SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3e54'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CET_A_CLQA1001_0
(PROTEIN (L-LACTATE
DEHYDROGENASE))		 3e54 RRNA INTRON-ENCODED
ENDONUCLEASE
(Vulcanisaeta
distributa) 		5 / 9 VAL A 116
GLY A 114
ALA A 112
PHE A 105
ILE A  88
 None
 1.20A 1cetA-3e54A:
undetectable		 1cetA-3e54A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADS_A_IMNA1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3e54 RRNA INTRON-ENCODED
ENDONUCLEASE
(Vulcanisaeta
distributa) 		5 / 10 ILE A 156
GLY A  35
ARG A  37
LEU A 115
ILE A  26
 None
 1.07A 3adsA-3e54A:
undetectable		 3adsA-3e54A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		 3e54 RRNA INTRON-ENCODED
ENDONUCLEASE
(Vulcanisaeta
distributa) 		4 / 7 LEU A  38
ALA A 133
SER A  23
THR A 137
 None
 0.95A 4d7bA-3e54A:
undetectable		 4d7bA-3e54A:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WS0_A_URFA301_1
(URACIL-DNA
GLYCOSYLASE)		 3e54 RRNA INTRON-ENCODED
ENDONUCLEASE
(Vulcanisaeta
distributa) 		4 / 7 GLY A  20
TYR A  76
SER A  43
PHE A  42
 None
 1.14A 4ws0A-3e54A:
undetectable		 4ws0A-3e54A:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHZ_B_REAB602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)		 3e54 RRNA INTRON-ENCODED
ENDONUCLEASE
(Vulcanisaeta
distributa) 		5 / 9 ILE A 111
GLY A 114
LEU A 115
LEU A 126
LEU A 121
 None
 1.25A 5fhzB-3e54A:
undetectable		 5fhzB-3e54A:
15.84