SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3e49'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LHU_A_ESTA301_1
(SEX HORMONE-BINDING
GLOBULIN)		 3e49 UNCHARACTERIZED
PROTEIN DUF849 WITH
A TIM BARREL FOLD
(Paraburkholderia
xenovorans) 		5 / 12 GLY A  15
ASN A  83
LEU A 233
ILE A  17
LEU A 202
 ZN  A 500 ( 4.7A)
None
None
None
None
 1.34A 1lhuA-3e49A:
undetectable		 1lhuA-3e49A:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OE2_A_CUA502_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 3e49 UNCHARACTERIZED
PROTEIN DUF849 WITH
A TIM BARREL FOLD
(Paraburkholderia
xenovorans) 		3 / 3 GLU A 258
HIS A  49
HIS A  51
 ZN  A 500 (-2.4A)
ZN  A 500 (-3.3A)
ZN  A 500 (-3.4A)
 0.64A 1oe2A-3e49A:
undetectable		 1oe2A-3e49A:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZZ_A_ACTA421_0
(ACLACINOMYCIN-10-HYD
ROXYLASE)		 3e49 UNCHARACTERIZED
PROTEIN DUF849 WITH
A TIM BARREL FOLD
(Paraburkholderia
xenovorans) 		4 / 8 GLY A 207
GLY A 205
GLY A 204
LEU A 202
 None
 0.61A 1qzzA-3e49A:
undetectable		 1qzzA-3e49A:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VPT_A_SAMA400_1
(VP39)		 3e49 UNCHARACTERIZED
PROTEIN DUF849 WITH
A TIM BARREL FOLD
(Paraburkholderia
xenovorans) 		3 / 3 ASP A  54
ARG A  56
ASP A  63
 None
 0.85A 1vptA-3e49A:
undetectable		 1vptA-3e49A:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GLU_B_SAMB302_0
(YCGJ)		 3e49 UNCHARACTERIZED
PROTEIN DUF849 WITH
A TIM BARREL FOLD
(Paraburkholderia
xenovorans) 		5 / 12 GLY A  39
THR A  78
THR A 271
ALA A  12
ALA A  45
 None
 0.96A 2gluB-3e49A:
undetectable		 2gluB-3e49A:
24.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_4
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 3e49 UNCHARACTERIZED
PROTEIN DUF849 WITH
A TIM BARREL FOLD
(Paraburkholderia
xenovorans) 		4 / 5 ALA A 291
ALA A 247
ALA A 243
VAL A 255
 None
 0.93A 2nyrB-3e49A:
undetectable		 2nyrB-3e49A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_NCAA493_0
(CHORISMATE SYNTHASE)		 3e49 UNCHARACTERIZED
PROTEIN DUF849 WITH
A TIM BARREL FOLD
(Paraburkholderia
xenovorans) 		5 / 11 ALA A  40
ILE A   9
ILE A  48
ALA A  80
ALA A  46
 None
 1.02A 2qhfA-3e49A:
undetectable		 2qhfA-3e49A:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_A_RBFA200_1
(DODECIN)		 3e49 UNCHARACTERIZED
PROTEIN DUF849 WITH
A TIM BARREL FOLD
(Paraburkholderia
xenovorans) 		4 / 8 TYR A 173
ARG A  97
HIS A  51
GLN A  62
 None
None
ZN  A 500 (-3.4A)
None
 1.42A 2vxaA-3e49A:
undetectable
2vxaC-3e49A:
undetectable
2vxaE-3e49A:
undetectable		 2vxaA-3e49A:
14.19
2vxaC-3e49A:
14.19
2vxaE-3e49A:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_B_RBFB200_1
(DODECIN)		 3e49 UNCHARACTERIZED
PROTEIN DUF849 WITH
A TIM BARREL FOLD
(Paraburkholderia
xenovorans) 		4 / 8 TYR A 173
ARG A  97
HIS A  51
GLN A  62
 None
None
ZN  A 500 (-3.4A)
None
 1.42A 2vxaA-3e49A:
undetectable
2vxaB-3e49A:
undetectable
2vxaK-3e49A:
undetectable		 2vxaA-3e49A:
14.19
2vxaB-3e49A:
14.19
2vxaK-3e49A:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_C_RBFC200_1
(DODECIN)		 3e49 UNCHARACTERIZED
PROTEIN DUF849 WITH
