11B-3e3xA:
undetectable		 1z11B-3e3xA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_C_8MOC501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		 3e3x BIPA
(Vibrio
parahaemolyticus) 		5 / 10 PHE A 179
PHE A 175
ASN A 142
ILE A 139
GLY A 138
 None
 1.00A 1z11C-3e3xA:
undetectable		 1z11C-3e3xA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_D_8MOD501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		 3e3x BIPA
(Vibrio
parahaemolyticus) 		5 / 10 PHE A 179
PHE A 175
ASN A 142
ILE A 139
GLY A 138
 None
 1.03A 1z11D-3e3xA:
undetectable		 1z11D-3e3xA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXF_A_DZPA2001_1
(SERUM ALBUMIN)		 3e3x BIPA
(Vibrio
parahaemolyticus) 		5 / 12 ILE A  55
LEU A  63
LEU A  69
VAL A  82
LEU A  93
 None
 1.25A 2bxfA-3e3xA:
undetectable		 2bxfA-3e3xA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q7K_A_TESA304_1
(ANDROGEN RECEPTOR)		 3e3x BIPA
(Vibrio
parahaemolyticus) 		5 / 12 LEU A  59
VAL A 106
MET A  33
MET A  97
LEU A 104
 None
 1.26A 2q7kA-3e3xA:
undetectable		 2q7kA-3e3xA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD2_A_CHDA2_0
(FERROCHELATASE)		 3e3x BIPA
(Vibrio
parahaemolyticus) 		4 / 8 LEU A  90
ARG A  70
PRO A 123
SER A 169
 None
None
None
EDO  A1001 ( 4.5A)
 1.02A 2qd2A-3e3xA:
undetectable		 2qd2A-3e3xA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A3Y_A_OBNA6000_1
(NA, K-ATPASE ALPHA
SUBUNIT)		 3e3x BIPA
(Vibrio
parahaemolyticus) 		5 / 10 GLU A 241
PHE A  42
VAL A 302
ALA A 105
LEU A 316
 None
MLZ  A  45 ( 4.4A)
None
None
None
 1.32A 3a3yA-3e3xA:
undetectable		 3a3yA-3e3xA:
16.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCN_A_CHDA3_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3e3x BIPA
(Vibrio
parahaemolyticus) 		4 / 7 LEU A  90
ARG A  70
PRO A 123
SER A 169
 None
None
None
EDO  A1001 ( 4.5A)
 0.97A 3hcnA-3e3xA:
undetectable		 3hcnA-3e3xA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCR_A_CHDA424_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3e3x BIPA
(Vibrio
parahaemolyticus) 		4 / 8 LEU A  90
ARG A  70
PRO A 123
SER A 169
 None
None
None
EDO  A1001 ( 4.5A)
 0.95A 3hcrA-3e3xA:
undetectable		 3hcrA-3e3xA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCR_B_CHDB924_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3e3x BIPA
(Vibrio
parahaemolyticus) 		4 / 7 LEU A  90
ARG A  70
PRO A 123
SER A 169
 None
None
None
EDO  A1001 ( 4.5A)
 1.00A 3hcrB-3e3xA:
undetectable		 3hcrB-3e3xA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PCQ_B_PQNB842_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 3e3x BIPA
(Vibrio
parahaemolyticus) 		5 / 11 MET A  33
PHE A  35
SER A 107
ILE A 309
LEU A 104
 None
None
MLY  A 314 ( 4.8A)
None
None
 1.12A 3pcqB-3e3xA:
undetectable		 3pcqB-3e3xA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9V_B_DXCB1_0
(INVASIN IPAD)		 3e3x BIPA
(Vibrio
parahaemolyticus) 		4 / 7 ILE A  55
LEU A 104
SER A 107
VAL A  31
 None
None
MLY  A 314 ( 4.8A)
None
 0.90A 3r9vA-3e3xA:
undetectable
3r9vB-3e3xA:
undetectable		 3r9vA-3e3xA:
25.14
3r9vB-3e3xA:
25.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_A_9PLA501_1
(CYTOCHROME P450 2A6)		 3e3x BIPA
(Vibrio
parahaemolyticus) 		5 / 11 PHE A 179
PHE A 175
ASN A 142
ILE A 139
GLY A 138
 None
 0.88A 3t3rA-3e3xA:
undetectable		 3t3rA-3e3xA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_B_9PLB501_1
(CYTOCHROME P450 2A6)		 3e3x BIPA
(Vibrio
parahaemolyticus) 		5 / 9 PHE A 179
PHE A 175
ASN A 142
ILE A 139
GLY A 138
 None
 0.87A 3t3rB-3e3xA:
undetectable		 3t3rB-3e3xA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_C_9PLC501_1
(CYTOCHROME P450 2A6)		 3e3x BIPA
(Vibrio
parahaemolyticus) 		5 / 9 PHE A 179
PHE A 175
ASN A 142
ILE A 139
GLY A 138
 None
 0.93A 3t3rC-3e3xA:
undetectable		 3t3rC-3e3xA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_D_9PLD501_1
(CYTOCHROME P450 2A6)		 3e3x BIPA
(Vibrio
parahaemolyticus) 		5 / 10 PHE A 179
PHE A 175
ASN A 142
ILE A 139
GLY A 138
 None
 0.93A 3t3rD-3e3xA:
undetectable		 3t3rD-3e3xA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLR_A_CHDA504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3e3x BIPA
