SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3e53'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EA1_A_TPFA470_1
(CYTOCHROME P450
51-LIKE RV0764C)		 3e53 FATTY-ACID-COA
LIGASE FADD28
(Mycobacterium
tuberculosis) 		4 / 8 TYR A 199
PHE A 200
MET A 196
LEU A 213
 None
 0.90A 1ea1A-3e53A:
undetectable		 1ea1A-3e53A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EA1_A_TPFA470_1
(CYTOCHROME P450
51-LIKE RV0764C)		 3e53 FATTY-ACID-COA
LIGASE FADD28
(Mycobacterium
tuberculosis) 		4 / 8 TYR A 199
PHE A 200
MET A 196
PHE A 192
 None
 0.94A 1ea1A-3e53A:
undetectable		 1ea1A-3e53A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J96_A_TESA903_1
(3ALPHA-HYDROXYSTEROI
D DEHYDROGENASE TYPE
3)		 3e53 FATTY-ACID-COA
LIGASE FADD28
(Mycobacterium
tuberculosis) 		4 / 6 VAL A 324
ILE A 325
TRP A 254
LEU A 217
 None
 1.29A 1j96A-3e53A:
undetectable		 1j96A-3e53A:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_A_ACTA1866_0
(FPRA)		 3e53 FATTY-ACID-COA
LIGASE FADD28
(Mycobacterium
tuberculosis) 		4 / 4 ARG A 323
LEU A 320
ASN A 319
VAL A 324
 None
 1.42A 1lqtA-3e53A:
undetectable		 1lqtA-3e53A:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_B_ACTB1875_0
(FPRA)		 3e53 FATTY-ACID-COA
LIGASE FADD28
(Mycobacterium
tuberculosis) 		4 / 4 ARG A 323
LEU A 320
ASN A 319
VAL A 324
 None
 1.44A 1lqtB-3e53A:
undetectable		 1lqtB-3e53A:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_A_ACTA1423_0
(FPRA)		 3e53 FATTY-ACID-COA
LIGASE FADD28
(Mycobacterium
tuberculosis) 		4 / 4 ARG A 323
LEU A 320
ASN A 319
VAL A 324
 None
 1.42A 1lquA-3e53A:
2.2		 1lquA-3e53A:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_B_ACTB1432_0
(FPRA)		 3e53 FATTY-ACID-COA
LIGASE FADD28
(Mycobacterium
tuberculosis) 		4 / 4 ARG A 323
LEU A 320
ASN A 319
VAL A 324
 None
 1.45A 1lquB-3e53A:
undetectable		 1lquB-3e53A:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_J_FUAJ711_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3e53 FATTY-ACID-COA
LIGASE FADD28
(Mycobacterium
tuberculosis) 		5 / 11 THR A 118
TYR A  75
PHE A  79
LEU A 108
VAL A 107
 None
 1.38A 1q23J-3e53A:
undetectable		 1q23J-3e53A:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WOP_A_FFOA2888_0
(AMINOMETHYLTRANSFERA
SE)		 3e53 FATTY-ACID-COA
LIGASE FADD28
(Mycobacterium
tuberculosis) 		5 / 10 LEU A  80
LEU A   6
ILE A 229
ILE A 206
LEU A 234
 None
 1.23A 1wopA-3e53A:
undetectable		 1wopA-3e53A:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOH_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 3e53 FATTY-ACID-COA
LIGASE FADD28
(Mycobacterium
tuberculosis) 		4 / 5 LEU A 234
GLY A  81
ALA A   9
ILE A 233
 None
 0.72A 2aohB-3e53A:
undetectable		 2aohB-3e53A:
11.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_C_SAMC301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 3e53 FATTY-ACID-COA
LIGASE FADD28
(Mycobacterium
tuberculosis) 		4 / 4 LYS A 454
GLU A 348
SER A 375
ASP A 351
 None
 1.39A 2br4C-3e53A:
0.0		 2br4C-3e53A:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CL9_A_MTXA602_2
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE (DHFR-TS))		 3e53 FATTY-ACID-COA
LIGASE FADD28
(Mycobacterium
tuberculosis) 		4 / 4 VAL A 240
ARG A 288
ILE A 293
THR A 242
 None
 1.06A 3cl9A-3e53A:
0.7		 3cl9A-3e53A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB150_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 3e53 FATTY-ACID-COA
LIGASE FADD28
(Mycobacterium
tuberculosis) 		5 / 12 PHE A 273
ILE A 325
THR A 340
VAL A 226
ILE A 227
 None
 0.97A 3em0B-3e53A:
undetectable		 3em0B-3e53A:
14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F33_A_PFLA2001_1
(FERRITIN LIGHT CHAIN)		 3e53 FATTY-ACID-COA
LIGASE FADD28
(Mycobacterium
tuberculosis) 		4 / 6 LEU A  44
TYR A  45
ARG A  47
LEU A  10
 None
 0.91A 3f33A-3e53A:
undetectable		 3f33A-3e53A:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RAV_A_RAVA183_1
(FERRITIN LIGHT CHAIN)		 3e53 FATTY-ACID-COA
LIGASE FADD28
(Mycobacterium
tuberculosis) 		4 / 6 LEU A  44
TYR A  45
ARG A  47
LEU A  10
 None
 0.92A 3ravA-3e53A:
undetectable		 3ravA-3e53A:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_A_ACTA504_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 3e53 FATTY-ACID-COA
LIGASE FADD28
(Mycobacterium
tuberculosis) 		3 / 3 THR A 444
VAL A 405
GLU A 333
 None
 0.70A 3v4tA-3e53A:
undetectable
3v4tD-3e53A:
undetectable		 3v4tA-3e53A:
23.48
3v4tD-3e53A:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQ8_B_DVAB8_0
(VAL-GRAMICIDIN A)		 3e53 FATTY-ACID-COA
LIGASE FADD28
(Mycobacterium
tuberculosis) 		3 / 3 TRP A 216
VAL A 240
TRP A 254
 None
 1.36A 3zq8A-3e53A:
undetectable
3zq8B-3e53A:
undetectable		 3zq8A-3e53A:
3.00
3zq8B-3e53A:
3.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E0F_A_RBFA301_1
(RIBOFLAVIN SYNTHASE
SUBUNIT ALPHA)		 3e53 FATTY-ACID-COA
LIGASE FADD28
(Mycobacterium
tuberculosis) 		5 / 11 SER A  68
VAL A  65
LEU A 117
THR A 118
VAL A 114
 None
 1.13A 4e0fA-3e53A:
undetectable		 4e0fA-3e53A:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OK1_A_198A1001_1
(ANDROGEN RECEPTOR)		 3e53 FATTY-ACID-COA
LIGASE FADD28
(Mycobacterium
tuberculosis) 		5 / 12 LEU A  83
LEU A  80
GLY A  81
LEU A 117
VAL A 114
 None
 1.12A 4ok1A-3e53A:
undetectable		 4ok1A-3e53A:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UDA_A_DEXA1985_1
(MINERALOCORTICOID
RECEPTOR)		 3e53 FATTY-ACID-COA
LIGASE FADD28
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 195
ASN A 191
MET A 183
SER A 184
ARG A   4
 None
 1.42A 4udaA-3e53A:
undetectable		 4udaA-3e53A:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZB_C_ACTC401_0
(PROTON-GATED ION
CHANNEL)		 3e53 FATTY-ACID-COA
LIGASE FADD28
(Mycobacterium
tuberculosis) 		4 / 7 ILE A 325
PHE A 311
VAL A 324
ILE A 293
 None
 0.98A 4zzbC-3e53A:
undetectable
4zzbD-3e53A:
undetectable		 4zzbC-3e53A:
22.29
4zzbD-3e53A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GPG_A_RAPA301_2