A TIM BARREL FOLD
(Paraburkholderia
xenovorans) 		4 / 8 TYR A 173
ARG A  97
HIS A  51
GLN A  62
 None
None
ZN  A 500 (-3.4A)
None
 1.42A 2vxaB-3e49A:
undetectable
2vxaC-3e49A:
undetectable
2vxaG-3e49A:
undetectable		 2vxaB-3e49A:
14.19
2vxaC-3e49A:
14.19
2vxaG-3e49A:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_D_RBFD200_1
(DODECIN)		 3e49 UNCHARACTERIZED
PROTEIN DUF849 WITH
A TIM BARREL FOLD
(Paraburkholderia
xenovorans) 		4 / 8 TYR A 173
ARG A  97
HIS A  51
GLN A  62
 None
None
ZN  A 500 (-3.4A)
None
 1.41A 2vxaD-3e49A:
undetectable
2vxaF-3e49A:
undetectable
2vxaI-3e49A:
undetectable		 2vxaD-3e49A:
14.19
2vxaF-3e49A:
14.19
2vxaI-3e49A:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_E_RBFE200_1
(DODECIN)		 3e49 UNCHARACTERIZED
PROTEIN DUF849 WITH
A TIM BARREL FOLD
(Paraburkholderia
xenovorans) 		4 / 8 TYR A 173
ARG A  97
HIS A  51
GLN A  62
 None
None
ZN  A 500 (-3.4A)
None
 1.41A 2vxaD-3e49A:
undetectable
2vxaE-3e49A:
undetectable
2vxaL-3e49A:
undetectable		 2vxaD-3e49A:
14.19
2vxaE-3e49A:
14.19
2vxaL-3e49A:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_G_RBFG200_1
(DODECIN)		 3e49 UNCHARACTERIZED
PROTEIN DUF849 WITH
A TIM BARREL FOLD
(Paraburkholderia
xenovorans) 		4 / 8 ARG A  97
HIS A  51
GLN A  62
TYR A 173
 None
ZN  A 500 (-3.4A)
None
None
 1.41A 2vxaF-3e49A:
undetectable
2vxaG-3e49A:
undetectable
2vxaI-3e49A:
undetectable		 2vxaF-3e49A:
14.19
2vxaG-3e49A:
14.19
2vxaI-3e49A:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_H_RBFH200_1
(DODECIN)		 3e49 UNCHARACTERIZED
PROTEIN DUF849 WITH
A TIM BARREL FOLD
(Paraburkholderia
xenovorans) 		4 / 8 ARG A  97
HIS A  51
GLN A  62
TYR A 173
 None
ZN  A 500 (-3.4A)
None
None
 1.43A 2vxaB-3e49A:
undetectable
2vxaG-3e49A:
undetectable
2vxaH-3e49A:
undetectable		 2vxaB-3e49A:
14.19
2vxaG-3e49A:
14.19
2vxaH-3e49A:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_I_RBFI200_1
(DODECIN)		 3e49 UNCHARACTERIZED
PROTEIN DUF849 WITH
A TIM BARREL FOLD
(Paraburkholderia
xenovorans) 		4 / 8 TYR A 173
ARG A  97
HIS A  51
GLN A  62
 None
None
ZN  A 500 (-3.4A)
None
 1.41A 2vxaH-3e49A:
undetectable
2vxaI-3e49A:
undetectable
2vxaJ-3e49A:
undetectable		 2vxaH-3e49A:
14.19
2vxaI-3e49A:
14.19
2vxaJ-3e49A:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_J_RBFJ200_1
(DODECIN)		 3e49 UNCHARACTERIZED
PROTEIN DUF849 WITH
A TIM BARREL FOLD
(Paraburkholderia
xenovorans) 		4 / 8 ARG A  97
HIS A  51
GLN A  62
TYR A 173
 None
ZN  A 500 (-3.4A)
None
None
 1.39A 2vxaD-3e49A:
undetectable
2vxaJ-3e49A:
undetectable
2vxaL-3e49A:
undetectable		 2vxaD-3e49A:
14.19
2vxaJ-3e49A:
14.19
2vxaL-3e49A:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_K_RBFK200_1
(DODECIN)		 3e49 UNCHARACTERIZED
PROTEIN DUF849 WITH
A TIM BARREL FOLD
(Paraburkholderia
xenovorans) 		4 / 8 ARG A  97
HIS A  51
GLN A  62
TYR A 173
 None
ZN  A 500 (-3.4A)
None
None
 1.41A 2vxaH-3e49A:
undetectable
2vxaJ-3e49A:
undetectable
2vxaK-3e49A:
undetectable		 2vxaH-3e49A:
14.19
2vxaJ-3e49A:
14.19
2vxaK-3e49A:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_L_RBFL200_1
