SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3e48'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NCW_H_BEZH601_0
(IMMUNOGLOBULIN IGG2A)		 3e48 PUTATIVE
NUCLEOSIDE-DIPHOSPHA
TE-SUGAR EPIMERASE
(Staphylococcus
aureus) 		5 / 9 ALA A 249
ASN A 113
LEU A 254
GLY A 253
TYR A 107
 None
 1.10A 1ncwH-3e48A:
undetectable
1ncwL-3e48A:
undetectable		 1ncwH-3e48A:
18.95
1ncwL-3e48A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RU9_H_BEZH601_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 3e48 PUTATIVE
NUCLEOSIDE-DIPHOSPHA
TE-SUGAR EPIMERASE
(Staphylococcus
aureus) 		5 / 9 ALA A 249
ASN A 113
LEU A 254
GLY A 253
TYR A 107
 None
 1.12A 1ru9H-3e48A:
undetectable
1ru9L-3e48A:
undetectable		 1ru9H-3e48A:
18.95
1ru9L-3e48A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RUA_H_BEZH601_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 3e48 PUTATIVE
NUCLEOSIDE-DIPHOSPHA
TE-SUGAR EPIMERASE
(Staphylococcus
aureus) 		5 / 10 ALA A 249
ASN A 113
LEU A 254
GLY A 253
TYR A 107
 None
 1.08A 1ruaH-3e48A:
undetectable
1ruaL-3e48A:
undetectable		 1ruaH-3e48A:
18.95
1ruaL-3e48A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RUL_H_BEZH601_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 3e48 PUTATIVE
NUCLEOSIDE-DIPHOSPHA
TE-SUGAR EPIMERASE
(Staphylococcus
aureus) 		5 / 9 ALA A 249
ASN A 113
LEU A 254
GLY A 253
TYR A 107
 None
 1.11A 1rulH-3e48A:
undetectable
1rulL-3e48A:
undetectable		 1rulH-3e48A:
18.95
1rulL-3e48A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RUM_H_BEZH1601_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 3e48 PUTATIVE
NUCLEOSIDE-DIPHOSPHA
TE-SUGAR EPIMERASE
(Staphylococcus
aureus) 		5 / 9 ALA A 249
ASN A 113
LEU A 254
GLY A 253
TYR A 107
 None
 1.10A 1rumH-3e48A:
undetectable
1rumL-3e48A:
undetectable		 1rumH-3e48A:
18.95
1rumL-3e48A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RUP_H_BEZH601_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 3e48 PUTATIVE
NUCLEOSIDE-DIPHOSPHA
TE-SUGAR EPIMERASE
(Staphylococcus
aureus) 		5 / 9 ALA A 249
ASN A 113
LEU A 254
GLY A 253
TYR A 107
 None
 1.11A 1rupH-3e48A:
undetectable
1rupL-3e48A:
0.0		 1rupH-3e48A:
18.95
1rupL-3e48A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BUF_A_AEGA394_0
(BETA-SECRETASE 1)		 3e48 PUTATIVE
NUCLEOSIDE-DIPHOSPHA
TE-SUGAR EPIMERASE
(Staphylococcus
aureus) 		4 / 5 LEU A   5
ILE A  25
ILE A  30
GLY A  13
 None
 0.91A 3bufA-3e48A:
undetectable		 3bufA-3e48A:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU5_B_478B401_2
(PROTEASE)		 3e48 PUTATIVE
NUCLEOSIDE-DIPHOSPHA
TE-SUGAR EPIMERASE
(Staphylococcus
aureus) 		5 / 12 LEU A 226
GLY A 165
ALA A 164
GLY A 253
PRO A 114
 None
 1.00A 3nu5B-3e48A:
undetectable		 3nu5B-3e48A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_C_SAMC300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3e48 PUTATIVE
NUCLEOSIDE-DIPHOSPHA
TE-SUGAR EPIMERASE
(Staphylococcus
aureus) 		5 / 12 TYR A 171
ALA A 141
GLY A 199
ASP A 176
ALA A 108
 None
 1.30A 3ou6C-3e48A:
4.5		 3ou6C-3e48A:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P4W_B_DSFB319_1
(GLR4197 PROTEIN)		 3e48 PUTATIVE
NUCLEOSIDE-DIPHOSPHA
TE-SUGAR EPIMERASE
(Staphylococcus
aureus) 		5 / 9 ILE A   3
ILE A  25
VAL A  70
ILE A 182
ILE A  16
 None
 1.25A 3p4wB-3e48A:
undetectable		 3p4wB-3e48A:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S8P_B_SAMB500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 3e48 PUTATIVE
NUCLEOSIDE-DIPHOSPHA
TE-SUGAR EPIMERASE
(Staphylococcus
aureus) 		3 / 3 HIS A 248
SER A 118
ASN A 112
 None
 0.89A 3s8pB-3e48A:
undetectable		 3s8pB-3e48A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZT_A_SAMA1472_1
