SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3e4c'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_A_SC2A1290_1
(FICOLIN-2)		 3e4c CASPASE-1
(Homo
sapiens) 		4 / 5 ASP A 185
SER A 347
LEU A 353
GLY A 351
 None
 1.20A 2j2pA-3e4cA:
undetectable
2j2pB-3e4cA:
undetectable		 2j2pA-3e4cA:
22.81
2j2pB-3e4cA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GN8_A_DEXA247_2
(GLUCOCORTICOID
RECEPTOR 2)		 3e4c CASPASE-1
(Homo
sapiens) 		3 / 3 MET A 189
MET A 345
PHE A 349
 None
 1.14A 3gn8A-3e4cA:
undetectable		 3gn8A-3e4cA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZMD_A_SALA201_1
(PUTATIVE
TRANSCRIPTIONAL
REGULATOR)		 3e4c CASPASE-1
(Homo
sapiens) 		4 / 8 ARG A 371
TYR A 360
GLU A 368
HIS A 356
 None
 1.41A 3zmdA-3e4cA:
undetectable
3zmdB-3e4cA:
undetectable		 3zmdA-3e4cA:
22.48
3zmdB-3e4cA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_H_ZPCH1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3e4c CASPASE-1
(Homo
sapiens) 		4 / 7 ILE A 328
HIS A 356
VAL A 133
PHE A 231
 None
 1.01A 4a97H-3e4cA:
undetectable		 4a97H-3e4cA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DJF_A_C2FA300_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 3e4c CASPASE-1
(Homo
sapiens) 		5 / 12 ASN A 170
PHE A 173
ILE A 261
GLY A 242
ILE A 243
 None
 1.28A 4djfA-3e4cA:
undetectable		 4djfA-3e4cA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1801_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 3e4c CASPASE-1
(Homo
sapiens) 		4 / 6 ILE A 328
ILE A 243
LEU A 258
PHE A 262
 None
 0.93A 5vkqA-3e4cA:
undetectable
5vkqB-3e4cA:
undetectable		 5vkqA-3e4cA:
10.61
5vkqB-3e4cA:
10.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1806_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 3e4c CASPASE-1
(Homo
sapiens) 		4 / 6 ILE A 328
ILE A 243
LEU A 258
PHE A 262
 None
 0.92A 5vkqB-3e4cA:
undetectable
5vkqC-3e4cA:
undetectable		 5vkqB-3e4cA:
10.61
5vkqC-3e4cA:
10.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1807_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 3e4c CASPASE-1
(Homo
sapiens) 		4 / 6 ILE A 328
ILE A 243
LEU A 258
PHE A 262
 None
 0.91A 5vkqC-3e4cA:
undetectable
5vkqD-3e4cA:
undetectable		 5vkqC-3e4cA:
10.61
5vkqD-3e4cA:
10.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1807_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 3e4c CASPASE-1
(Homo
sapiens) 		4 / 6 ILE A 328
ILE A 243
LEU A 258
PHE A 262
 None
 0.91A 5vkqA-3e4cA:
undetectable
5vkqD-3e4cA:
undetectable		 5vkqA-3e4cA:
10.61
5vkqD-3e4cA:
10.61