SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3e4p'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WOP_A_FFOA2887_1
(AMINOMETHYLTRANSFERA
SE)		 3e4p C4-DICARBOXYLATE
TRANSPORT SENSOR
PROTEIN DCTB
(Sinorhizobium
meliloti) 		3 / 3 ASP A 206
GLU A 119
ARG A 175
 None
 0.72A 1wopA-3e4pA:
undetectable		 1wopA-3e4pA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z95_A_198A501_2
(ANDROGEN RECEPTOR)		 3e4p C4-DICARBOXYLATE
TRANSPORT SENSOR
PROTEIN DCTB
(Sinorhizobium
meliloti) 		4 / 6 LEU A 104
ASN A 108
LEU A  86
ILE A 123
 None
 1.01A 1z95A-3e4pA:
undetectable		 1z95A-3e4pA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_A_SAMA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 3e4p C4-DICARBOXYLATE
TRANSPORT SENSOR
PROTEIN DCTB
(Sinorhizobium
meliloti) 		5 / 12 ILE A 194
ILE A 180
ILE A 126
ASP A 161
ALA A 158
 None
 0.95A 3uj7A-3e4pA:
undetectable		 3uj7A-3e4pA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7Q_C_ZMRC601_2
(NEURAMINIDASE)		 3e4p C4-DICARBOXYLATE
TRANSPORT SENSOR
PROTEIN DCTB
(Sinorhizobium
meliloti) 		3 / 3 ARG A 220
ARG A 219
ILE A 247
 None
 0.86A 4b7qC-3e4pA:
undetectable		 4b7qC-3e4pA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_A_CHDA506_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3e4p C4-DICARBOXYLATE
TRANSPORT SENSOR
PROTEIN DCTB
(Sinorhizobium
meliloti) 		4 / 4 PRO A 257
LEU A 258
ILE A 247
ARG A 220
 None
 1.41A 4f4dA-3e4pA:
undetectable		 4f4dA-3e4pA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4D_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 3e4p C4-DICARBOXYLATE
TRANSPORT SENSOR
PROTEIN DCTB
(Sinorhizobium
meliloti) 		4 / 8 THR A 298
LEU A 198
VAL A  76
VAL A 216
 SR  A 502 ( 4.3A)
None
None
None
 1.13A 4l4dA-3e4pA:
undetectable		 4l4dA-3e4pA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4E_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 3e4p C4-DICARBOXYLATE
TRANSPORT SENSOR
PROTEIN DCTB
(Sinorhizobium
meliloti) 		4 / 8 THR A 298
LEU A 198
VAL A  76
VAL A 216
 SR  A 502 ( 4.3A)
None
None
None
 1.14A 4l4eA-3e4pA:
undetectable		 4l4eA-3e4pA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4F_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 3e4p C4-DICARBOXYLATE
TRANSPORT SENSOR
PROTEIN DCTB
(Sinorhizobium
meliloti) 		4 / 8 THR A 298
LEU A 198
VAL A  76
VAL A 216
 SR  A 502 ( 4.3A)
None
None
None
 1.14A 4l4fA-3e4pA:
undetectable		 4l4fA-3e4pA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0R_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 3e4p C4-DICARBOXYLATE
TRANSPORT SENSOR
PROTEIN DCTB
(Sinorhizobium
meliloti) 		4 / 4 SER A  70
ALA A  69
GLN A 304
THR A 293
 None
 1.11A 5n0rA-3e4pA:
undetectable		 5n0rA-3e4pA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0S_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 3e4p C4-DICARBOXYLATE
TRANSPORT SENSOR
PROTEIN DCTB
(Sinorhizobium
meliloti) 		4 / 4 SER A  70
ALA A  69
GLN A 304
THR A 293
 None
 1.08A 5n0sA-3e4pA:
undetectable		 5n0sA-3e4pA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0T_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 3e4p C4-DICARBOXYLATE
TRANSPORT SENSOR
PROTEIN DCTB
(Sinorhizobium
meliloti) 		4 / 5 SER A  70
ALA A  69
GLN A 304
THR A 293
 None
 1.12A 5n0tA-3e4pA:
undetectable		 5n0tA-3e4pA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0W_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 3e4p C4-DICARBOXYLATE
TRANSPORT SENSOR
PROTEIN DCTB
(Sinorhizobium
meliloti) 		4 / 4 SER A  70
ALA A  69
GLN A 304
THR A 293
 None
 1.12A 5n0wA-3e4pA:
undetectable		 5n0wA-3e4pA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0W_B_SAMB501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 3e4p C4-DICARBOXYLATE
TRANSPORT SENSOR
PROTEIN DCTB
(Sinorhizobium
meliloti) 		4 / 5 SER A  70
ALA A  69
GLN A 304
THR A 293
 None
 1.15A 5n0wB-3e4pA:
undetectable		 5n0wB-3e4pA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0X_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 3e4p C4-DICARBOXYLATE
TRANSPORT SENSOR
PROTEIN DCTB
(Sinorhizobium
meliloti) 		4 / 4 SER A  70
ALA A  69
GLN A 304
THR A 293
 None
 1.11A 5n0xA-3e4pA:
undetectable		 5n0xA-3e4pA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N4I_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 3e4p C4-DICARBOXYLATE
TRANSPORT SENSOR
PROTEIN DCTB
(Sinorhizobium
meliloti) 		4 / 5 SER A  70
ALA A  69
GLN A 304
THR A 293
 None
 1.11A 5n4iA-3e4pA:
undetectable		 5n4iA-3e4pA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_D_ADND502_1
(ADENOSYLHOMOCYSTEINA
SE)		 3e4p C4-DICARBOXYLATE
TRANSPORT SENSOR
PROTEIN DCTB
(Sinorhizobium
meliloti) 		3 / 3 LEU A 157
ASN A 299
LEU A 178
 None
SR  A 502 (-3.9A)
None
 0.75A 6exiD-3e4pA:
undetectable		 6exiD-3e4pA:
18.25