SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3e57'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JTX_A_CVIA200_0
(HYPOTHETICAL
TRANSCRIPTIONAL
REGULATOR IN QACA
5'REGION)		 3e57 UNCHARACTERIZED
PROTEIN TM1382
(Thermotoga
maritima) 		5 / 12 ILE A  63
GLU A 114
TYR A  60
ILE A  58
THR A  72
 None
 1.07A 1jtxA-3e57A:
undetectable		 1jtxA-3e57A:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MEH_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 3e57 UNCHARACTERIZED
PROTEIN TM1382
(Thermotoga
maritima) 		5 / 10 SER A 134
ASN A 133
ILE A 132
GLY A 145
GLU A  52
 None
 1.29A 1mehA-3e57A:
undetectable		 1mehA-3e57A:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRK_B_TFPB203_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 3e57 UNCHARACTERIZED
PROTEIN TM1382
(Thermotoga
maritima) 		4 / 5 PHE A  32
LEU A 144
PHE A 128
SER A 187
 None
 1.35A 1wrkB-3e57A:
undetectable		 1wrkB-3e57A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X8V_A_ESLA472_1
(CYTOCHROME P450 51)		 3e57 UNCHARACTERIZED
PROTEIN TM1382
(Thermotoga
maritima) 		4 / 6 VAL A 190
LEU A 191
PHE A 195
MET A  64
 None
 0.97A 1x8vA-3e57A:
undetectable		 1x8vA-3e57A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8L_A_SAMA400_0
(HYPOTHETICAL PROTEIN
LMO1582)		 3e57 UNCHARACTERIZED
PROTEIN TM1382
(Thermotoga
maritima) 		5 / 12 ASN A 193
LEU A 192
VAL A  61
LEU A 129
GLY A  90
 None
 1.14A 2f8lA-3e57A:
undetectable		 2f8lA-3e57A:
25.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_B_9PLB501_1
(CYTOCHROME P450 2A6)		 3e57 UNCHARACTERIZED
PROTEIN TM1382
(Thermotoga
maritima) 		5 / 9 PHE A  18
PHE A  21
ASN A 133
GLY A 145
PHE A  35
 None
 1.32A 3t3rB-3e57A:
undetectable		 3t3rB-3e57A:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_B_9PLB501_1
(CYTOCHROME P450 2A6)		 3e57 UNCHARACTERIZED
PROTEIN TM1382
(Thermotoga
maritima) 		5 / 9 PHE A  21
PHE A  32
ASN A 133
GLY A 145
PHE A  35
 None
 1.25A 3t3rB-3e57A:
undetectable		 3t3rB-3e57A:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_C_9PLC501_1
(CYTOCHROME P450 2A6)		 3e57 UNCHARACTERIZED
PROTEIN TM1382
(Thermotoga
maritima) 		5 / 9 PHE A  18
PHE A  21
ASN A 133
GLY A 145
PHE A  35
 None
 1.30A 3t3rC-3e57A:
undetectable		 3t3rC-3e57A:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_D_9PLD501_1
(CYTOCHROME P450 2A6)		 3e57 UNCHARACTERIZED
PROTEIN TM1382
(Thermotoga
maritima) 		5 / 10 PHE A  18
PHE A  21
ASN A 133
GLY A 145
PHE A  35
 None
 1.25A 3t3rD-3e57A:
undetectable		 3t3rD-3e57A:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_D_9PLD501_1
(CYTOCHROME P450 2A6)		 3e57 UNCHARACTERIZED
PROTEIN TM1382
(Thermotoga
maritima) 		5 / 10 PHE A  21
PHE A  32
ASN A 133
GLY A 145
PHE A  35
 None
 1.28A 3t3rD-3e57A:
undetectable		 3t3rD-3e57A:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AJQ_A_DB8A800_2
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 3e57 UNCHARACTERIZED
PROTEIN TM1382
(Thermotoga
maritima) 		4 / 4 VAL A   9
ILE A  58
ASN A 133
VAL A 142
 None
 1.31A 5ajqA-3e57A:
undetectable		 5ajqA-3e57A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IH0_A_ERYA404_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 3e57 UNCHARACTERIZED
PROTEIN TM1382
(Thermotoga
maritima) 		5 / 12 ILE A 132
GLY A  23
ASN A 133
GLU A 127
PHE A  32
 None
 1.25A 5ih0A-3e57A:
undetectable		 5ih0A-3e57A:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AN0_A_HISA520_0
(HISTIDINOL
DEHYDROGENASE)		 3e57 UNCHARACTERIZED
PROTEIN TM1382
(Thermotoga
maritima) 		4 / 6 GLU A  49
ARG A  45
GLU A  47
ALA A  48
 None
 1.22A 6an0A-3e57A:
undetectable		 6an0A-3e57A:
20.32