SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3e4w'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IE4_B_T44B328_1
(TRANSTHYRETIN)		 3e4w PUTATIVE
UNCHARACTERIZED
PROTEIN
(Mycobacterium
avium) 		4 / 8 ALA A 212
LEU A 214
GLU A 191
ALA A 158
 None
 0.76A 1ie4B-3e4wA:
undetectable
1ie4D-3e4wA:
undetectable		 1ie4B-3e4wA:
19.46
1ie4D-3e4wA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_B_SAMB303_1
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 3e4w PUTATIVE
UNCHARACTERIZED
PROTEIN
(Mycobacterium
avium) 		3 / 3 THR A  37
ASP A  54
SER A  48
 None
 0.84A 2nxeB-3e4wA:
undetectable		 2nxeB-3e4wA:
25.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS6_B_EPAB1_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3e4w PUTATIVE
UNCHARACTERIZED
PROTEIN
(Mycobacterium
avium) 		5 / 12 GLY A  79
ASN A  66
GLY A  19
ALA A  26
GLY A  67
 None
None
None
HEM  A 501 (-3.4A)
HEZ  A1100 ( 3.7A)
 1.02A 3hs6B-3e4wA:
undetectable		 3hs6B-3e4wA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_M_TFPM201_1
(PROTEIN S100-A4)		 3e4w PUTATIVE
UNCHARACTERIZED
PROTEIN
(Mycobacterium
avium) 		4 / 7 GLY A  55
PHE A 168
GLY A 250
PHE A 223
 None
 0.99A 3ko0M-3e4wA:
undetectable
3ko0P-3e4wA:
undetectable		 3ko0M-3e4wA:
16.25
3ko0P-3e4wA:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5K_A_08JA1_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 3e4w PUTATIVE
UNCHARACTERIZED
PROTEIN
(Mycobacterium
avium) 		4 / 8 VAL A 219
LEU A 214
LEU A 210
ILE A  62
 None
 0.89A 3u5kA-3e4wA:
undetectable		 3u5kA-3e4wA:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5K_C_08JC3_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 3e4w PUTATIVE
UNCHARACTERIZED
PROTEIN
(Mycobacterium
avium) 		4 / 8 VAL A 219
LEU A 214
LEU A 210
ILE A  62
 None
 0.94A 3u5kC-3e4wA:
undetectable		 3u5kC-3e4wA:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VLN_A_ASCA904_0
(GLUTATHIONE
S-TRANSFERASE
OMEGA-1)		 3e4w PUTATIVE
UNCHARACTERIZED
PROTEIN
(Mycobacterium
avium) 		4 / 6 LEU A 193
PRO A 154
GLU A 191
SER A 156
 None
 1.31A 3vlnA-3e4wA:
undetectable		 3vlnA-3e4wA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9J_A_TYLA1188_1
(BROMODOMAIN
CONTAINING 2)		 3e4w PUTATIVE
UNCHARACTERIZED
PROTEIN
(Mycobacterium
avium) 		4 / 5 VAL A 219
LEU A 214
LEU A 210
ILE A  62
 None
 0.97A 4a9jA-3e4wA:
undetectable		 4a9jA-3e4wA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9J_C_TYLC1184_1
(BROMODOMAIN
CONTAINING 2)		 3e4w PUTATIVE
UNCHARACTERIZED
PROTEIN
(Mycobacterium
avium) 		4 / 5 VAL A 219
LEU A 214
LEU A 210
ILE A  62
 None
 0.93A 4a9jC-3e4wA:
undetectable		 4a9jC-3e4wA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LAJ_B_ACAB512_1
(HIV-1 YU2 GP120
ENVELOPE
GLYCOPROTEIN)		 3e4w PUTATIVE
UNCHARACTERIZED
PROTEIN
(Mycobacterium
avium) 		4 / 6 GLY A 164
ASP A  96
PRO A 272
ARG A 290
 HEM  A 501 (-4.1A)
None
None
HEM  A 501 (-3.3A)
 1.02A 4lajA-3e4wA:
undetectable
4lajB-3e4wA:
undetectable		 4lajA-3e4wA:
21.84
4lajB-3e4wA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZY_A_CE3A1103_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 3e4w PUTATIVE
UNCHARACTERIZED
PROTEIN
(Mycobacterium
avium) 		4 / 8 TYR A  34
ASP A 208
GLY A  31
ARG A  63
 None
None
None
HEM  A 501 (-3.6A)
 0.95A 5nzyA-3e4wA:
undetectable		 5nzyA-3e4wA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YOD_H_BEZH201_0
(NS3 PROTEASE)		 3e4w PUTATIVE
UNCHARACTERIZED
PROTEIN
(Mycobacterium
avium) 		4 / 5 HIS A  28
TYR A 162
GLY A  82
TYR A 157
 HEM  A 501 ( 3.5A)
None
HEM  A 501 ( 4.2A)
None
 1.43A 5yodH-3e4wA:
undetectable		 5yodH-3e4wA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BPL_B_PA1B605_1
(LIPID A EXPORT
ATP-BINDING/PERMEASE
PROTEIN MSBA)		 3e4w PUTATIVE
UNCHARACTERIZED
PROTEIN
(Mycobacterium
avium) 		3 / 3 ARG A 274
ARG A 301
ARG A 261
 None
HEM  A 501 (-3.8A)
None
 1.05A 6bplA-3e4wA:
undetectable
6bplB-3e4wA:
undetectable		 6bplA-3e4wA:
13.65
6bplB-3e4wA:
13.65