(DODECIN)		 3e49 UNCHARACTERIZED
PROTEIN DUF849 WITH
A TIM BARREL FOLD
(Paraburkholderia
xenovorans) 		4 / 8 ARG A  97
HIS A  51
GLN A  62
TYR A 173
 None
ZN  A 500 (-3.4A)
None
None
 1.42A 2vxaA-3e49A:
undetectable
2vxaK-3e49A:
undetectable
2vxaL-3e49A:
undetectable		 2vxaA-3e49A:
14.19
2vxaK-3e49A:
14.19
2vxaL-3e49A:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZWE_B_DAHB98_1
(TYROSINASE
MELC)		 3e49 UNCHARACTERIZED
PROTEIN DUF849 WITH
A TIM BARREL FOLD
(Paraburkholderia
xenovorans) 		5 / 11 ILE A  17
HIS A  49
HIS A  51
HIS A  18
PRO A  27
 None
ZN  A 500 (-3.3A)
ZN  A 500 (-3.4A)
None
None
 1.48A 2zweA-3e49A:
undetectable
2zweB-3e49A:
undetectable		 2zweA-3e49A:
22.16
2zweB-3e49A:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZWF_B_DAHB98_1
(TYROSINASE
MELC)		 3e49 UNCHARACTERIZED
PROTEIN DUF849 WITH
A TIM BARREL FOLD
(Paraburkholderia
xenovorans) 		5 / 11 ILE A  17
HIS A  49
HIS A  51
HIS A  18
PRO A  27
 None
ZN  A 500 (-3.3A)
ZN  A 500 (-3.4A)
None
None
 1.47A 2zwfA-3e49A:
undetectable
2zwfB-3e49A:
undetectable		 2zwfA-3e49A:
22.16
2zwfB-3e49A:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_A_CHDA3_0
(FERROCHELATASE)		 3e49 UNCHARACTERIZED
PROTEIN DUF849 WITH
A TIM BARREL FOLD
(Paraburkholderia
xenovorans) 		3 / 3 PRO A 210
LEU A 213
ARG A 217
 None
None
ETX  A 501 (-3.5A)
 0.81A 3aqiA-3e49A:
undetectable		 3aqiA-3e49A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_B_CHDB5_0
(FERROCHELATASE)		 3e49 UNCHARACTERIZED
PROTEIN DUF849 WITH
A TIM BARREL FOLD
(Paraburkholderia
xenovorans) 		3 / 3 PRO A 210
LEU A 213
ARG A 217
 None
None
ETX  A 501 (-3.5A)
 0.76A 3aqiB-3e49A:
undetectable		 3aqiB-3e49A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_A_SAMA301_0
(UNCHARACTERIZED
PROTEIN MJ0489)		 3e49 UNCHARACTERIZED
PROTEIN DUF849 WITH
A TIM BARREL FOLD
(Paraburkholderia
xenovorans) 		6 / 12 ILE A 157
LEU A  98
THR A 166
GLY A 162
GLY A 301
PHE A 170
 None
 1.42A 5d4uA-3e49A:
undetectable		 5d4uA-3e49A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_B_SAMB301_0
(UNCHARACTERIZED
PROTEIN MJ0489)		 3e49 UNCHARACTERIZED
PROTEIN DUF849 WITH
A TIM BARREL FOLD
(Paraburkholderia
xenovorans) 		6 / 12 ILE A 157
LEU A  98
THR A 166
GLY A 162
GLY A 301
PHE A 170
 None
 1.40A 5d4uB-3e49A:
undetectable		 5d4uB-3e49A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_B_1GNB603_1
(PHIAB6 TAILSPIKE)		 3e49 UNCHARACTERIZED
PROTEIN DUF849 WITH
A TIM BARREL FOLD
(Paraburkholderia
xenovorans) 		3 / 3 VAL A  13
GLU A 171
GLU A 169
 None
ZN  A 500 ( 4.5A)
None
 0.85A 5jsdB-3e49A:
0.2
5jsdC-3e49A:
undetectable		 5jsdB-3e49A:
17.76
5jsdC-3e49A:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NUK_A_Z80A201_1
(BETA-LACTOGLOBULIN)		 3e49 UNCHARACTERIZED
PROTEIN DUF849 WITH
A TIM BARREL FOLD
(Paraburkholderia
xenovorans) 		5 / 10 ALA A  12
VAL A  13
PHE A  70
ILE A  74
ILE A  82
 None
 0.91A 5nukA-3e49A:
undetectable		 5nukA-3e49A:
14.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UVM_B_ADNB207_1
(HISTIDINE TRIAD
(HIT) PROTEIN)		 3e49 UNCHARACTERIZED
PROTEIN DUF849 WITH