(METHYLTRANSFERASE
WBDD)		 3e48 PUTATIVE
NUCLEOSIDE-DIPHOSPHA
TE-SUGAR EPIMERASE
(Staphylococcus
aureus) 		3 / 3 GLN A  19
ASP A 176
GLN A 271
 None
 0.72A 4aztA-3e48A:
undetectable		 4aztA-3e48A:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LUH_A_ACTA610_0
(SERUM ALBUMIN)		 3e48 PUTATIVE
NUCLEOSIDE-DIPHOSPHA
TE-SUGAR EPIMERASE
(Staphylococcus
aureus) 		3 / 3 VAL A 224
SER A 225
THR A 228
 None
 0.41A 4luhA-3e48A:
undetectable		 4luhA-3e48A:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LV9_A_20JA602_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 3e48 PUTATIVE
NUCLEOSIDE-DIPHOSPHA
TE-SUGAR EPIMERASE
(Staphylococcus
aureus) 		4 / 7 VAL A  70
ILE A 185
ILE A 182
ALA A  20
 None
 0.86A 4lv9A-3e48A:
undetectable		 4lv9A-3e48A:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LV9_B_20JB602_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 3e48 PUTATIVE
NUCLEOSIDE-DIPHOSPHA
TE-SUGAR EPIMERASE
(Staphylococcus
aureus) 		4 / 7 VAL A  70
ILE A 185
ILE A 182
ALA A  20
 None
 0.88A 4lv9B-3e48A:
undetectable		 4lv9B-3e48A:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X3M_A_ADNA301_1
(RNA 2'-O RIBOSE
METHYLTRANSFERASE)		 3e48 PUTATIVE
NUCLEOSIDE-DIPHOSPHA
TE-SUGAR EPIMERASE
(Staphylococcus
aureus) 		5 / 9 PRO A 163
GLY A 240
GLU A 231
ILE A 161
SER A 225
 None
 1.13A 4x3mA-3e48A:
2.7		 4x3mA-3e48A:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BMV_C_VLBC507_2
(TUBULIN ALPHA-1B
CHAIN)		 3e48 PUTATIVE
NUCLEOSIDE-DIPHOSPHA
TE-SUGAR EPIMERASE
(Staphylococcus
aureus) 		4 / 7 VAL A 181
ILE A 185
VAL A  70
ILE A 104
 None
 0.73A 5bmvC-3e48A:
2.1		 5bmvC-3e48A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CPR_B_SAMB402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 3e48 PUTATIVE
NUCLEOSIDE-DIPHOSPHA
TE-SUGAR EPIMERASE
(Staphylococcus
aureus) 		3 / 3 HIS A 248
SER A 118
ASN A 112
 None
 0.88A 5cprB-3e48A:
undetectable		 5cprB-3e48A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EML_A_SAMA701_1
(PROTEIN ARGININE
N-METHYLTRANSFERASE
5)		 3e48 PUTATIVE
NUCLEOSIDE-DIPHOSPHA
TE-SUGAR EPIMERASE
(Staphylococcus
aureus) 		4 / 6 TYR A 171
TYR A 106
GLY A 250
ASP A 166
 None
 1.32A 5emlA-3e48A:
2.4		 5emlA-3e48A:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TJY_A_BEZA304_0
(4-HYDROXY-TETRAHYDRO
DIPICOLINATE
REDUCTASE)		 3e48 PUTATIVE
NUCLEOSIDE-DIPHOSPHA
TE-SUGAR EPIMERASE
(Staphylococcus
aureus) 		3 / 3 MET A   4
GLU A  61
ARG A  49
 None
 0.70A 5tjyA-3e48A:
7.3		 5tjyA-3e48A:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TJZ_A_BEZA302_0
(4-HYDROXY-TETRAHYDRO
DIPICOLINATE
REDUCTASE)		 3e48 PUTATIVE
NUCLEOSIDE-DIPHOSPHA
TE-SUGAR EPIMERASE
(Staphylococcus
aureus) 		3 / 3 MET A   4
GLU A  61
ARG A  49
 None
 0.70A 5tjzA-3e48A:
7.9		 5tjzA-3e48A:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_A_ACRA1421_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 3e48 PUTATIVE
NUCLEOSIDE-DIPHOSPHA
TE-SUGAR EPIMERASE
(Staphylococcus
aureus) 		4 / 5 MET A 142
TYR A 247
GLY A 250
GLY A 253
 None
 1.16A 5x7pA-3e48A:
undetectable		 5x7pA-3e48A:
13.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DGX_A_017A101_2
(PROTEASE)		 3e48 PUTATIVE
NUCLEOSIDE-DIPHOSPHA
TE-SUGAR EPIMERASE
(Staphylococcus
aureus) 		3 / 3 GLY A  65
ASP A  67
ILE A   3
 None
 0.60A 6dgxB-3e48A:
undetectable		 6dgxB-3e48A:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GTQ_A_ACTA204_0
(N-ACETYLTRANSFERASE)		 3e48 PUTATIVE
NUCLEOSIDE-DIPHOSPHA
TE-SUGAR EPIMERASE
(Staphylococcus
aureus) 		4 / 5 LEU A  51
THR A   6
THR A   9
GLY A   7
 None
 1.16A 6gtqA-3e48A:
undetectable		 6gtqA-3e48A:
19.03