SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3e4d'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAA_D_DMED999_1
(ACETYLCHOLINESTERASE)		 3e4d ESTERASE D
(Agrobacterium
fabrum) 		4 / 8 GLY A 145
SER A 168
TYR A  65
HIS A 272
 None
 0.97A 1maaD-3e4dA:
16.8		 1maaD-3e4dA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZEA_A_DHIA6_0
(MONOCLONAL
ANTI-CHOLERA TOXIN
IGG1 KAPPA ANTIBODY,
H CHAIN
MONOCLONAL
ANTI-CHOLERA TOXIN
IGG1 KAPPA ANTIBODY,
L CHAIN
SHORT SYNTHETIC
D-AMINO ACID PEPTIDE
D2)		 3e4d ESTERASE D
(Agrobacterium
fabrum) 		3 / 3 TRP A  47
ARG A 163
PHE A 164
 None
 1.49A 1zeaH-3e4dA:
undetectable
1zeaL-3e4dA:
undetectable		 1zeaH-3e4dA:
21.60
1zeaL-3e4dA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVD_B_SAMB601_0
(CATECHOL-O-METHYLTRA
NSFERASE)		 3e4d ESTERASE D
(Agrobacterium
fabrum) 		5 / 12 GLY A 229
PHE A 225
ALA A 175
ASP A 180
ALA A 179
 None
 1.19A 2avdB-3e4dA:
undetectable		 2avdB-3e4dA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_A_CHDA702_0
(FERROCHELATASE)		 3e4d ESTERASE D
(Agrobacterium
fabrum) 		4 / 7 ARG A 140
LEU A 276
PRO A  79
VAL A  76
 None
 1.18A 2hrcA-3e4dA:
2.4		 2hrcA-3e4dA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PKK_A_2FAA501_2
(ADENOSINE KINASE)		 3e4d ESTERASE D
(Agrobacterium
fabrum) 		4 / 4 ALA A 169
VAL A 174
PHE A 215
THR A 155
 None
 1.21A 2pkkA-3e4dA:
2.3		 2pkkA-3e4dA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD3_A_CHDA502_0
(FERROCHELATASE)		 3e4d ESTERASE D
(Agrobacterium
fabrum) 		4 / 8 PRO A 176
SER A 182
GLY A 152
MET A 148
 None
 1.11A 2qd3A-3e4dA:
2.4		 2qd3A-3e4dA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCR_A_CHDA424_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3e4d ESTERASE D
(Agrobacterium
fabrum) 		4 / 8 PRO A 176
SER A 182
GLY A 152
MET A 148
 None
 1.09A 3hcrA-3e4dA:
3.2		 3hcrA-3e4dA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UGR_A_IMNA2001_2
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 3e4d ESTERASE D
(Agrobacterium
fabrum) 		4 / 7 TYR A 200
ASN A 160
GLU A 124
GLN A 117
 None
 1.27A 3ugrA-3e4dA:
undetectable		 3ugrA-3e4dA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J14_A_X2NA602_1
(CHOLESTEROL
24-HYDROXYLASE)		 3e4d ESTERASE D
(Agrobacterium
fabrum) 		5 / 10 ALA A 157
LEU A 158
ILE A 239
ALA A 238
ALA A 175
 None
 1.05A 4j14A-3e4dA:
undetectable		 4j14A-3e4dA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_B_FOLB301_1
(FOLATE RECEPTOR
ALPHA)		 3e4d ESTERASE D
(Agrobacterium
fabrum) 		3 / 3 ASP A 223
TRP A  95
SER A 147
 CL  A 280 ( 4.7A)
None
CL  A 279 (-2.9A)
 0.75A 4lrhB-3e4dA:
undetectable		 4lrhB-3e4dA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_F_FOLF301_1
(FOLATE RECEPTOR
ALPHA)		 3e4d ESTERASE D
(Agrobacterium
fabrum) 		3 / 3 ASP A 223
TRP A  95
SER A 147
 CL  A 280 ( 4.7A)
None
CL  A 279 (-2.9A)
 0.78A 4lrhF-3e4dA:
undetectable		 4lrhF-3e4dA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM4_B_8PRB603_1
(TRANSPORTER)		 3e4d ESTERASE D
(Agrobacterium
fabrum) 		5 / 12 VAL A  76
TYR A  33
VAL A  34
SER A  70
GLY A  73
 None
 1.18A 4mm4B-3e4dA:
undetectable		 4mm4B-3e4dA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOI_A_ML1A303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3e4d ESTERASE D
(Agrobacterium
fabrum) 		4 / 8 PHE A 260
TYR A 258
GLY A 150
ILE A 173
 None
 0.96A 4qoiA-3e4dA:
2.6
4qoiB-3e4dA:
undetectable		 4qoiA-3e4dA:
20.77
4qoiB-3e4dA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_R_BEZR801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 3e4d ESTERASE D
(Agrobacterium
fabrum) 		4 / 7 PHE A 215
ALA A 169
HIS A 272
LEU A 216
 None
 1.15A 5dzkD-3e4dA:
undetectable
5dzkR-3e4dA:
undetectable		 5dzkD-3e4dA:
23.32
5dzkR-3e4dA:
0.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1808_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 3e4d ESTERASE D
(Agrobacterium
fabrum) 		4 / 5 LEU A 269
LYS A 270
ALA A 273
LEU A 276
 None
 0.73A 5vkqA-3e4dA:
undetectable
5vkqD-3e4dA:
undetectable		 5vkqA-3e4dA:
10.47
5vkqD-3e4dA:
10.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1805_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 3e4d ESTERASE D
(Agrobacterium
fabrum) 		4 / 5 LEU A 269
LYS A 270
ALA A 273
LEU A 276
 None
 0.73A 5vkqA-3e4dA:
undetectable
5vkqB-3e4dA:
undetectable		 5vkqA-3e4dA:
10.47
5vkqB-3e4dA:
10.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1806_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 3e4d ESTERASE D
(Agrobacterium
fabrum) 		4 / 5 LEU A 269
LYS A 270
ALA A 273
LEU A 276
 None
 0.72A 5vkqB-3e4dA:
undetectable
5vkqC-3e4dA:
undetectable		 5vkqB-3e4dA:
10.47
5vkqC-3e4dA:
10.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1806_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 3e4d ESTERASE D
(Agrobacterium
fabrum) 		4 / 5 LEU A 269
LYS A 270
ALA A 273
LEU A 276
 None
 0.73A 5vkqC-3e4dA:
undetectable
5vkqD-3e4dA:
undetectable		 5vkqC-3e4dA:
10.47
5vkqD-3e4dA:
10.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YF0_A_SAMA505_0
(CARNOSINE
N-METHYLTRANSFERASE)		 3e4d ESTERASE D
(Agrobacterium
fabrum) 		5 / 12 GLY A 149
GLY A 145
PHE A 103
THR A  81
TYR A 258
 None
 1.48A 5yf0A-3e4dA:
undetectable		 5yf0A-3e4dA:
20.74