A TIM BARREL FOLD
(Paraburkholderia
xenovorans) 		5 / 12 VAL A  33
PHE A  70
ILE A  48
ASN A  83
LEU A  71
 None
 1.01A 5uvmB-3e49A:
undetectable		 5uvmB-3e49A:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YBB_A_SAMA601_0
(TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT)		 3e49 UNCHARACTERIZED
PROTEIN DUF849 WITH
A TIM BARREL FOLD
(Paraburkholderia
xenovorans) 		5 / 12 ALA A  52
GLY A  58
PRO A  27
LEU A  84
PHE A  67
 None
 1.08A 5ybbA-3e49A:
undetectable		 5ybbA-3e49A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0I_B_DAHB98_0
(MELC
TYROSINASE)		 3e49 UNCHARACTERIZED
PROTEIN DUF849 WITH
A TIM BARREL FOLD
(Paraburkholderia
xenovorans) 		5 / 11 ILE A  17
HIS A  49
HIS A  51
HIS A  18
PRO A  27
 None
ZN  A 500 (-3.3A)
ZN  A 500 (-3.4A)
None
None
 1.46A 5z0iA-3e49A:
undetectable
5z0iB-3e49A:
undetectable		 5z0iA-3e49A:
14.98
5z0iB-3e49A:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_A_EY4A501_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 3e49 UNCHARACTERIZED
PROTEIN DUF849 WITH
A TIM BARREL FOLD
(Paraburkholderia
xenovorans) 		4 / 5 GLN A 197
VAL A 196
TRP A 230
THR A 219
 None
 1.08A 6cduA-3e49A:
undetectable
6cduB-3e49A:
undetectable		 6cduA-3e49A:
23.36
6cduB-3e49A:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_B_EY4B500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 3e49 UNCHARACTERIZED
PROTEIN DUF849 WITH
A TIM BARREL FOLD
(Paraburkholderia
xenovorans) 		5 / 6 GLN A 197
VAL A 196
TRP A 230
ALA A 220
THR A 219
 None
 1.37A 6cduB-3e49A:
undetectable
6cduC-3e49A:
undetectable		 6cduB-3e49A:
23.36
6cduC-3e49A:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_E_EY4E500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 3e49 UNCHARACTERIZED
PROTEIN DUF849 WITH
A TIM BARREL FOLD
(Paraburkholderia
xenovorans) 		5 / 8 GLN A 197
VAL A 196
TRP A 230
ALA A 220
THR A 219
 None
 1.34A 6cduD-3e49A:
undetectable
6cduE-3e49A:
undetectable		 6cduD-3e49A:
23.36
6cduE-3e49A:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_F_EY4F500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 3e49 UNCHARACTERIZED
PROTEIN DUF849 WITH
A TIM BARREL FOLD
(Paraburkholderia
xenovorans) 		5 / 7 ALA A 220
THR A 219
GLN A 197
VAL A 196
TRP A 230
 None
 1.41A 6cduF-3e49A:
undetectable
6cduJ-3e49A:
undetectable		 6cduF-3e49A:
23.36
6cduJ-3e49A:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_I_EY4I500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 3e49 UNCHARACTERIZED
PROTEIN DUF849 WITH
A TIM BARREL FOLD
(Paraburkholderia
xenovorans) 		4 / 5 GLN A 197
VAL A 196
TRP A 230
THR A 219
 None
 1.24A 6cduI-3e49A:
undetectable
6cduJ-3e49A:
undetectable		 6cduI-3e49A:
23.36
6cduJ-3e49A:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GTQ_B_ACTB207_0
(DUF1778
DOMAIN-CONTAINING
PROTEIN
N-ACETYLTRANSFERASE)		 3e49 UNCHARACTERIZED
PROTEIN DUF849 WITH
A TIM BARREL FOLD
(Paraburkholderia
xenovorans) 		4 / 6 LEU A  26
THR A  14
GLY A  15
ARG A  53
 None
None
ZN  A 500 ( 4.7A)
None
 1.29A 6gtqB-3e49A:
undetectable
6gtqD-3e49A:
undetectable		 6gtqB-3e49A:
21.43
6gtqD-3e49A:
10.03