SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3e4f'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J3J_A_CP6A609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3e4f AMINOGLYCOSIDE
N3-ACETYLTRANSFERASE
(Bacillus
anthracis) 		5 / 10 ILE A  17
ASN A 242
SER A   7
ILE A   4
ILE A  41
 None
 1.22A 1j3jA-3e4fA:
undetectable		 1j3jA-3e4fA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X1A_A_SAMA4264_0
(CRTF-RELATED PROTEIN)		 3e4f AMINOGLYCOSIDE
N3-ACETYLTRANSFERASE
(Bacillus
anthracis) 		5 / 12 GLY A  42
GLY A 241
ILE A  17
ASP A   3
ILE A   4
 None
 1.15A 1x1aA-3e4fA:
undetectable		 1x1aA-3e4fA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BLA_A_CP6A302_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3e4f AMINOGLYCOSIDE
N3-ACETYLTRANSFERASE
(Bacillus
anthracis) 		5 / 11 ILE A  17
ASN A 242
SER A   7
ILE A   4
ILE A  41
 None
 1.22A 2blaA-3e4fA:
undetectable		 2blaA-3e4fA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C12_C_SPMC1434_1
(NITROALKANE OXIDASE)		 3e4f AMINOGLYCOSIDE
N3-ACETYLTRANSFERASE
(Bacillus
anthracis) 		5 / 12 GLU A 155
VAL A 187
LEU A 153
SER A 152
ASP A 214
 None
 1.17A 2c12C-3e4fA:
undetectable		 2c12C-3e4fA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C12_F_SPMF1433_1
(NITROALKANE OXIDASE)		 3e4f AMINOGLYCOSIDE
N3-ACETYLTRANSFERASE
(Bacillus
anthracis) 		5 / 11 GLU A 155
VAL A 187
LEU A 153
SER A 152
ASP A 214
 None
 1.09A 2c12F-3e4fA:
undetectable		 2c12F-3e4fA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZUL_A_SAMA376_1
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 3e4f AMINOGLYCOSIDE
N3-ACETYLTRANSFERASE
(Bacillus
anthracis) 		3 / 3 SER A 157
GLU A 186
ASP A 220
 None
 0.81A 2zulA-3e4fA:
undetectable		 2zulA-3e4fA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DMH_A_SAMA384_1
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 3e4f AMINOGLYCOSIDE
N3-ACETYLTRANSFERASE
(Bacillus
anthracis) 		3 / 3 SER A 157
GLU A 186
ASP A 220
 None
 0.80A 3dmhA-3e4fA:
undetectable		 3dmhA-3e4fA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q1E_D_T44D328_1
(5-HYDROXYISOURATE
HYDROLASE)		 3e4f AMINOGLYCOSIDE
N3-ACETYLTRANSFERASE
(Bacillus
anthracis) 		5 / 9 PRO A  68
THR A 180
LEU A 159
LEU A 153
SER A 152
 None
 1.42A 3q1eB-3e4fA:
undetectable
3q1eD-3e4fA:
undetectable		 3q1eB-3e4fA:
18.55
3q1eD-3e4fA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HBF_A_DXCA75_0
(PPCA)		 3e4f AMINOGLYCOSIDE
N3-ACETYLTRANSFERASE
(Bacillus
anthracis) 		4 / 7 ILE A 143
LEU A 165
LYS A  28
GLY A  29
 None
 1.01A 4hbfA-3e4fA:
undetectable		 4hbfA-3e4fA:
12.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAQ_A_2GMA2001_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 1B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 3e4f AMINOGLYCOSIDE
N3-ACETYLTRANSFERASE
(Bacillus
anthracis) 		4 / 6 TRP A 260
ILE A 253
VAL A 223
ASP A 218
 None
 1.10A 4iaqA-3e4fA:
undetectable		 4iaqA-3e4fA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYK_B_IMNB300_1
(LACTOYLGLUTATHIONE
LYASE)		 3e4f AMINOGLYCOSIDE
N3-ACETYLTRANSFERASE
(Bacillus
anthracis) 		5 / 12 PHE A 133
ALA A 134
LEU A 159
GLY A 111
MET A 110
 None
None
None
CIT  A 267 (-3.6A)
None
 1.14A 4kykA-3e4fA:
undetectable
4kykB-3e4fA:
undetectable		 4kykA-3e4fA:
19.78
4kykB-3e4fA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWR_A_ZMRA513_2
(NEURAMINIDASE)		 3e4f AMINOGLYCOSIDE
N3-ACETYLTRANSFERASE
(Bacillus
anthracis) 		4 / 5 LEU A 130
ASP A  76
TRP A  80
ILE A  93
 None
 1.47A 4mwrA-3e4fA:
undetectable		 4mwrA-3e4fA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_G_SAMG301_1
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 3e4f AMINOGLYCOSIDE
N3-ACETYLTRANSFERASE
(Bacillus
anthracis) 		3 / 3 GLU A 186
HIS A 183
ASP A 220
 None
 0.83A 5c0oG-3e4fA:
2.6		 5c0oG-3e4fA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_B_BEZB203_0
(HYDROXYNITRILE LYASE)		 3e4f AMINOGLYCOSIDE
N3-ACETYLTRANSFERASE
(Bacillus
anthracis) 		4 / 4 VAL A 123
ALA A 140
ILE A  65
THR A  64
 None
 1.14A 5e4dB-3e4fA:
undetectable		 5e4dB-3e4fA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBV_D_FI8D1904_0
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		 3e4f AMINOGLYCOSIDE
N3-ACETYLTRANSFERASE
(Bacillus
anthracis) 		4 / 8 ILE A  65
THR A 144
VAL A 145
GLU A 141
 None
 1.02A 6fbvC-3e4fA:
undetectable		 6fbvC-3e4fA:
12.60