(Vibrio
parahaemolyticus) 		4 / 7 LEU A  90
ARG A  70
PRO A 123
SER A 169
 None
None
None
EDO  A1001 ( 4.5A)
 0.96A 4klrA-3e3xA:
undetectable		 4klrA-3e3xA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLR_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3e3x BIPA
(Vibrio
parahaemolyticus) 		4 / 8 LEU A  90
ARG A  70
PRO A 123
SER A 169
 None
None
None
EDO  A1001 ( 4.5A)
 1.01A 4klrB-3e3xA:
undetectable		 4klrB-3e3xA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5O_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 3e3x BIPA
(Vibrio
parahaemolyticus) 		4 / 7 ARG A 146
ILE A 143
PRO A 168
ILE A 204
 None
None
MLY  A 147 ( 4.7A)
MLY  A 147 ( 4.5A)
 1.07A 4w5oA-3e3xA:
undetectable		 4w5oA-3e3xA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y1D_D_DVAD5_0
(CYCLIC HEXAPEPTIDE
CYC[NDPOPPKID]
INTEGRASE)		 3e3x BIPA
(Vibrio
parahaemolyticus) 		3 / 3 GLU A 103
LYS A  49
ASN A  38
 MLZ  A  45 ( 3.8A)
MLY  A  48 ( 3.3A)
None
 0.92A 4y1dA-3e3xA:
undetectable
4y1dD-3e3xA:
undetectable		 4y1dA-3e3xA:
20.67
4y1dD-3e3xA:
1.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4E_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 3e3x BIPA
(Vibrio
parahaemolyticus) 		4 / 7 ARG A 146
ILE A 143
PRO A 168
ILE A 204
 None
None
MLY  A 147 ( 4.7A)
MLY  A 147 ( 4.5A)
 1.04A 4z4eA-3e3xA:
undetectable		 4z4eA-3e3xA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4G_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 3e3x BIPA
(Vibrio
parahaemolyticus) 		4 / 7 ARG A 146
ILE A 143
PRO A 168
ILE A 204
 None
None
MLY  A 147 ( 4.7A)
MLY  A 147 ( 4.5A)
 1.07A 4z4gA-3e3xA:
undetectable		 4z4gA-3e3xA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_2_BEZ2801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 3e3x BIPA
(Vibrio
parahaemolyticus) 		4 / 4 LEU A 212
ARG A 233
ILE A 250
ILE A 285
 None
 1.36A 5dzk2-3e3xA:
undetectable
5dzkM-3e3xA:
undetectable
5dzkN-3e3xA:
undetectable		 5dzk2-3e3xA:
1.04
5dzkM-3e3xA:
20.00
5dzkN-3e3xA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZX_A_9F2A1102_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 3e3x BIPA
(Vibrio
parahaemolyticus) 		4 / 8 PHE A 295
ARG A 233
ILE A 250
GLY A 232
 None
 0.88A 5nzxA-3e3xA:
undetectable		 5nzxA-3e3xA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZY_A_CE3A1103_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 3e3x BIPA
(Vibrio
parahaemolyticus) 		4 / 8 THR A 282
PRO A 284
VAL A 240
GLY A 239
 None
 0.97A 5nzyA-3e3xA:
undetectable		 5nzyA-3e3xA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OY0_2_PQN2843_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 3e3x BIPA
(Vibrio
parahaemolyticus) 		5 / 12 MET A  33
PHE A  35
SER A 107
ILE A 309
LEU A 104
 None
None
MLY  A 314 ( 4.8A)
None
None
 1.16A 5oy02-3e3xA:
undetectable		 5oy02-3e3xA:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OY0_B_PQNB1844_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 3e3x BIPA
(Vibrio
parahaemolyticus) 		5 / 10 MET A  33
PHE A  35
SER A 107
ILE A 309
LEU A 104
 None
None
MLY  A 314 ( 4.8A)
None
None
 1.21A 5oy0b-3e3xA:
undetectable		 5oy0b-3e3xA:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YF9_X_NIOX401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 3e3x BIPA
(Vibrio
parahaemolyticus) 		5 / 9 LEU A 189
VAL A 127
ILE A 143
PHE A 165
ILE A 139
 None
 1.23A 5yf9X-3e3xA:
undetectable		 5yf9X-3e3xA:
14.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZJI_A_PQNA844_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 3e3x BIPA
(Vibrio
parahaemolyticus) 		5 / 10 MET A  33
PHE A  35
SER A 107
ILE A 309
LEU A 104
 None
None
MLY  A 314 ( 4.8A)
None
None
 1.20A 5zjiA-3e3xA:
undetectable
5zjiJ-3e3xA:
undetectable		 5zjiA-3e3xA:
14.20
5zjiJ-3e3xA:
10.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B0C_D_TA1D502_1
(TUBULIN BETA CHAIN)		 3e3x BIPA
(Vibrio
parahaemolyticus) 		5 / 12 VAL A 242
ALA A 220
LEU A 281
THR A 282
GLY A 249
 None
 0.94A 6b0cD-3e3xA:
undetectable		 6b0cD-3e3xA:
17.52