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP3
SERINE/THREONINE-PRO
TEIN KINASE MTOR)		 3e53 FATTY-ACID-COA
LIGASE FADD28
(Mycobacterium
tuberculosis) 		5 / 9 LEU A  80
ARG A  87
THR A 119
TYR A  75
PHE A  79
 None
 1.36A 5gpgB-3e53A:
0.2		 5gpgB-3e53A:
12.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 3e53 FATTY-ACID-COA
LIGASE FADD28
(Mycobacterium
tuberculosis) 		5 / 12 ILE A 457
ASP A 222
VAL A 338
ALA A 334
VAL A 405
 None
 1.12A 5igiA-3e53A:
undetectable		 5igiA-3e53A:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 3e53 FATTY-ACID-COA
LIGASE FADD28
(Mycobacterium
tuberculosis) 		5 / 12 ILE A 457
VAL A 338
ALA A 334
VAL A 405
THR A 171
 None
 1.23A 5igiA-3e53A:
undetectable		 5igiA-3e53A:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGJ_A_CTYA402_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 3e53 FATTY-ACID-COA
LIGASE FADD28
(Mycobacterium
tuberculosis) 		5 / 12 ILE A 457
ASP A 222
VAL A 338
ALA A 411
VAL A 405
 None
 1.05A 5igjA-3e53A:
undetectable		 5igjA-3e53A:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_A_ACTA609_0
(NADH DEHYDROGENASE,
PUTATIVE)		 3e53 FATTY-ACID-COA
LIGASE FADD28
(Mycobacterium
tuberculosis) 		3 / 3 VAL A 214
SER A 215
TRP A 254
 None
 0.99A 5jwaA-3e53A:
undetectable		 5jwaA-3e53A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K9D_A_CE9A402_0
(DIHYDROOROTATE
DEHYDROGENASE
(QUINONE),
MITOCHONDRIAL)		 3e53 FATTY-ACID-COA
LIGASE FADD28
(Mycobacterium
tuberculosis) 		5 / 12 ALA A 272
LEU A 275
ALA A 276
THR A 280
PHE A 315
 None
 0.83A 5k9dA-3e53A:
undetectable		 5k9dA-3e53A:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODQ_A_ACTA703_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A)		 3e53 FATTY-ACID-COA
LIGASE FADD28
(Mycobacterium
tuberculosis) 		4 / 6 ARG A   4
ALA A   8
PRO A   7
GLU A 161
 None
 1.21A 5odqA-3e53A:
2.2		 5odqA-3e53A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA307_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 3e53 FATTY-ACID-COA
LIGASE FADD28
(Mycobacterium
tuberculosis) 		4 / 5 ASP A 124
PRO A  70
GLU A  74
THR A 119
 None
 1.42A 5uxcA-3e53A:
undetectable		 5uxcA-3e53A:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DGX_A_017A101_2
(PROTEASE)		 3e53 FATTY-ACID-COA
LIGASE FADD28
(Mycobacterium
tuberculosis) 		3 / 3 GLY A 453
ASP A 397
ILE A 386
 None
 0.60A 6dgxB-3e53A:
undetectable		 6dgxB-3e53A:
10.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_C_GLYC713_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 3e53 FATTY-ACID-COA
LIGASE FADD28
(Mycobacterium
tuberculosis) 		3 / 3 GLN A 194
TYR A 337
ASN A 191
 None
 0.91A 6dwdC-3e53A:
undetectable		 6dwdC-3e53A:
25.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKZ_A_SNPA414_0
(AROMATIC
PEROXYGENASE)		 3e53 FATTY-ACID-COA
LIGASE FADD28
(Mycobacterium
tuberculosis) 		4 / 5 PHE A 219
VAL A 336
PRO A 232
VAL A  76
 None
 1.17A 6ekzA-3e53A:
undetectable		 6ekzA-3e53A:
9.51